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Search Results for " sepsis "

Targets Recommended: Others

57

抑制剂 & 化合物

13

天然产物

14

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40423	L48H37	Others	Others
	L48H37是Curcumin的一个化学稳定类似物。它对髓系分化蛋白2 (MD2) 表现出强效的抑制性质，作为一个特异性抑制剂。其机制包括抑制LPS-TLR4/MD2的相互作用和信号传导。L48H37主要用于脓血症和肺损伤研究[1]。
T10831L	Cl-amidine hydrochloride	Apoptosis; PAD	Apoptosis; Chromatin/Epigenetic
	Cl-amidine hydrochloride 是一种口服有效的PAD 抑制剂，可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。它可诱导癌细胞凋亡，还可诱导 miR-16 引起细胞周期阻滞。
T4989	Fosfomycin Tromethamine	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin tromethamine 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T1001	Dicloxacillin Sodium hydrate Dicloxacillin sodium salt monohydrate,双氯西林钠,Dicloxacillin sodium monohydrate	Antibacterial; Antibiotic	Microbiology/Virology
	Dicloxacillin Sodium hydrate 是一种青霉素类窄谱β内酰胺抗生素，可研究革兰氏阳性菌感染。
T3131	Fosfomycin calcium Phosphomycin calcium salt,Fosmicin,磷霉素钙	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T12242	Norvancomycin hydrochloride Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素	Antibacterial	Microbiology/Virology
	Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) 可用于葡萄球菌所致的心内膜炎、骨髓炎、肺炎、败血症或软组织感染。
T9543	Syk Inhibitor II hydrochloride	Others	Others
	Syk Inhibitor II hydrochloride 信号传导的影响在狼疮中可能很突出。
T8134	Cefathiamidine	Antibacterial; Antibiotic	Microbiology/Virology
	Cefathiamidine 是一种头孢菌素抗菌剂，可研究由易感细菌引起的感染，还可用于呼吸道、肝脏、五官感觉、尿路感染以及心内膜炎和败血症的研究。
T67965	Torbafylline	cAMP; PI3K; PDE	GPCR/G Protein; Metabolism; PI3K/Akt/mTOR signaling
	Torbafylline 是黄嘌呤衍生物，是磷酸二酯酶（PDE）抑制剂，通过激活 PDE4/cAMP/EPAC/PI3K/Akt 途径减弱烧伤诱导的大鼠骨骼肌蛋白水解，抑制癌症和败血症大鼠增强的骨骼肌泛素 - 蛋白酶体依赖性蛋白水解。
T76662	Ac-Pro-Gly-Pro-OH	Apoptosis; CXCR; Antibiotic	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Ac-Pro-Gly-Pro-OH 是乙酰基修饰的三肽化合物，可用作 CXCR2 激动剂。Ac-Pro-Gly-Pro-OH 具有杀菌和抗炎活性，抑制免疫细胞凋亡，抑制促炎细胞因子的产生。Ac-Pro-Gly-Pro-OH 可用于研究脓毒症和肺部炎症。
T74398	DATPT	Reactive Oxygen Species; Antibacterial	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	DATPT 是一种小分子 12WLVSKF17 肽模拟分子。DATPT 抑制 SNX9-p47phox 相互作用，抑制活性氧和炎性细胞因子的产生。DATPT 具有抗炎和抗菌活性，通过减少 ATP 的产生发挥作用。DATPT 是治疗脓毒症的潜在化合物。
TP1570	Cortistatin-14	Somatostatin	GPCR/G Protein
	Cortistatin-14 是一种与生长抑素-14结构相似的神经肽，具有抗惊厥和神经保护作用，通过激活 sst（2）、生长素释放肽和 GABA（A/B）受体损害小鼠的识别记忆巩固，可用于研究脓毒症引发的认知障碍。
T60437	PNU-282987 free base	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	PNU-282987 free base 是一种具有选择性和高效性的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，也是5-HT3受体的拮抗剂，具有抗炎活性，对脓毒症诱导的小鼠急性肺损伤有保护作用，可减弱 ILC2s 活化和链格孢菌诱导的气道炎症。PNU-282987 free base 可用于研究神经系统疾病。
T74485	STC314	Others	Others
	STC314 具有抗感染作用，通过中和胞外组蛋白和中性粒细胞诱捕网来逆转机体过度免疫反应造成的器官损伤，可用于研究脓毒症和急性呼吸窘迫综合征(ARDS)。STC314 可保护脂质双层的稳定性，抑制血小板活化和红细胞损伤。
T77097	Nerelimomab
	Nerelimomab (BAYX1351) 是一种抗TNF-α抗体。Nerelimomab 可用于脓毒症研究。
T40225	JH-X-119-01 hydrochloride	Others	Others
	JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). It effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.
T60563	NLRP3/AIM2-IN-1	Others	Others
	NLRP3/AIM2-IN-1是热脓毒症的抑制剂(IC50 = 3.136 ± 0.7667 μM)，显示出适度的反热光活性。
T70480	FPL-65447 hydrochloride	Others	Others
	FPL-65447 hydrochloride is a selective D1 receptor agonist that has potential for the acute treatment of renal and cardiac failure and of sepsis and septic shock.
T61957	Aldose reductase-IN-3	Others	Others
	Aldose reductase-IN-3 (Compound 5) 是有效的、中等选择性的醛糖还原酶 (AR) 抑制剂（IC50= 3.99 μM）。醛糖还原酶是参与各种炎症性疾病 (包括败血症) 的分子靶标。Aldose reductase-IN-3在脓毒症中具有研究的潜力。
T62275	BET-IN-8	Others	Others
	BET-IN-8 (Compound 27) 是一种 BET 的有效抑制剂 (Ki: 0.83 μM, Kd: 0.571 μM)。BET-IN-8 能够改善体内 LPS 诱导的脓毒症。BET-IN-8 对脓毒症表现出研究潜力。
T77095	Nebacumab
	Nebacumab (HA-1A)为一种与内毒素的脂质A部分结合的单克隆抗体，适用于败血症研究。
T70874	Vipoglanstat	Others	Others
	Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury.
T39009	CAP18 (rabbit) CAP18 (rabbit)
	CAP18 (rabbit) is a 37 amino acid antimicrobial peptide derived from rabbit granulocytes. It exhibits extensive antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. Thus, CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.
T61253	BET-IN-7	Others	Others
	BET-IN-7 (Compound 1) is a highly effective BET inhibitor, possessing a K i of 12.27 μM and a K d of 89.3 μM. It exhibits promising properties for sepsis-related research [1].
T74179	1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine	Others	Others
	1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine，一种血液中的内源性代谢物，主要用于妊娠和败血症的研究。
T70268	3A-MPLA	Others	Others
	Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.
T79790	ALPK1-IN-3	NF-κB	NF-κB
	ALPK1-IN-3 (T007)为ALPK1抑制剂。在脓毒症引起的急性肾损伤动物模型中，ALPK1-IN-3能够降低肾脏促炎基因的表达并增加动物的存活率。
T80535	AMPR-22
	AMPR-22 是一种具有抗菌作用的肽类化合物，能够与细菌膜结合并诱导透化作用，对 MDR 菌株引起的败血症小鼠模型表现出有效的对抗性。
T76902	Afelimomab
	Afelimomab (MAK 195F)为F(ab')2型单克隆抗体片段，针对肿瘤坏死因子抗体，应用于脓毒症研究。
T82505	Edobacomab XMMEN-0E5,E5
	Edobacomab (E5) 是小鼠来源的抗内毒素单克隆IgM抗体，常用于研究由革兰氏阴性细菌引起的败血症。
T76822	Pagibaximab
	Pagibaximab为一种嵌合IgG1抗体，针对金黄色葡萄球菌与表皮链球菌的表面脂肪酸成分具有特异性识别能力。其主要应用于预防葡萄球菌所引起的败血症。
T70145	LYRM03	Others	Others
	LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced ALI by inhibiting the expression of pro-inflammatory mediators and Myd88-dependent TLR4 signaling pathways in alveolar macrophages. LYRM03 may serve as a potential treatment for sepsis-mediated lung injuries.
T63660	Anti-inflammatory agent 19	Others	Others
	Anti-inflammatory agent 19 能够抑制 NO (IC50: 36.00 μM)。Anti-inflammatory agent 19 对 HMGB1 诱导的后期炎症反应表现出抑制作用。Anti-inflammatory agent 19 能够用于研究后期炎症疾病，如冠状病毒病 (COVID-19)、败血症等。
T78561	M62812 free base	Others	Others
	M62812 (free base) 是一种TLR4信号转导抑制剂，能够抑制内皮细胞和白细胞的活化，有效预防小鼠致死性感染性休克，适用于脓毒症的研究。
T84943	5-Androstenetriol Δ5-AT	Others	Others
	5-Androstenetriol, a steroid and active metabolite of dehydroepiandrosterone (DHEA), demonstrates significant therapeutic effects. Administered at 0.75 mg/25 g body weight, it mitigates radiation-induced mortality and facilitates hematopoietic recovery from surviving stem cells in mice. Moreover, a dosage of 40 mg/kg enhances survival rates in rats subjected to surgical trauma-induced sepsis. Additionally, elevated urinary levels of 5-androstenetriol are observed in women suffering from androgen...
T81269	RIPK1-IN-16	RIP kinase	Apoptosis; NF-κB
	RIPK1-IN-16是口服活性的RIPK1抑制剂，有效阻断RIPK1介导的necroptosis，抑制炎症反应。在小鼠模型中，RIPK1-IN-16通过抵御TNF引发的全身性炎症综合症和败血症来展现保护作用。
T63473	Anti-inflammatory agent 18	Others	Others
	Anti-inflammatory agent 18 能够抑制NO 的活性 (IC50: 15.94 μM)，对 HMGB1 诱导的后期炎症反应具有抑制作用，能够用于研究后期炎症疾病，如冠状病毒病 (COVID-19)、败血症等。
T80062	Mitogen-activated protein kinase 1 MAPK1	NF-κB	NF-κB
	Mitogen-activated protein kinase1 (MAPK1) 能够激活下游的 p38/NF-κB 通路，并调控多种与脓毒症相关的疾病细胞过程。此外，MAPK1 通过磷酸化催化底物蛋白，起到调节底物蛋白活性开关的作用。
T62229	BBS-4	Others	Others
	BBS-4 是一种选择性的、有效的诱导型一氧化氮合酶 (NOS2) 二聚抑制剂 (IC50: 0.49 nM)，BBS-4 能够保护小鼠，使其免受败血症的心血管功能障碍的影响。
T75011	STING-IN-5	STING	Immunology/Inflammation
	STING-IN-5为有效STING抑制剂，IC50达1.15 μM，能在巨噬细胞内抑制LSP诱导之NO合成，从而抑制炎症反应，主用于抗炎疾病与败血症研究。
T66175	Ceftriaxone Sodium	GSK-3; Antibiotic; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells
	Ceftriaxone Sodium 是一种广谱 β-内酰胺类三代头孢菌素类抗生素 (antibiotic)，具有抗炎、抗肿瘤、抗菌和抗氧化活性。Ceftriaxone Sodium 是一种共价 GSK3β和 Aurora B 抑制剂，可用于研究败血症和感染性心内膜炎。
T78056	HMGB1-IN-1	Others	Others
	HMGB1-IN-1（化合物6）在RAW264.7细胞中具有显著的NO抑制活性，其IC50为15.9 ± 0.6 μM。该化合物能够抑制HMGB1/NF-κB/NLRP3信号通路，并且在肾损伤模型中展现出优异的抗炎及抗脓毒症效果。
T76327	CTCE-0214
	CTCE-0214 是一种 CXCR4(chemokine CXC receptor 4) 激动剂，是 SDF-1α 肽类似物。CTCE-0214 具有抗炎活性，可用于炎症败血症和系统性炎症综合征的研究。
T83685	UFP101 TFA
	UFP101是一种合成肽类物质，作为nociceptin受体的拮抗剂（Ki为0.06 nM，测试于表达人类受体的CHO细胞中）。它对nociceptin受体的选择性高于κ-opioid受体（Ki为204 nM，测试于表达大鼠受体的CHO细胞中）。UFP101能抑制表达于CHO细胞膜的nociceptin受体释放GTPγS（EC50为1.86 nM）。通过脑室内给药，UFP101（10 nmol/每只动物）能延长小鼠尾巴甩动试验中的尾巴撤回潜伏期。在由盲肠结扎和穿刺诱发的小鼠败血症模型中，UFP101（0.003、0.03及0.3 mg/kg）能提高生存率。
T63793	Tauro-ω-muricholic acid sodium	Others	Others
	Tauro-ω-muricholic acid sodium (TωMCA sodium) 是一种tauro-α-muricholic acid 的类似物，是来源于肝脏的胆汁酸。Tauro-ω-muricholic acid sodium 能用作早发性新生儿败血症 (EOS) 和胆汁淤积的血清标志物。
T79409	Antibacterial agent 154	Others	Others
	Antibacterialagent 154（compound 7）作为Fluoroquinolones类衍生物，适用于口服的抗菌治疗。它针对革兰氏阳性菌与阴性菌具有抑制作用，并在小鼠葡萄球菌败血症模型中显示出了体内效力。
T76958	Vilobelimab
	Vilobelimab (CaCP-29, IFX-1) 是一种单克隆抗 C5a 抗体，过敏毒素 C5a 是一种促炎补体分裂产物，在介导器官功能障碍中起核心作用。Vilobelimab 可作为一种 C5a 抑制剂，抑制中性粒细胞活化、趋化性,减少炎症信号等，可用于败血症，COVID-19 等相关研究。
T82526	Drotrecogin alfa (activated)	Others	Others
	Drotrecogin alfa activated (DrotAA)为重组人活化蛋白C（APC）。该化合物能够抑制由烟雾引起的大鼠肺微血管通透性上升及促炎细胞因子IL-1β水平增加，具有抗凝血与抗炎作用，并促进纤溶过程。Drotrecogin alfa activated主要用于重症脓毒症的实验研究。
T60934	PDE4-IN-9	Others	Others
	PDE4-IN-9 (Compound 5j) 是 PDE4的有效抑制剂。在体外酶学测定结果表明，PDE4-IN-9 对 PDE4 的IC50值为1.4 μM ，低于母体咯利普兰的2.0 μM。PDE4-IN-9 在 LPS 诱导的哮喘/COPD 和脓毒症动物模型中也表现出良好的体内活性。
T78829	JNK2-IN-1	JNK	MAPK
	JNK2-IN-1（Compound J27）是一款具有抗炎活性的JNK2抑制剂，其解离常数为79.2 μM。该化合物能通过阻断NF-κB/MAPK信号通路来降低肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的释放，从而减轻脂多糖（LPS）引起的急性肺损伤（ALI）及脓毒症症状。

化合物

Cat.No: T40423

Target: Others

Cl-amidine hydrochloride

Cat.No: T10831L

Target: Apoptosis, PAD

Fosfomycin Tromethamine

Cat.No: T4989

Target: Antibacterial, Antibiotic

Dicloxacillin Sodium hydrate

Cat.No: T1001

Synonym: Dicloxacillin sodium salt monohydrate,双氯西林钠,Dicloxacillin sodium monohydrate

Target: Antibacterial, Antibiotic

Fosfomycin calcium

Cat.No: T3131

Synonym: Phosphomycin calcium salt,Fosmicin,磷霉素钙

Target: Antibacterial, Antibiotic

Norvancomycin hydrochloride

Cat.No: T12242

Synonym: Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素

Target: Antibacterial

Syk Inhibitor II hydrochloride

Cat.No: T9543

Target: Others

Cat.No: T8134

Target: Antibacterial, Antibiotic

Cat.No: T67965

Target: cAMP, PI3K, PDE

Ac-Pro-Gly-Pro-OH

Cat.No: T76662

Target: Apoptosis, CXCR, Antibiotic

Cat.No: T74398

Target: Reactive Oxygen Species, Antibacterial

Cat.No: TP1570

Target: Somatostatin

PNU-282987 free base

Cat.No: T60437

Target: 5-HT Receptor, AChR

Cat.No: T74485

Target: Others

Cat.No: T77097

JH-X-119-01 hydrochloride

Cat.No: T40225

Target: Others

NLRP3/AIM2-IN-1

Cat.No: T60563

Target: Others

FPL-65447 hydrochloride

Cat.No: T70480

Target: Others

Aldose reductase-IN-3

Cat.No: T61957

Target: Others

Cat.No: T62275

Target: Others

Cat.No: T77095

Cat.No: T70874

Target: Others

Cat.No: T39009

Synonym: CAP18 (rabbit)

Cat.No: T61253

Target: Others

1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine

Cat.No: T74179

Target: Others

Cat.No: T70268

Target: Others

Cat.No: T79790

Target: NF-κB

Cat.No: T80535

Cat.No: T76902

Cat.No: T82505

Synonym: XMMEN-0E5,E5

Cat.No: T76822

Cat.No: T70145

Target: Others

Anti-inflammatory agent 19

Cat.No: T63660

Target: Others

M62812 free base

Cat.No: T78561

Target: Others

5-Androstenetriol

Cat.No: T84943

Synonym: Δ5-AT

Target: Others

Cat.No: T81269

Target: RIP kinase

Anti-inflammatory agent 18

Cat.No: T63473

Target: Others

Mitogen-activated protein kinase 1

Cat.No: T80062

Synonym: MAPK1

Target: NF-κB

Cat.No: T62229

Target: Others

Cat.No: T75011

Target: STING

Ceftriaxone Sodium

Cat.No: T66175

Target: GSK-3, Antibiotic, Aurora Kinase

Cat.No: T78056

Target: Others

Cat.No: T76327

Cat.No: T83685

Tauro-ω-muricholic acid sodium

Cat.No: T63793

Target: Others

Antibacterial agent 154

Cat.No: T79409

Target: Others

Cat.No: T76958

Drotrecogin alfa (activated)

Cat.No: T82526

Target: Others

Cat.No: T60934

Target: Others

Cat.No: T78829

Target: JNK

Cat. No.	Product Name	Target	Signaling Pathways
TN1039	Tamarixetin 柽柳黄素,4'-O-Methyl Quercetin	Endogenous Metabolite; Immunology/Inflammation related	Immunology/Inflammation; Metabolism
	Tamarixetin (4'-O-Methyl Quercetin) 是一种槲皮素的天然类黄酮衍生物，具有抗氧化、抗炎作用，能够防止心肌肥厚。
T1221	Acetylcholine chloride ACh chloride,Pilofrin,氯化乙酰胆碱	Calcium Channel; Endogenous Metabolite; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Acetylcholine chloride (Pilofrin) 是一种神经递质，是胆碱能激动剂，通过刺激烟碱乙酰胆碱受体调节多巴胺能神经元活性，在体外抑制 p53 突变肽的聚集。
T8262	Fosfomycin sodium Fosfomycin Disodium,磷霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药的细菌。
TN6926	Paeonoside	Others	Others
	Paeonoside 发现与P. suffruticosa 中，具有生物活性，可以促进成骨细胞分化过程中的伤口愈合和迁移。Paeonoside 具有一定的抗糖尿病活性，可防止脓毒症和败血症引起的死亡。Paeonoside 对 MC3T3-E1细胞的前成骨细胞没有细胞毒性作用，以剂量依赖性的方式显著恢复伤口区域并促进细胞迁移和促进碱性磷酸酶（ALP）染色及其活性。
TN1594	DL-Syringaresinol (±)-Syringaresinol	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素，具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化，通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。
TN6774	Emodin 6-O-β-D-glucoside 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin	Others	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性，可用于研究动脉粥样硬化及糖尿病并发症。
T5S0167	Atractylenolide I 白术内酯 I,白术内酯I；苍术内酯I	IL Receptor; TNF; TLR; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Atractylenolide I 是从白术根中得到的一种倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂，在 A375 细胞中，能够降低JAK2和STAT3的磷酸化水平。
T0186	Docetaxel trihydrate RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物	Apoptosis; BCL; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂，抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物，能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期，导致细胞凋亡。
TN4992	Senkyunolide G	Others	Others
	Senkyunolide G and senkyunolide I could serve as pharmacokinetic markers for sepsis care.
TN4679	Nudiposide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in a mouse model and can decrease the plasma levels of TNF-α, IL-10 and ALT activity.
TN1374	α-Chaconine alpha-Chaconine,卡茄碱,阿尔法卡茄碱	IL Receptor; COX; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience
	Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects.
TN1874	Liriodendrin 鹅掌楸苦素	ATPase; Potassium Channel; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel
	Liriodendrin 调节肺部炎症、NF-kB (p65) 的磷酸化和血管内皮生长因子 (VEGF) 的表达。Liriodendrin 具有抗炎、镇痛、降血糖活性，在脓毒症引起的急性肺损伤中起保护作用。
TN4490	Manassantin B	ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection	Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa...

天然产物

Cat.No: TN1039

Synonym: 柽柳黄素,4'-O-Methyl Quercetin

Target: Endogenous Metabolite, Immunology/Inflammation related

Acetylcholine chloride

Cat.No: T1221

Synonym: ACh chloride,Pilofrin,氯化乙酰胆碱

Target: Calcium Channel, Endogenous Metabolite, AChR

Fosfomycin sodium

Cat.No: T8262

Synonym: Fosfomycin Disodium,磷霉素钠

Target: Antibacterial, Antibiotic

Cat.No: TN6926

Target: Others

DL-Syringaresinol

Cat.No: TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

Emodin 6-O-β-D-glucoside

Cat.No: TN6774

Synonym: 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin

Target: Others

Atractylenolide I

Cat.No: T5S0167

Synonym: 白术内酯 I,白术内酯I；苍术内酯I

Target: IL Receptor, TNF, TLR, JAK, STAT

Docetaxel trihydrate

Cat.No: T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物

Target: Apoptosis, BCL, Microtubule Associated

Cat.No: TN4992

Target: Others

Cat.No: TN4679

Target: IL Receptor, TNF

Cat.No: TN1374

Synonym: alpha-Chaconine,卡茄碱,阿尔法卡茄碱

Target: IL Receptor, COX, DNA/RNA Synthesis

Cat.No: TN1874

Synonym: 鹅掌楸苦素

Target: ATPase, Potassium Channel, Prostaglandin Receptor

Cat.No: TN4490

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01246	GDF-15 Protein, Mouse, Recombinant (His) MIC1,Placental TGF-beta,Placental TGF-β,PTGF-beta,PTGFBPTGF-...	Mouse	E. coli
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec...
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPK-01165	MCEMP1 Protein, Mouse, Recombinant (hFc) MGC132456,C19orf59,MCEMP1	Mouse	HEK293 Cells
	A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). MCEMP1 in T lymphocytes isolated from sepsis mice were up- or downregulated by exogenous transfection in an attempt to investigate their effects on the release of inflammatory factors, the expression of immunoglobulins, the activity of T cell subsets and natural killer (NK) cells, as well as T lymphocyte apoptosis.
TMPJ-00033	UBE2B Protein, Human, Recombinant (His) Ubiquitin-Conjugating Enzyme E2 B,hHR6B,Ubiquitin-Conjugatin...	Human	HEK293 Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18, UBR2, and WAC. UBE2B is required for post-replicative DNA damage repair. Additional, UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.
TMPK-00665	GDF-15 Protein, Cynomolgus, Recombinant (His) PTGFBPTGF-beta,PTGFBPTGF-β,MIC-1,NAG-1,MIC1,PTGF-beta,PTGF-β...	Cynomolgus	E. coli
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus...
TMPK-00663	GDF-15 Protein, Cynomolgus, Recombinant (hFc) PTGF-β,GDF-15,NAG-1,PTGF-beta,PDF,PTGFBPTGF-beta,GDF15,Place...	Cynomolgus	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus...
TMPK-01244	GDF-15 Protein, Mouse, Recombinant (hFc) PTGFBPTGF-beta,PTGFB,PLAB,NAG-1,Placental TGF-β,RG-1,GDF15,G...	Mouse	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec...
TMPK-01245	GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated RG-1,GDF15,Placental TGF-beta,GDF-15,PTGFBPTGF-beta,NAG-1,PT...	Mouse	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00197	GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated Placental TGF-β,GDF15,RG-1,MIC-1,PTGFB,PTGF-beta,PDF,PTGF-β,...	Human	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPJ-00003	DEFB1 Protein, Human, Recombinant Beta-Defensin 1,BD-1,HBD1,Defensin β1,BD1,Defensin Beta 1,β-...	Human	E. coli
	β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensin 1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. Defects in β-Defensin-1 contribute to asthma diagnosis,...
TMPK-00664	GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated Placental TGF-beta,PTGFBPTGF-β,PLAB,MIC-1,GDF15,NAG-1,RG-1,P...	Cynomolgus	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00198	GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated MIC-1,PTGFBPTGF-β,GDF15,PTGF-β,GDF-15,PTGF-beta,Placental TG...	Human	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPJ-00981	PTX3 Protein, Mouse, Recombinant (His) alpha-induced protein 5,pentraxin 3, long,pentaxin-related g...	Mouse	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator...
TMPJ-01047	UBE2H Protein, Human, Recombinant (GST) UBE2H,UbcH2,Ubiquitin-Conjugating Enzyme E2 H,Ubiquitin-Prot...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in ...

重组蛋白

GDF-15 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01246

Species: Mouse

Expression System: E. coli

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

MCEMP1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01165

Species: Mouse

Expression System: HEK293 Cells

UBE2B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00033

Species: Human

Expression System: HEK293 Cells

GDF-15 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00665

Species: Cynomolgus

Expression System: E. coli

GDF-15 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPK-00663

Species: Cynomolgus

Expression System: HEK293 Cells

GDF-15 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01244

Species: Mouse

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated

Cat.No: TMPK-01245

Species: Mouse

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated

Cat.No: TMPK-00197

Species: Human

Expression System: HEK293 Cells

DEFB1 Protein, Human, Recombinant

Cat.No: TMPJ-00003

Species: Human

Expression System: E. coli

GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00664

Species: Cynomolgus

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00198

Species: Human

Expression System: HEK293 Cells

PTX3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00981

Species: Mouse

Expression System: HEK293 Cells

UBE2H Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01047

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71984	Enrofloxacin-d5
	Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model...

同位素标记化合物

Enrofloxacin-d5

Cat.No: T71984

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