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Search Results for " breakdown "
Targets Recommended: Others Endogenous Metabolite

41

抑制剂 & 化合物

35

天然产物

2

化合物库

20

重组蛋白

7

同位素标记化合物

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Cat. No. Product Name
L1100 蛋白酶抑制剂库

343 compounds
343 种已知的小分子蛋白酶抑制剂的特有集合,可用于高通量筛选和高内涵筛选;
L2510 脂代谢化合物库

492 compounds
492 个脂代谢相关的化合物集合,可用于高通量和高内涵筛选;

化合物库

蛋白酶抑制剂库
Cat.No: L1100
Compounds: 343
脂代谢化合物库
Cat.No: L2510
Compounds: 492
Cat. No. Product Name Target Signaling Pathways
T8104 Glycyl-L-valine

Others; Endogenous Metabolite Metabolism; Others
Glycyl-L-valine 是含有甘氨酸和缬氨酸的二肽。
T20540 N-Valyltryptophan

二肽-2,Val-trp,L-Valyl-L-tryptophan

Others Others
N-Valyltryptophan (Val-trp) 是蛋白质分解代谢或蛋白质消化的不完全分解产物。
T77763 Wu-5

DUB Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
Wu-5 是一种有效的 USP10 抑制剂,对 FLT3 和 AMPK 通路有抑制作用,促使 FLT3-ITD 分解并诱导细胞凋亡(apoptosis)。
T7507 γ-L-Glutamyl-L-alanine

Others; Endogenous Metabolite Metabolism; Others
γ-L-Glutamyl-L-alanine 由γ-谷氨酸和丙氨酸组成,是CRF21(γ-谷氨酰环转移酶,GGCT)的底物,是较大蛋白质的蛋白水解分解产物。γ-L-Glutamyl-L-alanine 是钙敏感受体 (CaR) 功能的正调节剂。
T50064 2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate

KLF MAPK
2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate 是一种用于增强认知功能的促神经药物,通过增加大脑中乙酰胆碱的合成和释放以及通过抑制乙酰胆碱酯酶对乙酰胆碱的分解而发挥作用。
T76890 Petosemtamab

MCLA 158

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Petosemtamab (MCLA 158) 是一种高效的抗 EGFR (Kd: 0.22 nM) 和抗 LGR5 (Kd: 0.86 nM) 单克隆抗体。Petosemtamab 促使 LGR5+ 癌细胞中的 EGFR 信号传导中断和受体分解。Petosemtamab 可用于头颈部鳞状细胞癌 (HNSCC)、转移性结直肠癌 (CRC) 等实体瘤的研究。
T50041 N-(4-methoxyphenyl)prop-2-enamide

N-(4-Methoxyphenyl)acrylamide,N-(4-甲氧苯基)丙烯酰基酰胺

Others Others
N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) 是一种用作分子结构单元的丙烯酰胺类化合物。它可以抑制乙酰胆碱酯酶,增加突触间隙中的乙酰胆碱水平;也可以抑制多巴胺的分解,导致大脑中多巴胺水平的升高。
TP1266 γ-Glu-Phe TFA(7432-24-8 free base)

γ-Glu-Phe TFA(7432-24-8,FREE)

Endogenous Metabolite Metabolism
γ-Glu-Phe TFA(7432-24-8 free base) 是由γ-谷氨酸和苯丙氨酸组成的二肽,是较大蛋白质的蛋白水解分解产物。它可能是由谷胱甘肽与相应氨基酸之间的转肽作用形成的,由γ-谷氨酰转肽酶催化。
T2319 Acotiamide monohydrochloride trihydrate

Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl

AChE Neuroscience
Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱,从而增强胃排空和胃部适应性,有潜力用于功能性消化不良的研究。
T32677 Leucylproline

Leu-pro

Others Others
Leucylproline is a peptide that proteolytic breakdown product by larger proteins.
T13422L Talarozole (R enantiomer)

(R)-Talarozole,Talarozole R enantiomer

Others Others
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid.
T70584 FLA-99

Others Others
FLA-99 inhibits breakdown of inositol-1,4,5-triphosphate by inositol-1,4,5-triphosphate 5-phosphatase.
T31162 Cysteinyltyrosine

N-L-Cysteinyl-L-tyrosine,Cys-tyr

Others Others
Cysteinyltyrosine is a dipeptide composed of cysteine and tyrosine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T32900 Saccharopine

L-Saccharopine,accharopin

Others Others
L-Saccharopine is a product of the breakdown of essential amino acid Lysine.
T35032 Valyllysine

Val-lys,Valyl-lysine

Others Others
Valyllysine is a dipeptide composed of valine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T31161 Cysteinyllysine

Others Others
Cysteinyllysine is a dipeptide composed of cysteine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T30128 Arginylphenylalanine

L-Arg-L-phe

Others Others
Arginylphenylalanine, a dipeptide composed of arginine and phenylalanine, is an incomplete breakdown product of protein digestion or protein catabolism.
T30129 Arginylproline

Arg-pro

Others Others
Arginylproline is a dipeptide composed of arginine and proline. It is an incomplete breakdown product of protein digestion or protein catabolism.
T29828 Alanyltyrosine

Alanyltyrosine is a dipeptide composed of alanine and tyrosine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T38736 Nattokinase

Others Others
Nattokinase is a powerful fibrinolytic enzyme that effectively hydrolyzes fibrin and plasmin substrate, leading to the breakdown of blood clots. Its efficacy renders it valuable for cardiovascular disease studies.
T33083 Lysyl threonine

L-Threonine, l-lysyl-,Dipeptide-7,Dipeptide KT

Others Others
Lysyl threonine is a dipeptide composed of lysine and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T33323 Methionyltryptophan

Met-trp,Methionyl-tryptophan,Methionyl tryptophan

Others Others
Methionyl-Tryptophan is a dipeptide composed of methionine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism.
T14967 Cimlanod

BMS-986231,CXL-1427

Others Others
Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloo
T70311 Demecarium Free Base

Others Others
Demecarium Free Base is a quaternary ammonium compound that serves as a long-acting cholinesterase inhibitor with parasympathomimetic activity. When used topically, demecarium inactivates both pseudocholinesterase and acetylcholinesterase, thereby preventing acetylcholine breakdown and increasing acetylcholine activity.
T80055 Beta-glucuronidase (bovine liver)

Others Others
Beta-glucuronidase是一种关键溶酶体酶,主要功能是参与糖胺聚糖中含有葡萄糖醛酸成分的降解过程。
T74078 N-Nitrosoglyphosate sodium

Others Others
N-Nitrosoglyphosate sodium 是亚硝胺的降解产物,是草甘膦除草剂的合成杂质。
T33091 Lysyllysine

Lys-lys,L-Lys-L-lys

Others Others
Lysyllysine is a dipeptide composed of two lysine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived in
T34019 Phenylalanylglutamate

Phe-glu

Others Others
Phenylalanylglutamate is a dipeptide composed of phenylalanine and glutamate. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are sim
T33088 Lysylcysteine

LYS CYS,LYS-CYS,L-Cysteine, L-lysyl-,LYSCYS

Others Others
Lysylcysteine is a dipeptide composed of lysine and cysteine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived
T69306 Lubabegron fumarate

Others Others
Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasin...
T84648 2-Linoleoyl Glycerol

2-LG

Others Others
2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decreas...
T76135 Hemicellulase

Others Others
Hemicellulase(半纤维素酶),糖苷水解酶家族成员,广泛应用于生化研究领域。该酶能够分解植物纤维中的葡萄糖及其与水分子的聚合物,是自然界植物生物量及碳流降解的关键酶类。
T84534 Arachidonoyl-N-methyl amide

Others Others
Anandamide (AEA), an endogenous cannabinoid, interacts with both central (CB1) and peripheral (CB2) cannabinoid receptors. Its effects are concluded through the cellular uptake and enzymatic breakdown of its amide bond by fatty acid amide hydrolase. Arachidonoyl-N-methyl amide, an analog of anandamide, specifically targets the human CB1 receptor, displaying a binding affinity with a Ki of 60 nM. It completely inhibits rat glial gap junction intercellular communication at a concentration of 50 µM...
T84418 (E)-2-Hexadecenal

trans-2-Hexadecenal

Others Others
Sphingosine-1-phosphate (S1P), a bioactive lipid crucial in numerous signaling pathways, undergoes irreversible degradation by membrane-bound S1P lyase, producing (E)-2-Hexadecenal, a derivative of sphingolipid breakdown. This compound can be oxidized to (2E)-hexadecenoic acid by long-chain fatty aldehyde dehydrogenase before being activated through linkage to coenzyme A. Notably, (E)-2-Hexadecenal induces cytoskeletal reorganization, leading to cell rounding, detachment, activation of JNK pathw...
T37276 2,5-Deoxyfructosazine (hydrochloride)

Others Others
2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL...
T36912 17α,20β-Dihydroxy-4-pregnen-3-one

17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one

Others Others
17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DHP) is an endogenous, maturation-inducing steroid that stimulates oocyte maturation in females of several teleost species. For example, 1 μg/ml of 17α,20β-DHP applied to Persian sturgeon oocytes has been shown to effectively induce germinal vesicle breakdown, an essential step during oocyte maturation.1 Gonadotropin-releasing hormone and the gonadotropins, follicle-stimulating hormone and luteinizing hormone, have been shown to stimulate the production...
T76130 Acetylcholinesterase

Others Others
Acetylcholinesterase(ACHE; EC 3.1.1.7), 即乙酰胆碱酯酶,是一种胆碱能酶,主要存在于神经肌肉接头和胆碱能类型的化学突触中,常用于生化研究。Acetylcholinesterase 可以催化乙酰胆碱和其他一些充当神经递质的胆碱酯分解或水解为乙酸和胆碱。Acetylcholinesterase 主要作用是终止突触之间的神经元传递和信号传导,以防止 ACh 扩散和附近受体的激活。
T78871 PLM-101

Others Others
PLM-101是一种口服抗癌剂,针对FLT3和RET具有选择性抑制作用,有效抑制急性髓系白血病(AML)细胞。通过抑制RET,PLM-101促使FLT3的自噬降解,并且通过抑制PI3K和Ras/ERK信号通路来发挥其抗白血病的活性。在小鼠MV4-11侧翼异种移植模型中,PLM-101以口服剂量3及10 mg/kg显示出抗肿瘤效果,并且在同种异种移植小鼠模型中,剂量为40 mg/kg(口服)亦展现出明显的抗肿瘤功效。
T83663 Mn(III) Protoporphyrin IX Chloride

Manganese(III) Protoporphyrin IX Chloride

Others Others
Mn(III) protoporphyrin IX chloride是一种金属卟啉,当浓度为10 µM时,能在鸡胚肝细胞中诱导δ-氨基酮戊二酸合成酶和血红素加氧酶(HO)基因的mRNA表达,这些酶分别催化血红素生物合成和降解的限速步骤。Mn(III) protoporphyrin IX chloride含纳米仿生物已被用于体外纤维蛋白凝块的磁共振成像(MRI)研究。此外,它还被用于Mn(III) protoporphyrin IX-6(7)-甘氨酰-甘氨酰-L-组氨酸甲酯(MnGGH)的合成,MnGGH是一种具有微过氧化物酶活性的金属卟啉衍生物。
T13421 (-)-Cevimeline hydrochloride hemihydrate

(-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate

ALK Angiogenesis; Tyrosine Kinase/Adaptors
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) 是一种新型mAChR 激动剂,是一种治疗干燥综合征口干症的候选治疗药物。
T35416 α-D-Glucose-1-phosphate (sodium salt hydrate)

Others Others
α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-...

化合物

Glycyl-L-valine
Cat.No: T8104
Synonym:
Target: Others, Endogenous Metabolite
N-Valyltryptophan
Cat.No: T20540
Synonym: 二肽-2,Val-trp,L-Valyl-L-tryptophan
Target: Others
Wu-5
Cat.No: T77763
Synonym:
Target: DUB
γ-L-Glutamyl-L-alanine
Cat.No: T7507
Synonym:
Target: Others, Endogenous Metabolite
2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
Cat.No: T50064
Synonym:
Target: KLF
Petosemtamab
Cat.No: T76890
Synonym: MCLA 158
Target: EGFR
N-(4-methoxyphenyl)prop-2-enamide
Cat.No: T50041
Synonym: N-(4-Methoxyphenyl)acrylamide,N-(4-甲氧苯基)丙烯酰基酰胺
Target: Others
γ-Glu-Phe TFA(7432-24-8 free base)
Cat.No: TP1266
Synonym: γ-Glu-Phe TFA(7432-24-8,FREE)
Target: Endogenous Metabolite
Acotiamide monohydrochloride trihydrate
Cat.No: T2319
Synonym: Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl
Target: AChE
Leucylproline
Cat.No: T32677
Synonym: Leu-pro
Target: Others
Talarozole (R enantiomer)
Cat.No: T13422L
Synonym: (R)-Talarozole,Talarozole R enantiomer
Target: Others
FLA-99
Cat.No: T70584
Synonym:
Target: Others
Cysteinyltyrosine
Cat.No: T31162
Synonym: N-L-Cysteinyl-L-tyrosine,Cys-tyr
Target: Others
Saccharopine
Cat.No: T32900
Synonym: L-Saccharopine,accharopin
Target: Others
Valyllysine
Cat.No: T35032
Synonym: Val-lys,Valyl-lysine
Target: Others
Cysteinyllysine
Cat.No: T31161
Synonym:
Target: Others
Arginylphenylalanine
Cat.No: T30128
Synonym: L-Arg-L-phe
Target: Others
Arginylproline
Cat.No: T30129
Synonym: Arg-pro
Target: Others
Alanyltyrosine
Cat.No: T29828
Synonym:
Target:
Nattokinase
Cat.No: T38736
Synonym:
Target: Others
Lysyl threonine
Cat.No: T33083
Synonym: L-Threonine, l-lysyl-,Dipeptide-7,Dipeptide KT
Target: Others
Methionyltryptophan
Cat.No: T33323
Synonym: Met-trp,Methionyl-tryptophan,Methionyl tryptophan
Target: Others
Cimlanod
Cat.No: T14967
Synonym: BMS-986231,CXL-1427
Target: Others
Demecarium Free Base
Cat.No: T70311
Synonym:
Target: Others
Beta-glucuronidase (bovine liver)
Cat.No: T80055
Synonym:
Target: Others
N-Nitrosoglyphosate sodium
Cat.No: T74078
Synonym:
Target: Others
Lysyllysine
Cat.No: T33091
Synonym: Lys-lys,L-Lys-L-lys
Target: Others
Phenylalanylglutamate
Cat.No: T34019
Synonym: Phe-glu
Target: Others
Lysylcysteine
Cat.No: T33088
Synonym: LYS CYS,LYS-CYS,L-Cysteine, L-lysyl-,LYSCYS
Target: Others
Lubabegron fumarate
Cat.No: T69306
Synonym:
Target: Others
2-Linoleoyl Glycerol
Cat.No: T84648
Synonym: 2-LG
Target: Others
Hemicellulase
Cat.No: T76135
Synonym:
Target: Others
Arachidonoyl-N-methyl amide
Cat.No: T84534
Synonym:
Target: Others
(E)-2-Hexadecenal
Cat.No: T84418
Synonym: trans-2-Hexadecenal
Target: Others
2,5-Deoxyfructosazine (hydrochloride)
Cat.No: T37276
Synonym:
Target: Others
17α,20β-Dihydroxy-4-pregnen-3-one
Cat.No: T36912
Synonym: 17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one
Target: Others
Acetylcholinesterase
Cat.No: T76130
Synonym:
Target: Others
PLM-101
Cat.No: T78871
Synonym:
Target: Others
Mn(III) Protoporphyrin IX Chloride
Cat.No: T83663
Synonym: Manganese(III) Protoporphyrin IX Chloride
Target: Others
(-)-Cevimeline hydrochloride hemihydrate
Cat.No: T13421
Synonym: (-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate
Target: ALK
α-D-Glucose-1-phosphate (sodium salt hydrate)
Cat.No: T35416
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T1341 Nortropine

Nortropenol,去甲托品醇

AChR Neuroscience
Nortropine (Nortropenol) 是托品碱分解和反应生成琥珀酸的中间体,可从Convolvulus subhirsutus 生物碱中分离得到。
T4886 Dihydrouracil

二氢尿嘧啶,5,6-Dihydrouracil

Endogenous Metabolite Metabolism
Dihydrouracil (5,6-Dihydrouracil) 是一种尿嘧啶的代谢产物,能够作为鉴定二氢嘧啶脱氢酶 (DPD) 缺陷的标志物。
T0529 Dulcite

Galactitol,Dulcitol,Euonymit,NSC 1944,D-Galactitol,Melampyrit,半乳糖醇

Endogenous Metabolite Metabolism
Dulcite (D-Galactitol) 是一种具有微甜味的糖醇,其是半乳糖的代谢分解产物。
T19529 Proteinase

Others Others
Proteinase 是一种催化蛋白质分解的酶。它们通过水解作用来裂解蛋白质内的肽键,将蛋白质分解成更小的多肽或单个氨基酸。Proteinase 参与许多生物功能,包括消化进食的蛋白质、旧蛋白质的分解,以及细胞信号传递。它们同时促进新的蛋白质产物的形成
T0496 Creatinine

肌酸酐,NSC13123

Endogenous Metabolite Metabolism
Creatinine (NSC-13123) 由肌肉中磷酸肌酸分解产生。
T5855 Edrophonium chloride

AChE Neuroscience
Edrophonium chloride 是一种乙酰胆碱酯酶抑制剂,可通过特异性结合其催化位点来防止神经递质乙酰胆碱的分解。
TN3831 (-)-Denudatin B

Denudatin B

ATPase; Potassium Channel; Calcium Channel; PAFR GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
(-)-Denudatin B (Denudatin B) 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解,在高浓度下具有非特异性抗血小板作用。
T4934 1-Methyl-L-histidine

1-甲基-L-组氨酸,3-(1-Methylimidazol-4-yl)-L-alanine,Nτ-Methyl-L-histidine

Endogenous Metabolite Metabolism
1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine),一种人内源性代谢物,是肉类和外源性 3-methylhistidine 摄入的客观生物标记。
T1136 Amylase

Diastase,淀粉酶

Others Others
Amylase (Diastase) 是由胰腺和唾液腺分泌得到的一种酶,能够将淀粉水解为糖类。它大致可分为 α 亚型、 β 亚型 和 γ 亚型三种亚型。
T4762 L-Pipecolic acid

L-哌啶酸,L-Homoproline,H-HoPro-OH

Endogenous Metabolite Metabolism
L-Pipecolic acid (L-Homoproline) 是赖氨酸的分解产物,它能在患有常染色体遗传性疾病的婴儿体液中积累,比如新生儿肾上腺机能障碍, Zellweger 综合征等。
TN1196 17-Hydroxyisolathyrol

Others Others
17-Hydroxyisolathyrol 是一种大环千金子二萜醇衍生物,分离自Euphorbla luthyrrs种子。17-Hydroxyisolathyrol 抑制蛋白质-蛋白质相互作用。
T4854 Acetoacetic acid lithium salt

LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂

Others; Endogenous Metabolite Metabolism; Others
Acetoacetic acid lithium salt (Lithium 3-Oxobutyrate) 是内源性代谢产物的一种。
T4734 Suberic acid

Octanedioic acid,1,8-Octanedioic acid,辛二酸

Others; Endogenous Metabolite Metabolism; Others
Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。
T4811 D-Alanine

D-α-Alanine,Ba 2776,(R)-Alanine,D-丙氨酸,(R)-2-Aminopropionic acid

Chloride channel; Endogenous Metabolite Membrane transporter/Ion channel; Metabolism
D-Alanine ((R)-Alanine) 是一种GlyR 和PMBA 的弱激动剂,其对GlyR 的EC50=9 mM。
T4744 5-HYDROXYINDOLE-3-ACETIC ACID

5-羟基吲哚-3-乙酸,5-HIAA

Others; Endogenous Metabolite Metabolism; Others
5-Hydroxyindole-3-acetic acid (5-HIAA) 是 甲氧基肾上腺素或5-羟色胺的主要代谢产物,被用作神经内分泌肿瘤的生物标志物。它是血清素的分解产物,能够从尿液中排出。
T8264 3-Methyl-2-oxovaleric acid

Endogenous Metabolite Metabolism
3-Methyl-2-oxovaleric acid 是神经毒素,代谢毒素和酸性原,它是支链氨基酸不完整分解产生的异常代谢物。
T5222 N-(5-Aminopentyl)acetamide

Monoacetylcadaverine,N-(5-氨基戊基)乙酰胺,N-Acetylcadaverine,N-Acetyl-1,5-pentanediamine

Others; Endogenous Metabolite Metabolism; Others
N-(5-Aminopentyl)acetamide (N-Acetylcadaverine) 是用作多胺尸胺的乙酰化形式。尸胺是有机体中的氨基酸分解产生的,大剂量时有毒。
T4928 L-Kynurenine

L-犬尿氨酸,(S)-Kynurenine

AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite Immunology/Inflammation; Metabolism
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T50050 2,3-dihydroxy-3-methylbutanoic acid

Others Others
2,3-dihydroxy-3-methylbutanoic acid 是支链氨基酸亮氨酸的天然代谢产物。它通过激活mTOR 信号通路发挥作用,促进新肌肉蛋白的合成,减少现有蛋白质的分解,从而增加肌肉质量,改善运动后的恢复。
T5232 3-Methyl-2-oxobutanoic acid

3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid

Others; Endogenous Metabolite Metabolism; Others
3-Methyl-2-oxobutanoic acid (2-Oxoisovaleric acid) 是大肠杆菌中泛酸的前体。它是由支链氨基酸的不完全分解产生的一种异常代谢物。
T3O2749 L-Leucine

(S)-Leucine,Leu,L-亮氨酸,亮氨酸

mTOR PI3K/Akt/mTOR signaling
L-Leucine ((S)-Leucine) 是必需的支链氨基酸,能够激活 mTOR 信号通路。
T4827 Trimethylammonium chloride

三甲胺盐酸盐,Trimethylamine hydrochloride

Others; Endogenous Metabolite; AChE Metabolism; Neuroscience; Others
Trimethylammonium chloride 是动植物分解的产物,是的非竞争性乙酰胆碱酯酶抑制剂。 。它是造成鱼腥味的主要物质,通常与脏鱼、细菌性阴道感染和口臭有关。它也与服用大剂量胆碱有关。三甲胺尿是一种遗传性疾病,身体无法从食物中代谢三甲胺。食用富含胆碱的食物后,患者的汗液、尿液和呼吸中会出现特有的鱼腥味。三甲胺尿症是一种常染色体隐性遗传病,涉及三甲胺氧化酶缺乏症。三甲氨基尿症在罗德岛红鸡中也有发现,这种鸡产的蛋有腥味。尿液中的 Trimethylammonium chloride 是食用豆类的生物标志物。
T4705 Aminoadipic acid

DL-2-Aminoadipic acid,DL-2-氨基己二酸

Others; Endogenous Metabolite Metabolism; Others
Aminoadipic acid (DL-2-Aminoadipic acid) 是赖氨酸主要生化途径中的代谢物。 它是赖氨酸和糖碱代谢的中间体。 它拮抗由谷氨酸受体 N-甲基-D-天冬氨酸调节的神经兴奋特性。
T4919 Ureidopropionic acid

Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid

Endogenous Metabolite Metabolism
Ureidopropionic acid (3-Ureidopropionic acid) 是尿嘧啶代谢的中间体。更具体地说,它是二氢尿嘧啶的分解产物,由二氢嘧啶酶产生。它通过β -脲丙酸酶进一步分解为β -丙氨酸。尿素丙酸本质上是β -丙氨酸的尿素衍生物。高水平的尿丙酸存在于β -尿丙酸酶(UP)缺乏的个体中。嘧啶代谢中的酶缺乏与抗肿瘤药物5-氟尿嘧啶的严重毒性风险有关。
T5S1632 Barlerin

8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

VEGFR; TNF; NF-κB; Akt; Caspase Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。
T3893 Forsythoside B

连翘酯苷 B,连翘脂苷B

TNF; NF-κB Apoptosis; NF-κB
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。
T4889 2,6-Diaminoheptanedioic acid

Others; Endogenous Metabolite Metabolism; Others
2,6-Diaminoheptanedioic acid 是内源性代谢产物的一种。
T64812 Collagenase Type I

Collagenase I,Collagenase Type I (From microorganisms)

Others Others
Collagenase Type I 是一种蛋白水解酶,能分解胶原蛋白中的肽键(胶原蛋白是结缔组织的主要结构蛋白)。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质,从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组,潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。
T4881 Phosphorylethanolamine

O-Phosphorylethanolamine,乙醇胺磷酸酯

Others; Endogenous Metabolite Metabolism; Others
Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体,也是磷脂分解的产物。与其他器官相比,大脑中磷酸单酯的含量要高得多。在大脑发育过程中,磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯,在阿尔茨海默病患者的大脑中减少。
T8274 3-Methyl-L-histidine

Endogenous Metabolite Metabolism
3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T20555 Glycyltyrosine

NSC 118362,Gly Tyr,NSC-118362,Gly-Tyr,NSC118362,N-Glycyl-L-tyrosine

Others Others
Glycyltyrosine, a dipeptide composed of tyrosine and glycine, is an incomplete breakdown product of protein catabolism or protein digestion.
T15417 Griseoluteic acid

Others Others
Griseoluteic acid is a breakdown product of griseolutein A and B. Griseoluteic acid is a phenazine antibiotic and is originally isolated from S. griseoluteus.
T19128 3-Pyridineacetic acid

Others Others
3-Pyridineacetic acid is a homolog of nicotinic acid, a breakdown product of nicotine and other tobacco alkaloids.
TMA1944 Protopine hydrochloride

EGFR; cAMP Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MD
T75639 Cellohexaose

Others Others
Cellohexaose,一种由β(1-4)链接的D-葡萄糖单体通过缩合反应形成的葡萄糖聚合物,来源于纤维素的分解,包含两个或更多的葡萄糖单体。

天然产物

Nortropine
Cat.No: T1341
Synonym: Nortropenol,去甲托品醇
Target: AChR
Dihydrouracil
Cat.No: T4886
Synonym: 二氢尿嘧啶,5,6-Dihydrouracil
Target: Endogenous Metabolite
Dulcite
Cat.No: T0529
Synonym: Galactitol,Dulcitol,Euonymit,NSC 1944,D-Galactitol,Melampyrit,半乳糖醇
Target: Endogenous Metabolite
Proteinase
Cat.No: T19529
Synonym:
Target: Others
Creatinine
Cat.No: T0496
Synonym: 肌酸酐,NSC13123
Target: Endogenous Metabolite
Edrophonium chloride
Cat.No: T5855
Synonym:
Target: AChE
(-)-Denudatin B
Cat.No: TN3831
Synonym: Denudatin B
Target: ATPase, Potassium Channel, Calcium Channel, PAFR
1-Methyl-L-histidine
Cat.No: T4934
Synonym: 1-甲基-L-组氨酸,3-(1-Methylimidazol-4-yl)-L-alanine,Nτ-Methyl-L-histidine
Target: Endogenous Metabolite
Amylase
Cat.No: T1136
Synonym: Diastase,淀粉酶
Target: Others
L-Pipecolic acid
Cat.No: T4762
Synonym: L-哌啶酸,L-Homoproline,H-HoPro-OH
Target: Endogenous Metabolite
17-Hydroxyisolathyrol
Cat.No: TN1196
Synonym:
Target: Others
Acetoacetic acid lithium salt
Cat.No: T4854
Synonym: LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂
Target: Others, Endogenous Metabolite
Suberic acid
Cat.No: T4734
Synonym: Octanedioic acid,1,8-Octanedioic acid,辛二酸
Target: Others, Endogenous Metabolite
D-Alanine
Cat.No: T4811
Synonym: D-α-Alanine,Ba 2776,(R)-Alanine,D-丙氨酸,(R)-2-Aminopropionic acid
Target: Chloride channel, Endogenous Metabolite
5-HYDROXYINDOLE-3-ACETIC ACID
Cat.No: T4744
Synonym: 5-羟基吲哚-3-乙酸,5-HIAA
Target: Others, Endogenous Metabolite
3-Methyl-2-oxovaleric acid
Cat.No: T8264
Synonym:
Target: Endogenous Metabolite
N-(5-Aminopentyl)acetamide
Cat.No: T5222
Synonym: Monoacetylcadaverine,N-(5-氨基戊基)乙酰胺,N-Acetylcadaverine,N-Acetyl-1,5-pentanediamine
Target: Others, Endogenous Metabolite
L-Kynurenine
Cat.No: T4928
Synonym: L-犬尿氨酸,(S)-Kynurenine
Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite
2,3-dihydroxy-3-methylbutanoic acid
Cat.No: T50050
Synonym:
Target: Others
3-Methyl-2-oxobutanoic acid
Cat.No: T5232
Synonym: 3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid
Target: Others, Endogenous Metabolite
L-Leucine
Cat.No: T3O2749
Synonym: (S)-Leucine,Leu,L-亮氨酸,亮氨酸
Target: mTOR
Trimethylammonium chloride
Cat.No: T4827
Synonym: 三甲胺盐酸盐,Trimethylamine hydrochloride
Target: Others, Endogenous Metabolite, AChE
Aminoadipic acid
Cat.No: T4705
Synonym: DL-2-Aminoadipic acid,DL-2-氨基己二酸
Target: Others, Endogenous Metabolite
Ureidopropionic acid
Cat.No: T4919
Synonym: Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid
Target: Endogenous Metabolite
Barlerin
Cat.No: T5S1632
Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01
Target: VEGFR, TNF, NF-κB, Akt, Caspase
Forsythoside B
Cat.No: T3893
Synonym: 连翘酯苷 B,连翘脂苷B
Target: TNF, NF-κB
2,6-Diaminoheptanedioic acid
Cat.No: T4889
Synonym:
Target: Others, Endogenous Metabolite
Collagenase Type I
Cat.No: T64812
Synonym: Collagenase I,Collagenase Type I (From microorganisms)
Target: Others
Phosphorylethanolamine
Cat.No: T4881
Synonym: O-Phosphorylethanolamine,乙醇胺磷酸酯
Target: Others, Endogenous Metabolite
3-Methyl-L-histidine
Cat.No: T8274
Synonym:
Target: Endogenous Metabolite
Glycyltyrosine
Cat.No: T20555
Synonym: NSC 118362,Gly Tyr,NSC-118362,Gly-Tyr,NSC118362,N-Glycyl-L-tyrosine
Target: Others
Griseoluteic acid
Cat.No: T15417
Synonym:
Target: Others
3-Pyridineacetic acid
Cat.No: T19128
Synonym:
Target: Others
Protopine hydrochloride
Cat.No: TMA1944
Synonym:
Target: EGFR, cAMP
Cellohexaose
Cat.No: T75639
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPH-03338 CHRM1 Protein, Rat, Recombinant (His)

Muscarinic acetylcholine receptor M1,CHRM1

Rat E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482.
TMPH-01714 CHRM1 Protein, Human, Recombinant (His)

Muscarinic acetylcholine receptor M1,CHRM1

Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229.
TMPH-03261 Cathepsin D Protein, Rat, Recombinant (His & Myc)

Ctsd,Cathepsin D

Rat E. coli
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Cathepsin D Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.2 kDa and the accession number is P24268.
TMPH-01717 CHRM5 Protein, Human, Recombinant (His)

CHRM5,Muscarinic acetylcholine receptor M5

Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is P08912.
TMPH-01716 CHRM3 Protein, Human, Recombinant (B2M & His)

Muscarinic acetylcholine receptor M3,CHRM3

Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM3 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 40.7 kDa and the accession number is P20309.
TMPH-01272 TRIM9 Protein, Human, Recombinant (His & SUMO)

RING finger protein 91,RING-type E3 ubiquitin transferase TR...

Human E. coli
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
TMPH-01715 CHRM2 Protein, Human, Recombinant (His)

CHRM2,Muscarinic acetylcholine receptor M2

Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. CHRM2 Protein, Human, Recombinant (His) is expressed in E. col...
TMPK-00150 FOLR1 Protein, Human, Recombinant (His & Avi)

Folate receptor 1,Folbp1,Folate receptor alpha,FR-alpha,FR a...

Human HEK293 Cells
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into t...
TMPJ-01301 GGACT Protein, Human, Recombinant (His)

Gamma-Glutamylaminecyclotransferase,A2LD1,AIG2-Like Domain-C...

Human E. coli
Gamma-Glutamylaminecyclotransferase is an enzyme that converts gamma-glutamylamines to free amines and 5-oxoproline which belongs to the gamma-glutamylcyclotransferase family. It shows high activity toward gamma-glutamyl-epsilon-lysine, derived from the breakdown of fibrin and contributes to degradation of proteins cross-linked by transglutaminases. It degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by transglutaminases. This pro...
TMPJ-00447 MMP-3 Protein, Human, Recombinant (His)

Transin-1,Stromelysin-1,MMP-3,Matrix metalloproteinase-3,MMP...

Human HEK293 Cells
MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 c...
TMPJ-00496 PGM2 Protein, Human, Recombinant (His)

Phosphopentomutase,Phosphodeoxyribomutase,Glucose phosphomut...

Human E. coli
Phosphoglucomutase-2 (PGM2) is a member of PGM family, which catalyzes the inter-conversion of sugar phosphates and participates in anabolic and catabolic reactions. When cells are grown in glucose, PGM catalyzes the conversion of glucose-6-phosphate to glucose-1-phosphate an important precursor required for the synthesis of UDP glucose and trehalose. PGM2 catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphope...
TMPJ-00727 PGK1 Protein, Human, Recombinant (His)

Phosphoglycerate kinase 1,Primer recognition protein 2,PGK1,...

Human HEK293 Cells
Phosphoglycerate kinase 1(PGK1) is an enzyme. It is mainly expressed in spermatogonia and Localized on the principle piece in the sperm. Its expression significantly decreased in the testis of elderly men. PGK1 involved in a critical energy-producing process known as glycolysis. It helps carry out a chemical reaction that converts a molecule called 1,3-diphosphoglycerate, which is produced during the breakdown of glucose, to another molecule called 3-phosphoglycerate during glycolysis. PGK1 may ...
TMPJ-00851 IDE Protein, Human, Recombinant (His)

Insulysin,Insulinase,Insulin-Degrading Enzyme,IDE,Abeta-Degr...

Human HEK293 Cells
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted...
TMPY-05066 IVD Protein, Mouse, Recombinant (His)

6720455E18Rik,AI463340,isovaleryl-CoA dehydrogenase,1300016K...

Mouse Baculovirus Insect Cells
IVD (Isovaleryl-CoA Dehydrogenase) is a Protein Coding gene. IVD is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. IVD plays an essential role in processing proteins obtained from the diet. The body breaks down proteins from food into smaller parts called amino acids. Amino acids can be further processed to provide energy for growth and development. Isovaleryl-CoA dehydrogenase helps process a particular amino acid called leucine. Specifically, isovaleryl-CoA ...
TMPY-02965 MMP-19 Protein, Human, Recombinant

MMP18,matrix metallopeptidase 19,RASI-1

Human E. coli
MMP19, also known as RASI-1, is a member of the peptidase M1A family. It contains 4 hemopexin-like domains and is expressed in the mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart, and blood vessel walls. It is a matrix metalloproteinase (MMP). Proteins of the MMP family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well a...
TMPY-00140 ABP1/AOC1 Protein, Human, Recombinant (His)

amine oxidase, copper containing 1,DAO,ABP1,ABP,KAO,DAO1

Human HEK293 Cells
Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under co...
TMPY-02765 GM2A Protein, Human, Recombinant (His)

GM2 ganglioside activator,SAP-3,GM2-AP

Human Baculovirus Insect Cells
GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexo...
TMPY-02689 MMP-3 Protein, Human, Recombinant

STMY,MMP-3,matrix metallopeptidase 3,CHDS6,STMY1,SL-1,STR1

Human E. coli
Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in the extracellular matrix. This prot...
TMPY-01290 CHIT1 Protein, Human, Recombinant (His)

chitinase 1 (chitotriosidase),CHITD,CHI3,CHIT

Human HEK293 Cells
Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitinases from other species, is synthesized and secreted by specifically activated macrophages. Chitotriosidase is a polymer of N-acetylglucosamine. Serum and plasma chitotriosidase activity is usually measured as the first step in diagnosis of Gaucher disease. Monitoring chitotriosid...
TMPY-04542 CDK2 Protein, Human, Recombinant (His)

CDKN2,cyclin-dependent kinase 2,p33(CDK2)

Human Baculovirus Insect Cells
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...

重组蛋白

CHRM1 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03338
Species: Rat
Expression System: E. coli
CHRM1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01714
Species: Human
Expression System: E. coli
Cathepsin D Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03261
Species: Rat
Expression System: E. coli
CHRM5 Protein, Human, Recombinant (His)
Cat.No: TMPH-01717
Species: Human
Expression System: E. coli
CHRM3 Protein, Human, Recombinant (B2M & His)
Cat.No: TMPH-01716
Species: Human
Expression System: E. coli
TRIM9 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01272
Species: Human
Expression System: E. coli
CHRM2 Protein, Human, Recombinant (His)
Cat.No: TMPH-01715
Species: Human
Expression System: E. coli
FOLR1 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00150
Species: Human
Expression System: HEK293 Cells
GGACT Protein, Human, Recombinant (His)
Cat.No: TMPJ-01301
Species: Human
Expression System: E. coli
MMP-3 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00447
Species: Human
Expression System: HEK293 Cells
PGM2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00496
Species: Human
Expression System: E. coli
PGK1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00727
Species: Human
Expression System: HEK293 Cells
IDE Protein, Human, Recombinant (His)
Cat.No: TMPJ-00851
Species: Human
Expression System: HEK293 Cells
IVD Protein, Mouse, Recombinant (His)
Cat.No: TMPY-05066
Species: Mouse
Expression System: Baculovirus Insect Cells
MMP-19 Protein, Human, Recombinant
Cat.No: TMPY-02965
Species: Human
Expression System: E. coli
ABP1/AOC1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00140
Species: Human
Expression System: HEK293 Cells
GM2A Protein, Human, Recombinant (His)
Cat.No: TMPY-02765
Species: Human
Expression System: Baculovirus Insect Cells
MMP-3 Protein, Human, Recombinant
Cat.No: TMPY-02689
Species: Human
Expression System: E. coli
CHIT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01290
Species: Human
Expression System: HEK293 Cells
CDK2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04542
Species: Human
Expression System: Baculovirus Insect Cells
Cat. No. Product Name Target Signaling Pathways
TMID-0162 Creatinine-d5

Creatinine-d5 是 Creatinine 的氘代化合物。Creatinine 的 CAS 号为 60-27-5。Creatinine 由肌肉中磷酸肌酸分解产生。
TMID-0160 5-Hydroxyindole-3-acetic Acid-d6

5-Hydroxyindole-3-acetic Acid-d6 是 5-Hydroxyindole-3-acetic Acid 的氘代化合物。5-Hydroxyindole-3-acetic Acid 的 CAS 号为 54-16-0。5-Hydroxyindole-3-acetic acid 是 甲氧基肾上腺素或5-羟色胺的主要代谢产物,被用作神经内分泌肿瘤的生物标志物。它是血清素的分解产物,能够从尿液中排出。
TMIJ-0374 L-Leucine-d3

L-Leucine-d3 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸,能够激活mTOR信号通路。
TMIJ-0518 L-Kynurenine-d4-1

L-Kynurenine-d4-1 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
TMID-0071 L-Kynurenine-d4

L-Kynurenine-d4 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
TMIJ-0081 L-Leucine-d10

L-Leucine-d10 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸,能够激活mTOR信号通路。
TMID-0096 P-CRESOL-d3 (METHYL-d3)

P-CRESOL-d3 (METHYL-d3) 是 P-CRESOL 的氘代化合物。P-CRESOL 的 CAS 号为 106-44-5。p-Cresol 是一种部分亲脂性部分,在正常条件下与血浆蛋白(接近 100%)强烈结合。对甲酚通过结合代谢,主要是硫酸化和葡萄糖醛酸化,但未结合的对甲酚至少部分通过尿液去除。

同位素标记化合物

Creatinine-d5
Cat.No: TMID-0162
Synonym:
Target:
5-Hydroxyindole-3-acetic Acid-d6
Cat.No: TMID-0160
Synonym:
Target:
L-Leucine-d3
Cat.No: TMIJ-0374
Synonym:
Target:
L-Kynurenine-d4-1
Cat.No: TMIJ-0518
Synonym:
Target:
L-Kynurenine-d4
Cat.No: TMID-0071
Synonym:
Target:
L-Leucine-d10
Cat.No: TMIJ-0081
Synonym:
Target:
P-CRESOL-d3 (METHYL-d3)
Cat.No: TMID-0096
Synonym:
Target:
TargetMol Loading
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