IL-22RA1 Protein, Canine, Recombinant (His)

产品编号 TMPY-04087

IL-22RA1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is A0A8C0M3C4.

IL-22RA1 Protein, Canine, Recombinant (His)

产品编号 TMPY-04087

IL-22RA1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is A0A8C0M3C4.

规格	价格	库存	数量
100 μg	¥ 3,820	5日内发货

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产品信息

生物活性	Immobilized canine IL22RA1-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22 , The EC50 of biotinylated IL22 is 0.23-0.55 μg/ml.
产品描述	IL-22RA1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is A0A8C0M3C4.
种属	Canine
表达系统	HEK293 Cells
标签	C-His
蛋白编号	A0A8C0M3C4
别名	interleukin 22 receptor, α1,interleukin 22 receptor, alpha 1
蛋白构建	A DNA sequence encoding the canine IL22RA1 (XP_855113.2) (Met1-The226) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Ala 15
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	25.6 kDa (predicted); 36 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptors for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.