41
2
35
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T76139 |
Cholesterol esterase
|
Others | Others |
胆固醇酯酶 (Cholesterol esterase) 是一种在肠道内将胆固醇酯水解为胆固醇和游离脂肪酸的酶。胆固醇在腺泡细胞中合成,储存在酶原颗粒中。胆固醇酯酶又称胆盐刺激脂肪酶、羧基酯脂肪酶,具有促进胆固醇吸收的作用。 | |||
T15082 |
DDAO
|
Others | Others |
DDAO 是有潜在用途的近红外红色荧光探针,其激发波长 (600-650 nm) 和长发射波长 (λem = 656 nm)可以调节。它可用于不同酶活性的检测,如 β-半乳糖苷酶,羧酸酯酶 2,硫酸酯酶,蛋白质磷酸酶 2A,人白蛋白和酯酶。 | |||
T0157 |
Roxatidine Acetate hydrochloride
HOE 760,盐酸罗沙替丁醋酸酯,Roxatidine Acetate HCl |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Roxatidine Acetate hydrochloride (HOE 760) 是一种特异性和竞争性的组胺 H2 受体拮抗剂,能抑制胃酸分泌,可用于胃溃疡和十二指肠溃疡的研究。 | |||
T18894 |
5(6)-CFDA
CFDA,5-(6)-Carboxyfluorescein diacetate,5(6)-羧基荧光素二乙酸酯 |
Others | Others |
5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) 是具有细胞渗透性的胺反应型绿色荧光探针(λex: 492 nm; λem: 517 nm),可用于细胞染色分析。 | |||
T77524 |
Carboxylesterase-IN-2
|
Wnt/beta-catenin; Lipid | Cytoskeletal Signaling; Metabolism; Stem Cells |
Carboxylesterase-IN-2 是一种有效的 Carboxylesterase Notum 抑制剂(IC50 ≤10 nM)。Carboxylesterase-IN-2具有研究癌症疾病的潜力。 | |||
T60788 |
Carboxylesterase-IN-3
|
Wnt/beta-catenin; Lipid | Cytoskeletal Signaling; Metabolism; Stem Cells |
Carboxylesterase-IN-3 是一种有效的Carboxylesterase Notum 抑制剂(IC50≤ 10 nM)。Carboxylesterase-IN-3 具有研究癌症疾病的潜力。 | |||
T60057 |
Notum pectinacetylesterase-1
|
Others | Others |
Notum pectinacetylesterase-1是一种 Notum Pectinacetylesterase 抑制剂, IC50 < 0.025 μM。 | |||
T76138 |
Phosphodiesterase
|
Others | Others |
Phosphodiesterase(PDE) 是一种可以催化环核苷酸3 '环磷酸键水解的酶,常用于生化研究。Phosphodiesterase 可作为第二信使分子 cAMP 和 cGMP 介导的信号转导的重要调节因子。根据其对环核苷酸的特异性也可以分别不同类型,如 PDE1-PDE11,在多种疾病方面也具有一定的潜力。 | |||
T76156 |
Sphingomyelin phosphodiesterase
|
Others | Others |
Sphingomyelinphosphodiesterase 是一种水解酶,参与鞘磷脂代谢过程。Sphingomyelinphosphodiesterase 水解鞘磷脂,使其向磷酸胆碱和神经酰胺转化。Sphingomyelinphosphodiesterase 还在细胞分化、各种免疫和炎症反应以及细胞内胆固醇运输和代谢中发挥重要作用。 | |||
T40237 |
Carboxylesterase-IN-1
|
Others | Others |
Carboxylesterase-IN-1, a novel pesticide, acts as an inhibitor of carboxylesterase at a concentration of 50 μg/mL, displaying comparable inhibitory activity to the established inhibitor triphenyl phosphate. | |||
T63015 |
Pancreatic lipase/Carboxylesterase 1-IN-1
|
Others | Others |
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂,作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。 | |||
T76123 |
Carboxylesterase
|
Others | Others |
Carboxylesterase (CESs), 即羧酸酯水解酶,广泛分布于自然界,常见于哺乳动物肝脏,常用于生化研究。Carboxylesterase 催化多种内源和外源底物的水解,包括酯、硫酯、氨基甲酸酯和酰胺,使羧酸酯水解成相应的醇和羧酸。 | |||
T36018 |
Phosphodiesterase 4 Inhibitor
|
Others | Others |
Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme. | |||
T76133 |
Phosphodiesterase II
|
Others | Others |
PhosphodiesteraseII,即磷酸二酯酶 2,主要参与水解重要的第二信使环磷酸腺苷 (cAMP) 和环磷酸鸟苷 (cGMP),常用于生化研究。PhosphodiesteraseII 表达于多种组织,如肾上腺髓质、脑、心脏、血小板、巨噬细胞和内皮细胞,可参与调节许多不同的细胞内过程。 | |||
T76130 |
Acetylcholinesterase
|
Others | Others |
Acetylcholinesterase(ACHE; EC 3.1.1.7), 即乙酰胆碱酯酶,是一种胆碱能酶,主要存在于神经肌肉接头和胆碱能类型的化学突触中,常用于生化研究。Acetylcholinesterase 可以催化乙酰胆碱和其他一些充当神经递质的胆碱酯分解或水解为乙酸和胆碱。Acetylcholinesterase 主要作用是终止突触之间的神经元传递和信号传导,以防止 ACh 扩散和附近受体的激活。 | |||
T5943 |
4,4'-DIMETHOXYBENZIL
p-Anisil,4,4'-二甲氧基苯酚酯 |
Others | Others |
4,4'-Dimethoxybenzil (trans-4-Sphingenine) 是人肠胃羧基酯酶抑制剂(Ki:70 nM)。 | |||
T18880 |
BCDA
酯酶显色底物-1,5-bromo-4-chloroindoxyl acetate |
Others | Others |
BCDA (5-bromo-4-chloroindoxyl acetate) 是酯酶的显色底物,可有效检测酯酶的活性。 | |||
T19323 |
Fluorescein diacetate
荧光素二乙酸酯,3,6-Diacetoxyfluoran,Di-O-acetylfluorescein |
Others | Others |
Fluorescein diacetate (Di-O-acetylfluorescein) 是一种人谷胱甘肽硫转移酶 Pi 的荧光底物,是一种细胞渗透性的酯酶底物。 | |||
T17028 |
Tefinostat
CHR-2845 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Tefinostat (CHR-2845) 是一种有效的单核细胞/巨噬细胞靶向组蛋白脱乙酰酶 (HDAC) 抑制剂。 Tefinostat 可被胞内酯酶人羧酸酯酶-1 (hCE-1) 裂解成活性酸 CHR-2847。Tefinostat 具有抗肿瘤活性,可用于研究白血病和晚期血液系统恶性肿瘤。 | |||
T12936 |
SMP-028
|
Others | Others |
SMP-028 is a neutral cholesterol esterase (CEase) inhibitor(IC50 : 1.01 μM). | |||
T38119 |
4-Methylumbelliferyl Caprylate
|
Others | Others |
4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase. MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. | |||
T24256 |
KBR 2822
|
Others | Others |
KBR 2822 is an inhibitor of esterase. | |||
T78413 |
ETZ
C3-CA-DTZ |
||
ETZ (C3-CA-DTZ) 是一种具潜力的荧光素酶前体,能在体内经非特异性酯酶活化,促进荧光素在脑部的传输。 | |||
T70577 |
PEN-866
|
Others | Others |
PEN-866 is a potential agent for controlling early stage tumor growth for non-small cell lung cancer (NSCLC). PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor, SN-38 | |||
T13529 |
Acetylhydrolase-IN-1
|
Others | Others |
Acetylhydrolase-IN-1 is an inhibitor of the esterase 1-Alkyl-2-acetylglycerophosphocholine (Alkylacetyl-GPC: acetylhydrolase). | |||
T83294 |
5-Bromo-1H-indol-3-yl octanoate
|
||
5-Bromo-1H-indol-3-yl octanoate 是一种酯酶的显色底物,具有 C8 活性。该化合物在裂解时产生蓝色沉淀。 | |||
T38895 |
Zanapezil free base
TAK-147 free base,Zanapezil free base |
Others | Others |
Zanapezil (TAK-147) is a powerful and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant and reversible inhibition of AChE activity in rat cerebral cortex homogenates (IC50 = 51.2 nM). Furthermore, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. This compound holds promise for the investigation of the initial stages of Alzheimer's disease (AD). | |||
T76145 |
Clostripain
|
Others | Others |
Clostripain(Clostridiopeptidase B)为源自Clostridium histolyticum的蛋白质水解酶,展现酯酶、酰胺酶及蛋白酶活性,特异性高,针对精氨酸羧基肽键。 | |||
T85005 |
4-Nitrophenyl Palmitate
p-Nitrophenyl Palmitate |
Others | Others |
4-Nitrophenyl palmitate serves as a colorimetric substrate for lipase and esterase, enabling the quantification of enzyme activity through the release and colorimetric detection of 4-nitrophenol at 410 nm following enzymatic hydrolysis. This compound facilitates the characterization of enzyme activity across diverse bacterial and mammalian sources, including Burkholderia and porcine pancreatic lipases. | |||
T74382 |
AChE-IN-4
|
Others | Others |
AChE-IN-4为乙酰胆碱酯酶抑制(AChEI),其 IC50值为24.1μM。 | |||
T84549 |
CAY10455
SKM 4-45-1 |
Others | Others |
CAY10455, an analog of arachidonoyl ethanolamide (anandamide; AEA), is non-fluorescent extracellularly but exhibits bright fluorescence at 530 nm inside cells due to esterase-mediated cleavage. Its uptake by C6 glioma cells is competitively inhibited by AEA and its analogs, suggesting that CAY10455 and AEA utilize the same transporter. Conversely, CAY10455 also inhibits the uptake of tritiated AEA, further indicating competition for the AEA transporter. | |||
TD0055 |
Fluo-8, AM
|
||
Fluo-8,AM is one of the most commonly used fluorescent probes to detect intracellular calcium concentration.Fluo-8, which penetrates the cell membrane and enters the cell, is cut by the intracellular esterase to form fluO-8, and thus is trapped in the cel | |||
T84541 |
Vinclozolin M2
M2 |
Others | Others |
Vinclozolin M2, an active metabolite of vinclozolin, is generated through successive esterase activity and decarboxylation in C. elegans, as well as decarboxylation in human liver microsomes. It functions as an antagonist to the mineralocorticoid (IC50= 1,400 nM) and androgen receptors (IC50= 0.17 nM), demonstrated in reporter assays with MCF-7 cells. This compound is exclusively sold for research and analytical purposes, tailored for controlled laboratory use, and is not available in bulk sizes... | |||
T60579 |
CEase-IN-1
|
Others | Others |
CEase-IN-1 (Compound A1H3) 是胆固醇酯酶(CEase)有效的、选择性的抑制剂,IC50值为 0.36 μM,它可用于研究高胆固醇血症。 | |||
T35979 |
Benastatin C
|
Others | Others |
Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecul... | |||
T79493 |
HIV-1 protease-IN-10
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
HIV-1protease-IN-10(化合物2)显示出对HIV-1潜伏期的逆转活性,IC50值为0.22 μM。该化合物通过与PKCδC1b结构域结合展现活性,IC50值为0.69 μM。此外,HIV-1protease-IN-10对于酯酶介导的水解表现出稳定性。 | |||
T81115 |
sPLA2-IIA Inhibitor
|
||
sPLA2-IIA Inhibitor 是 FLSYK 的环状五肽类似物,具有环2-Nal-Leu-Ser-2-Nal-Arg (c2) 结构,能够特异性结合 hGIIA(人类 IIA 磷脂酶 A2),有效抑制其酯键水解活性。该化合物作为酯酶超家族的一员,主要作用于甘油磷脂 sn-2 位置的酯键,从而阻断游离脂肪酸和花生四烯酸等物质的释放。 | |||
T83293 |
5-CFDA-AM
|
||
5-CFDA-AM作为一种细胞渗透性的酯酶底物,用于测定酶活性和细胞膜完整性,该化合物为电子中性,其渗透细胞的能力超过CFDA且所需浓度更低。在细胞内部,5-CFDA-AM经酯酶水解生成羧基荧光素,后者带有额外负电荷,因此能更有效地在细胞内保留。 | |||
T63941 |
α-Glycosidase-IN-1
|
Others | Others |
α-Glycosidase-IN-1 (compound MZ7) 是 α-GLY(α- 糖苷酶) 的有效抑制剂 (IC50: 44.72 nM, Ki: 44.74 nM)。α-Glycosidase-IN-1 也能够抑制人碳酸酐酶同工酶 I 和 II (hCA I 和hCA II)以及乙酰胆碱酯酶 (AChE),其IC50值分别为 104.87、100.04 和 654.87 nM。α-Glycosidase-IN-1 能够用于研究糖尿病、阿尔茨海默病、溃疡、心力衰竭、癫痫等多种疾病。 | |||
T37214 |
5-trans Latanoprost (free acid)
|
Others | Others |
Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as a ligand for the human recombinant FP receptor. 5-trans Latanoprost (free acid) is an isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from ci... | |||
T36593 |
TEI-9648
|
Others | Others |
TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3820 |
Demethoxydeacetoxypseudolaric acid B
|
Others | Others |
Demethoxydeacetoxypseudolaric acid B 是 pseudolaric acid C2 的一种代谢物。 | |||
T11203 |
Enocyanin
|
Others | Others |
Enocyanin, an anthocyanin extracted from grapes, exhibits inhibitory effects on leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase, and esterase activity. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00459 |
Esterase D Protein, Human, Recombinant (His)
FGH,Methylumbelliferyl-Acetate Deacetylase,ESD,S-Formylgluta... |
Human | E. coli |
Human Esterase D is a cytoplasmic serine hydrolase that belongs to the esterase D family. Esterase D is involved in the detoxification of formaldehyde. Esterase D plays a part in a variety of substrates, including O-acetylated sialic acids, which may involves in the recycling of sialic acids. Esterase D is used as a genetic marker for retinoblastoma and Wilson’s disease. | |||
TMPH-01141 |
Human coronavirus HKU1 (isolate N2) Hemagglutinin-esterase (His)
HE,E3 glycoprotein,Hemagglutinin-esterase |
HCoV-HKU1 | E. coli |
Human coronavirus HKU1 (isolate N2) Hemagglutinin-esterase (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 45.9 kDa and the accession number is Q14EB1. | |||
TMPH-00232 |
Bovine coronavirus (strain Mebus) Hemagglutinin-esterase Protein (His)
Hemagglutinin-esterase,E3 glycoprotein,HE,HE protei... |
Bovine | P. pastoris (Yeast) |
Bovine coronavirus (strain Mebus) Hemagglutinin-esterase Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 47.7 kDa and the accession number is P15776. | |||
TMPY-05159 |
Granzyme A/GZMA Protein, Human, Recombinant (His)
CTLA3,granzyme A (granzyme 1, cytotoxic T-lymphocyte-associa... |
Human | HEK293 Cells |
Granzyme A/GZMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.5 kDa and the accession number is P12544-1. | |||
TMPY-03391 |
ESD Protein, Human, Recombinant (His)
esterase D,FGH |
Human | E. coli |
Esterase D, also known as ESD, is a serine hydrolase that belongs to the esterase D family. Esterase D is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. Esterase D gene is used as a genetic marker and a diagnostic tool for retinoblastoma, Wilson's disease and other hereditary or acquired diseases controlled by genes located at the 13 chromosome 13q14 region. | |||
TMPH-03323 |
LIPA Protein, Rat, Recombinant (His)
Lysosomal acid lipase/cholesteryl ester hydrolase,Lipa,Lipas... |
Rat | E. coli |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is Q64194. | |||
TMPY-02332 |
UCHL3 Protein, Rat, Recombinant (His)
ubiquitin carboxyl-terminal esterase L3 (ubiquitin ... |
Rat | E. coli |
UCHL3 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.5 kDa and the accession number is Q91Y78. | |||
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,granzyme B (granzyme 2... |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPH-01625 |
LIPA Protein, Human, Recombinant (His)
Cholesteryl esterase,Lysosomal acid lipase/choleste... |
Human | P. pastoris (Yeast) |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P38571. | |||
TMPH-01626 |
LIPA Protein, Human, Recombinant (GST)
Lysosomal acid lipase/cholesteryl ester hydrolase,Lipase A,S... |
Human | E. coli |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.0 kDa and the accession number is P38571. | |||
TMPY-02190 |
UCHL3 Protein, Mouse, Recombinant (His)
ubiquitin carboxyl-terminal esterase L3 (ubiquitin ... |
Mouse | E. coli |
UCHL3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.5 kDa and the accession number is Q9JKB1. | |||
TMPH-00482 |
Arginine esterase Protein, Canine, Recombinant (His & SUMO)
|
Canine | E. coli |
Arginine esterase Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-02331 |
UCHL1 Protein, Rat, Recombinant (His)
ubiquitin carboxyl-terminal esterase L1 (ubiquitin ... |
Rat | E. coli |
UCHL1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.2 kDa and the accession number is Q00981. | |||
TMPY-01548 |
UCHL3 Protein, Human, Recombinant (His)
ubiquitin carboxyl-terminal esterase L3 (ubiquitin ... |
Human | E. coli |
UCHL3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27 kDa and the accession number is A0A140VJZ4. | |||
TMPY-05673 |
Human coronavirus (HCoV-OC43) Hemagglutinin esterase Protein (His)
|
HCoV-OC43 | HEK293 Cells |
Human coronavirus (HCoV-OC43) Hemagglutinin esterase Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is A0A1L7H9D0. | |||
TMPJ-00553 |
Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His)
PAF Acetylhydrolase,LDL-Associated Phospholipase A2,LDL-PLA(... |
Human | HEK293 Cells |
Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presen... | |||
TMPH-02903 |
PON1 Protein, Mouse, Recombinant
Pon1,Aromatic esterase 1,Serum aryldialkylphosphata... |
Mouse | E. coli |
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification. PON1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 39.4 kDa and the accession number is P52430. | |||
TMPH-02102 |
PON1 Protein, Human, Recombinant (GST)
Serum paraoxonase/arylesterase 1,K-45,Aromatic ... |
Human | E. coli |
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. | |||
TMPJ-01064 |
Serpin G1 Protein, Mouse, Recombinant (His)
Serping1,Plasma protease C1 inhibitor,C1 Inh,C1 esterase... |
Mouse | HEK293 Cells |
SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later... | |||
TMPY-01547 |
UCHL1 Protein, Human, Recombinant (His)
Uch-L1,PGP9.5,ubiquitin carboxyl-terminal esterase ... |
Human | E. coli |
UCHL1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P09936. | |||
TMPH-00711 |
BioH Protein, E. coli, Recombinant (His & Myc)
bioB,Carboxylesterase BioH,Biotin synthesis protein... |
E. coli | E. coli |
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes. BioH shows a preference for short chain fatty acid esters (acyl c... | |||
TMPH-00672 |
Metalloprotease stcE Protein, E. coli O157:H7, Recombinant (His)
stcE,Neutral zinc metalloprotease StcE,Metalloprotease StcE,... |
E. coli | E. coli |
Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as... | |||
TMPJ-00502 |
Serpin G1 Protein, Human, Recombinant (His)
C1-Inhibiting Factor,Serpin G1,SERPING1,C1 Esterase... |
Human | HEK293 Cells |
As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein. It is the largest member among the serpin class of proteins. Remarkably, Serpin G1 has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of Serpin G1 provides the inhibitory activity. The N-terminal domain ... | |||
TMPY-02175 |
UCHL1 Protein, Mouse, Recombinant (His)
UCHL-1,C88048,ubiquitin carboxyl-terminal esterase ... |
Mouse | E. coli |
UCHL1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.2 kDa and the accession number is Q9R0P9. | |||
TMPH-03448 |
EHT1 Protein, S. cerevisiae, Recombinant (His)
EHT1,Ethanol hexanoyl transferase 1,Alcohol O-acetyltransfer... |
Saccharomyces cerevisiae | E. coli |
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification. EHT1 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 57.3 kDa and the accession number is P38295. | |||
TMPH-02603 |
C1SB Protein, Mouse, Recombinant (His & Myc)
C1sb,C1s,Gm5077,Complement C1s-1 subcomponent,Complement com... |
Mouse | E. coli |
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. | |||
TMPY-01776 |
Carboxylesterase 2/CES2 Protein, Human, Recombinant (His)
carboxylesterase 2,CES2A1,CE-2,PCE-2,iCE |
Human | HEK293 Cells |
Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is O00748-1. | |||
TMPY-01596 |
Butyrylcholinesterase Protein, Mouse, Recombinant (His)
C730038G20Rik,butyrylcholinesterase |
Mouse | HEK293 Cells |
Butyrylcholinesterase Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.7 kDa and the accession number is Q03311. | |||
TMPY-01742 |
Acetylcholinesterase Protein, Mouse, Recombinant (His)
Acre,Chrne,acetylcholinesterase (Yt blood group) |
Mouse | HEK293 Cells |
Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and ... | |||
TMPH-00571 |
ACP phosphodiesterase Protein, E. coli, Recombinant (His & Myc)
yajB,acpH,Acyl carrier protein phosphodiesterase |
E. coli | E. coli |
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP. | |||
TMPY-01693 |
Butyrylcholinesterase Protein, Human, Recombinant (His)
CHE1,E1,butyrylcholinesterase,CHE2 |
Human | HEK293 Cells |
Butyrylcholinesterase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.5 kDa and the accession number is P06276. | |||
TMPH-03234 |
Acetylcholinesterase Protein, Rat, Recombinant (His)
AChE,EC:3.1.1.7 |
Rat | E. coli |
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.9 kDa and the accession number is P37136. | |||
TMPY-01690 |
Carboxylesterase 2/CES2 Protein, Mouse, Recombinant (His)
carboxylesterase 2,ces2A3 |
Mouse | HEK293 Cells |
Carboxylesterase 2/CES2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is Q91WG0. | |||
TMPJ-01045 |
Lysozyme C Protein, Human, Recombinant (His)
1, 4-beta-N-acetylmuramidase C,LYZ,Lysozyme C,LZM,1,4-beta-N... |
Human | HEK293 Cells |
lysozyme C is a secreted protein and belongs to the glycosyl hydrolase 22 family. Lysozymes have primarily a bacteriolytic function, damage bacterial cell walls by catalyzing hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lysozyme C is capable... | |||
TMPJ-01440 |
Cutinase Protein, Thermobifida fusca, Recombinant (His)
Cutinase |
Thermobifida fusca | E. coli |
Cutinase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cutin hydrolase. Cutinase is a serine esterase containing the classical Ser, His, Asp triad of serine hydrolases. The protein belongs to the alpha-beta class, with a central beta-sheet of 5 parallel strands covered by 5 helices on either side of the sheet. Cutin monomers released from the cuticle by small amounts of cutinase on fungal spore surfaces can g... |