99
20
2
140
Cat. No. | Product Name | ||
---|---|---|---|
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; | |||
L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8527 |
CPYPP
|
Others | Others |
CPYPP 是DOCK2-Rac1相互作用的抑制剂。它能够结合DOCK2DHR-2结构域,并以剂量依赖性方式抑制 DOCK2DHR-2 (IC50:22.8 µM) 对 Rac1 的鸟嘌呤核苷酸交换因子活性。它还抑制DOCK180和DOCK5,对 DOCK9 的抑制作用较小。 | |||
T3481 |
Bimolane
|
Topoisomerase | DNA Damage/DNA Repair |
Bimolane 是一种拓扑异构酶 II 抑制剂。 | |||
T23256 |
RS-25344 hydrochloride
|
PDE | Metabolism |
RS 25344 hydrochloride 是 cAMP-磷酸二酯酶 4 的选择性抑制剂,在人淋巴细胞中的 IC50为 0.28 nM,对 PDE I、II、III 仅具有微弱的抑制作用,IC50分别为 >100 μM、160 μM、330 μM。它具有抗炎、增强记忆力和认知能力以及抗肿瘤活性。 | |||
T6588 |
Mitoxantrone
米托蒽醌,mitozantrone |
Topoisomerase; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair |
Mitoxantrone (mitozantrone) 是一种拓扑异构酶 II (Topo II) 的抑制剂,一种蛋白激酶 C (PKC) 的抑制剂 (IC50=8.5 μM)。Mitoxantrone 具有抗肿瘤活性,可以治疗急性髓系白血病、肝细胞癌、乳腺癌等。 | |||
T6403 |
Siponimod
辛波莫德,BAF-312 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
Siponimod (BAF-312) 是有效,选择性的鞘氨醇-1-磷酸 (S1P)受体调节剂,对 S1P1 和 S1P5 受体具有特异性,EC50 分别为 0.39 nM 和 0.98 nM。 BAF312 对 S1P1 和 S1P5 受体的特异性比 S1P2、S1P3 和 S1P4 受体高 1000 倍以上。 | |||
T10765 |
Eragidomide
CC-90009,Cereblon modulator 1 |
Apoptosis; Ligand for E3 Ligase; Molecular Glues | Apoptosis; PROTAC |
Cereblon modulator 1 是一种 GSPT1 选择性cereblon (CRBN)E3 连接酶调节剂,以分子胶的方式作用。它通过 CRL4CRBN选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。 | |||
T7739 |
L-Leucyl-L-Leucine methyl ester hydrochloride
Leu-Leu-ome hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物,能够选择性消除具有细胞毒性潜能的淋巴细胞,也能够诱导溶酶体途径应激。 | |||
T0158 |
Mitoxantrone dihydrochloride
米托蒽醌二盐酸盐,盐酸米托蒽醌,Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride |
Topoisomerase; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair |
Mitoxantrone dihydrochloride (NSC-301739) 是一种拓扑异构酶 II 的抑制剂;也可抑制蛋白激酶C (PKC),IC50值为8.5 μM。 | |||
T6933 |
Peficitinib
ASP015K,JNJ-54781532 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Peficitinib (ASP015K) 是一种可口服的 JAK 抑制剂,对 JAK1、JAK2、JAK3 和 Tyk2 的IC50值分别为 3.9、5.0、0.7 和 4.8 nM。 | |||
T25705 |
Imupedone
LF1695,LF-1695,LF 1695 |
Others | Others |
Imupedone (LF 1695) 是一种合成免疫调节剂,可调节 T 淋巴细胞和巨噬细胞,诱导骨髓前体细胞的 T 细胞分化,增加淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应。 | |||
T16716 |
Rabacfosadine
VDC-1101,GS-9219 |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Rabacfosadine (GS-9219) 是向肿瘤淋巴细胞的无环核苷酸膦酸 PMEG 的新型双前药,可用于研究淋巴瘤。 | |||
T10565 |
BMS-1001 hydrochloride
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1001 hydrochloride 是一种人 PD-L1/PD-1免疫检查点的抑制剂,具有口服活性且细胞毒性低。 | |||
T26637 |
Antipain dihydrochloride
Antipain 2HCl,BDBM-32804,BDBM 32804, Antipain,BDBM32804 |
Protease | Proteases/Proteasome |
Antipain dihydrochloride (Antipain 2HCl) 是一种从 Actinomycetes 提取到的蛋白酶抑制剂,具有镇痛活性,抑制 X 射线诱导的人淋巴细胞染色体畸变。 | |||
TP1758L |
LCMV gp33-41 acetate
LCMV gp33-41 acetate(151705-84-9 Free base) |
Others | Others |
LCMV gp33-41 acetate 是淋巴细胞性脉络丛脑膜炎病毒的序列,受主要组织相容性复合体 I 类 H-2Db 限制,呈递给细胞毒性 T 淋巴细胞。 | |||
T21443 |
Prednicarbate
Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D |
Others | Others |
Prednicarbate (Hoe 777) 是一种外用皮质类固醇。Prednicarbate 可用于炎症性皮肤病的研究,如特应性皮炎。 | |||
T28918 |
Talviraline
Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979 |
HIV Protease; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
Talviraline (Bay 10-8979) 是一种 RNA 引导的 DNA 聚合酶抑制剂。Talviraline 对多种人类细胞系以及新鲜人类外周血淋巴细胞和巨噬细胞中的 HIV-1 诱导的细胞杀伤和 HIV-1 复制具有很强的抑制作用。 | |||
T6964 |
Resiquimod
R848,雷西莫特,S28463 |
HCV Protease; TLR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂,可诱导细胞因子上调。 | |||
T9919 |
Alemtuzumab
|
Others | Others |
Alemtuzumab 是人源化抗 CD52单克隆抗体, CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原,诱导淋巴细胞深度耗竭,恢复具有调节表型的 T 细胞和 B 细胞。 | |||
T36879L |
H-Leu-Leu-OMe . HBr
H-Leu-Leu-OMe . HBr (16689-14-8 Free base) |
Others | Others |
H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。 | |||
TP1527 |
CEF8, Influenza Virus NP (383-391)
CEF8, Influenza Virus NP 383-391 |
Others | Others |
CEF8, Influenza Virus NP (383-391) 是一种甲型流感病毒核蛋白,含有 383-391 残基,是甲型流感病毒核蛋白中重要的 HLA-B*2705 限制性表位,与细胞毒性 T 淋巴细胞介导的免疫逃逸有关。 | |||
T24362 |
L 756423
L756423,MK-944a,MK944a,L-756,423,L-756423,MK 944a |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
L 756423 (L756423) 是一种新型有效且具有选择性和竞争性的HIV蛋白酶抑制剂,对 HIV-1 PR 的 Ki 值为0.049 nM。L 756423 能阻止HIV(IIIb)感染的 MT25 淋巴细胞在0.50-0.1nM处的扩散,可用于研究获得性免疫缺陷综合征(AIDS)。 | |||
T4387 |
evobrutinib
MSC2364447C,M2951 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Evobrutinib(M2951) 也称为 M-2951 和 MSC-2364447C,是布鲁顿酪氨酸激酶(BTK) 的高选择性抑制剂,BTK 对包括 B 淋巴细胞和巨噬细胞在内的各种免疫细胞的发育和功能很重要。临床前研究表明它可能对某些自身免疫性疾病有治疗作用。 | |||
T2171 |
SEW2871
SEW2871 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
SEW 2871 是一种可口服的高选择性 S1P1激动剂,EC50为 13.8 nM。它减少血液中的淋巴细胞数量,可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路,并诱导 S1P1 内在化和再循环。 | |||
TP1543L |
G280-9 acetate(156761-76-1 free base)
|
Others | Others |
G280-9 acetate(156761-76-1 free base) 是一种常见的黑色素瘤 gp100 表位,受 MHC 相关 HLA-A2 限制。 G280-9 序列是独特的,因为它可以在非常低的浓度下被细胞毒性 T 淋巴细胞识别,但是它显示出低的总免疫原性,这可能是由于该肽对 HLA-A2 的亲和力相对较低。 | |||
T4674 |
SB297006
SB 297006 |
CCR | Immunology/Inflammation; Microbiology/Virology |
SB297006 是一种CCR3拮抗剂,IC50为39 nM。它能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。 | |||
TQ0291 |
Firategrast
SB 683699 |
Integrin | Cytoskeletal Signaling |
Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输,降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4,CD8和CD19淋巴细胞计数的适度降低有关。 | |||
T7055 |
Bz-RS-ISer(3-Ph)-Ome
Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物,在低细胞毒性下抑制 HSV 复制周期,阻断 Vero 细胞的有丝分裂,影响 M-MSV 诱导的肿瘤大小,并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。 | |||
T16132 |
MRE3008F20
|
cAMP; Adenosine Receptor | GPCR/G Protein; Neuroscience |
MRE3008F20 是一种具有种属选择性和高效性的腺苷 A3 受体(AA3R)拮抗剂,抑制 Cl-IB-MECA 诱导的 cAMP 的产生,可用于研究青光眼和哮喘。 | |||
T6665 |
Sertaconazole nitrate
FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑 |
Antibiotic; Antifungal | Microbiology/Virology |
Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药,可用于治疗浅表皮肤和粘膜感染。 | |||
T2548 |
Diflorasone
|
Glucocorticoid Receptor | Endocrinology/Hormones |
Diflorasone 是一种皮质类固醇激素受体激动剂,具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞,并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。 | |||
T28408 |
Phosphostim Sodium
IPH1101,Phosphostim,IPH 1101,IPH-1101 |
Others | Others |
Phosphostim, a gamma9deta2 T lymphocytes agonist, is used potentially for the treatment of renal cell carcinoma, HCV infection. | |||
T39145 |
4,6-Dichloroguaiacol
|
Others | Others |
4,6-Dichloroguaiacol elicits biochemical and morphological alterations in human peripheral blood lymphocytes in vitro. | |||
T31018 |
CP 115953
CP115953,Cp-115,953,CP-115953 |
Others | Others |
CP 115953 stimulated the production of cytokines by lymphocytes. CP 115953 inhibits the activity of topoisomerase II by interacting with the enzyme. | |||
T70889 |
Oxeclosporin
|
Others | Others |
Oxeclosporin is a hydroxyethyl derivative of serine(8)-cyclosporine; inhibits proliferation and functions of lymphocytes. | |||
T70307 |
POM2-C-HMBP
|
Others | Others |
POM2-C-HMBP is a potent Activator of Vγ9Vδ2 T-Lymphocytes. It is also an HMBPP ananlog prodrug. | |||
T30136 |
Armepavine hydrochloride, (+/-)-
DL-Armepavine hydrochloride |
Others | Others |
Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice. | |||
T14909 |
CCX140
3-三氟甲基-4-氯-N-[2-[7H-吡咯并[2,3-D]嘧啶-4-羰基]-5-甲基-3-吡啶基]苯磺酰胺,CCX140-B |
CCR | Immunology/Inflammation; Microbiology/Virology |
CCX140 (CCX140-B) 是 CCR2 的拮抗剂。 | |||
T69137 |
Oxophenarsine hydrochloride
|
Others | Others |
Oxophenarsine hydrochloride is a classical drug used to treat syphilis. Oxophenarsine HCl inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes. | |||
T11319 |
FR183998 free base
|
Na+/Ca2+ Exchanger | Membrane transporter/Ion channel |
FR183998 free base 是 Na+/Ca2+ 交换剂的抑制剂。 | |||
T39014 |
KSPWFTTL
|
||
KSPWFTTL is an immunodominant epitope derived from the p15E transmembrane protein. It is Kb-restricted and can enhance the susceptibility of a tumor cell line to cytotoxic T lymphocytes targeting anti-AKR/Gross MuLV. | |||
T17099 |
Timapiprant sodium
OC000459 sodium |
Others | Others |
Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), ra | |||
T28585 |
Ro 31-8588
Ro-31-8588 |
Others | Others |
Talviraline is a RNA-directed DNA polymerase inhibitor. HBY 097 is a highly potent inhibitor of HIV-1 replication and HIV-1 induced cell killing in a variety of human cell lines as well as in fresh human peripheral blood lymphocytes and macrophages. | |||
T69723 |
Taminadenant mesylate
|
Others | Others |
Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell sur... | |||
T76835 | Tositumomab | ||
Tositumomab 是一种靶向CD20抗原的小鼠IgG2a lambda 单克隆抗体,CD20抗原存在于正常和恶性B 淋巴细胞表面。 | |||
T27192 |
DMI-9523
DA-DKP,Ampion,DMI 9523,DM-9523 |
Others | Others |
DMI-9523 is nuclear factor NF-κB activation inhibitor. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. DA-DKP can modul | |||
T9901A-012 |
Ibritumomab
|
Others | Others |
Ibritumomab 是鼠 IgG1k 单克隆抗体,Ibritumomab 的互补-决定区域与 B 淋巴细胞上的 CD20 抗原结合。 | |||
TP1629 |
LCMV gp33-41 (TFA) (151705-84-9 free base)
LCMV gp33-41 (TFA) |
||
LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1]. | |||
T82060 |
Interleukin-6 fragment (human)
|
||
Interleukin-6 fragment (human) 是一种多效性细胞因子,由淋巴细胞及非淋巴细胞产生。该分子的编码基因位于人类第7号染色体,长度大约为5 kb。Interleukin-6 fragment (human) 在免疫响应、急性相应、炎症过程、癌症治疗及血液造血方面均有重要的潜在应用。 | |||
T35906 |
Padanamide A
|
Others | Others |
Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines, but is cytotoxic to Jurkat T lymphocytes with an IC50 value of approximately 60 μg/ml. | |||
TP1075 |
AUNP-12 TFA (1353563-85-5 free base)
AUNP-12 TFA,NP-12 TFA |
||
AUNP-12 TFA (NP-12 TFA) is a polypeptide antagonist in the pd-1 signaling pathway, which has the same antagonistic effect on pd-l1 and pd-l2, and can protect the proliferation and effector function of lymphocytes. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1697 |
Glucosyringic acid
葡萄糖基丁香酸 |
Immunology/Inflammation related | Immunology/Inflammation |
Glucosyringic acid 具有免疫抑制作用,在体外能抑制鼠 B 淋巴细胞的增殖。 | |||
T7924 |
8-Bromoguanosine
|
Others | Others |
8-Bromoguanosine 是鸟苷的溴化衍生物。它是通过细胞内机制激活淋巴细胞发挥免疫刺激作用。 | |||
T5S0777 |
Phellodendrine chloride
|
Others | Others |
Phellodendrine chloride 是一种Phellodendron amurense 中的生物碱。它通过巨胞饮抑制营养物质的吸收,进而抑制 KRAS 突变的胰腺癌细胞的增殖。 | |||
T37705 |
1,2,4-Trihydroxybenzene
Benzene-1,2,4-triol |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) 是咖啡豆烘焙的副产品,是在小鼠、阿拉伯咖啡中发现的。1,2,4-Trihydroxybenzene 是一种苯三醇, 它能增加大鼠胸腺淋巴细胞内的Ca2+浓度。 | |||
T6S0781 |
Phellodendrine
黄柏碱,Phallodendrin |
Others; NF-κB; Akt | Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling |
Phellodendrine (Phallodendrin) 是异喹啉生物碱,是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化,抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
TN1861 |
Licoflavone C
4',5,7-Trihydroxy-8-prenylflavone |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
Licoflavone C (4',5,7-Trihydroxy-8-prenylflavone) 是从 Glycyrrhiza inflata 的根部分离出来的异戊二烯基黄酮化合物,具有抗氧化和抗真菌活性,在培养的人类外周淋巴细胞中,它对 DAU 或 MMC 诱导的染色体损伤具有保护作用。Licoflavone C 可用于研究真菌感染。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
T2563 |
Acetyl-L-carnitine hydrochloride
Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂,具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外,乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应,并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。 | |||
T2144 |
Tacrolimus
他克莫司,Fujimycin,FK506,FR900506 |
Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling |
Tacrolimus (Fujimycin) 属于大环内酯类抗生素,可以与 FKBP12 结合形成高亲和力复合物 (Ki=0.2 nM),抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。Tacrolimus 是一种免疫抑制剂,通过抑制 IL-2 的释放,全面抑制 T 淋巴细胞的作用。 | |||
T13969L |
Xanthopterin
黄蝶呤,Ksantopterin |
Others | Others |
Xanthopterin could inhibit the growth of lymphocytes produced by concanavalin. | |||
T70221 |
Dibefurin
|
Others | Others |
Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes. | |||
T16160 |
Musk tibetene
Musk tibetine |
Others | Others |
Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity. | |||
T75502 |
Brazilein
|
Others | Others |
Brazilein为从Caesalpinia sappan L.中提取的关键免疫抑制成分,能够诱导小鼠脾淋巴细胞(apoptosis)。 | |||
TN5138 |
Teuclatriol
|
TNF; NF-κB; TLR | Apoptosis; Immunology/Inflammation; NF-κB |
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312µM and higher. It showed a significant anti-proliferative effect on human activated-peripheral blood lymphocytes (IC50, 72.8 ± 5.4 µg/ml). | |||
T14995 |
Concanamycin A
Folimycin,Concanamycin,X 4357B,Antibiotic X 4357B |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Concanamycin A (Folimycin) 是一种多聚环内酯类抗生素,是选择性空泡状 H+-ATP 酶 (V-ATPase) 和溶酶体酸化抑制剂,可用于研究炎症。Concanamycin A 可增强细胞毒性 T 淋巴细胞对受感染原代细胞的免疫清除,抑制来自 HIV 和猿猴免疫缺陷病毒不同分支的 Nef 等位基因,可用于研究HIV 感染。 | |||
T75692 |
Hypoglaunine D
|
Others | Others |
Hypoglaunine D 是 Triptonine B 的类似物,是一种抗HIV 的化合物,Hypoglaunine D 抑制 H9 淋巴细胞中HIV 病毒复制的EC50值为 22 μg/ml。 | |||
TN3152 |
6-Acetonyldihydrochelerythrine
|
ERK; BCL; Akt; HIV Protease; PPAR; p53 | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is | |||
TN4084 |
Fumitremorgin B
|
Antifection | Microbiology/Virology |
Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03956 |
Fas Ligand Protein, Human, Recombinant (His)
TNLG1A,FASL,FASLG,CD178,CD95-L,APT1LG1,APTL,CD95L,Fas ligand... |
Human | P. pastoris (Yeast) |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei... | |||
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,granzyme B (granzyme 2... |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPY-04779 |
BTN3A2 Protein, Human, Recombinant (His)
BTF3,BT3.2,BTF4,BTN3.2,CD277,butyrophilin subfamily 3 member... |
Human | HEK293 Cells |
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted... | |||
TMPY-00369 |
LY6D Protein, Human, Recombinant (mFc)
E48,lymphocyte antigen 6 complex, locus D,Ly-6D |
Human | HEK293 Cells |
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane protein... | |||
TMPJ-01469 |
NGF Protein, Human, Recombinant (E. colli)
NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Nerve Growt... |
Mouse | E. coli |
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo... | |||
TMPJ-00994 |
LTBR Protein, Mouse, Recombinant (hFc)
Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept... |
Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs... | |||
TMPY-02700 |
BCL2 Protein, Human, Recombinant (His)
Bcl-2,PPP1R50,B-cell CLL/lymphoma 2 |
Human | E. coli |
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins... | |||
TMPY-02153 |
TNF beta Protein, Human, Recombinant
LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α |
Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS... | |||
TMPK-01494 |
HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Tetramer Protein, Human, MHC (His & Avi)
HLA-A,HLA-A*0101,HLA class I,MHC,MHC HLA-A alpha,CT83,MHC cl... |
Human | HEK293 Cells |
Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy. | |||
TMPK-01496 |
HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Monomer Protein, Human, MHC (His & Avi)
HLA-A,CT83,HLA-A*0101,HLA class I,MHC class I,MHC,MHC HLA-A ... |
Human | HEK293 Cells |
Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy. | |||
TMPK-01541 |
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated
QA1,MHC HLA-E alpha-2.1,MHC,HLAE,MHC class I antigen E,MHC H... |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
TMPK-01544 |
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi)
MHC class I antigen E,HLAE,sHLA-E,QA1,MHC HLA-E alpha-2.1,MH... |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
TMPY-02795 |
Eotaxin-2 Protein, Human, Recombinant (His)
MPIF-2,chemokine (C-C motif) ligand 24,SCYA24,MPIF2,Ckb-6 |
Human | Baculovirus Insect Cells |
CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is als... | |||
TMPK-01545 |
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
sHLA-E,MHC,MHC class I antigen E,HLAE,MHC HLA-E alpha-1,MHC ... |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
TMPY-03779 |
CCL27 Protein, Human, Recombinant (His)
SCYA27,CTAK,ESKINE,ALP,PESKY,ILC,chemokine (C-C motif) ligan... |
Human | E. coli |
CCL27, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27 is chemotactic for skin-associated memory T lymphocytes. CCL27 may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27 plays a pivotal role in establishing the inflammatory infiltrate characteristic for common inflammatory skin diseases. Through binding to the chemokine receptor 1 (CCR1), CCL27 mediates ... | |||
TMPK-01452 |
HLA-E*01:03&B2M&Peptide (VMAPKTLVL) Monomer Negative Control Protein, Human, MHC (His & Avi)
HLAE,MHC class I antigen E,MHC,QA1,sHLA-E |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
TMPK-01514 |
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi)
sHLA-E,MHC class I antigen E,MHC HLA-E alpha-1,MHC,HLAE,QA1,... |
Human | HEK293 Cells |
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ... | |||
TMPJ-00759 |
VDB Protein, Human, Recombinant (His)
Group-Specific Component,DBP,VDB,GC,Gc-Globulin,Vitamin D-Bi... |
Human | HEK293 Cells |
Vitamin D-Binding Protein (DBP) is a member of the ALB/AFP/VDB family. DBP is a secreted protein and contains three albumin domains. The primary structure contains 28 cysteine residues forming multiple disulfide bonds. DBP acts as a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. DBP binds to vitamin D and its plasma metabolites and transports them to target tissues. DBP associates with membrane-bound immunoglobulin on... | |||
TMPK-01468 |
HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi)
SK29-AA,MLANA,LB39-AA,Melan-A,MART1 |
Human | HEK293 Cells |
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma. | |||
TMPJ-00824 |
Ig lambda constant 2 Protein, Human, Recombinant (His)
Ig λ constant 2 Protein, Human, Recombinant (His),MGC45681,I... |
Human | HEK293 Cells |
Immunoglobulin lambda constant region is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. IGLC2 is 105 amino acids (aa) in length. I... | |||
TMPJ-01341 |
CCL24 Protein, Mouse, Recombinant
Scya24,Eosinophil chemotactic protein 2,Small-inducible cyto... |
Mouse | E. coli |
Mouse CCL24 is a secreted protein, which is a member of the CC chemokine subfamily. Mouse Ccl24 cDNA encodes a 119 amino acid residue precursor protein, shares approximately 58% amino acid sequence identity with human Ccl24. It is predominantly expressed in the jejunum and spleen and also be induced in the lung by allergen challengeand IL4. Mouse ccl24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Ccl24 is chemotactic for resting T-lymphocytes, ... | |||
TMPK-01469 |
HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Monomer Protein, Human, MHC (His & Avi)
MLANA,SK29-AA,Melan-A,MART1,LB39-AA |
Human | HEK293 Cells |
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma. | |||
TMPH-01620 |
TNF beta Protein, Human, Recombinant (His)
Lymphotoxin-alpha,TNF-beta,LTA,Tumor necrosis factor ligand ... |
Human | HEK293 Cells |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. | |||
TMPK-00721 |
CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated
Neurotactin,CXC3C,ABCD-3,Fkn,Fractalkine,NTT,Cx3cl1,SCYD1,Cx... |
Mouse | HEK293 Cells |
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma. | |||
TMPH-03545 |
Enterotoxin type E Protein, S. aureus, Recombinant (His & SUMO)
Enterotoxin type E,SEE,entE |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. | |||
TMPJ-00223 |
SLAMF1 Protein, Human, Recombinant (His & Avi), Biotinylated
CDw150,CD150,SLAM,IPO-3,SLAMF1,Signaling Lymphocytic Activat... |
Human | HEK293 Cells |
SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. | |||
TMPH-03539 |
Enterotoxin type B Protein, S. aureus, Recombinant (His)
Enterotoxin type B,SEB,entB |
Staphylococcus aureus | P. pastoris (Yeast) |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. | |||
TMPK-01318 |
CD24 Protein-VLP, Cynomolgus, Recombinant
MGC75043,CD 24,FLJ43543,FLJ22950,CD24 molecule,CD24A |
Cynomolgus | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. CD24 Protein-VLP, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 3.8 kDa and the accession number is XP_015304503.1. | |||
TMPJ-00110 |
GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)
Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis factor receptor su... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and... | |||
TMPH-02176 |
Talin-1 Protein, Human, Recombinant (GST)
TLN1,Talin-1 |
Human | E. coli |
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Talin-1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 62.8?kDa and the accession number is Q9Y490. | |||
TMPK-00234 |
CD84 Protein, Human, Recombinant (His & Avi)
CD84,DKFZp781E2378,Hly9-beta,Hly9-β,CD84 molecule,SLAMF5,LY9... |
Human | HEK293 Cells |
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells. | |||
TMPK-01278 |
CD69 Protein, Cynomolgus, Recombinant (His)
CLEC2C,AIM,EA1,MLR-3,GP32,BL-AC,BL-AC/P26,P26,28,CD69,Leu 23 |
Cynomolgus | HEK293 Cells |
CLEC2C (CD69) is a membrane-bound, type II C-lectin receptor and acts as a costimulatory molecule for T cell activation and proliferation. It is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. CLEC2C is a disulfide-linked homodimer protein with two differentially glycosylated subunits. | |||
TMPK-00001 |
CD24 Protein-VLP, Human, Recombinant
CD24A,MGC75043,FLJ43543,CD 24,FLJ22950,CD24 molecule |
Human | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. CD24 Protein-VLP, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 5.0 kDa and the accession number is P25063-1. | |||
TMPH-02551 |
CD20 Protein, Mouse, Recombinant (His)
Membrane-spanning 4-domains subfamily A member 1,CD20,B-lymp... |
Mouse | P. pastoris (Yeast) |
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. CD20 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 22.3 kDa and the accession number is P19437. | |||
TMPK-01269 |
CXCL10 Protein, Cynomolgus, Recombinant (His)
IFI10,gIP-10,CXCL10,IP-10,SCYB10,C-X-C motif chemokine 10,cr... |
Cynomolgus | E. coli |
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes. | |||
TMPJ-00398 |
IL-12RB2 Protein, Mouse, Recombinant (hFc)
interleukin-12 receptor β-2 chain,IL-12RB2,interleukin-12 re... |
Mouse | HEK293 Cells |
The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is ... | |||
TMPK-00002 |
CD24 Protein, Human, Recombinant (His & Avi)
MGC75043,FLJ22950,CD 24,FLJ43543,CD24A,CD24 molecule |
Human | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. CD24 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 6.5 kDa and the accession number is P25063... | |||
TMPJ-00028 |
CCL2 Protein, Mouse, Recombinant
Ccl2,Je,Mcp1,C-C motif chemokine 2,Platelet-derived growth f... |
Mouse | E. coli |
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major... | |||
TMPK-00004 |
CD24 Protein, Human, Recombinant (GST)
CD 24,CD24 molecule,FLJ22950,FLJ43543,CD24A,MGC75043 |
Human | E. coli |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. CD24 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.6 kDa and the accession number is P25063. | |||
TMPK-00674 |
CD24 Protein, Cynomolgus, Recombinant (hFc)
FLJ22950,CD 24,MGC75043,FLJ43543,CD24A,CD24 molecule |
Cynomolgus | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. CD24 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 30.2 kDa and the accession number is I7GKK1-1. | |||
TMPJ-00748 |
Ig kappa Protein, Human, Recombinant (His)
Ig κ chain C region AG,Ig κ,Ig kappa chain C region AG,Ig ka... |
Human | HEK293 Cells |
Immunoglobulin Kappa is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humo... | |||
TMPH-02451 |
IFN gamma Protein, Marmota monax, Recombinant (His)
IFNG,Interferon gamma |
Marmota monax | P. pastoris (Yeast) |
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. IFN gamma Protein, Marmota monax, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.6 kDa and the accession numb... | |||
TMPK-00003 |
CD24 Protein, Human, Recombinant (His & Avi), Biotinylated
FLJ22950,CD24 molecule,MGC75043,CD 24,CD24A,FLJ43543 |
Human | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. CD24 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 6.5 kDa and the accession nu... | |||
TMPK-00005 |
CD24 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
CD24A,FLJ22950,CD24 molecule,CD 24,FLJ43543,MGC75043 |
Human | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. CD24 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 29.9 kDa and ... | |||
TMPH-02770 |
TNF beta Protein, Mouse, Recombinant (His)
Lta,TNF-beta,Tumor necrosis factor ligand superfamily member... |
Mouse | E. coli |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225. | |||
TMPJ-00008 |
CXCL10 Protein, Human, Recombinant (hFc & His)
INP10,10 kDa Interferon Gamma-Induced Protein,C-X-C Motif Ch... |
Human | HEK293 Cells |
Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemoattraction for activated T-lymphocytes, inhibition of angiogenesis, and antitumor activity. | |||
TMPK-01042 |
FcRH6/FCRL6 Protein, Human, Recombinant (His)
Fc receptor homolog 6,IFGP6,FcR-like protein 6,FLJ16056,Fc r... |
Human | HEK293 Cells |
Fc receptor-like 6 (FCRL6), the most recently characterized member of the FCRL family, is a cell surface glycoprotein with tyrosine-based regulatory potential. An extensive survey of human hematopoietic tissues disclosed that FCRL6 expression by NK- and T-cell subpopulations increases as a function of differentiation and is remarkably restricted to mature lymphocytes with cytotoxic capability. | |||
TMPH-01654 |
MAGEA1 Protein, Human, Recombinant (His)
Antigen MZ2-E,MAGE-1 antigen,Cancer/testis antigen 1.1,Melan... |
Human | P. pastoris (Yeast) |
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. MAGEA1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 36.3 kDa and the accession number... | |||
TMPK-00327 |
CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
CVID3,CD19,MGC12802,B4,Leu-12 |
Cynomolgus,Rhesus | HEK293 Cells |
CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2 stores. | |||
TMPH-02908 |
AICDA Protein, Mouse, Recombinant (His & Myc)
Single-stranded DNA cytosine deaminase,Cytidine aminohydrola... |
Mouse | E. coli |
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | |||
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