66
6
180
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1098 |
Motilin, canine
Motilin (canine) |
||
Motilin canine, a 22-amino acid peptide, functions as a robust gastrointestinal smooth muscle contraction agonist. | |||
TP1085L |
Neuromedin N acetate(92169-45-4 free base)
Neuromedin N (rat, mouse, porcine, canine) acetate |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Neuromedin N acetate(92169-45-4 free base) 是一种神经肽,其衍生自与神经降压素相同的前体多肽,具有相似但略有不同的表达和作用。Neuromedin N 是多巴胺 D2 受体激动剂与大鼠新纹状体膜结合的有效调节剂。 | |||
TP1610 |
Secretin, canine
|
||
Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Canine secretin can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway. | |||
TP1174 |
Endothelin-2 (49-69), human
Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine),人内皮素2 |
Others | Others |
Endothelin-2 (49-69), human (Human endothelin-2) 是一种由 21 个氨基酸组成的血管活性肽。它可与 G 蛋白连接的跨膜受体,ET-RA 和ET-RB 结合。 | |||
TP1085 |
Neuromedin N
Neuromedin N (rat, mouse, porcine, canine) |
||
Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects. | |||
TP1016 |
Aviptadil
Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔 |
||
Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction. | |||
TP2143 |
Endothelin-2 (49-69), human TFA
Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA |
Others | Others |
Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB. | |||
T16347 |
NS3623
|
Potassium Channel | Membrane transporter/Ion channel |
NS3623 是 hERG1 (KV11.1)钾通道激活剂,激活IKr 和Ito 电流,具有抗心律失常作用。NS3623也是 hERG1 通道抑制剂。 | |||
T80148 |
GRP (14-27) (human, porcine, canine)
|
Bombesin Receptor | GPCR/G Protein |
GRP (14-27) (human, porcine, canine) 表现为铃蟾肽受体配体。其特异性结合受到 GTP 和 GDP 的抑制作用,但 GMP 对此无影响。 | |||
T0696 |
Naftopidil
KT-611,萘哌地尔,BM-15275 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Naftopidil (KT-611) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂,对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM 、1.2 nM。它具有抗增殖活性,可用于研究前列腺增生。 | |||
T76651 |
Peptide YY (13-36) (canine, mouse, porcine, rat)
|
||
Peptide YY (13-36) (canine, mouse, porcine, rat) 是 Y2受体的激动剂。 | |||
T8236 |
RHC 80267
U-57908 |
Others; Phospholipase; COX; Acyltransferase; AChR | Immunology/Inflammation; Metabolism; Neuroscience; Others |
RHC 80267 (U-57908) 是一种选择性二酰基甘油脂酶(DAGL)抑制剂,对犬血小板的IC50为 4 μM。它抑制COX 活性和磷脂酰胆碱的水解,还抑制胆碱酯酶活性,IC50为 4 μM,增强乙酰胆碱引起的松弛。 | |||
T6600 |
Naftopidil dihydrochloride
KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl |
5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Naftopidil dihydrochloride (KT-611 2HCl) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂,对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性,可用于研究前列腺增生。 | |||
TP1016L |
Aviptadil Acetate
醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt |
RAAS; SARS-CoV | Endocrinology/Hormones; Microbiology/Virology |
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物,具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。 | |||
T9220 |
Naftopidil hydrochloride
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Naftopidil hydrochloride (BM-15275 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂,对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性,可用于研究前列腺增生。 | |||
T22893 |
L-168049
L-168,049 |
Glucagon Receptor | GPCR/G Protein |
L-168049 是一种选择性和非竞争性人胰高血糖素受体拮抗剂,对人、鼠和犬的 IC50 分别为 3.7 nM、63 nM 和 60 nM。 | |||
T15209 |
Elobixibat
AZD 7806,A 3309 |
Others | Others |
Elobixibat (A 3309) 是回肠胆汁酸转运蛋白的抑制剂(小鼠、人和犬 IBAT 的 IC50:0.13 nM、0.53 nM 和 5.8 nM)。 Elobixibat 可用于慢性特发性便秘的研究。 | |||
T0489 |
Flutamide
SCH 13521,氟他胺 |
Androgen Receptor | Endocrinology/Hormones |
Flutamide (SCH 13521) 是一种抗雄激素化合物,在啮齿动物和犬科动物中的效力与环丙孕酮大致相同。 | |||
T28895 |
T-0509
T 0509,T0509 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
T-0509 是一种选择性 beta 1 受体激动剂,可增加犬心室肌的肌力,选择性下调大鼠心脏 β 1-肾上腺素受体。 | |||
T12321 |
ORM-10103
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ORM-10103 是一种新型有效且具有选择性的 Na+/Ca2+ 交换体 (NCX) 抑制剂。ORM-10103 对 NCX 电流有抑制作用,在 -80 和 20 mV 下的 IC50 的估算值分别为 55 和 67 nM,可减少犬心脏的早期和延迟后去极化。 | |||
T17030 |
Tegoprazan
|
ATPase; Proton pump | Membrane transporter/Ion channel |
Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,能够控制胃酸分泌和运动,在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。 | |||
T82525L |
DT-2 acetate
DT-2 acetate(1220985-78-3 Free base) |
PKA | Tyrosine Kinase/Adaptors |
DT-2 acetate 是一种具有选择性的 cGMP 依赖性蛋白激酶 (PKG) 抑制剂,是一种靶向犬胸腺细胞的小鼠单克隆抗体。DT-2 acetate 抑制 PKG 催化的磷酸化 ,逆转8-Br-cGMP诱导的扩张,可用于研究免疫疾病。 | |||
T17006 |
TC-I 2014
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
TC-I 2014 是一种口服有效的、强效的、苯并咪唑类的、 TRPM8 的拮抗剂,其对犬类、人和大鼠通道的 IC50 值分别为 0.8 nM, 3.0 nM 和 4.4 nM。在疼痛动物模型中具有抗痛觉超敏作用。 | |||
T20714 |
Levolansoprazole
左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole |
Proton pump | Membrane transporter/Ion channel |
Levolansoprazole ((S)-Lansoprazole) 是一种质子泵抑制剂,不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50:82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性,具有相似的效力。 | |||
T7339 |
Angiotensin (1-7)
Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO |
RAAS; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性,因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮,是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大,并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。 | |||
T1325 |
Carprofen
卡洛芬,Ridamyl,Imadyl,Rimadyl |
FAAH; COX; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; Neuroscience |
Carprofen (Ridamyl) 是多靶点FAAH/COX 抑制剂,能够抑制 COX-2,COX-1 和 FAAH 的活性,IC50值分别为 3.9 μM,22.3 μM 和 78.6 μM。它是一种丙酸衍生物和非甾体抗炎药,具有抗炎、镇痛和解热活性。 | |||
T1546 |
Nitazoxanide
NSC 697855,硝唑尼特 |
Others; Influenza Virus; Parasite; Autophagy | Autophagy; Microbiology/Virology; Others |
Nitazoxanide (NSC-697855) 是一种广谱驱虫剂,对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。 它在无菌培养中抑制Giardia lamblia 滋养体增殖,IC50为 2.4 μM。它可研究寄生虫性胃肠炎,具有抗病毒特性。 | |||
T15487 |
HMR 1556
|
Others | Others |
HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively). | |||
T27278 |
Epsiprantel
|
Others | Others |
Epsiprantel is an antiparasitic for canine worms. | |||
T31030 |
CP 71362
CP71362 |
Others | Others |
CP 71362 is a selective pentapeptide renin inhibitor for canine enzymes. | |||
TC0008 |
Desoxycorticosterone pivalate
DOCP |
Others | Others |
Deoxycorticosterone (DOCP) is a mineralocorticoid and is an analog of deoxycorticosterone. Deoxycorticosterone pivalate is used in the treatment of canine low adrenal cortex hormones. | |||
T76816 | Lokivetmab | ||
Lokivetmab(Anti-Canine IL31 Recombinant Antibody)为针对犬特应性皮炎(AD)研究的抗犬IL-31单克隆抗体。 | |||
T13340 |
Win-62005
|
Others | Others |
Win-62005 is an inhibitor of cyclic AMP phosphodiesterase III (PDE III)(Kis: 25 and 26 nM for rat heart and canine aorta). | |||
T71421 |
Bemoradan
|
Others | Others |
Bemoradan is an inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue | |||
T70510 |
CVS-1123
|
Others | Others |
CVS-1123 is a direct thrombin inhibitor, preventing occlusive arterial and venous thrombosis in a canine model of vascular injury. | |||
T26312 |
Uredofos
Sansalid,RH 32565,RH32565,RH-32565 |
Others | Others |
Uredofos 是一种广谱驱虫药,它犬绦虫、蛔虫、钩虫和鞭虫都非常有效。 | |||
T76932 | Blontuvetmab | ||
Blontuvetmab (AT 004),犬源化CD20单克隆抗体,主要用于研究犬B细胞淋巴瘤。 | |||
T41020 |
Melarsomine dihydrochloride
|
Others | Others |
Melarsomine dihydrochloride is a trivalent arsenical compound employed as an adulticide in the treatment of canine heartworm disease and other helminth infections. It is also utilized for research purposes in the study of these conditions. | |||
T38686 |
Melarsomine
|
Others | Others |
Melarsomine, a trivalent arsenical compound, is employed as an adulticide for canine heartworm disease and other helminth infections. It has significant utility in the research of these conditions. | |||
T78300 |
Anivovetmab
KIND-030 |
||
Anivovetmab (KIND-030)为针对细小病毒主要衣壳蛋白的IgG2型单克隆抗体,潜在应用于研究犬细小病毒感染。 | |||
T71601 |
CU-2010
|
Others | Others |
CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model. | |||
TP2010 |
Kisspeptin 10 (dog)
|
||
Endogenous ligand for the canine KISS1 receptor (Kisspeptin receptor or GPR54). Stimulates section of luteinizing hormone, follicle stimulating hormone and estradiol in vivo. | |||
T28884 |
SUN-C5174
SUNC-5174 |
Others | Others |
SUN-C5174 is a sleective 5-HT2 antagonist (pA2=8.98+/-0.06). SUN C5174 showed a marked inhibitory effect on the platelet aggregation induced by serotonin in combination with collagen and adenosine diphosphate (ADP) in canine or human platelet-rich plasma | |||
T16906 |
Sograzepide
YM-220,Netazepide,YF 476 |
Others | Others |
Sograzepide is an effective and highly selective Gastrin/CCK-B antagonist (IC50: 0.1 nM), has an inhibitory effect on Gastrin/CCK-A activity (IC50: 502 nM). Sograzepide replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine, and cloned human Gastrin/CCK-B receptors (Ki: 0.068, 0.62 and 0.19 nM, respectively). | |||
T70379 |
PF-04479745 tartrate
|
Others | Others |
PF-04479745, also known as PF-4479745, is a potent and selective 5-HT2C agonist (EC50 = 10 nM). PF-4479745 displayed robust pharmacology in a preclinical canine model of stress urinary incontinence (SUI) and no measurable functional agonism at the key selectivity targets 5-HT2A and 5-HT2B in relevant tissue-based assay systems. | |||
T35463 |
(±)14(15)-EET
(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET |
Others | Others |
(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o... | |||
T27038 |
CL385319 HCl
CL-385319,CL385319 hydrochloride,CL 385319,CL385319 |
Others | Others |
CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2. | |||
T80990 |
Thrombostatin cont-1
|
||
Thrombostatin cont-1为缓激肽代谢物,归属于凝血抑制素类似物。该化合物在犬颈动脉球囊成形术损伤模型中,能有效减少血小板活化。 | |||
T71426 |
STA-1474
|
Others | Others |
STA-1474 is a water soluble prodrug of ganetespib (formerly STA-9090). STA-1474 will metabolized to Ganetespib, which is a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts. The purpose of the following study was to extend these observations and investigate the safety and efficacy of STA-1474 in dogs with spontaneous tumors. | |||
T72515 |
Elobixibat hydrate
A 3309 hydrate ; AZD 7806 hydrate,AZD 7806 hydrate,A 3309 hydrate |
Others | Others |
Elobixibat hydrate是一有效胆汁酸转运体(IBAT)抑制剂,对人类IBAT、小鼠IBAT及犬类IBAT的IC50值分别为0.53±0.17 nM、0.13±0.03 nM和5.8±1.6 nM。适用于研究老年慢性功能性便秘(CIC)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN5768 |
Chiricanine A
|
||
Chiricanine A 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5768,CAS号为 350593-30-5。 | |||
TN1485 |
Chicanine
|
Others; NF-κB; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; NF-κB; Others |
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways. | |||
T33817 |
Orellanine
2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one |
Others | Others |
Orellanine 是一种从蘑菇 Cortinarius orellanus 中提取的肾毒性化合物。 Orellanine 强烈抑制 Madin-Darby 犬肾细胞和大鼠肝线粒体中大分子(蛋白质、RNA 和 DNA)的合成。 | |||
T2S2046 |
Bruceine A
Dihydrobrusatol,鸦胆子素 A,NSC31616 |
Antibiotic; Parasite | Microbiology/Virology |
Bruceine A (NSC-31616) 是一种从鸦胆子 (L.) 的干果中提取的天然类苦素化合物,有治疗犬巴贝斯虫病的潜力。 | |||
T27380 |
FR-198248
|
Others | Others |
FR-198248, a new anti-influenza agent, shows antiinfluenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro. | |||
TN1875 |
Liriodenine
鹅掌揪碱 |
BCL; Caspase; p53 | Apoptosis; Proteases/Proteasome |
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibiti |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02789 |
IL-33 Protein, Canine, Recombinant
白介素,interleukin 33,白细胞介素 |
Canine | E. coli |
IL-33 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.8 kDa and the accession number is O97863. | |||
TMPY-04342 |
PD-1 Protein, Canine, Recombinant (His)
programmed cell death 1 |
Canine | HEK293 Cells |
PD-1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is XP_022265285.1. | |||
TMPY-00237 |
PD-L1 Protein, Canine, Recombinant (hFc)
CD274 molecule |
Canine | HEK293 Cells |
PD-L1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.5 kDa and the accession number is A0A8C0MRV9. | |||
TMPY-03719 |
HER2/ERBB2 Protein, Canine, Recombinant (His)
erb-b2 receptor tyrosine kinase 2,EGFR2 |
Canine | HEK293 Cells |
HER2/ERBB2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is A8WED5. | |||
TMPY-05815 |
PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated
programmed cell death 1 |
Canine | HEK293 Cells |
PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 19.41 kDa and the accession number is A0A090BAM7. | |||
TMPY-00616 |
CD3 epsilon/CD3e Protein, Canine, Recombinant (hFc)
CD3e molecule, ε (CD3-TCR complex),CD3 ε/CD3e,CD3e molecule,... |
Canine | HEK293 Cells |
CD3 epsilon/CD3e Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.2 kDa and the accession number is P27597. | |||
TMPY-02638 |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
transforming growth factor, beta 1,转化生长因子,transforming growt... |
Human,Rhesus,Cynomolgus,Canine | CHO Cells |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2. | |||
TMPY-02568 |
IL-1 beta/IL-1F2 Protein, Canine, Recombinant
interleukin 1, beta,IL-1 β,interleukin 1, β |
Canine | E. coli |
IL-1 beta/IL-1F2 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is Q28292. | |||
TMPY-00680 |
BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc)
bone morphogenetic protein 2 |
Human,Mouse,Rat,Rhesus,Canine | HEK293 Cells |
BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.5 kDa and the accession number is C8C060. | |||
TMPY-00456 |
HGF Protein, Canine, Recombinant
肝细胞生长因子,scatter factor),hepatocyte growth factor (hepapoieti... |
Canine | HEK293 Cells |
HGF Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.9 kDa and the accession number is Q867B7. | |||
TMPY-04884 |
EGF Protein, Canine, Recombinant
epidermal growth factor,表皮生长因子 |
Canine | P. pastoris (Yeast) |
EGF Protein, Canine, Recombinant is expressed in yeast. The predicted molecular weight is 6.2 kDa and the accession number is Q9BEA0. | |||
TMPY-03898 |
Fractalkine Protein, Canine, Recombinant
chemokine (C-X3-C motif) ligand 1 |
Canine | HEK293 Cells |
Fractalkine Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.2 kDa and the accession number is H1ADY9. | |||
TMPY-03944 |
CD40 Protein, Canine, Recombinant
CD40 molecule, TNF receptor superfamily member 5 |
Canine | HEK293 Cells |
CD40 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.9 kDa and the accession number is Q7YRL5. | |||
TMPY-03711 |
TrkA Protein, Canine, Recombinant (hFc)
neurotrophic tyrosine kinase, receptor, type 1 |
Canine | HEK293 Cells |
TrkA Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.3 kDa and the accession number is XP_851619.3. | |||
TMPY-02539 |
EGF Protein, Canine, Recombinant (His)
epidermal growth factor,表皮生长因子 |
Canine | E. coli |
EGF Protein, Canine, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 8.3 kDa and the accession number is Q9BEA0. | |||
TMPY-00455 |
PDGFA Protein, Canine, Recombinant (hFc)
血小板源生长因子,platelet-derived growth factor α polypeptide,platel... |
Canine | HEK293 Cells |
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site. PDG... | |||
TMPK-01385 |
CRTAM Protein, Canine, Recombinant (His)
CRTAM,CD355 antigen,CD355 |
Canine | HEK293 Cells |
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr... | |||
TMPY-01594 |
TNF alpha Protein, Canine, Recombinant
肿瘤坏死因子,TNF-α,tumor necrosis factor |
Canine | E. coli |
TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0. | |||
TMPY-03724 |
EGFR Protein, Canine, Recombinant (His)
epidermal growth factor receptor |
Canine | Baculovirus Insect Cells |
EGFR Protein, Canine, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 69.8 kDa and the accession number is XP_533073.3. | |||
TMPY-03635 |
TrkB Protein, Canine, Recombinant (His)
neurotrophic tyrosine kinase, receptor, type 2 |
Canine | HEK293 Cells |
TrkB Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is XP_541264.2. | |||
TMPK-01375 |
PRLR Protein, Canine, Recombinant (hFc)
PRL-R,Prolactin R,MFAB,HPRL |
Canine | HEK293 Cells |
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Canine, Recombinant (hFc) is expressed in HEK293 ... | |||
TMPY-03705 |
VEGF164 Protein, Canine, Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Canine | HEK293 Cells |
VEGF164 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9MYV3-3. | |||
TMPH-00498 |
Prorelaxin Protein, Canine, Recombinant (His)
RLN,Prorelaxin |
Canine | E. coli |
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Prorelaxin Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q9TRM8. | |||
TMPH-00487 |
EPOR Protein, Canine, Recombinant (His)
EPOR,Erythropoietin receptor |
Canine | E. coli |
EPOR Protein, Canine, Recombinant (His) is expressed in E. coli. | |||
TMPY-00228 |
TrkB Protein, Canine, Recombinant (hFc)
neurotrophic tyrosine kinase, receptor, type 2 |
Canine | HEK293 Cells |
TrkB Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.2 kDa and the accession number is XP_541264.2. | |||
TMPK-01257 |
DDT Proten, Canine, Recombinant (His)
EC 4.1.1.84,DDCT,D-DT,MIF2 |
Canine | E. coli |
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Proten, Canine, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predict... | |||
TMPY-03897 |
Fractalkine Protein, Canine, Recombinant (hFc)
chemokine (C-X3-C motif) ligand 1 |
Canine | HEK293 Cells |
Fractalkine Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.4 kDa and the accession number is H1ADY9. | |||
TMPY-04535 |
GDNF Protein, Canine, Recombinant (hFc)
glial cell derived neurotrophic factor,胶质细胞生长因子 |
Canine | HEK293 Cells |
GDNF Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40 kDa and the accession number is XP_005619436.1. | |||
TMPY-04665 |
Fractalkine Protein, Canine, Recombinant (His)
chemokine (C-X3-C motif) ligand 1 |
Canine | HEK293 Cells |
Fractalkine Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.9 kDa and the accession number is A0A8C0YVN8. | |||
TMPY-03712 |
TrkA Protein, Canine, Recombinant (His)
neurotrophic tyrosine kinase, receptor, type 1 |
Canine | HEK293 Cells |
TrkA Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is XP_851619.3. | |||
TMPY-05076 |
PDGFB Protein, Canine, Recombinant (His)
platelet-derived growth factor beta polypeptide,platelet-der... |
Canine | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Canine, Recombinant (His) is expressed in yeast with His tag. The predicte... | |||
TMPK-01097 |
AFP Protein, Canine, Recombinant (His)
Alpha-fetoprotein,HPAFP,Alpha-1-fetoprotein,α-1-fetoprotein,... |
Canine | HEK293 Cells |
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. AFP Protei... | |||
TMPY-05075 |
PDGFA Protein, Canine, Recombinant (His)
platelet-derived growth factor α polypeptide,血小板源生长因子,platel... |
Canine | P. pastoris (Yeast) |
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site. PDG... | |||
TMPY-03622 |
FGF-1 Protein, Canine, Recombinant
fibroblast growth factor 1 (acidic) |
Canine | E. coli |
FGF-1 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is A0A8C0QGP1. | |||
TMPY-02809 |
IL-21 Protein, Canine, Recombinant
interleukin 21,白细胞介素,白介素 |
Canine | E. coli |
IL-21 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is Q6L7I9. | |||
TMPY-02790 |
IL-4 Protein, Canine, Recombinant
白介素,interleukin 4,白细胞介素 |
Canine | E. coli |
IL-4 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13 kDa and the accession number is O77762. | |||
TMPY-04033 |
FGF-14 Protein, Canine, Recombinant
fibroblast growth factor 14 |
Canine | E. coli |
FGF-14 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.1 kDa and the accession number is XP_003363267.1. | |||
TMPK-00571 |
OSMR Protein, Canine, Recombinant (His)
OSMRB,IL-31R-β,OSMR,OSMRBMGC150626,OSMR β,IL-31R subunit β,I... |
Canine | HEK293 Cells |
OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death. OSMR Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted mole... | |||
TMPY-03896 |
CXCL16 Protein, Canine, Recombinant (hFc)
chemokine (C-X-C motif) ligand 16 |
Canine | HEK293 Cells |
CXCL16 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.1 kDa and the accession number is XP_849304.2. | |||
TMPY-02834 |
RBP4 Protein, Canine, Recombinant (hFc)
retinol binding protein 4, plasma |
Canine | HEK293 Cells |
RBP4 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is F1PQI4. | |||
TMPY-00626 |
CD2 Protein, Canine, Recombinant (hFc)
CD2 molecule |
Canine | HEK293 Cells |
CD2 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.6 kDa and the accession number is A0A8C0SEN8. | |||
TMPY-04086 |
CD40 Ligand Protein, Canine, Recombinant
CD40 ligand |
Canine | HEK293 Cells |
CD40 Ligand Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16 kDa and the accession number is O97626. | |||
TMPY-03907 |
CD40 Protein, Canine, Recombinant (hFc)
CD40 molecule, TNF receptor superfamily member 5 |
Canine | HEK293 Cells |
CD40 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is Q7YRL5. | |||
TMPY-04084 |
ANGPTL1 Protein, Canine, Recombinant (hFc)
angiopoietin-like 1 |
Canine | HEK293 Cells |
Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre... | |||
TMPK-01387 |
EPhA3 Protein, Canine, Recombinant (His)
HEK4,TYRO4,ETK1,EPHA3,HEK,ETK,EK4 |
Canine | HEK293 Cells |
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. The interaction of AR and SP1 contributes to regulate EPHA3 expression, and the SP1 binding sites (‑295~‑261) in the EPHA3 core promoter region is crucial to the regulation of EPHA3 expression in response to androgen hormone stimuli. | |||
TMPY-03906 |
IL-17 Protein, Canine, Recombinant
白细胞介素,interleukin 17A,白介素 |
Canine | E. coli |
IL-17 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is C6L8D7. | |||
TMPY-03517 |
FGF-12 Protein, Canine, Recombinant
fibroblast growth factor 12 |
Canine | E. coli |
FGF12 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. ... | |||
TMPH-00486 |
Chymase Protein, Canine, Recombinant (His & SUMO)
Chymase,Alpha-chymase,CMA1,Mast cell protease I |
Canine | E. coli |
Chymase Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-04089 |
CD40 Protein, Canine, Recombinant (His)
CD40 molecule, TNF receptor superfamily member 5 |
Canine | HEK293 Cells |
CD40 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q7YRL5. | |||
TMPY-02417 |
FOLR1 Protein, Canine, Recombinant (hFc)
folate receptor 1 (adult) |
Canine | HEK293 Cells |
FOLR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is A0A8C0Z2T7. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0209 |
Elobixibat-d5
|
||
Elobixibat-d5 是 Elobixibat 的氘代化合物。Elobixibat 的 CAS 号为 439087-18-0。Elobixibat 是回肠胆汁酸转运蛋白的抑制剂(小鼠、人和犬 IBAT 的 IC50:0.13 nM、0.53 nM 和 5.8 nM)。 Elobixibat 可用于慢性特发性便秘的研究。 | |||
TMIH-0301 |
Levolansoprazole-d4
|
||
Levolansoprazole-d4 是 Levolansoprazole 的氘代化合物。Levolansoprazole 的 CAS 号为 138530-95-7。Levolansoprazole 是一种质子泵抑制剂,不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50:82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性,具有相似的效力。 | |||
T71143 |
Ambroxol-d5
|
||
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous part... | |||
T69995 |
Chlorhexidine-d8 HCl
|
||
Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC... |