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Search Results for " oncogenic "

Targets Recommended: TAM Receptor

67

抑制剂 & 化合物

5

天然产物

1

化合物库

42

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L9420	外泌体相关化合物库		76 compounds
	76 种外泌体相关的化合物，可以用于高通量和高内涵筛选；

化合物库

外泌体相关化合物库

Cat.No: L9420

Compounds: 76

Cat. No.	Product Name	Target	Signaling Pathways
T21302	UNC569 UNC 569	TAM Receptor	Tyrosine Kinase/Adaptors
	UNC569 (UNC 569) 是一种ATP 竞争性的、可逆、具有口服活性的Mer 激酶抑制剂，其IC50=2.9 nM，Ki=4.3 nM。它还抑制Axl 和Tyro3，IC50分别为 37 nM 和 48 nM。它可用于研究急性淋巴细胞白血病和非典型畸胎瘤/横纹肌瘤。
T4230	PF-3758309 hydrochloride PF-03758309 hydrochloride	Apoptosis; PAK	Apoptosis; Cytoskeletal Signaling
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) 是一种口服的、可逆的 ATP 竞争性PAK4抑制剂，Kd 为 2.7 nM，Ki 为 18.7 nM。它抑制锚定独立生长、诱导凋亡、细胞骨架重塑和抑制增殖，具有 PAK4 抑制剂的预期细胞功能。
T6626	PF-3758309 PF-309,PF-03758309,PF 3758309	Apoptosis; PAK	Apoptosis; Cytoskeletal Signaling
	PF-3758309 (PF-03758309) 是一种可口服的、可逆的 ATP 竞争性 PAK4抑制剂。它是一种 PAK4 抑制剂，可抑制锚定独立生长、诱导凋亡、细胞骨架重塑和抑制增殖。
T37422L	Ras Inhibitory Peptide acetate Ras Inhibitory Peptide acetate(159088-48-9 Free base)	Ras	GPCR/G Protein; MAPK
	Ras Inhibitory Peptide acetate 是一种参与 Ras 依赖性信号通路的肽，Ras 在致癌受体引发的人类癌症中起重要作用。
T7326	6H05 (TFA) 6H05 TFA,6H05 trifluoroacetate	Ras	GPCR/G Protein; MAPK
	6H05 TFA (6H05 trifluoroacetate) 是一种选择性变构致癌突变体 K-Ras(G12C) 抑制剂。
T6556	K-Ras(G12C) inhibitor 9	Raf	MAPK
	K-Ras(G12C) inhibitor 9 是致癌 K-Ras(G12C) 的变构抑制剂。
T9589	SI-113	SGK	Metabolism
	SI-113 是一种有效的选择性 SGK1 抑制剂，SGK1 是一种丝氨酸/苏氨酸蛋白激酶，可调节多种致癌信号级联反应。
T1744	BIX02188	Apoptosis; MEK	Apoptosis; MAPK
	BIX02188 是一种具有选择性和有效性的 MEK5 抑制剂，抑制 MEK5 诱导表达致癌突变体FLT3-ITD的细胞凋亡。
T6555	K-Ras(G12C) inhibitor 12	Apoptosis; Raf; Ras	Apoptosis; GPCR/G Protein; MAPK
	K-Ras(G12C) inhibitor 12是一种K-Ras(G12C)抑制剂，作用于H1792细胞，EC50为0.32 μM。
T2275	YK-4-279 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	YK 4-279是一种RNA 解旋酶A 与致癌转录因子EWS-FLI1结合抑制剂，能抑制ESFT 细胞增长，诱导凋亡。
T69980	XMU-MP-2	BTK; Protease	Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	XMU-MP-2 是一种有效和选择性的蛋白酶抑制剂，具有抗癌活性，在小鼠异种移植模型中抑制致癌 BRK 驱动的肿瘤的生长。
T6284	Onalespib AT13387,Onalespib (AT13387)	HSP	Cytoskeletal Signaling; Metabolism
	Onalespib (AT13387) 是一种合成的、口服生物可利用的热休克蛋白 90 (Hsp90) 小分子抑制剂，Kd 值为 0.71 nM。具有潜在的抗肿瘤活性。它选择性地与 Hsp90 结合，从而抑制其伴侣功能并促进参与肿瘤细胞增殖和存活的致癌信号蛋白的降解。
T60031	NRX-1933	Others	Others
	NRX-1933 是一种分子胶，可增强致癌转录因子 β-Catenin 与其同源 E3 连接酶 SCFβ-TrCP 之间的相互作用。
T8402	Regorafenib Hydrochloride 瑞戈非尼盐酸盐,BAY73-4506 hydrochloride	Raf; VEGFR; c-RET; PDGFR; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib Hydrochloride (BAY73-4506 hydrochloride) 是一种新型口服多激酶抑制剂，可抑制血管生成、基质和致癌受体酪氨酸激酶，具有强大的临床前抗肿瘤活性。它靶向作用于 VEGFR1/2/3、PDGFRβ、Kit、RET 和 Raf-1，IC50值分别为 13/4.2/46、22、7、1.5 和 2.5 nM。
T3646	RSL3 RSL3 1S,1S,3R-RSL3	Ferroptosis; GPX; Glutathione Peroxidase	Apoptosis; Metabolism; oxidation-reduction
	RSL3 (RSL3 1S) 是一种 GPX4 的抑制剂，抑制阻断 GSH 合成的 system xc- (IC50=100 nM)。RSL3 是一种不依赖 VDAC 的铁死亡激活剂，对携带致癌 RAS 的肿瘤细胞具有选择性。
T9072	Tuxobertinib BDTX-189	EGFR; HER; BTK; RIP kinase	Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂，具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。
TQ0048	BI-882370	Raf	MAPK
	BI-882370 是高选择性的RAF 激酶抑制剂，其结合位于 BRAF 激酶的 DFG-out 无活性构象处 (ATP 结合位点)。它抑制 SRC 家族激酶，也抑制 BRAFV600E-mutant、WT BRAF 和 CRAF 激酶，IC50值分别为 0.4、0.8 和 0.6 nM。
T17065	TFMB-(R)-2-HG	Others	Others
	TFMB-(R)-2-HG 是一种具有细胞膜渗透性的 (R)-2-HG，急性髓细胞性白血病的致癌因子。它能够响应雌激素戒断损害SCF ER-Hoxb8 细胞分化。
T21981	Phthalazinone pyrazole	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂，IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。
T20168	Aurothiomalate sodium 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂，可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂，也是一种抗风湿剂。
T63049	CHD1Li 6.11	Others	Others
	CHD1Li 6.11 是一种致癌 CHD1L 的有效抑制剂，能够作用于 cat-CHD1L 重组蛋白 (IC50: 3.3 μM)。CHD1Li 6.11 是一种口服具有活力的抗肿瘤剂，明显减少由分离的准间充质细胞 (M 表型) 产生的 CRC 异种移植物的肿瘤体积，这些细胞具有增强的致瘤特性。
T6017	Linsitinib OSI-906,林西替尼	IGF-1R	Tyrosine Kinase/Adaptors
	Linsitinib (OSI-906) 是选择性的、有效的、具有口服活性的IGF-1和胰岛素受体(IR)的双重抑制剂，IC50分别为 35 和 75 nM。
T8488	GMB-475	Bcr-Abl; PROTACs	Angiogenesis; Cytoskeletal Signaling; PROTAC; Tyrosine Kinase/Adaptors
	GMB-475 是一种基于PROTAC 的BCR-ABL1酪氨酸激酶降解剂，克服了BCR-ABL1依赖的耐药性。 GMB-475 靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel Lindau (VHL)。导致泛素化和随后的致癌融合蛋白降解
T68405	KW-2450 free base	IGF-1R	Tyrosine Kinase/Adaptors
	KW-2450 free base 是一种 IGF-1R/IR和酪氨酸激酶多重抑制剂具有抗肿瘤活性。KW-2450 free base 在小鼠 HT-29/GFP 结肠癌异种移植模型中显示出适度的生长抑制活性并抑制 IGF-1 诱导的信号转导。
T1931	6H05 K-Ras inhibitor	Raf; Ras	GPCR/G Protein; MAPK
	6H05 (K-Ras inhibitor) 是致癌突变体 K-Ras(G12C) 的选择性变构抑制剂。
T10846	CMLD010509 SDS-1-021	Others	Others
	CMLD010509 (SDS-1-021) is a highly selective inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MDM2, CCND1, MYC, MAF, and MCL-1.
T70476	SML-10-70-1	Others	Others
	SML-10-70-1 is a Novel Active Site Inhibitor of Oncogenic K-Ras G12C.
T33219	MB725 MB 725,MB-725	Others	Others
	MB725 is a strong and selective inducer of viability reduction in several cancer cell lines containing the oncogenic p53-Y220C mutation.
T32419	KRAS4b-PDEδ stabilizer C19	Others	Others
	KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via decreased activation of oncogenic KRAS4b signaling.
T34670	SNIPER(ABL)-38	Others	Others
	SNIPER(ABL)-38 is a specific and nongenetic IAP-dependent protein eraser (SNIPER) which acts as a protein degradation inducer of oncogenic BCR-ABL protein.
T71635	Murayaquinone	Others	Others
	Murayaquinone is a hepatitis C virus proteinase inhibitor and small molecule antagonist of the oncogenic Tcf/β-catenin protein complex.
T29159	WJD008 WJD-008,WJD 008	Others	Others
	WJD008 is a dual inhibitor of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin. WJD008 prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant. WJD008 has antiproliferative and anticlonogeni
T71717	KRAS4b-IN-D14	Others	Others
	KRAS4b-IN-D14 is a specific inhibitor of oncogenic KRAS4b signaling which stabilizes the KRAS4b-PDEδ complex and remarkably decreases tumor size and triggered apoptosis of tumor cells.
T69264	Aristeromycin diphosphate	Others	Others
	Aristeromycin diphosphate is an inhibitor of S-adenosylhomocysteine hydrolase (AHCY), inducing miR-26a and regulating oncogenic EZH2 expression, showing high inhibitory activity against AHCY, and causing growth inhibition of prostate cancer.
TP1979	NLS-StAx-h
	Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
T68383	BIIB028	Others	Others
	BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o...
T82381	Fmoc-Thr(GalNAc(Ac)3-β-D)-OH
	Fmoc-Thr(GalNAc(Ac)3-β-D)-OH 通过抑制癌细胞生长及增强免疫反应的方式，针对特定癌症途径发挥作用。
T71837	HBX	Others	Others
	HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also significantly inhibits virus genome replication and progeny release of all adenovirus types tested, with the exception of types 12 and 31, from tested species.
T75140	CPD-1224	Others	Others
	CPD-1224 是口服有效的 ALK 抑制剂，是耦连cereblon 配体的ALK 抑制剂衍生物。CPD-1224 靶向 EML4-ALK 致癌融合蛋白，并降解 ALK 和突变体 L1196M/G1202R。
T39688	Zeteletinib BOS-172738,DS-5010,Zeteletinib	Others	Others
	Zeteletinib (BOS-172738; DS-5010) is a highly potent and selective orally active inhibitor of the RET kinase. It demonstrates nanomolar potency against RET while exhibiting over 300-fold selectivity against VEGFR2. Zeteletinib exhibits remarkable efficacy against the wild-type RET, RET V804M/L gatekeeper mutants, as well as the frequently occurring oncogenic RET mutation M918T. Its antitumor activity is potent.
T38128	Leukotriene D4 LTD4	Endogenous Metabolite; Drug Metabolite	Metabolism
	Leukotriene D4 (LTD4) 是一种由花生四烯酸形成的强效促炎介质，是一种支气管收缩剂，可诱导成骨细胞衰老。Leukotriene D4 诱导潜在致癌基因的转录活性，可用于研究哮喘。
T70424	EBI-907	Others	Others
	EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E)-dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases i...
T9661	MB710	Others	Others
	MB710 是一种氨基苯并噻唑衍生物，是致癌 p53 突变体 Y220C 的稳定剂。MB710 与 Y220C 口袋紧密结合并稳定p53-Y220C，Kd 值为 4 μM。 MB710 在 p53-Y220C 细胞系中显示抗癌活性。
T39927	Zeteletinib hemiadipate BOS-172738 hemiadipate,DS-5010hemiadipate,Zeteletinib hemiadipate	Others	Others
	Zeteletinib hemiadipate (BOS-172738; DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various forms of RET, including the wild type, RET V804M/L gatekeeper mutants, and the oncogenic RET mutation M918T. Additionally, Zeteletinib hemiadipate exerts potent antitumor effects.
T74278	HSP70-IN-3	Others	Others
	HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的 IC50分别为1.1和1.9 μM)。HSP70-IN-3 具有抗 Hedgehog 信号转导通路活性和抗增殖活性，并降低致癌转录因子 GLI1 的表达。
T63970	EZH2-IN-11	Others	Others
	EZH2-IN-11 是 E2HZ 的有效抑制剂。其中 EZH2 的致癌活性已被各种不同癌症类型中的大量研究中证实。EZH2-IN-11 对癌症疾病表现出研究潜力。
T69055	PD153035 nitrate	Others	Others
	PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also...
T68760	Luminespib mesylate	Others	Others
	Luminespib, also known as AUY-922, NVP-AUY922, VER52296, is a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range of human tumor cell lines.
T35538	HPI-1 (hydrate) HPI-1 hydrate	Others	Others
	HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, prev...
T78694	SHP2-IN-13	Others	Others
	SHP2-IN-13是一种针对SHP2“tunnel site” 的变构抑制剂，具备高选择性及口服活性，IC50值为83.0 nM。该化合物可作为研究潜力药物，用于治疗携带RTK致癌驱动因素的癌症以及SHP2相关疾病。

化合物

Cat.No: T21302

Synonym: UNC 569

Target: TAM Receptor

PF-3758309 hydrochloride

Cat.No: T4230

Synonym: PF-03758309 hydrochloride

Target: Apoptosis, PAK

Cat.No: T6626

Synonym: PF-309,PF-03758309,PF 3758309

Target: Apoptosis, PAK

Ras Inhibitory Peptide acetate

Cat.No: T37422L

Synonym: Ras Inhibitory Peptide acetate(159088-48-9 Free base)

Target: Ras

Cat.No: T7326

Synonym: 6H05 TFA,6H05 trifluoroacetate

Target: Ras

K-Ras(G12C) inhibitor 9

Cat.No: T6556

Target: Raf

Cat.No: T9589

Target: SGK

Cat.No: T1744

Target: Apoptosis, MEK

K-Ras(G12C) inhibitor 12

Cat.No: T6555

Target: Apoptosis, Raf, Ras

Cat.No: T2275

Synonym: 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T69980

Target: BTK, Protease

Cat.No: T6284

Synonym: AT13387,Onalespib (AT13387)

Target: HSP

Cat.No: T60031

Target: Others

Regorafenib Hydrochloride

Cat.No: T8402

Synonym: 瑞戈非尼盐酸盐,BAY73-4506 hydrochloride

Target: Raf, VEGFR, c-RET, PDGFR, Autophagy

Cat.No: T3646

Synonym: RSL3 1S,1S,3R-RSL3

Target: Ferroptosis, GPX, Glutathione Peroxidase

Cat.No: T9072

Synonym: BDTX-189

Target: EGFR, HER, BTK, RIP kinase

Cat.No: TQ0048

Target: Raf

Cat.No: T17065

Target: Others

Phthalazinone pyrazole

Cat.No: T21981

Target: Aurora Kinase

Aurothiomalate sodium

Cat.No: T20168

Synonym: 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Target: Others, PKC

Cat.No: T63049

Target: Others

Cat.No: T6017

Synonym: OSI-906,林西替尼

Target: IGF-1R

Cat.No: T8488

Target: Bcr-Abl, PROTACs

KW-2450 free base

Cat.No: T68405

Target: IGF-1R

Cat.No: T1931

Synonym: K-Ras inhibitor

Target: Raf, Ras

Cat.No: T10846

Synonym: SDS-1-021

Target: Others

Cat.No: T70476

Target: Others

Cat.No: T33219

Synonym: MB 725,MB-725

Target: Others

KRAS4b-PDEδ stabilizer C19

Cat.No: T32419

Target: Others

Cat.No: T34670

Target: Others

Cat.No: T71635

Target: Others

Cat.No: T29159

Synonym: WJD-008,WJD 008

Target: Others

Cat.No: T71717

Target: Others

Aristeromycin diphosphate

Cat.No: T69264

Target: Others

Cat.No: TP1979

Cat.No: T68383

Target: Others

Fmoc-Thr(GalNAc(Ac)3-β-D)-OH

Cat.No: T82381

Cat.No: T71837

Target: Others

Cat.No: T75140

Target: Others

Cat.No: T39688

Synonym: BOS-172738,DS-5010,Zeteletinib

Target: Others

Cat.No: T38128

Synonym: LTD4

Target: Endogenous Metabolite, Drug Metabolite

Cat.No: T70424

Target: Others

Cat.No: T9661

Target: Others

Zeteletinib hemiadipate

Cat.No: T39927

Synonym: BOS-172738 hemiadipate,DS-5010hemiadipate,Zeteletinib hemiadipate

Target: Others

Cat.No: T74278

Target: Others

Cat.No: T63970

Target: Others

PD153035 nitrate

Cat.No: T69055

Target: Others

Luminespib mesylate

Cat.No: T68760

Target: Others

HPI-1 (hydrate)

Cat.No: T35538

Synonym: HPI-1 hydrate

Target: Others

Cat.No: T78694

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S1683	Demethoxycurcumin Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin	Apoptosis; Antioxidant; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction
	Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分，有抗炎和抗癌作用。
T3763	Fumaric acid Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸	Endogenous Metabolite	Metabolism
	Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关，是癌症相关的内源性代谢物。
T40667	L-Azatyrosine	Others	Others
	L-Azatyrosine, an antitumor antibiotic derived from Streptomyces chibaensis, exhibits the ability to restore the normal phenotypic behavior of transformed cells that carry oncogenic Ras genes.
TN4028	Euchrestaflavanone B	PARP; Antifection	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of
T82326	Genkwadaphnin
	Genkwadaphnin是一种瑞香烷二萜，能够靶向内输蛋白importin-β1，减少CRPC核心驱动因子在细胞核内的积累，并关闭其下游致癌信号通路。此外，Genkwadaphnin在小鼠体内显现出能显著抑制去势抵抗性前列腺癌(CRPC)发展的抗癌活性。

天然产物

Demethoxycurcumin

Cat.No: T6S1683

Synonym: Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Cat.No: T3763

Synonym: Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸

Target: Endogenous Metabolite

Cat.No: T40667

Target: Others

Euchrestaflavanone B

Cat.No: TN4028

Target: PARP, Antifection

Cat.No: T82326

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03382	FGF-6 Protein, Human, Recombinant HBGF-6,HST2,fibroblast growth factor 6	Human	E. coli
	FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene d...
TMPY-04125	PTP1B Protein, Human, Recombinant (His) protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN...	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p...
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain) HME,ME,MMP-12,MME,matrix metallopeptidase 12	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ...
TMPJ-00375	HGF Protein, Human, Recombinant (His) Scatter factor,Hepatocyte growth factor,HGF,SF,Hepatopoietin...	Human	HEK293 Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelia...
TMPH-00547	Epstein-Barr virus (strain B95-8) BARF1 Protein (His & Myc) 33 kDa early protein,p33,Secreted protein BARF1	EBV	E. coli
	Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.
TMPH-00546	Epstein-Barr virus (strain GD1) BARF1 Protein (His) 33 kDa early protein,BARF1,p33,Secreted protein BARF1	EBV	E. coli
	Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.
TMPK-01381	CSPG4/MCSP Protein, Cynomolgus, Recombinant (His) MCSPG,CSPG4,MCSP,NG2	Cynomolgus	HEK293 Cells
	The chondroitin sulfate proteoglycan-4 (CSPG4) is a cell surface proteoglycan overexpressed in a huge range of human and canine neoplastic lesions by tumor cells, tumor microenvironment and cancer initiating cells. CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization.
TMPK-00927	ALK Protein, Mouse, Recombinant (hFc) CD246,Anaplastic lymphoma kinase,ALK tyrosine kinase recepto...	Mouse	HEK293 Cells
	Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises.
TMPK-01045	IL-20RA Protein, Mouse, Recombinant (hFc) IL-20R1,CRF2-8,IL-20R-alpha,IL-20RA,IL-20R-α,FLJ40993,ZcytoR...	Mouse	HEK293 Cells
	IL-20RA was highly expressed in the tumor tissue of CRC and related to the advanced stage.IL-20RA was involved in regulating oncogenic and immune pathways and affecting the expression of genes related to cell proliferation and immune evasion in CRC.Super-enhancer inhibition by JQ-1 or iBET-151 suppressed the growth of tumor cells and inhibited the expression of IL-20RA.
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST) pellino E3 ubiquitin protein ligase 1,PRISM	Human	Baculovirus Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages.
TMPK-00479	AGER Protein, Cynomolgus, Recombinant (His) AGER,RAGE,SCARJ1	Cynomolgus	HEK293 Cells
	The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) PEMT,Episialin,Mucin1,PUM,KL-6,MUC-1,Mucin-1,H23AG,PEM,CA 15...	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.
TMPJ-00703	Gankyrin Protein, Human, Recombinant PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulatory Subunit...	Human	E. coli
	Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
TMPK-00952	CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc) BILL-cadherin,Cadherin-17,LI-cadherin,CDH16,cadherin-16,Cdh1...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc) is exp...
TMPK-00947	CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated CDH16,Cdh17,P130,cadherin-16,HPT-1,LI-cadherin,Cadherin-17,B...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated...
TMPK-00950	CDH17 Domain 6-7 Protein, Human, Recombinant (hFc) HPT-1,P130,MGC138218,LI-cadherin,FLJ26931,cadherin-16,Cdh17,...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 6-7 Protein, Human, Recombinant (hFc) is expre...
TMPK-01223	CDH17 Protein, Mouse, Recombinant (His) CDH16,LI-cadherin,Cdh17,MGC138218,HPT-1,MGC142024,FLJ26931,B...	Mouse	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Mouse, Recombinant (His) is expressed in HEK...
TMPK-00473	CDH17 Protein, Rhesus macaque, Recombinant (His) CDH16,Cdh17,MGC142024,Cadherin-17,cadherin-16,P130,MGC138218...	Rhesus	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Rhesus macaque, Recombinant (His) is express...
TMPK-01224	CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated P130,BILL-cadherin,LI-cadherin,MGC138218,FLJ26931,CDH16,Cadh...	Mouse	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant ...
TMPK-00949	CDH17 Domain 7 Protein, Human, Recombinant (hFc) CDH16,P130,MGC142024,Cdh17,FLJ26931,Cadherin-17,MGC138218,ca...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 7 Protein, Human, Recombinant (hFc) is express...
TMPK-00555	CDH17 Protein, Cynomolgus, Recombinant (His) Cdh17,HPT-1,FLJ26931,LI-cadherin,BILL-cadherin,P130,Cadherin...	Cynomolgus	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Cynomolgus, Recombinant (His) is expressed i...
TMPK-00948	CDH17 Protein, Human, Recombinant (hFc) Cdh17,cadherin-16,FLJ26931,Cadherin-17,HPT-1,P130,CDH16,LI-c...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Human, Recombinant (hFc) is expressed in HEK...
TMPY-01584	PR-Set7 Protein, Human, Recombinant SET8,SET07,PR-Set7,SET domain containing (lysine methyltrans...	Human	E. coli
	KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a re...
TMPH-02835	PDGFD Protein, Mouse, Recombinant (His & SUMO) Platelet-derived growth factor D,Pdgfd,Spinal cord-derived g...	Mouse	E. coli
	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including inf...
TMPJ-00465	PTP1C Protein, Human, Recombinant (His) HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase,SH-PTP1,...	Human	E. coli
	Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter...
TMPY-03125	SHP-2 Protein, Mouse, Recombinant (His) SAP-2,Syp,PTP1D,SH-PTP2,SH-PTP3,SHP-2,PTP2C,2700084A17Rik,AW...	Mouse	HEK293 Cells
	SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat...
TMPY-03296	SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) SH-PTP1,Hcph,70Z-SHP,Ptp1C,protein tyrosine phosphatase, non...	Mouse	Baculovirus Insect Cells
	PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ...
TMPJ-01113	RCN2 Protein, Human, Recombinant (His) Reticulocalbin-2,ERC55,RCN2,E6BP	Human	HEK293 Cells
	Reticulocalbin-2 (RCN2, also named as ERC-55), is a 55-kDa Ca2+-binding protein containing six EF-hands, which was identified to be localized in endoplasmic reticulum. RCN2 is belonging to Reticulocalbin (RCN) family, the family members could play oncogenic roles in human malignancies and facilitate tumor cell proliferation and metastasis. Recently, studies on RCN2 functions mainly focused on its role in differentiation and endocrine regulation in mouse. Another study has suggested that RCN2 cou...
TMPH-02312	Wilms tumor protein/WT1 Protein, Human, Recombinant (His & SUMO) WT1,WT33,Wilms tumor protein	Human	E. coli
	Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may b...
TMPK-00953	CDH17 Domain 6-7 Protein, Human, Recombinant (mFc) Cdh17,CDH16,MGC138218,BILL-cadherin,HPT-1,cadherin-16,MGC142...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 6-7 Protein, Human, Recombinant (mFc) is expre...
TMPK-00951	CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated FLJ26931,CDH16,LI-cadherin,MGC138218,cadherin-16,Cadherin-17...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, R...
TMPY-03263	RUVBL1 Protein, Human, Recombinant (His) TIH1,ECP54,TIP49,RuvB-like AAA ATPase 1,PONTIN,TIP49A,INO80H...	Human	Baculovirus Insect Cells
	RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. RUVBL1 is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. RUVBL1 plays an essential role in oncogenic transformati...
TMPY-04205	AGR3 Protein, Human, Recombinant (mFc) hAG-3,AG3,HAG3,anterior gradient 3,PDIA18,BCMP11,AG-3	Human	HEK293 Cells
	Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been...
TMPJ-00319	PFKFB3 Protein, Human, Recombinant (His) PFK/FBPase 3,PFK2,IPFK2,iPFK-2	Human	E. coli
	Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic c...
TMPY-03047	Stathmin 1 Protein, Human, Recombinant (His) SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR22	Human	E. coli
	Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom...
TMPY-04474	PFKFB3 Protein, Human, Recombinant (His & GST) IPFK2,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3,...	Human	Baculovirus Insect Cells
	Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, is a potent activator of phosphofructokinase, which is a rate-limiting enzyme of glycolysis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control point in glycolysis. The concentration of PFK2 de...
TMPY-02763	DEP-1 Protein, Human, Recombinant (aa 997-1337, His) HPTPeta,SCC1,protein tyrosine phosphatase, receptor type, J,...	Human	E. coli
	DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His) eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...
TMPY-01769	4EBP1 Protein, Human, Recombinant (His) 4E-BP1,eukaryotic translation initiation factor 4E binding p...	Human	E. coli
	The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, a...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc) Thyroid receptor-interacting protein 12,E3 ubiquitin-protein...	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag...
TMPY-02198	ILKAP Protein, Human, Recombinant (His) ILKAP3,PP2C-δ,PP2C-DELTA,integrin-linked kinase-associated s...	Human	HEK293 Cells
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels are evident in various smooth muscle tissues. ILKAP may play a role in the regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferat...
TMPY-02527	p53R2 Protein, Human, Recombinant (His) P53R2,MTDPS8A,MTDPS8B,ribonucleotide reductase M2 B (TP53 in...	Human	E. coli
	Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. RRM2B is a phospho...

重组蛋白

FGF-6 Protein, Human, Recombinant

Cat.No: TMPY-03382

Species: Human

Expression System: E. coli

PTP1B Protein, Human, Recombinant (His)

Cat.No: TMPY-04125

Species: Human

Expression System: E. coli

MMP-12 Protein, Human, Recombinant (catalytic domain)

Cat.No: TMPY-02869

Species: Human

Expression System: E. coli

HGF Protein, Human, Recombinant (His)

Cat.No: TMPJ-00375

Species: Human

Expression System: HEK293 Cells

Epstein-Barr virus (strain B95-8) BARF1 Protein (His & Myc)

Cat.No: TMPH-00547

Species: EBV

Expression System: E. coli

Epstein-Barr virus (strain GD1) BARF1 Protein (His)

Cat.No: TMPH-00546

Species: EBV

Expression System: E. coli

CSPG4/MCSP Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01381

Species: Cynomolgus

Expression System: HEK293 Cells

ALK Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00927

Species: Mouse

Expression System: HEK293 Cells

IL-20RA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01045

Species: Mouse

Expression System: HEK293 Cells

Pellino-1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00361

Species: Human

Expression System: Baculovirus Insect Cells

AGER Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00479

Species: Cynomolgus

Expression System: HEK293 Cells

Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00828

Species: Human

Expression System: HEK293 Cells

Gankyrin Protein, Human, Recombinant

Cat.No: TMPJ-00703

Species: Human

Expression System: E. coli

CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc)

Cat.No: TMPK-00952

Species: Human

Expression System: HEK293 Cells

CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00947

Species: Human

Expression System: HEK293 Cells

CDH17 Domain 6-7 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00950

Species: Human

Expression System: HEK293 Cells

CDH17 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01223

Species: Mouse

Expression System: HEK293 Cells

CDH17 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00473

Species: Rhesus

Expression System: HEK293 Cells

CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated

Cat.No: TMPK-01224

Species: Mouse

Expression System: HEK293 Cells

CDH17 Domain 7 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00949

Species: Human

Expression System: HEK293 Cells

CDH17 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00555

Species: Cynomolgus

Expression System: HEK293 Cells

CDH17 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00948

Species: Human

Expression System: HEK293 Cells

PR-Set7 Protein, Human, Recombinant

Cat.No: TMPY-01584

Species: Human

Expression System: E. coli

PDGFD Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02835

Species: Mouse

Expression System: E. coli

PTP1C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00465

Species: Human

Expression System: E. coli

SHP-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03125

Species: Mouse

Expression System: HEK293 Cells

SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)

Cat.No: TMPY-03296

Species: Mouse

Expression System: Baculovirus Insect Cells

RCN2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01113

Species: Human

Expression System: HEK293 Cells

Wilms tumor protein/WT1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02312

Species: Human

Expression System: E. coli

CDH17 Domain 6-7 Protein, Human, Recombinant (mFc)

Cat.No: TMPK-00953

Species: Human

Expression System: HEK293 Cells

CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00951

Species: Human

Expression System: HEK293 Cells

RUVBL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03263

Species: Human

Expression System: Baculovirus Insect Cells

AGR3 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04205

Species: Human

Expression System: HEK293 Cells

PFKFB3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00319

Species: Human

Expression System: E. coli

Stathmin 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03047

Species: Human

Expression System: E. coli

PFKFB3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04474

Species: Human

Expression System: Baculovirus Insect Cells

DEP-1 Protein, Human, Recombinant (aa 997-1337, His)

Cat.No: TMPY-02763

Species: Human

Expression System: E. coli

EIF5A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03795

Species: Human

Expression System: E. coli

4EBP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01769

Species: Human

Expression System: E. coli

TRIP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01273

Species: Human

Expression System: E. coli

ILKAP Protein, Human, Recombinant (His)

Cat.No: TMPY-02198

Species: Human

Expression System: HEK293 Cells

p53R2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02527

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0181	Demethoxy Curcumin-d4
	Demethoxy Curcumin-d4 是 Demethoxy Curcumin 的氘代化合物。Demethoxy Curcumin 的 CAS 号为 22608-11-3。Demethoxycurcumin是姜黄素的主要活性成分，有抗炎和抗癌作用。

同位素标记化合物

Demethoxy Curcumin-d4

Cat.No: TMIH-0181

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