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Targets Recommended: Caspase

29

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11696	Ivachtin Caspase-3 Inhibitor VII	Caspase	Apoptosis; Proteases/Proteasome
	Ivachtin (Caspase-3 Inhibitor VII) 是一种非肽，非竞争性和可逆的caspase-3抑制剂，IC50为 23 nM。它是其余胱天蛋白酶的适度抑制剂。
T6139	A-674563 A674563	ERK; GSK-3; Akt; PKA; CDK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	A-674563 是一种口服有效，选择性的Akt1抑制剂，Ki=11 nM。
T11381	Pictilisib dimethanesulfonate GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt	Apoptosis; DNA-PK; PI3K; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) 是一种 PI3Kα/δ抑制剂，IC50值为 3 nM。对 p110β 和 p110γ的选择性分别为11倍和25倍。
T12338	OXFBD04	Epigenetic Reader Domain	Chromatin/Epigenetic
	OXFBD04 是有效的、选择性的 BRD4 抑制剂(IC50= 166 nM)。OXFBD04 是有效的 BET 溴结构域配体，具有对 CREBBP 溴结构域额外的适度亲和力。OXFBD04 显示出抗癌活性。
TQ0101	MKC3946	IRE1	Cell Cycle/Checkpoint
	MKC3946 是一种有效的可溶性 IRE1α 抑制剂，可在多发性骨髓瘤细胞系中引发适度的生长抑制，可用于癌症研究。
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))	ERK; Akt; PKA; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	A-674563 2HCl(552325-73-2(fb-2hcl)) 是一种 Akt1 抑制剂，Ki 为 11 nM，对 PKA 有效，对 Akt1 的选择性比 PKC 高 30 倍以上。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T6419	BMS-536924 HY-10262,胰岛素样生长因子-1 受体拮抗剂,BMS 536924,CS-0117	Apoptosis; FAK; MEK; IGF-1R; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	BMS-536924 (BMS 536924) 是一种具有口服活性，竞争性和选择性的胰岛素样生长因子受体激酶和胰岛素受体抑制剂，IC50分别为 100 nM 和 73 nM。它具有抗癌活性。
T6865	Quisinostat dihydrochloride Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。
T11143	EB-47	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	EB-47 是一种有效的 PARP-1/ARTD-1 选择性抑制剂，IC50 值为 45 nM，对 ARTD5 的IC50 值为 410 nM，表现出温和的药效。EB-47 模拟底物 NAD+，从烟酰胺延伸至腺苷亚区结合。
T2329	Dolutegravir sodium 度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Dolutegravir sodium (GSK-1349572A) 是一种高效、口服的 HIV 整合酶链转移抑制剂，在 HIV-1 整合酶催化的链转移中的 IC50值为 2.7 nM，抑制 HIV-1 病毒在外周血单个核细胞中的复制，IC50为 0.51 nM。它对 Y143R，N155H 和 G140S/Q148H 突变体也保持高效。
T15781	LP-935509	Serine/threonin kinase; AAK1 (AP2 associated kinase 1)	Cell Cycle/Checkpoint; Metabolism; Neuroscience
	LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂，其 IC50=3.3 nM，Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。
TQ0291	Firategrast SB 683699	Integrin	Cytoskeletal Signaling
	Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输，降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4，CD8和CD19淋巴细胞计数的适度降低有关。
T68095	Losulazine	Dopamine Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Losulazine 是一种新型的降压化合物。其确切的作用机制尚未确定，但其降压作用取决于完整的、功能性交感神经系统的存在。
T6055	Quisinostat 奎诺司他,JNJ-26481585	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat (JNJ-26481585) 是一种高效的，具有口服活性的 pan-HDAC 抑制剂，对 HDAC1、HDAC2、HDAC4、HDAC10、HDAC11 作用的 IC50值范围为 0.11-0.64 nM。它在成神经细胞瘤中能诱导自噬，具有广泛的抗肿瘤活性。
T28163	NEU-730	Others	Others
	NEU-730, a novel inhibitor of TbrPDEB1, shows modest inhibition of T. brucei proliferation.
T26710	Azapropazone DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85	Others	Others
	Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering
T32458	L 653328 L 653,328,L653328,L653,328,L-653,328,L-653328	Others	Others
	L 653328 is an ocular hypotensive agent that has modest beta-receptor blocking activity.
T41065	Atrial natriuretic factor (1-28) (human, porcine) Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28)
	Atrial natriuretic factor (1-28) from both human and porcine sources is a powerful suppressor of pro-opiomelanocortin (POMC) mRNA, while it only has a modest inhibition effect on βEP-LI release.
T68409	SHP244	Others	Others
	SHP244 is an allosteric inhibitor of SHP2 with modest thermal stabilization of the enzyme.
T26580	AI-4-57 Hydrochloride AI457 HCl,AI-4-57 HCl,AI 4 57 HCl	Others	Others
	AI-4-57 Hydrochloride is a ligand to the CBFß. AI-4-57 Hydrochloride is a modest potency inhibitor of the binding of wildtype CBFß to the RUNX1 Runt domain.
T71231	VMY-1-101	Others	Others
	VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B.
T84739	Topoisomerase IIα-IN-8	Others	Others
	TopoisomeraseIIα-IN-8 (compound 15)，作为人DNA拓扑异构酶IIa (htIIa) 的抑制剂，其IC50值为462 ± 38.0 μM，显示出较弱的抑制效果。
T32341	JWH-251	Others	Others
	JWH 251, a cannabimimetic indole, has a high affinity tothe central cannabinoid (CB1) receptor (Ki = 29 nM) and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM). JWH 251 can stimulates GTPγS and bind to CB1 and
T61335	Rucaparib hydrochloride	Others	Others
	Rucaparib hydrochloride, also known as AG014699, is a powerful and orally active compound that inhibits PARP proteins including PARP-1, PARP-2, and PARP-3 with a Ki value of 1.4 nM for PARP1. Additionally, Rucaparib hydrochloride acts as a modest inhibitor of hexose-6-phosphate dehydrogenase (H6PD). This compound shows potential in research for castration-resistant prostate cancer (CRPC) [1] [2] [3] [4].
T79606	CAF-382	CDK	Cell Cycle/Checkpoint
	CAF-382（compound B1）为SNS-032类似物，同时兼具CDKL5和泛CDK抑制功能，对GSK3α/β展现出较弱亲和性（>1.8 μM）及抑制效力。该化合物通过抑制CDKL5作用，进而阻止CDKL5 E2结构域发生磷酸化。
T73842	Leriglitazone hydrochloride	Others	Others
	Leriglitazone (Hydroxypioglitazone) hydrochloride，吡格列酮的代谢产物。Leriglitazone (Hydroxypioglitazone) hydrochloride 是PPARγ激动剂，通过稳定PPARγ(AF-2) 共激活剂结合表面和增强共激活剂结合能力，提供高转录效力。 Leriglitazone (Hydroxypioglitazone) hydrochloride 与 PPARγC (LBD) 结合，其Ki 值为 1.2 μM，诱导PPARγ(LBD) 转录效率，EC50为 680 nM。
T81772	MOG (92–106), mouse, rat
	MOG (92–106), mouse, rat 是一种来自小鼠/大鼠髓磷脂少突胶质细胞糖蛋白的生物活性肽，包含氨基酸片段92至106。在MOG (92–106) 诱导的实验性自身免疫性脑脊髓炎模型中，小鼠会对次级髓磷脂抗原呈现出广泛的B细胞反应性，尽管T细胞反应较弱。该肽段在SJL小鼠、DA大鼠以及恒河猴中均可诱导严重的脑炎。
T78135	Nicotelline Nicotellin	Others	Others
	Nicotelline（Nicotellin）是一种与尼古丁相关的生物碱，作为人类cDNA表达的细胞色素P-450 2A6（CYP2A6）的弱抑制剂，不显著抑制该酶介导的香豆素7-羟基化反应，在300 μM浓度下效果更是如此。此外，Nicotelline还被用作烟草烟雾中颗粒物（PM）的示踪剂和生物标记物。

化合物

Cat.No: T11696

Synonym: Caspase-3 Inhibitor VII

Target: Caspase

Cat.No: T6139

Synonym: A674563

Target: ERK, GSK-3, Akt, PKA, CDK

Pictilisib dimethanesulfonate

Cat.No: T11381

Synonym: GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T12338

Target: Epigenetic Reader Domain

Cat.No: TQ0101

Target: IRE1

A-674563 2HCl(552325-73-2(fb-2hcl))

Cat.No: T6139L

Target: ERK, Akt, PKA, CDK, PKC

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Cat.No: T6419

Synonym: HY-10262,胰岛素样生长因子-1 受体拮抗剂,BMS 536924,CS-0117

Target: Apoptosis, FAK, MEK, IGF-1R, Src

Quisinostat dihydrochloride

Cat.No: T6865

Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl

Target: Apoptosis, HDAC, Autophagy

Cat.No: T11143

Target: PARP

Dolutegravir sodium

Cat.No: T2329

Synonym: 度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A

Target: HIV Protease

Cat.No: T15781

Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1)

Cat.No: TQ0291

Synonym: SB 683699

Target: Integrin

Cat.No: T68095

Target: Dopamine Receptor, Norepinephrine

Cat.No: T6055

Synonym: 奎诺司他,JNJ-26481585

Target: Apoptosis, HDAC, Autophagy

Cat.No: T28163

Target: Others

Cat.No: T26710

Synonym: DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85

Target: Others

Cat.No: T32458

Synonym: L 653,328,L653328,L653,328,L-653,328,L-653328

Target: Others

Atrial natriuretic factor (1-28) (human, porcine)

Cat.No: T41065

Synonym: Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28)

Cat.No: T68409

Target: Others

AI-4-57 Hydrochloride

Cat.No: T26580

Synonym: AI457 HCl,AI-4-57 HCl,AI 4 57 HCl

Target: Others

Cat.No: T71231

Target: Others

Topoisomerase IIα-IN-8

Cat.No: T84739

Target: Others

Cat.No: T32341

Target: Others

Rucaparib hydrochloride

Cat.No: T61335

Target: Others

Cat.No: T79606

Target: CDK

Leriglitazone hydrochloride

Cat.No: T73842

Target: Others

MOG (92–106), mouse, rat

Cat.No: T81772

Cat.No: T78135

Synonym: Nicotellin

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T68351	Homodestcardin	Others	Others
	Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells.
TMA1890	Icariside F2 淫羊藿次苷F2	NF-κB	NF-κB
	Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-ÎºB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM.
TN3707	Coronarin B	Antifection	Microbiology/Virology
	Coronarin B has cytotoxic activity, it also has modest antiplasmodial activity.
TN5134	Tetrahydroxysqualene	Antifection	Microbiology/Virology
	Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.
TN4835	Przewalskin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
T38777	Ilexoside O	Others	Others
	Ilexoside O, a triterpene saponin derived from Ilex pubescens roots, demonstrates modest inhibition of xanthine oxidase (XOD) activity with an IC50 value of 53.05 μM.
T83481	1,1′-Disinomenine
	1,1'-Disinomenine，一种从Sinomenium acutum茎部分离得到的生物碱，对A549和Hela细胞表现出较弱的抑制效果。
T79960	Aloveroside A	Others	Others
	Aloveroside A为芦荟乙醇提取物分离得到的三葡萄糖基萘衍生物，其在100 μg/mL的剂量下展现出约18.68%的bACE抑制活性。
T80778	weak Hepatoprotective agent-1
	Weak Hepatoprotective agent-1 (Compound 11)，一种从Arctium lappa L. 分离得到的天然产物，在10 μM浓度下具有弱肝保护活性。
T75461	Harzianum A	Others	Others
	Harzianum A 是一种单端孢霉烯化合物，可从 Trichoderma harzianum 中分离得到。Harzianum A 对小仓鼠肾细胞没有细胞毒性，对革兰氏阴性和革兰氏阳性细菌没有活性，但在 100 μg/mL 时具有适度的抗真菌活性。
T75566	11-Oxomogroside II A1	Others	Others
	11-Oxomogroside II A1（化合物 7）是一种从罗汉果乙醇提取物中分离的氧化葫芦苷，对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）活化具有抑制效果，并对一氧化氮（NO）供体（+/-）-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺（NOR 1）的活化也展示出轻微的抑制作用。

天然产物

Cat.No: T68351

Target: Others

Cat.No: TMA1890

Synonym: 淫羊藿次苷F2

Target: NF-κB

Cat.No: TN3707

Target: Antifection

Tetrahydroxysqualene

Cat.No: TN5134

Target: Antifection

Cat.No: TN4835

Target: HIV Protease

Cat.No: T38777

Target: Others

1,1′-Disinomenine

Cat.No: T83481

Cat.No: T79960

Target: Others

weak Hepatoprotective agent-1

Cat.No: T80778

Cat.No: T75461

Target: Others

11-Oxomogroside II A1

Cat.No: T75566

Target: Others

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