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Search Results for " non-toxicity "

Targets Recommended: Parasite

33

抑制剂 & 化合物

4

天然产物

4

化合物库

1

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；
L2010	高选择性抑制剂库		575 compounds
	575种具有高选择性的抑制剂集合
DO2200	共价抑制剂库CD		12000 compounds
	数量多：超过12000种共价结合化合物，并且数量在持续增加；
L6620	抗寄生虫天然产物库		253 compounds
	253 个抗寄生虫相关的天然产物集合，是药物开发、药理研究的有效工具；

化合物库

共价抑制剂库

Cat.No: L9410

Compounds: 1920

高选择性抑制剂库

Cat.No: L2010

Compounds: 575

共价抑制剂库CD

Cat.No: DO2200

Compounds: 12000

抗寄生虫天然产物库

Cat.No: L6620

Compounds: 253

Cat. No.	Product Name	Target	Signaling Pathways
T2180	Hexythiazox	Parasite	Microbiology/Virology
	Hexythiazox 是一种螨类生长调节剂和噻唑烷类杀螨剂，对多种螨类具有长效杀虫作用，适用于植物从萌芽到结果的任何生长阶段。
TP2333	cyclo(L-Pro-L-Tyr)	Others	Others
	cyclo(L-Pro-L-Tyr) 是真菌和细菌的次生代谢产物。
T3202	Fluensulfone MCW-2	Parasite	Microbiology/Virology
	Fluensulfone (MCW-2) 是一种新型杀线虫剂，可化学防治植物寄生线虫。
T39954	AU-15330	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	AU-15330是SWI/SNF ATPase亚基SMARCA2和SMARCA4的蛋白水解靶向嵌合体（PROTAC）降解剂。AU-15330 能有效抑制肿瘤在前列腺癌异种移植模型中的生长，并与 AR 拮抗剂恩杂鲁胺具有协同作用。AU-15330在去势抵抗性前列腺癌（CRPC）模型中显示出部分治疗效果和AU-15330具有无毒性的特点。
T37482	Diclofenac methyl ester	Others	Others
	Diclofenac methyl ester 是双氯芬酸(diclofenac)的疏水性前药形式，它是一种非甾体抗炎药 (NSAID)。它比双氯芬酸更易溶于肉豆蔻酸异丙酯，但毒性更高。
T6568	Licofelone 利克飞龙,ML-3000	Apoptosis; Lipoxygenase; COX	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Licofelone (ML-3000) 是一种 COX/LOX 双重抑制剂，IC50分别为 0.21和0.18 μM，有潜力研究骨关节炎，具有抗炎和抗增殖作用。它可诱导细胞凋亡，减少促炎性白三烯和前列腺素的产生。
T22204	LY 2389575 hydrochloride	Beta Amyloid; GluR	Neuroscience
	LY2389575 hydrochloride 是一种 mGlu3 负变构调节剂 (NAM)，具有选择性和非竞争性，其IC50 值为 190 nM。LY2389575 hydrochloride 能诱导 Mrc1 水平升高，对β 淀粉样蛋白 (Aβ) 的毒性具有放大作用，可用于研究阿尔兹海默症。
T6918	Olmutinib HM61713, BI 1482694,奥莫替尼,BI 1482694,HM61713	EGFR; BTK	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Olmutinib (HM61713, BI 1482694) 是可口服的不可逆 EGFR 酪氨酸激酶抑制剂，其与激酶结构域附近的半胱氨酸残基结合，可用于非小细胞肺癌的研究。
T21537L	TMC647055 Choline Hydroxide Salt TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	TMC647055 Choline Hydroxide Salt 是一种新型有效的 HCV NS5B 聚合酶非核苷抑制剂，可用于治疗 HCV 感染。它具有纳摩尔级细胞效力（EC(50) 为 82 nM），相关细胞毒性较小（CC(50)>20 μM），在大鼠和狗中具有良好的药代动力学特征。 TMC647055 显示出有体外生化、动力学和病毒学特征的前景。
T3024	Avitinib AC0010,艾维替尼	EGFR; JAK; BTK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Avitinib (AC0010) 是一种不可逆的、突变体选择性的EGFR 抑制剂，可有效抑制非小细胞肺癌中EGFR T790M 耐药突变。阿比替尼也是一种新型BTK 抑制剂。
T12794	(S)-Carvedilol (S)-BM 14190,(S)-卡维地洛	Others	Others
	(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
T12615	(R)-Carvedilol (R)-BM 14190,(R)-卡维地洛	Others	Others
	(R)-Carvedilol is a non-selective blocker of β/α-1. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
T63517	BuChE-IN-4	Others	Others
	BuChE-IN-4 是 BuChE 的有效抑制剂 (IC50: 7.7 nM)，表现出温和的抗氧化能力、无毒、亲脂性和神经保护作用。
TD0005	SYBR GREEN II SUPER Green II RNA gel stain 10,000× concentrate in DMSO (Electrophoresis Grade),SUPER Green II （效果同SYBR Green II）RNA染料（10,000× DMSO溶液）（电泳级）
	1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity. 2) High sensitivity: at least 100pg ssDNA or RNA can be detected, which is 25 ~ 100 times higher than EB staining. 3) High SIGNal-to-noise ratio: the sample fluorescence signal is strong, while the background signal is low. 4) Simple operation: like EB, the dye does not degrade in the prefabricated gel and electrophoresis process;The dyeing process after electrophoresis takes only 30 minutes without decolor...
T76217	Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2	Others	Others
	Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 是一种血清稳定化合物，能够选择性地抑制 tau 蛋白的纤维化，并且对神经细胞无毒。
T62452	HIV-1 inhibitor-40	Others	Others
	HIV-1 inhibitor-40 (Compound 4ab) 是一种 HIV-1 非核苷型逆转录酶抑制剂 (NNRTI) (EC50: 1.9 nM)，体内没有明显急性毒性。HIV-1 inhibitor-40 对 CYP 的敏感性较低，作用于 CYP2C9 (IC50: 5.16 μM) 和 CYP2C19 (IC50: 4.51 μM)。
T3694L	Tebanicline tosylate	Others	Others
	Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine. Like epibatidine, tebanicline showed potent analgesic activity against neuropat
TD0002L	CelRed nucleic acid gel stain 10,000× concentrate in DMSO
	1) Non-toxicity: The unique oiliness and high molecular weight characteristics of CelRed prevent it from penetrating cell membranes into cells. Ames test results also show that the mutagenicity of CelRed dye is much less than that of EB. 2) High sensitivi
T36323	C8 Galactosylceramide (d18:1/8:0) C8 Galactosylceramide (d18:1/8:0)	Others	Others
	C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo....
T73419	JMX0293	Others	Others
	JMX0293是一种O-烷基氨基连接的水杨酰胺衍生物化合物，具有针对MDA-MB-231细胞系的高效力(IC50=3.38 μM)，且对MCF-10A人非致瘤性乳腺上皮细胞系的毒性极低(IC50>60 μM)。该化合物能抑制STAT3磷酸化，促进TNBC MDA-MB-231细胞的凋亡，同时在体内显著抑制MDA-MB-231异种移植肿瘤的生长，无明显毒性。
T72563	HIV-1 inhibitor-49	Others	Others
	HIV-1inhibitor-49 是一种口服有效的 HIV-1抑制剂，是一种 HEPT 类似物。HIV-1inhibitor-49 具有良好的药代动力学特征和有效的非核苷类逆转录酶 (Reverse Transcriptase ; IC50=30 nM) 抑制活性。HIV-1inhibitor-49 具有潜在的安全性，对小鼠无急性毒性。
T37117	Etodolac Acyl Glucuronide	Others	Others
	Etodolac acyl glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac .1It is formedviaglucuronidation of etodolac by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A10, and UGT2B7. 1.Kutsuno, Y., Itoh, T., Tukey, R.H., et al.Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 miceDrug Metab. Dispos.42(7)1146-1152(2014)
T61031	HIV-1 inhibitor-41	Others	Others
	HIV-1 inhibitor-41 (Compound B23) 是口服有效的非核苷 HIV-1 逆转录酶抑制剂，其对突变型 E138K 菌株和 HIV-1 野生型的EC50值分别为 50 nM 和 20.8 nM。HIV-1 inhibitor-41 表现出低 hERG 抑制作用，没有明显 CYP 酶抑制活性，也没有急性毒性。
T62526	HIV-1 inhibitor-8	Others	Others
	HIV-1 inhibitor-8 是一种有效的、口服具有活力的、低毒性的 HIV -1 非核苷逆转录酶抑制剂 (NNRTI)。HIV-1 inhibitor-8 能够作用于 WT HIV-1 逆转录酶 (IC50: 0.081 μM)。HIV-1 inhibitor-8 对各种 HIV -1 菌株表现出有效的抗病毒效果，其 EC50 值为 4.44-54.5 nM。
T36538	NO-Indomethacin	Others	Others
	NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone. NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indom...
T80263	Tet-20
	Tet-20是一种合成导管素衍生的生物活性肽。此化合物作为医疗器械抗感染涂层的测试表明，它固定于植入物表面后，在体内和体外均展现了广泛的抗菌活性，能有效抑制生物膜的形成，且对真核细胞无毒。
T61259	Valganciclovir	Others	Others
	Valganciclovir 是ganciclovir 的原药，具有抗巨细胞病毒CMV 感染的活性。
TD0002	CelRed nucleic acid gel stain 10,000× concentrate in water
	1) Non-toxicity: The unique oiliness and high molecular weight characteristics of CelRed prevent it from penetrating cell membranes into cells, and Ames test results also show that the mutagenicity of CelRed dye is much less than EB. 2) High sensitivity:
T70128	Olmutinib hydrochloride	Others	Others
	Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently binds a cysteine residue near the kinase domain of mutant EGFRs to prevent phosphorylation of the receptor. EGFRs are frequently over-expressed in lung cancer and contribute to activation of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways which both p...
T36474	TunR1	Others	Others
	TunR1 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. TunR1 (5 μg/ml) is cytotoxic to MDA-MB-231 breast cancer cells and non-cancerous CHO cells. Unlike tunicamycin, TunR1 does not inhibit glycosylation in a protein N-glycosylation assay. 1.Price, N.P., Hartman, T.M., Li, J., et al.Modified...
T66029	3,4-Dehydro-L-proline
	The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a de...
T36475	TunR2	Others	Others
	TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared wi...
T83856	AP-1	Others	Others
	AP-1是一种微型化的蛋白质水解靶向嵌合体（PROTAC），由吲哚美辛（±）连接的间变性淋巴瘤激酶（ALK）配体和E3泛素连接酶配体通过超短连接器相连。在10至300 nM浓度范围内使用时，AP-1能高效降解Karpas-299细胞中高表达的ALK融合蛋白NPM-ALK，此效应可被蛋白酶体抑制剂MG-132阻断。它还能降解在SN-N-SH和NCI H3122细胞中表达的ALK融合蛋白EML4-ALK及含有苯丙氨酸至亮氨酸替换突变（ALKF1174L）的ALK。AP-1对依赖ALK的Karpas-299细胞具有细胞毒性（IC50 = 0.1265 nM），但对非ALK依赖的THP-1细胞无细胞毒性（IC50 = 2,704 nM）。在给药剂量为25, 50, 和100 mg/kg时，能减小NCI H3122小鼠移植瘤模型中的肿瘤体积。

化合物

Cat.No: T2180

Target: Parasite

cyclo(L-Pro-L-Tyr)

Cat.No: TP2333

Target: Others

Cat.No: T3202

Synonym: MCW-2

Target: Parasite

Cat.No: T39954

Target: Epigenetic Reader Domain, PROTACs

Diclofenac methyl ester

Cat.No: T37482

Target: Others

Cat.No: T6568

Synonym: 利克飞龙,ML-3000

Target: Apoptosis, Lipoxygenase, COX

LY 2389575 hydrochloride

Cat.No: T22204

Target: Beta Amyloid, GluR

Cat.No: T6918

Synonym: HM61713, BI 1482694,奥莫替尼,BI 1482694,HM61713

Target: EGFR, BTK

TMC647055 Choline Hydroxide Salt

Cat.No: T21537L

Synonym: TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)

Target: HCV Protease

Cat.No: T3024

Synonym: AC0010,艾维替尼

Target: EGFR, JAK, BTK

Cat.No: T12794

Synonym: (S)-BM 14190,(S)-卡维地洛

Target: Others

Cat.No: T12615

Synonym: (R)-BM 14190,(R)-卡维地洛

Target: Others

Cat.No: T63517

Target: Others

Cat.No: TD0005

Synonym: SUPER Green II RNA gel stain *10,000× concentrate in DMSO* (Electrophoresis Grade),SUPER Green II （效果同SYBR Green II）RNA染料（10,000× DMSO溶液）（电泳级）

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2

Cat.No: T76217

Target: Others

HIV-1 inhibitor-40

Cat.No: T62452

Target: Others

Tebanicline tosylate

Cat.No: T3694L

Target: Others

CelRed nucleic acid gel stain *10,000× concentrate in DMSO*

Cat.No: TD0002L

C8 Galactosylceramide (d18:1/8:0)

Cat.No: T36323

Synonym: C8 Galactosylceramide (d18:1/8:0)

Target: Others

Cat.No: T73419

Target: Others

HIV-1 inhibitor-49

Cat.No: T72563

Target: Others

Etodolac Acyl Glucuronide

Cat.No: T37117

Target: Others

HIV-1 inhibitor-41

Cat.No: T61031

Target: Others

HIV-1 inhibitor-8

Cat.No: T62526

Target: Others

NO-Indomethacin

Cat.No: T36538

Target: Others

Cat.No: T80263

Cat.No: T61259

Target: Others

CelRed nucleic acid gel stain *10,000× concentrate in water*

Cat.No: TD0002

Olmutinib hydrochloride

Cat.No: T70128

Target: Others

Cat.No: T36474

Target: Others

3,4-Dehydro-L-proline

Cat.No: T66029

Cat.No: T36475

Target: Others

Cat.No: T83856

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T19317	Ethyl phenylacetate	Others	Others
	Ethyl phenylacetate 是天然香料，其感官阈值接近 73 µg/L。它可使葡萄酒具有强烈的蜂蜜样特性。它是一种毒性较小且对环境更友好的溶剂，是非诱变性的，并且是犹太食品添加剂。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
TN3868	Dihydroxyaflavinine	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea).
TN7514	Arsenobetaine	Others	Others
	Arsenobetaine, an organoarsenical and compatible solute, is discovered in numerous marine animals like lobsters and crabs, and terrestrial organisms such as earthworms and lichens. It protects against B. subtilis cell death caused by high osmolarity or extreme temperatures at 1 mM concentration. Notably, arsenobetaine exhibits non-toxicity to mice with an LD50 of 10 g/kg.

天然产物

Ethyl phenylacetate

Cat.No: T19317

Target: Others

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Dihydroxyaflavinine

Cat.No: TN3868

Target: GABA Receptor

Cat.No: TN7514

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST) v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor t...	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...

重组蛋白

C-ABL/ABL1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04396

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35521	Aflatoxin G2-13C17 Aflatoxin G2-13C17
	Aflatoxin G2-13C17is intended for use as an internal standard for the quantification of aflatoxin G2by GC- or LC-MS. Aflatoxin G2is a mycotoxin that has been found inAspergillus.1It is lethal to ducklings (LD50= 2.83 mg/kg) but is non-toxic to rats when administered at a dose of 200 mg/kg.2 1.Bennett, J.W., and Klich, M.MycotoxinsClin. Microbiol. Rev.16(3)497-516(2003) 2.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins a...

同位素标记化合物

Aflatoxin G2-13C17

Cat.No: T35521

Synonym: Aflatoxin G2-13C17

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