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Search Results for " neurogenic "

Targets Recommended: TRP/TRPV Channel

26

抑制剂 & 化合物

2

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2711	Chembridge-5861528 TCS 5861528	TRP/TRPV Channel	Membrane transporter/Ion channel
	Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T9263	cim0216 N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide	TRP/TRPV Channel	Membrane transporter/Ion channel
	CIM0216 是选择性的TRPM3激动剂，对 TRPM3 的选择性高于 TRPM1、TRPM2 和 TRPM4-8。它以TRPM3依赖性的方式引起疼痛并唤起感觉神经末梢的神经肽释放，可用于神经源性炎症的相关研究。
T2547	Droxidopa 屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Droxidopa (L-DOPS) 是 Droxidopa (w/w80%) 和 Pharmaceutical starch (w/w20%) 的混合物，能透过血脑屏障，可作为神经递质去甲肾上腺素和肾上腺素的原药。
T20423	Dibenzylamine 二苄胺,Dibenzyl-amine,N-Benzylbenzylamine,Bibenzylamine,N-benzyl-1-phenylmethanamine,Benzenemethanamine, N-(phenylmethyl)-,AI315327,AI3-15327,AI3 15327	Others	Others
	Dibenzylamine (N-Benzylbenzylamine) 是强效神经生成剂的一种成分。
T21244	NSI-189 Phosphate NSI189 Phosphate,NSI 189 Phosphate,NSI-189磷酸盐	Others	Others
	NSI-189 Phosphate 是一种新型神经源性分子，具有多效性，包括临床前研究中证明的抗抑郁、促认知、突触和神经营养活性。其抗抑郁活性不依赖于单胺。
T1833	NSI189 NSI-189,NSI 189	Others	Others
	NSI189 (NSI-189) 是一种促智和神经源性研究化学品，源自烟酰胺和吡嗪。
T25615	Lanepitant LY303870,LY-303870,LY 303870	Others	Others
	Lanepitant (LY303870) 是一种非肽类神经激肽-1（NK-1）拮抗剂,具有镇痛活性，可抑制神经源性硬脑膜炎症,可用于预防偏头痛。
T26781	BF-1 BF1,BF 1	5-HT Receptor	GPCR/G Protein; Neuroscience
	BF-1是一种新型选择性 5-HT2 受体拮抗剂，通过阻断间氯苯基哌嗪（mCPP）或BW723C86诱导的神经源性硬脑膜血浆蛋白外渗发挥作用。BF-1 可用于研究偏头痛。
T10012	P7C3-OMe	Others	Others
	P7C3-OMe 是促神经原性化合物，其 R-对映体活性远高于 S-对映体。可以用于研究神经精神疾病和神经退行性疾病。
T1993	J-147 J147	Epigenetic Reader Domain; Dopamine Receptor; Monoamine Oxidase	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂，可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体，EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
T25616	Lanepitant 2HCl LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Lanepitant 2HCl 是一种非肽类神经激肽-1 受体拮抗剂，具有镇痛和抗炎活性。Lanepitant 2HCl 抑制 P 物质与神经激肽-1 受体的结合，抑制神经源性炎症和疼痛传递，可用于研究偏头痛等疼痛性神经病变类疾病。
T39733	Hu7691 free base	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Hu7691 free base 是一种具有口服活性、高效性和选择性的 Akt 抑制剂，对多种神经母细胞瘤细胞系的抗增殖和神经发生作用。Hu7691 free base 抑制 Akt1、Akt2 和 Akt3 ，诱导神经母细胞瘤细胞分化。
T27059	CP-122288	Others	Others
	CP-122288 is a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. CP-122288 is potent as an inhibitor of plasma protein extravasation and neurogenic inflammation.
T78606	P2X3-IN-1	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	P2X3-IN-1（示例7）为P2X3受体抑制剂，适用于神经源性疾病的研究。
T7825	Distigmine Bromide BC 51,Ubretid,BC51,Hexamarium,BC-51	Others	Others
	Distigmine Bromide is an acetylcholinesterase inhibitor. It is used for the treatment of underactive neurogenic bladder and myasthenia gravis.
T3290L	Pikamilone Sodium GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na	Others	Others
	Pikamilone Sodium is a prodrug of GABA used for therapy of neurogenic bladder in spinal and benign prostatic hyperplasia.
T33652	Neurodazole	Others	Others
	Neurodazole is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons.
T27915	LY 302148 LY-302148,LY302148	Others	Others
	LY 302148 , a 5-HT1F receptor agonist, inhibits neurogenic dural inflammation in guinea pigs. It has potential for migraine therapeutics.
T25617	Lanepitant HCl trihydrate Lanepitant dihydrochloride trihydrate	Others	Others
	Lanepitant HCl trihydrate is an effective non-peptide neurokinin-1 receptor antagonist, suppresses neurogenic dural inflammation, and may have a role in migraine therapy.
T70248	4991W93	Others	Others
	4991W93 is a 5HT(1B/1D) receptor partial agonist, inhibiting electrically induced plasma extravasation, blocking neurogenic plasma protein extravasation, inhibiting release of calcitonin gene-related peptide.
T28516	ReN-1869 NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869	Others	Others
	ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy.
T61309	(R)-Oxybutynin	Others	Others
	(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3].
T76429	Neurokinin Receptor (393-407), rat
	Neurokinin Receptor(393-407), rat (SPR393–407) 是一段属于大鼠神经激肽1受体(NK1R)的特定肽。它与P物质(SP)结合后，通过内吞作用迅速被NK1R内化，并循环至质膜。此化合物主要应用于神经源性炎症研究领域。
T80172	Stromatoxin 1	Potassium Channel	Membrane transporter/Ion channel
	Stromatoxin 1是从狼蛛中分离出的肽类钾通道抑制剂，特异性地抑制K(V)2.1、K(V)2.2、K(V)4.2和K(V)2.1/9.3通道。其中，K(V)2.1和K(V)2.2通道亚基对大鼠肌源性和神经源性膀胱平滑肌(UBSM)的收缩起关键调控作用，然而K(V)4.2则不参与此作用。
T60369	Droxidopa hydrochloride	Others	Others
	Droxidopa (L-DOPS) hydrochloride 是一种有效的、具有口服活性的去甲肾上腺素前体。Droxidopa hydrochloride 可增加站立血压，改善直立性低血压症状并提高站立能力。Droxidopa hydrochloride 具有研究神经源性直立性低血压（nOH）和替代性多动症 (注意缺陷多动障碍) 的潜力[3]。

化合物

Chembridge-5861528

Cat.No: T2711

Synonym: TCS 5861528

Target: TRP/TRPV Channel

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

Cat.No: T9263

Synonym: N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide

Target: TRP/TRPV Channel

Cat.No: T2547

Synonym: 屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS

Target: Adrenergic Receptor

Cat.No: T20423

Synonym: 二苄胺,Dibenzyl-amine,N-Benzylbenzylamine,Bibenzylamine,N-benzyl-1-phenylmethanamine,Benzenemethanamine, N-(phenylmethyl)-,AI315327,AI3-15327,AI3 15327

Target: Others

NSI-189 Phosphate

Cat.No: T21244

Synonym: NSI189 Phosphate,NSI 189 Phosphate,NSI-189磷酸盐

Target: Others

Cat.No: T1833

Synonym: NSI-189,NSI 189

Target: Others

Cat.No: T25615

Synonym: LY303870,LY-303870,LY 303870

Target: Others

Cat.No: T26781

Synonym: BF1,BF 1

Target: 5-HT Receptor

Cat.No: T10012

Target: Others

Cat.No: T1993

Synonym: J147

Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase

Lanepitant 2HCl

Cat.No: T25616

Synonym: LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride

Target: Neurokinin receptor

Hu7691 free base

Cat.No: T39733

Target: Akt

Cat.No: T27059

Target: Others

Cat.No: T78606

Target: P2X Receptor

Distigmine Bromide

Cat.No: T7825

Synonym: BC 51,Ubretid,BC51,Hexamarium,BC-51

Target: Others

Pikamilone Sodium

Cat.No: T3290L

Synonym: GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na

Target: Others

Cat.No: T33652

Target: Others

Cat.No: T27915

Synonym: LY-302148,LY302148

Target: Others

Lanepitant HCl trihydrate

Cat.No: T25617

Synonym: Lanepitant dihydrochloride trihydrate

Target: Others

Cat.No: T70248

Target: Others

Cat.No: T28516

Synonym: NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869

Target: Others

Cat.No: T61309

Target: Others

Neurokinin Receptor (393-407), rat

Cat.No: T76429

Cat.No: T80172

Target: Potassium Channel

Droxidopa hydrochloride

Cat.No: T60369

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN5757	p-Hydroxybenzaldehyde glucoside 4-formylphenyl b-d-glucopyranoside,Gastrodin Impurity
	p-Hydroxybenzaldehyde glucoside (4-formylphenyl b-d-glucopyranoside) 是抑制天麻素衍生物，具有镇痛活性，可以用于研究神经源性疼痛。
TN6872	Trypsin	Protease-activated Receptor	GPCR/G Protein
	Trypsin 是一种可从鱼类分离出的丝氨酸蛋白酶，可水解赖氨酸或精氨酸羧基侧蛋白质。Trypsin 具有抗炎活性，可通过 PDCoV 的 S 糖蛋白与 pAPN 的相互作用诱导 PDCoV 感染的细胞膜融合，可激活 PAR2 和 PAR4，促进细胞增殖和分化。Trypsin 可用于促进伤口愈合和研究神经源性炎症。

天然产物

p-Hydroxybenzaldehyde glucoside

Cat.No: TN5757

Synonym: 4-formylphenyl b-d-glucopyranoside,Gastrodin Impurity

Cat.No: TN6872

Target: Protease-activated Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01452	Notch 1 Protein, Mouse, Recombinant (aa 18-526, His) mT14,Neurogenic locus notch homolog protein 1,Motch...	Mouse	HEK293 Cells
	Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain ...
TMPK-00383	ACE2/ACEH Protein, Human, Recombinant (His & Avi) ACE2,ACE-2,ACEH	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPY-04069	Neurotrophin 3 Protein, Human, Recombinant NGF2,HDNF,NT-3,neurotrophin 3,NGF-2,NT3	Human	E. coli
	NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. ...
TMPH-02118	SCN1A Protein, Human, Recombinant (His) Sodium channel protein brain I subunit alpha,Sodium channel ...	Human	E. coli
	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neur...
TMPJ-00882	Desmin Protein, Human, Recombinant (His) DES,Desmin	Human	E. coli
	Desmin is a cytoplasmic protein and belongs to the intermediate filament family. interacts with DST and MTM1. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. Desmin is the main intermediate filament in mature skeletal, cardiac and smooth-muscle cells. DES founctions as homopolymers to form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. .Defects in DES are cause of the myopathy myofibr...
TMPK-00382	ACE2/ACEH Protein, Human, Recombinant (hFc & Avi), Biotinylated ACE-2,ACE2,ACEH	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPK-00552	ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated ACEH,ACE-2,ACE2	Cynomolgus	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPK-00551	ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi) ACE-2,ACEH,ACE2	Cynomolgus	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...

重组蛋白

Notch 1 Protein, Mouse, Recombinant (aa 18-526, His)

Cat.No: TMPJ-01452

Species: Mouse

Expression System: HEK293 Cells

ACE2/ACEH Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00383

Species: Human

Expression System: HEK293 Cells

Neurotrophin 3 Protein, Human, Recombinant

Cat.No: TMPY-04069

Species: Human

Expression System: E. coli

SCN1A Protein, Human, Recombinant (His)

Cat.No: TMPH-02118

Species: Human

Expression System: E. coli

Desmin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00882

Species: Human

Expression System: E. coli

ACE2/ACEH Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPK-00382

Species: Human

Expression System: HEK293 Cells

ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00552

Species: Cynomolgus

Expression System: HEK293 Cells

ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi)

Cat.No: TMPK-00551

Species: Cynomolgus

Expression System: HEK293 Cells

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