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Cat. No. | Product Name | ||
---|---|---|---|
L6140 | 糖类及苷类化合物库 | 595 compounds | |
595 种糖类或苷类的化合物,可用于高通量筛选和高内涵筛选; | |||
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9353 |
OXOMEMAZINE
|
AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Oxomemazine 是毒菌碱 M1 受体的选择性拮抗剂,具有明显的抗毒蕈碱活性。它是基于吩噻嗪的组胺 H1 受体阻滞剂,是抗组胺和抗胆碱能试剂,可用于咳嗽相关研究。 | |||
T9519 |
Eliapixant
BAY 1817080 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Eliapixant (BAY 1817080) 是一种选择性的P2X3受体拮抗剂,IC50值为 8 nM,可用于难治性慢性咳嗽的研究。 | |||
T0828 |
Bromhexine hydrochloride
Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon |
SARS-CoV; HIV Protease; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Bromhexine hydrochloride (Bisolvon) 是TMPRSS2蛋白酶的一种特异性有效抑制剂,IC50为 0.75 μM。它可预防和控制SARS-CoV-2感染。它是一种粘液溶解剂,用于治疗与粘稠或过多粘液相关的呼吸系统疾病。 | |||
T5099 |
Gefapixant
RO 4926219,AF219,MK-7264 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Gefapixant (AF219) 是一个 P2X3 受体拮抗剂,其对人同源重组 hP2X3 和 hP2X2/3 的 IC50值分别是约 30 和 100-250 nM。 | |||
T8333 |
Aurintricarboxylic acid
ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056 |
Apoptosis; P2X Receptor; Influenza Virus; Topoisomerase | Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Aurintricarboxylic acid (NSC-4056) 是高效的αβ-亚甲基-ATP 敏感选择性P2X1Rs 和P2X3Rs 变构拮抗剂。 它是核糖核酸酶和拓扑异构酶 II 的有效抑制剂,可阻止核酸与酶结合。 | |||
T5007 |
Benproperine phosphate
磷酸苯丙哌林,Blascorid,Pirexyl phosphate |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的,肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移,有用于治疗止咳的潜力。 | |||
T3267 |
Potassium guaiacolsulfonate hemihydrate
愈创木酚磺酸钾水合物,Potassium guaiacolsulfonate,Potassium 4-guaiacolsulfonate hemihydrate,愈创木酚磺酸钾 |
Antibacterial; Antibiotic | Microbiology/Virology |
Potassium guaiacolsulfonate hemihydrate (Potassium guaiacolsulfonate) 是一种芳香族磺酸,在医药中用作祛痰剂,可治疗急性呼吸道感染。它可松弛粘液,与其他药物合用,可治疗普通感冒、感染或过敏引起的咳嗽。 | |||
T0768 |
Oxolamine citrate
柠檬酸奥索拉明,AF-438 citrate,SKF-9976 citrate |
Others | Others |
Oxolamine citrate (AF-438 citrate) 是一种止咳剂,也表现出抗炎作用,可用于呼吸道疾病的研究。 | |||
T0464 |
Carbetapentane citrate
托可拉斯,Pentoxyverine citrate,咳必清 |
AChR | Neuroscience |
Carbetapentane citrate (Pentoxyverine citrate) 能够选择性抑制咳嗽中枢,具有轻度的阿托品样作用和局麻作用。 | |||
T0452 |
Dropropizine
(±)-Dropropizine,UCB-196,羟丙哌嗪,UCB-1967 |
Others | Others |
Dropropizine (UCB-1967) 是外周镇咳剂,能够作用于外周受体及其传入导体,发挥抑制咳嗽反射的作用。 | |||
T0576 |
Diethylaminoethoxyethanol
|
Others | Others |
Diethylaminoethoxyethanol 用于生产止咳药Toclase 等。 | |||
T28728 |
SCH-486757
SCH 486757,SCH486757 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
SCH-486757是一种伤害感受素-1(NOP1)和孤儿素 FQ 肽受体激动剂,可用于研究咳嗽。 | |||
T0284 |
Sulfogaiacol
guaiacolsulfonate,愈创木酚磺酸钾 |
Others; Antibacterial | Microbiology/Virology; Others |
Sulfogaiacol (guaiacolsulfonate) 是一种镇咳剂,可研究急性呼吸道感染。 | |||
T12489L |
Pimethixene maleate
Pimetixene maleate |
Dopamine Receptor; 5-HT Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂,具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A,5-HT2A,5-HT2B,5-HT2C,组胺 H1,多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2,可用于研究儿童干咳和刺激性咳嗽。 | |||
T0217L |
(+)-Dropropizine
(+)-Dropropizine,右羟丙哌嗪 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
(+)-Dropropizine 可以抑制组胺受体,抗过敏,并通过调节参与咳嗽反射的神经肽和干扰感觉神经末梢的刺激激活来减少咳嗽。 | |||
T0056 |
Oxeladin citrate
|
Others | Others |
Oxeladin citrate 是止咳剂,能够对各种病因引发咳嗽进行有效研究。 | |||
T64394 |
GW 833972A
|
Cannabinoid Receptor | GPCR/G Protein |
GW 833972A 是一种选择性的 CB2 受体激动剂。GW 833972A 对诱导神经去极化具有抑制作用,且在动物模型中对柠檬酸引起的咳嗽具有抑制作用。 | |||
T6660 |
SB-705498
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
SB705498 是一种口服有效的 TRPV1选择性拮抗剂,pIC50值为 7.1。 | |||
T27158L |
DF-1012 FA
DF-1012 FA(163220-65-3 Free base) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
DF-1012 FA 是一种 DF-1012 的结构类似物,是一种神经肽类抑制剂,可用于研究哮喘和咳嗽。 | |||
T15689 |
L-798106
L 798106,CM9,GW-671021,CM-9,GW671021 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
L-798106 (CM9) 是一种具有选择性和高效性的前列腺素类 EP3 受体拮抗剂 ,抑制 EP4,EP1 和 EP2 受体,抑制动脉粥样硬化中促炎细胞因子的水平,可减弱 PGE2 诱导的咳嗽。 | |||
T1229 |
Erdosteine
厄多司坦,RV 144,KW-9144 |
NF-κB; Antibacterial; Adenosine deaminase | Metabolism; Microbiology/Virology; NF-κB |
Erdosteine (RV 144) 抑制脂多糖诱导的NF-κB 激活,具有粘液调节、抗菌、抗炎、抗氧化和自由基清除作用。 | |||
T67885 |
Camlipixant
BLU-5937 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Camlipixant (BLU-5937) 是一种具有口服活性的嘌呤P2X3受体拮抗剂,具有有效性、选择性和竞争性。Camlipixant 对 hP2X3 同型三聚体的 IC50 为 25 nM。Camlipixant 可用于治疗呼吸系统疾病和免疫系统疾病,研究难治性慢性咳嗽和特应性皮炎。Camlipixant 具有较强的止咳效果。 | |||
T19644 |
Benzonatate
|
Sodium Channel | Membrane transporter/Ion channel |
Benzonatate 是外周口服镇咳药,对咳嗽延伸受体 (cough stretch receptors) 的活性具有抑制作用。它是丁卡因样代谢物,能够阻断呼吸延伸受体的钠通道并产生局部麻醉作用。 | |||
T20056 |
Oxolamine
BRN 0527181,Bredon,AF-438,Ossolamina,AF 438 |
Others | Others |
Oxolamine is an agent of a cough suppressant. | |||
T34672 |
Sodium dibunate
L1633,Dibunato di sodio,L 1633,Becantex,L-1633 |
Others | Others |
Sodium dibunate is a type of cough suppressant. | |||
T0768L |
Oxolamine hydrochloride
Oxolamine HCl,683 M hydrochloride,AF 438 hydrochloride |
Others | Others |
Oxolamine hydrochloride is a cough suppressant which may be useful in the treatment of pediatric asthma. | |||
T21372 |
Chlophedianol Hydrochloride
clofedanol hydrochloride,clofedanol,chlophedianol |
Others | Others |
Chlophedianol hydrochloride, a centrally acting cough suppressant, is used in the treatment of dry cough. It has antihistamine and local anesthetic properties, and may have anticholinergic effects at high doses. | |||
T34068 |
Pipazethate
Pipazetatum,Lenopect,pipazethate monohydrochloride,Theratuss,Pipazetate |
Others | Others |
Pipipyrazine is a nonnarcotic oral cough suppressant, cough suppressant. | |||
T29880 |
Alloclamide hydrochloride
Alloclamide HCl,Hexacol |
Others | Others |
Alloclamide hydrochloride is a cough suppressant. | |||
T32739 |
Libexin
Lomapect,Toparten,HK 256,HK-256,Prenoxdiazine hydrochloride,HK256 |
Others | Others |
Libexin is a cough suppressant. | |||
T81457 |
Piperidione
|
Others | Others |
Piperidione是一种止咳药物。 | |||
T26924 |
Butamirate
|
Others | Others |
Butamirate is a cough suppressant, it works by acting centrally through the receptors in the brainstem. | |||
T3609 |
Dioxopromethazine
Prothanon,Dioxoprothazine,盐酸二氧丙嗪 |
Others | Others |
Dioxopromethazine (Dioxoprothazine) 是一种口服具有活性的抗组胺药,能够抑制哮喘症状。 | |||
T25189 |
Butopiprine
Butopiprinum |
Others | Others |
Butopiprine 是一种镇咳药,具有解痉、局部麻醉和镇咳活性。 | |||
T16406 |
Orvepitant maleate
GW823296 maleate |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatmen | |||
T68723 |
FPL-59257
|
Others | Others |
FPL-59257 is a leukotriene antagonist that has been shown to abolish cough response & partly inhibit bronchoconstriction produced by leukotrienes C & D. | |||
T25543 |
Isoaminile citrate
|
Others | Others |
Isoaminile citrate 是一种安全有效的中枢镇咳药。在动物实验中,它与 codeine 一样有效,但没有任何呼吸抑制作用。 | |||
T78523 |
Clobutinol hydrochloride
|
Potassium Channel | Membrane transporter/Ion channel |
Clobutinol hydrochloride是一种具有止咳作用的化合物,能够影响心率和血压,通常用于咳嗽相关的研究。 | |||
T60473 |
Nepinalone
|
Others | Others |
Nepinalone 是 β-tetralone 的alchilaminate 衍生物。Nepinalone 是一种口服活性止咳药,具有非阿片类止咳活性。 | |||
T63846 |
Gefapixant citrate
|
Others | Others |
Gefapixant citrate 是口服具有活力的 P2X3 受体 (P2X3R) 拮抗剂,能够作用于人同源重组 hP2X3 (IC50: ~30 nM)和 hP2X2/3 (IC50: 100-200 nM)。Gefapixant citrate 能够用于研究慢性咳嗽与膝骨关节炎。 | |||
T60393 |
Clobutinol
|
Others | Others |
Clobutinol 具有止咳作用。Clobutinol 影响心率和血压,可用于咳嗽的相关研究。 | |||
T62422 |
Nav1.8-IN-2
|
Others | Others |
Nav1.8-IN-2 (compound 35A) 是一种 Nav1.8 的有效抑制剂 (IC50: 0.4 nM)。Nav1.8-IN-2 能够用于疼痛障碍、咳嗽、急性和慢性瘙痒症的研究。 | |||
T68904 |
GW-833972A free base
|
Others | Others |
GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus nerve in vitro. GW 833972A also inhibited citric acid-induced cough but not plasma extravasation in the guinea-pig and this effect was blocked by a CB(2) receptor antagonist. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0691 |
Shionone
紫菀酮,Shionon |
Others | Others |
Shionone (Shionon) 是一种从Aster tataricus 中分离得到的三萜类化合物,具有独特的六元四环骨架和 3-氧代-4-单甲基结构。它具有镇咳、抗炎作用。 | |||
T0739 |
Guaifenesin
Glycerol guaiacolate,Guaiacol glyceryl ether,愈创甘油醚,Guaiphenesin |
Others | Others |
Guaifenesin (Guaiphenesin) 是一种祛痰剂,来自于 Guajacum officinale Linné 木材中。它可以增加痰液体积和降低其粘度,缓解咳嗽不适,促进有效的咳嗽。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T3370 |
Hederacoside C
常春藤苷C,Kalopanaxsaponin B,Hederasaponin C |
Others; Antibacterial | Microbiology/Virology; Others |
Hederacoside C (Hederasaponin C) 是常春藤的叶子组分中的主要成分,具有祛痰、抗菌、支气管扩张等作用,可研究呼吸系统疾病。 | |||
T6S2238 |
Eupalinolide B
|
Others | Others |
Eupalinolide B 是一种胚芽倍半萜,分离自Eupatorium lindleyanum 中。它对BGC-823、A-549 和 HL-60 等肿瘤细胞具有细胞毒性。 | |||
TN4540 | Methyl demethoxycarbonylchanofruticosinate | Others | Others |
Methyl demethoxycarbonylchanofruticosinate exhibits significant antitussive activity in a citric acid induced guinea pig cough model. | |||
T81584 |
Oxyresveratrol 4-O-β-D-glucopyranoside
|
Others | Others |
Oxyresveratrol 4-O-β-D-glucopyranoside (化合物 3),一种从Morus atropurpurea根皮分离的天然产物,具有研究治疗糖尿病、关节炎、风湿、咳嗽及头痛的潜力。 | |||
T4S0083 |
Protostemonine
|
Others | Others |
Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱,对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00206 |
Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO)
prn,P.93,Pertactin autotransporter |
Bordetella pertussis | E. coli |
Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.8 kDa and the accession number is P14283. | |||
TMPH-00208 |
Serotype 3 fimbrial subunit Protein, Bordetella pertussis, Recombinant (His)
fim3,Serotype 3 fimbrial subunit |
Bordetella pertussis | E. coli |
Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process. Serotype 3 fimbrial subunit Protein, Bordetella pertussis, Recombinant ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71141 |
Fenspiride-d5
|
||
Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ... |