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Search Results for " palmitoylation "

Targets Recommended: Others

20

抑制剂 & 化合物

3

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9032	MGH-CP1	Others	Others
	MGH-CP1 是 TEAD2 (IC50:710 nM) 及 TEAD4 (IC50:672 nM) 自棕榈酰化抑制剂，口服有活性，可降低细胞内源性或异位表达的 TEAD 蛋白棕榈酰化水平。MGH-CP1 与 Lats1/2 缺失，是 Myc 的表达受到抑制，阻碍上皮细胞过度增殖，诱导细胞凋亡。
T9028	STING-IN-2 C-170	STING	Immunology/Inflammation
	STING-IN-2 (C-170) 是一种 STING 共价抑制剂，可抑制小鼠 STING (mmSTING) 和人类 STING (hsSTING)，可用于自身炎症性疾病的研究。
T35364	2-Bromohexadecanoic acid 2-BP,2-溴十六烷酸,2-bromopalmitate,2-Bromohexadecanoic acid	Others	Others
	2-Bromohexadecanoic acid (2-BP) 是一种不可代谢的棕榈酸酯类似物，可用作棕榈酰化抑制剂。它直接且不可逆地抑制所有 DHHC (Asp-His-His-Cys) 蛋白的棕榈酰转移酶活性。
T62077	VT103 VT-103,VT 103	YAP	Stem Cells
	VT103 是一种具有口服活性和选择性的 TEAD1 蛋白棕榈酰化抑制剂，是 VT101 的类似物。 VT103 有潜在的抗肿瘤活性，可抑制 YAP/TAZ-TEAD 促进的基因转录，阻断 TEAD auto-palmitoylation，阻断 YAP/TAZ和TEAD 之间的相互作用。VT103 可用于研究HER2阳性乳腺癌、前列腺癌和三阴性乳腺癌。
T35545	VT107	YAP	Stem Cells
	VT107 是一种强效的泛 TEAD 自身棕榈酰化抑制剂。VT-107 可用于癌症研究。
T64342	DC-TEADin02	YAP	Stem Cells
	DC-TEADin02 是 TEAD 自棕榈酰化抑制剂 (IC50 = 197 nM)。 DC-TEADin02 可用于有关发育、再生和组织稳态的研究。
T7329	C-178	STING	Immunology/Inflammation
	C-178 是 STING 选择性共价抑制剂，与 Cys91 结合抑制小鼠中由不同的激活剂引起的 STING 反应。
T60148	MSC-4106	YAP	Stem Cells
	MSC-4106 是一种有效的、具有口服活性的 YAP/TAZ-TEAD 抑制剂。 MSC-4106 阻断 TEAD1 和 TEAD3 的自棕榈酰化，并且对 NCI-H226 异种移植瘤模型显示抑制作用。
T9029	STING-IN-3 C-171	STING	Immunology/Inflammation
	STING-IN-3 (C-171) 是干扰素基因刺激物 (STING) 的抑制剂。它与 STING 结合，抑制其棕榈酰化，并阻止 TBK1 的募集和磷酸化。
T21650	IWP-3	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	IWP-3 是一种对 Wnt 亲和力较高抑制剂，具有抗癌活性，抑制 Wnt 蛋白的棕榈酰化，消除过度诱导的Mg63细胞活力增加，可用于研究骨髓瘤。
T2702	IWP-2 IWP2	Casein Kinase; Wnt/beta-catenin; Porcupine	Cytoskeletal Signaling; Metabolism; Stem Cells
	IWP-2 是一种 Wnt 加工和分泌抑制剂，IC50为 27 nM。它还是一种具有 ATP 竞争能力的CK1δ抑制剂，对于M82FCK1δ的IC50为 40 nM。在无细胞试验中，它可选择性阻断 Porcn 介导的 Wnt 棕榈酰化。
T17181	TVB-3664	Fatty Acid Synthase	Metabolism
	TVB-3664 是一种具有口服具有活力的、选择性的、可逆的、具有高生物利用度的脂肪酸合酶抑制剂，其对人和老鼠棕榈酸酯合成的IC50分别为 18 nM 和 12 nM。可显著抑制微管蛋白棕榈酰化和 mRNA 表达。
T5674	H-151	STING	Immunology/Inflammation
	H-151 是一种 STING 拮抗剂，具有高效性和选择性。H-151 与 STING 的 Cys91 共价结合，抑制 Cys91 的棕榈酰化，从而抑制 STING 的活性。H-151 可用于体内外自身炎症性疾病的研究。
T77780	Zamaporvint RXC004	Others	Others
	Zamaporvint (RXC004) 是一种具有选择性、口服活性和有效性的 Wnt 途径抑制剂，作用于膜结合脂肪酰转移酶 Porcupine，阻断 Wnt 配体棕榈酰化、分泌及通路活化。Zamaporvint 在多种癌细胞系中显示出抗肿瘤和抗增殖活性。
T68934	VT101 free base	Others	Others
	VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T71424	VT-102 free base	Others	Others
	VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T81056	SWTX-143	YAP	Stem Cells
	SWTX-143，一新型共价YAP/TAZ-TEAD 抑制剂，能结合四种TEAD亚型的棕榈酰化口袋。SWTX-143特异性、不可逆地抑制YAP/TAZ-TEAD转录活性，表现出抗肿瘤活性。
T83951	TM2 TEAD inhibitor	Others	Others
	TM2 TEAD抑制剂是一种有效并且可逆的TEA领域转录因子抑制剂(IC50为TEAD4自动棕榈酰化和TEAD2棕榈酰化分别为38 nM和156 nM)。它抑制TEAD-YAP的结合和转录活性。TM2 TEAD抑制剂在YAP依赖型癌症细胞中，无论是单独使用还是与MEK抑制剂联合使用，都显示出强大的抗增殖效果。同时抑制体外YAP依赖的肝脏类器官生长。
T85158	Palmitoleic Acid Alkyne FA 16:3,Palmitoleate Alkyne,cis-Palmitoleic Acid Alkyne,n-7 Palmitoleate Alkyne,Click Tag™ Palmitoleic Acid Alkyne,9-cis-Hexadecanoic Acid Alkyne	Others	Others
	Palmitoleic acid alkyne, an ω-terminal alkyne derivative of palmitoleic acid, facilitates click chemistry applications. This compound has played a crucial role in examining protein palmitoylation processes. Specifically, the cis form of palmitoleic acid alkyne selectively tags wild-type Wnt3a protein within mouse fibroblast L-cells expressing Wnt3a and its secretion in conditioned media, distinguishing itself from the trans form and proving ineffective against the S209A mutant Wnt3a.
T62388	RUSKI-201 dihydrochloride	Others	Others
	RUSKI-201 dihydrochloride 是一种有效的、特异性的 Hedgehog 酰基转移酶 (Hhat) 抑制剂 (IC50: 0.20 μM)。RUSKI-201 dihydrochloride 可以阻断 Shh 过表达细胞的 Hh 信号，对 Hh 棕榈酰化具有抑制作用。RUSKI-201 dihydrochloride 是一种有潜力的 Hhat 化学探针，能够用于研究 Hhat 催化功能。

化合物

Cat.No: T9032

Target: Others

Cat.No: T9028

Synonym: C-170

Target: STING

2-Bromohexadecanoic acid

Cat.No: T35364

Synonym: 2-BP,2-溴十六烷酸,2-bromopalmitate,2-Bromohexadecanoic acid

Target: Others

Cat.No: T62077

Synonym: VT-103,VT 103

Target: YAP

Cat.No: T35545

Target: YAP

Cat.No: T64342

Target: YAP

Cat.No: T7329

Target: STING

Cat.No: T60148

Target: YAP

Cat.No: T9029

Synonym: C-171

Target: STING

Cat.No: T21650

Target: Wnt/beta-catenin

Cat.No: T2702

Synonym: IWP2

Target: Casein Kinase, Wnt/beta-catenin, Porcupine

Cat.No: T17181

Target: Fatty Acid Synthase

Cat.No: T5674

Target: STING

Cat.No: T77780

Synonym: RXC004

Target: Others

VT101 free base

Cat.No: T68934

Target: Others

VT-102 free base

Cat.No: T71424

Target: Others

Cat.No: T81056

Target: YAP

TM2 TEAD inhibitor

Cat.No: T83951

Target: Others

Palmitoleic Acid Alkyne

Cat.No: T85158

Synonym: FA 16:3,Palmitoleate Alkyne,cis-Palmitoleic Acid Alkyne,n-7 Palmitoleate Alkyne,Click Tag™ Palmitoleic Acid Alkyne,9-cis-Hexadecanoic Acid Alkyne

Target: Others

RUSKI-201 dihydrochloride

Cat.No: T62388

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01844	Paralemmin-1/PALM Protein, Human, Recombinant (His) Paralemmin,PALM,Paralemmin-1	Human	E. coli
	Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. Paralemmin-1/PALM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.7 kDa and the accession number is O75781.
TMPY-04423	CAMKI gamma/CAMK1G Protein, Human, Recombinant (His & GST) VWS1,RP1-272L16.2,calcium/calmodulin-dependent protein kinas...	Human	Baculovirus Insect Cells
	Calmodulin-Dependent Protein Kinase (CaM Kinase) is a kind of protein phosphorylate multiple downstream targets. Concentration of cytosolic calcium functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases referred to as CaM-kinases (CaMKs), such as CaMKI, CaMKII, CaMKIV and CaMKK. Calmodulin-dependent protein kinase CL3/CaMKIγ is a membera...
TMPY-02220	HRAS Protein, Human, Recombinant (His) HAMSV,Harvey rat sarcoma viral oncogene homolog,C-H-RAS,C-HA...	Human	Baculovirus Insect Cells
	HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is a rare condition characterized by prenatally increase...

重组蛋白

Paralemmin-1/PALM Protein, Human, Recombinant (His)

Cat.No: TMPH-01844

Species: Human

Expression System: E. coli

CAMKI gamma/CAMK1G Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04423

Species: Human

Expression System: Baculovirus Insect Cells

HRAS Protein, Human, Recombinant (His)

Cat.No: TMPY-02220

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...

同位素标记化合物

Palmitic acid-1-13C

Cat.No: T35789

Palmitic acid-13C

Cat.No: T35791

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