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Cat. No. | Product Name | ||
---|---|---|---|
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21616 |
L-006235
L 006235 |
Cysteine Protease | Proteases/Proteasome |
L-006235 是一种口服有活性的、可逆的cathepsin K 选择性抑制剂,在骨吸收试验中的IC50值为 5 nM。它能够抑制胶原蛋白降解,并较少骨质流失。 | |||
T13324 |
VUF11207 fumarate
|
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体,pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化,pEC50分别为 8.8 和 7.9。 | |||
T6451 |
Clodronic acid disodium salt
Loron,Clodronate Disodium,氯屈膦酸二钠,Lodronate |
Others | Others |
Clodronic acid disodium salt (Lodronate) 是一种口服具有活力的破骨细胞骨吸收 (osteoclastic bone resorption) 的抑制剂,是一代双磷酸盐。它可用于高骨转换状态、Paget’s 病和溶骨性骨转移中。 | |||
T7566 |
GRGDSPK
EMD 56574 |
Others | Others |
GRGDSPK (EMD 56574) 是一种包含精氨酸-甘氨酸-天冬氨酸 (RGD) 的多肽,也是一种竞争性且可逆的抑制肽,可抑制整联蛋白-纤连蛋白结合,可用于整联蛋白在骨形成和吸收中作用的研究。 | |||
T19501 |
Pamidronate disodium pentahydrate
|
Others | Others |
Pamidronate disodium pentahydrate 是一种骨吸收抑制剂,能够预防骨质疏松症的化合物。 | |||
T0308 |
Etidronic acid
HEDPA,Etidronate,HEDP,羟乙磷酸 |
Apoptosis; Phosphatase; Others; HBV | Apoptosis; Metabolism; Microbiology/Virology; Others |
Etidronic acid (HEDP) 是一种影响钙代谢的二膦酸盐,抑制异位钙化并减缓骨吸收和骨转换,可应用于洗涤,水处理,化妆品和制药业。 | |||
T0309 |
Ipriflavone
Osteofix,依普黄酮 |
advanced glycation end products | Others |
Ipriflavone (Osteofix) 是一种合成异黄酮衍生物,可用于抑制骨吸收。 | |||
T7566L1 |
GRGDSPK acetate
GRGDSPK acetate(111119-28-9 Free base) |
Beta Amyloid | Neuroscience |
GRGDSPK acetate 显示出对整合素-纤连蛋白结合的抑制活性,可用于研究整合素在骨形成和吸收中的作用。 | |||
T21299 |
Zoledronic acid monohydrate
唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate |
Apoptosis; Others; Autophagy | Apoptosis; Autophagy; Others |
Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐,具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡,有抗癌作用。 | |||
T16394 |
ONO-5334
|
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
ONO-5334 是一种具有选择性、口服活性和高效性的组织蛋白酶 K 抑制剂,具有抗 SAR-COV-2 和抗骨吸收活性,可用于研究骨质疏松症。 | |||
T0379 |
Risedronic Acid
Risedronate,利塞膦酸 |
Others; Transferase | Metabolism; Others |
Risedronic Acid (Risedronate) 具有抑制破骨细胞介导的骨重吸收的作用。 | |||
T0575 |
1-Methylimidazole
|
Others | Others |
1-Methylimidazole 是1-methyl-2-thioimidazole (methimazole)的代谢物,可抑制骨吸收。 | |||
T8489 |
Minodronic acid monohydrate
|
Transferase | Metabolism |
Minodronic acid monohydrate 是一种法尼基二磷酸合成酶抑制剂,可作为骨吸收抑制剂。 | |||
T6373 |
Alendronate sodium hydrate
G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax |
Transferase | Metabolism |
Alendronate sodium hydrate (MK 217) 是 farnesyl diphosphate synthase 抑制剂(IC50:460 nM)。 | |||
T1041 |
Risedronate Sodium
NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠 |
HBV; Transferase | Metabolism; Microbiology/Virology |
Risedronate Sodium (NE 58095 Sodium) 是一种双磷酸盐,对破骨细胞介导的骨吸收具有抑制作用。 | |||
T2188 |
Thonzonium Bromide
嘧苯十六铵,通佐溴胺 |
Proton pump; Antibacterial; Autophagy | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Thonzonium bromide 是一种单阳离子表面活性剂,在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收,并在体内阻止 LPS 诱导的骨丢失。 | |||
T1641 |
Strontium ranelate
Distrontium renelate,S12911,雷尼酸锶 |
Calcium Channel; CaSR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Strontium ranelate (S12911) 是抗骨质疏松的药物,能够抑制骨吸收,促进骨形成,进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR),进而促进肌醇 1,4,5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。 | |||
T3280 |
Clodronate disodium tetrahydrate
clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium |
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的,可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐,具有抗骨质疏松、抗炎作用,可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP,缓解慢性神经病理性疼痛和炎症性疼痛。 | |||
TP1906L1 |
DPC AJ1951 acetate
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
DPC-AJ1951 acetate 是一种 14 个氨基酸的肽,可作为甲状旁腺激素 (PTH)/PTH 相关肽受体 (PPR) 的有效激动剂。在骨吸收的体外和体内测定中表征了它的活性。 | |||
T1210 |
Sodium etidronate
依替膦酸钠,Didronel |
Phosphatase | Metabolism |
Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员,etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量,从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。 | |||
T0291 |
Flurbiprofen
氟比洛芬,dl-Flurbiprofen |
Apoptosis; COX; MRP | Apoptosis; Immunology/Inflammation; Neuroscience |
Flurbiprofen (dl-Flurbiprofen) 是一种高效的,具有口服活性的非甾体抗炎化合物,有退热止痛活性, 常用于炎症性疾病的研究。它是一种非选择性的环氧合酶抑制剂,可研究结肠癌。 | |||
T27366 |
FR 78844
FR78844,FR-78844 |
Others | Others |
FR 78844 is an antagonist of bone resorption. | |||
T20338 |
Methopterin
NSC 107144,alpha-Methopterin,NSC-107144,10-Methylfolic acid,NSC107144 |
Others | Others |
Methopterin shows the activation and bone resorption function of murine osteoclasts. | |||
T31902 |
Galactosylhydroxylysine
Hydroxylysine-galactose |
Others | Others |
Galactosylhydroxylysine residues present in bone type I collagen are terminal degradation products of the bone matrix that are released during bone resorption and excreted in the urine. | |||
T29109 |
VPC12249
VPC-12249,VPC 12249 |
Others | Others |
VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity. | |||
T70305 |
Zoledronate trisodium hydrate
|
Others | Others |
Zoledronate trisodium is a Bone Resorption Inhibitor and Osteoporosis Therapy Adjunct | |||
T31940 |
Glucosylgalactosylhydroxylysine
Hydroxylysine-glucose-galactose |
Others | Others |
Glucosylgalactosylhydroxylysine is a bone formation and bone resorption marker that is related to bone turnover processes during growth and development as well as metabolic bone diseases. | |||
T26512 |
ABD-295
|
Others | Others |
ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in vivo. | |||
T27602 |
Incadronate Disodium
YM-175,Cimadronate,YM175,YM 175 |
Others | Others |
Incadronate Disodium is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro. | |||
TP2055 |
Calcitonin (human)
|
||
Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption. | |||
T30836 |
Cgp 47072
Cgp-47072,Cgp47072 |
Others | Others |
Cgp 47072 is a bisphosphonate, used in the treatment of bone diseases, particularly where there is uncontrolled bone resorption. | |||
T69996 |
A-75943
|
Others | Others |
A-75943 is a bone resorption inhibitor from streptomyces. | |||
T15206 |
Eldecalcitol
艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 |
Others | Others |
Eldecalcitol possesses a potent inhibitory effect on bone resorption and induces a significant increase in bone mineral density. Eldecalcitol is an orally active analogue of active vitamin D. It also is used in the treatment of osteoporosis . | |||
T36065 |
N-Oleoyl-L-Serine
|
||
Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the maintenance of normal bone mass via signaling through the CB2 receptor. N-Oleoyl-L-serine is an endogenous lipid that has been reported to stimulate bone formation and to inhibit bone resorption. | |||
TP1779 |
C-telopeptide
|
||
C-telopeptide, a cross-linked peptide derived from type I collagen, is liberated through bone resorption and has demonstrated a correlation with bone mineral density (BMD). | |||
TP1779L |
C-telopeptide acetate
C-telopeptide acetate(162929-64-8 free base) |
Others | Others |
C-telopeptide acetate 是 I 型胶原蛋白的交联肽,可用作骨吸收的标志物。 | |||
T16092 |
L-873724
|
Others | Others |
L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of | |||
T10187 |
6-Raloxifene-β-D-glucopyranoside
|
Others | Others |
6-Raloxifene-β-D-glucopyranoside is a benzothiophene glucuronidated at the 6' position. It is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss, resorption, and lowering lipid | |||
T40463 |
Relacatib
SB-462795 |
Others | Others |
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in ... | |||
T69443 |
Aminobutane bisphosphonate
|
Others | Others |
Aminobutane bisphosphonate is a powerful inhibitor of bone resorption. It can potentially be a useful measure for controlling hypercalcemia in patients with carcinoma. | |||
T69082 |
Flurbiprofen sodium
|
Others | Others |
Flurbiprofen sodium is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting carbonic anhydrase. | |||
T74736 |
2MD
|
Others | Others |
2MD是一种口服活性维生素D类似物,能刺激骨膜骨形成并减少小梁骨吸收,从而恢复小梁和皮质骨的质量与强度。在非人灵长类动物研究中,2MD还可以调节(IOP)相关基因,降低眼压。 | |||
T71150 |
Incadronic acid
|
Others | Others |
Incadronate, also known as Cimadronate and YM-175, is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro. Incadronate disodium is a bone density conservation, antitumor and anti-inflammatory agent. | |||
T78278 |
Blosozumab
|
||
Blosozumab (LY2541546)为针对人sclerostin (SOST)的单克隆抗体。它能促进骨生成,同时抑制骨吸收,可应用于骨质疏松症相关研究。 | |||
T73770 |
Galactosylhydroxylysine hydrochloride
|
Others | Others |
Galactosylhydroxylysine hydrochloride, 一种羟基赖氨酸经糖基化转换后生成的骨胶原蛋白成分,该化合物在骨吸收过程中释放,其浓度在代谢性骨丢失疾病中会上升。 | |||
T35826 |
PKC fragment (530-558)
|
||
PKC fragment (530-558) 是蛋白激酶C (PKC) 的肽片段,是一种有效的 PKC 激活剂。Protein Kinase C (530-558) 可显著抑制破骨细胞骨吸收。 | |||
T76657 |
Human PTH-(1-31)
|
||
Human PTH-(1-31) 是人PTH的第1至31个氨基酸片段。它能够促进cAMP的释放,并作为25-羟基维生素D-1α-羟化酶的弱激活剂。此外,Human PTH-(1-31) 能够促进骨生成,而不引起骨质吸收,表明其在骨质疏松症研究中的应用潜力。 | |||
T81591 |
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)
Human PTHrP(107-111) amide |
||
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) 是一段具有抑制骨吸收作用的C端甲状旁腺激素相关蛋白片段。 | |||
T37413 |
Calcitonin (salmon) (trifluoroacetate salt)
|
Others | Others |
Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and ... | |||
T36144 |
11β-Prostaglandin E2
11β-PGE2,11β-Prostaglandin E2 |
Others | Others |
11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3] . |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1494 |
Cimicifugoside H-1
黑升麻苷H-1 |
Others | Others |
Cimicifugoside H1 是C. foetidaL.C 提取物的主要成分,是一种环甾烷醇木糖苷。它对骨吸收及卵巢切除术引起的骨质流失具有抑制作用。 | |||
T2988 |
(-)-Epigallocatechin Gallate
Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG |
Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
(-)-Epigallocatechin Gallate (EGCG) 属于茶类黄酮天然产物,可抑制 EGFR 信号传导,抑制 GLUD 1/2。(-)-Epigallocatechin Gallate 具有抗氧化、抗炎和抗肿瘤活性。(-)-Epigallocatechin Gallate 可以通过激活细胞色素 c 氧化酶来诱导氧化磷酸化。 | |||
TN1117 |
Veraguensin
|
p38 MAPK; NF-κB; Antibiotic; Parasite; Antifection | MAPK; Microbiology/Virology; NF-κB |
Veraguensin 来源于 Magnolia sp.。 Veraguensin 抑制骨吸收并显示出高抗寄生虫活性。 | |||
T3488 |
Tectorigenin
4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素 |
Apoptosis | Apoptosis |
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) 是一种从葛根汤干燥的花中分离出来的植物异黄酮。 | |||
T3808 |
Icariside I
淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I |
Others | Others |
Icariside I (Lcariside I) 是一种 Icarlin 的代谢产物,具有调节骨重塑的作用,可用于研究骨质疏松。 | |||
TN2143 |
3,7,4'-Trihydroxyflavone
Resokaempferol,5-Deoxykampferol |
DNA | DNA Damage/DNA Repair |
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物,可抑制 NF-κB 配体 (RANKL) 受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。 | |||
T6316 |
Calcitriol
Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3 |
Endogenous Metabolite | Metabolism |
Calcitriol (1,25-Dihydroxyvitamin D3) 是一种维他命 D 的代谢物,一种维他命 D 受体 (VDR) 的激动剂 (IC50=0.4 nM)。Calcitriol 增加肠道对钙和磷的吸收,并与甲状旁腺激素一起增加了骨吸收。 | |||
T3S2312 |
Poncirin
枸橘苷,Isosakuranetin-7-neohesperidoside |
Apoptosis; Others | Apoptosis; Others |
Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物,具有抗炎活性。 它防止脂肪生成,增强间充质干细胞中的成骨细胞分化,增加骨矿物质密度,改善小梁微结构,可能反映 GIO 小鼠的骨形成增加和骨吸收减少。 | |||
T3804 |
Neomangiferin
Mangiferin 7-glucoside,新芒果苷 |
Phosphatase | Metabolism |
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。 | |||
T3S0137 |
Bavachalcone
|
Antibacterial; Antibiotic | Microbiology/Virology |
Bavachalcone 是从补骨脂中分离的化合物,广泛用于中药,具有抗生素和抗癌等活性。 | |||
TN1711 |
Gossypetin
|
Antioxidant; p38 MAPK; MAPK; Antibacterial | MAPK; Microbiology/Virology; oxidation-reduction |
Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮,是一种有效的 MKK3 和 MKK6 抑制剂,可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用,它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。 | |||
TN1215 |
(2S)-2'-Methoxykurarinone
2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone |
Akt; Antifection | Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling |
(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物,具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号,抑制破骨细胞形成和骨吸收。 | |||
T4237 |
Rubiadin-1-methyl ether
Rubiadin 1-methyl ether,3-羟基-1-甲氧基-2-甲基蒽醌 |
Anti-infection; NF-κB | Microbiology/Virology; NF-κB |
Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) 是一种巴戟天中的蒽醌类化合物,能够抑制 NF-κB p65 的磷酸化和 IκBα 的降解以及减少 p65 的核转位,阻碍破骨细胞的骨吸收。 | |||
T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
T6677 |
Sophocarpine
|
ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长,具有抗肿瘤活性。 | |||
T38799 |
2,3-Bis(3-indolylmethyl)indole
|
Others | Others |
2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption. | |||
T31382 |
Deoxypyridinoline
Lysylpyridinoline |
||
Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity. | |||
TN1536 |
Curculigoside B
|
Others | Others |
Curculigoside B shows antioxidative and antiosteoporotic activities, it can decrease area of bone resorption pit, osteoclastic formation and TRAP activity. | |||
T36295 |
Echistatin TFA
|
Others | Others |
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ... | |||
T72916 |
Justicidin B
爵床脂素B |
Others | Others |
Justicidin B是一种高效的抗癌木脂素及促凋亡剂,同时具备显著的骨吸收抑制作用,并展现出强大的抗病毒、杀真菌和抗原虫能力。此外,Justicidin B能显着抑制血小板聚集。 | |||
T37008 |
Reveromycin A
|
Others | Others |
Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste... | |||
TN2775 |
2-Methoxystypandrone
|
MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01218 |
M-CSF/CSF1 Protein, Rat, Recombinant
CSF1,集落刺激因子,CSF-1,Macrophage colony-stimulating factor 1,M-C... |
Rat | HEK293 Cells |
Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. MCSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It is involved in the regu... | |||
TMPJ-00327 |
M-CSF/CSF1 Protein, Human, Recombinant (His)
Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St... |
Human | HEK293 Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio... | |||
TMPH-03262 |
Cathepsin K Protein, Rat, Recombinant (His)
CTSO,CTSO2,Cathepsin O2,Cathepsin X,Cathepsin O,CTSK,Catheps... |
Rat | E. coli |
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | |||
TMPH-03259 |
Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)
CA-II,Carbonate dehydratase II,Carbonic anhydrase II,Cyanami... |
Rat | E. coli |
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.7 kDa and the accession number is P27139. | |||
TMPH-01061 |
Cathepsin K Protein, Human, Recombinant (His)
CTSO2,Cathepsin X,Cathepsin O2,CTSK,Cathepsin O,Cathepsin K,... |
Human | E. coli |
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Cathepsin K Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The pre... | |||
TMPH-02565 |
Cathepsin K Protein, Mouse, Recombinant (His)
Cathepsin O,Cathepsin K,CTSK,Cathepsin O2,CTSO2,Cathepsin X,... |
Mouse | E. coli |
Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Cathepsin K Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.4 kDa and the accession number is P... | |||
TMPJ-00731 |
Carbonic Anhydrase 1 Protein, Human, Recombinant (His)
Carbonic Anhydrase B,Carbonate Dehydratase I,CA-I,Carbonic A... |
Human | E. coli |
Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. It is activated by imidazole, histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. At the same time, It is inhibited by sulfonam... | |||
TMPJ-00701 |
Carbonic Anhydrase 11 Protein, Human, Recombinant (His)
Carbonic Anhydrase-Related Protein 2,CARP XI,CA11,CARP-2,Car... |
Human | HEK293 Cells |
Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA11 is expressed abundantly in the brain with moder... | |||
TMPJ-00508 |
CTSL Protein, Human, Recombinant (His)
CTSL,CTSL1,Cathepsin L1,Major Excreted Protein,MEP |
Human | HEK293 Cells |
Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Unlike the precursor forms of other papain family members, the 43 kDa pro-cathepsin L itself is secreted from various cells. Pro-cathepsin L is the maj... | |||
TMPJ-00799 |
ANXA2 Protein, Human, Recombinant
ANXA2,Calpactin I Heavy Chain,ANX2,p36,LPC2D,PAP-IV,ANX2L4,C... |
Human | E. coli |
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression reduce of ANXA2 is associated with osteosarcoma metastases. ANXA2 functions as an autocrine factor, it can increases osteoclast formation and bone resorption. ANXA2 is involved in muscular dystrophies. In humans, the up-regulation of ANXA2 is related with colon adenocarcinoma cell... | |||
TMPJ-01000 |
CCL9 Protein, Mouse, Recombinant
Macrophage inflammatory protein 1-gamma,Macrophage inflammat... |
Mouse | E. coli |
C-C motif chemokine 9(CCL9) is an 11 kDa, secreted, monomeric polypeptide that belongs to the beta (or CC) intercrine family of chemokines. It is expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain. Monokine has inflammatory, pyrogenic and chemokinetic properties. It circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor,it activates calcium release in neutrophils... | |||
TMPY-01877 |
CA5A Protein, Human, Recombinant (His)
CA5,GS1-21A4.1,CA5AD,carbonic anhydrase VA, mitochondrial,CA... |
Human | E. coli |
Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospi... | |||
TMPY-02277 |
Carbonic Anhydrase 7 Protein, Human, Recombinant (His)
CAVII,carbonic anhydrase VII |
Human | E. coli |
Carbonic anhydrase 7, also known as carbonate dehydratase VII, carbonic anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to thealpha-carbonic anhydrase family. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, ... | |||
TMPY-02236 |
PTH1R Protein, Human, Recombinant (His)
PFE,PTHR1,MGC138452,parathyroid hormone 1 receptor,PTHR,MGC1... |
Human | HEK293 Cells |
Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase an... | |||
TMPJ-01419 |
CSF1R Protein, Cynomolgus, Recombinant (His)
CSF-1-R,CSF-1 receptor,Proto-oncogene c-Fms,M-CSF-R,Macropha... |
Cynomolgus | HEK293 Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ... | |||
TMPJ-01418 |
CSF1R Protein, Cynomolgus, Recombinant (hFc)
M-CSF-R,CSF1R,CSF-1-R,CSF-1 receptor,CSF-1R,Macrophage colon... |
Cynomolgus | HEK293 Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ... | |||
TMPH-02571 |
CD9 Protein, Mouse, Recombinant (His)
CD9 antigen,CD9 |
Mouse | E. coli |
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and... | |||
TMPH-02264 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His)
Tumor necrosis factor ligand superfamily member 11,Osteoprot... |
Human | HEK293 Cells |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl... | |||
TMPY-00732 |
Cathepsin C Protein, Human, Recombinant (His)
DPP-I,PLS,JP,cathepsin C,CPPI,DPPI,PDON1,PALS,DPP1,JPD,HMS |
Human | HEK293 Cells |
Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPPI/DPP1), activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides. This lysosomal exo-cysteine protease belonging to the peptidase C1 family. Active c... | |||
TMPY-02133 |
Carbonic Anhydrase VB Protein, Human, Recombinant (His)
carbonic anhydrase VB, mitochondrial,CA-VB,MGC39962 |
Human | E. coli |
Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological process... | |||
TMPY-01761 |
Carbonic Anhydrase 3 Protein, Human, Recombinant (His)
carbonic anhydrase III,CAIII,Car3 |
Human | E. coli |
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases (CAs) form a family of enzymes that catalyze the rapid conversion of carbon dioxide and water to bicarbonate an... |