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TMPJ-00261
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TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth inhibitor,G...
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Mouse,Rat
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HEK293 Cells
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Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... |
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TMPJ-00865
|
VEGF121 Protein, Human, Recombinant (His)
VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...
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Human
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HEK293 Cells
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Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel... |
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TMPJ-01204
|
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1...
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Human
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HEK293 Cells
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Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... |
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TMPH-01201
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DRD2 Protein, Human, Recombinant (His & Myc)
Dopamine D2 receptor,D(2) dopamine receptor,DRD2
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Human
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E. coli
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Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5. |
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TMPJ-01398
|
ITM2B Protein, Human, Recombinant (His)
Transmembrane Protein BRI,Protein E25B,BRI2,imBRI2,Immature ...
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Human
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HEK293 Cells
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Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervou... |
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TMPJ-00564
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PLXDC2 Protein, Mouse, Recombinant (His)
Tumor endothelial marker 7-related protein,Plexin domain-con...
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Mouse
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HEK293 Cells
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Mouse Plexin domain-containing protein 2(PLXDC2) is a single-pass type I membrane protein. The protein is expressed in tumor endothelium and in vessels of some normal tissues, such as the muscle and lung. PLXDC2 can interact with CTTN, and may play a role in tumor angiogenesis. |
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TMPK-00695
|
N Cadherin Protein, Human, Recombinant (hFc)
CDHN,Neural cadherin,CDH2,N-cadherin,CDw325,CD325,NCAD
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Human
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HEK293 Cells
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Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and hematopoietic microenvironment. |
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TMPH-01025
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CALCA Protein, Human, Recombinant (GST)
Calcitonin gene-related peptide 1,CGRP-I,CALCA,CALC1,Alpha-t...
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Human
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E. coli
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CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CALCA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.6 kDa and the accession number is P06881. |
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TMPY-01217
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ANGPTL5 Protein, Human, Recombinant (GST)
angiopoietin like 5,ANGPTL5
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Human
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Baculovirus Insect Cells
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The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. In addition, there are a number of proteins that are closely related to angiopoietins (ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL6, ANGPTL7). Angiopoietin-like 5 (ANGPTL5) is mainly expressed in adult heart. Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-te... |
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TMPJ-00533
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LYVE1 Protein, Human, Recombinant (His)
XLKD1,Cell Surface Retention Sequence-Binding Protein 1,Extr...
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Human
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HEK293 Cells
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Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention s... |
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TMPY-02983
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LYVE1 Protein, Mouse, Recombinant (hFc)
1200012G08Rik,Lyve-1,lymphatic vessel endothelial hyaluronan...
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Mouse
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HEK293 Cells
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LYVE1, also known as LYVE-1, is a type I integral membrane glycoprotein. It contains 1 Link domain and is mainly expressed in endothelial cells lining lymphatic vessels. LYVE1 acts as a receptor and binds to both soluble and immobilized hyaluronan. It may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE1 also is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental ... |
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TMPJ-01146
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LGALSL Protein, Human, Recombinant (His)
Lectin Galactoside-Binding-Like Protein,HSPC159,Galectin-Rel...
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Human
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E. coli
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Galectin-Related Protein (LGALSL) is a 172 amino acid protein that contains one Galectin domain. LGALSL does not appear to bind carbohydrates or lactose as the critical residues required for binding are not conserved. LGALSL may play a significant role in stimulating smooth muscle growth in developing alveolar wall vessels and the development of pulmonary capillaries. |
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TMPK-00978
|
ECSCR Protein, Human, Recombinant (hFc)
ECSM2,ECSCR,ARIA
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Human
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HEK293 Cells
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Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... |
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TMPK-00445
|
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
PCL,PCLFLT41,VEGFR3,FLT-4,LMPH1A,FLT-41,VEGFR-3
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Human
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HEK293 Cells
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Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly expressed in CRC cells and stromal vessels. VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery. VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 87.4 k... |
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TMPK-01153
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PLVAP Protein, Human, Recombinant (His)
PV1,FELS
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Human
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HEK293 Cells
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Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases... |
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TMPK-00446
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VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
PCL,FLT-41,LMPH1A,FLT-4,VEGFR3,PCLFLT41,VEGFR-3
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Human
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HEK293 Cells
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Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly expressed in CRC cells and stromal vessels. VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery. VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted m... |
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TMPK-00988
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ECSCR Protein, Mouse, Recombinant (hFc)
ECSCR,ARIA,ECSM2
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Mouse
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HEK293 Cells
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Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... |
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TMPK-01048
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Aggrecan Protein, Human, Recombinant (His)
CSPG1,MSK16,AGC1,ACAN
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Human
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HEK293 Cells
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Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vess... |
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TMPK-00872
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ICAM-1/CD54 Protein, Canine, Recombinant (His)
ICAM-1,CD54,BB2
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Canine
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HEK293 Cells
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Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. ICAM-1/CD... |
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TMPJ-01088
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PCDH1 Protein, Human, Recombinant (His)
PC42,PCDH1,Protocadherin-1,Cadherin-Like Protein 1,Protocadh...
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Human
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HEK293 Cells
|
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Protocadherin-1, also known as Cadherin-like protein 1, Protocadherin-42 and PCDH1, belongs to the protocadherin subfamily within the cadherin superfamily. PCDH1 contains seven cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. PCDH1 can be detected as early as embryonic day 9.5. In early embryogenesis, expression is especially prominent in blood vessels. The tight spatial and temporal regulation of Pcdh1 expression suggests that this protocadherin plays multiple ... |
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TMPK-00497
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ICAM-1/CD54 Protein, Cynomolgus, Recombinant (His)
ICAM-1,CD54,BB2
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Cynomolgus
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HEK293 Cells
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Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. ICAM-1/CD... |
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TMPH-00780
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CACNA1C Protein, Guinea Pig, Recombinant (His)
CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu...
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Guinea pig
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E. coli
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Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur... |
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TMPJ-00921
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COL8A1 Protein, Human, Recombinant (His)
Vastatin,Endothelial Collagen,Collagen Alpha-1(VIII) Chain,C...
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Human
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HEK293 Cells
|
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Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium o... |
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TMPJ-00771
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TGF beta 1 Protein, Mouse/Rat, Recombinant
TGFB,TGFbeta,CEDLAP,TGF-beta-1,TGF-beta 1 protein,latency-as...
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Mouse,Rat
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HEK293 Cells
|
|
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)... |
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TMPY-01345
|
ACBD6 Protein, Human, Recombinant (His)
acyl-CoA binding domain containing 6
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Human
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Baculovirus Insect Cells
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Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequenc... |
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TMPH-01213
|
DNASE1L3 Protein, Human, Recombinant (His)
DNase I homolog protein DHP2,DNAS1L3,DNase I-like 3,Deoxyrib...
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Human
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Baculovirus Insect Cells
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Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
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TMPJ-00012
|
CXCL4 Protein, Human, Recombinant (His)
SCYB4,PF4,Iroplact,Platelet Factor 4,PF-4,Oncostatin-A,CXCL4...
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Human
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HEK293 Cells
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Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokin... |
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TMPH-01214
|
DNASE1L3 Protein, Human, Recombinant
DHP2,Deoxyribonuclease I-like 3,Deoxyribonuclease gamma,DNas...
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Human
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E. coli
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Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
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TMPH-01212
|
DNASE1L3 Protein, Human, Recombinant (His & Myc)
LSD,Liver and spleen DNase,Deoxyribonuclease I-like 3,DNAS1L...
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Human
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E. coli
|
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Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
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TMPY-03963
|
CALCB Protein, Human, Recombinant (mFc)
CGRP-II,calcitonin-related polypeptide β,calcitonin-related ...
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Human
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HEK293 Cells
|
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CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ... |
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TMPJ-01166
|
IGFBP-7 Protein, Mouse, Recombinant (His)
TAF,IGFBP-rP1,Insulin-like growth factor-binding protein 7,T...
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Mouse
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HEK293 Cells
|
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Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of bloo... |
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TMPY-02839
|
Adrenomedullin Protein, Human, Recombinant (hFc)
AM,PAMP,adrenomedullin
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Human
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HEK293 Cells
|
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Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report... |
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TMPY-00741
|
CXCL4 Protein, Human, Recombinant
PF-4,platelet factor 4,SCYB4,CXCL4
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Human
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E. coli
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Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils a... |
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TMPJ-00055
|
Podoplanin Protein, Mouse, Recombinant (hFc)
T1-alpha,PA2.26 antigen,T1A,Podoplanin,T1-α,Glycoprotein 38,...
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Mouse
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HEK293 Cells
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Podoplanin belongs to the podoplanin family, also known as Glycoprotein 38. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. Detected at high levels in lung and brain, at lower levels in kidney, stomach, liver, spleen and esophagus, and not detected in skin and small intestine. Expressed in epithelial cells of choroid plexus, ependyma, glomerulus and ... |
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TMPY-02014
|
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin conversion acceler...
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Human
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HEK293 Cells
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Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... |
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