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Search Results for " necroptosis "

Targets Recommended: Necroptosis RIP kinase

29

抑制剂 & 化合物

2

天然产物

1

化合物库

2

重组蛋白

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Cat. No.	Product Name
L8700	铁死亡化合物库		779 compounds
	779 种与铁死亡通路相关的化合物，可用于高通量和高内涵筛选；

化合物库

铁死亡化合物库

Cat.No: L8700

Compounds: 779

Cat. No.	Product Name	Target	Signaling Pathways
T9305	Necroptosis-IN-1	RIP kinase	Apoptosis; NF-κB
	Necroptosis-IN-1 是一种 RIPK1 坏死性凋亡抑制剂。它是 Necrostatin-1 的类似物。
T64349	Necroptosis-IN-3 Cyclohexanecarboxamide, N-(2-thienylmethyl)-	Necroptosis	Apoptosis
	Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-)(Compound 69) 是一种坏死性凋亡 (necroptosis) 抑制剂，抑制 TNF-α 诱导的坏死性凋亡。Necroptosis-IN-3(Compound 69) 也抑制 11β-HSD1。
T9465	ZZW-115 hydrochloride	Apoptosis; Others	Apoptosis; Others
	ZZW-115 hydrochloride 是一种 NUPR1抑制剂，Kd 为 2.1 μM。它通过坏死和凋亡诱导肿瘤细胞死亡，具有抗癌活性。
T9079	Apostatin-1 Apt-1	Others	Others
	Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。
T9095	Necrostatin-34 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase	Apoptosis; NF-κB
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂，通过在激酶结构域中占据一个独特的结合口袋，将 RIPK1 激酶稳定在非活性构象中。
T7504	Necrostatin 2 racemate 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate	RIP kinase	Apoptosis; NF-κB
	Necrostatin 2 racemate (Necrostatin-2 racemate) 是一种特异性的RIPK1抑制剂，是一种稳定型 Nec-1。
T13603	CDDO-3P-Im	Necroptosis	Apoptosis
	CDDO-3P-Im 是一种具有口服活性的坏死性凋亡抑制剂，具有化学预防作用。 CDDO-3P-Im 可用于有关缺血/再灌注的研究。
T11520	GW806742X	MLK; VEGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	GW806742X 是ATP 模拟物，是MLKL 抑制剂，可结合 MLKL 假激酶结构域，Kd 值为 9.3μM。它对VEGFR2的IC50为 2 nM，延缓 MLKL 膜移位并抑制坏死。
T6904	Necrosulfonamide (E)-Necrosulfonamide	MLK	MAPK
	Necrosulfonamide ((E)-Necrosulfonamide) 是一种坏死性凋亡抑制剂，通过选择性靶向(MLKL)，可阻止 MLKL-RIP1-RIP3 坏死小体复合体与其下游效应子相互作用。MLKL 是诱导坏死过程中 RIP3 的重要底物。
T37558	Necrostatin-5 Nec-5	RIP kinase; Necroptosis	Apoptosis; NF-κB
	Necrostatin-5 (Nec-5)是一种RIP1激酶的选择性抑制剂，也是一种细胞坏死抑制剂，可防止TNF-α处理的fadd 缺陷Jurkat 细胞死亡，EC50值为240 nM。
T73279	MLKL-IN-5	Others	Others
	MLKL-IN-5 是一种有效的MLKL 抑制剂，可介导细胞坏死性凋亡。
T81269	RIPK1-IN-16	RIP kinase	Apoptosis; NF-κB
	RIPK1-IN-16是口服活性的RIPK1抑制剂，有效阻断RIPK1介导的necroptosis，抑制炎症反应。在小鼠模型中，RIPK1-IN-16通过抵御TNF引发的全身性炎症综合症和败血症来展现保护作用。
T40330	Anticancer agent 15	Others	Others
	Anticancer agent 15, an anticancer agent, exerts its efficacy by elevating intracellular levels of reactive oxygen species (ROS) and inducing cell death in melanoma cancer cells through necroptosis.
T12203L	Necrostatin 2	Others	Others
	Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.
T79347	Anticancer agent 146	Necroptosis	Apoptosis
	Anticanceragent 146（compound 1.19）是一种诱导坏死（Necroptosis）的化合物，它在小鼠MDA-MB-231异种移植模型中显示出抗肿瘤活性。
T81267	RIPK3-IN-4	RIP kinase	Apoptosis; NF-κB
	RIPK3-IN-4（Compound 42）是一种抑制RIPK3活性的化合物。它能有效减轻HK-2细胞的损伤和凋亡（necroptosis），同时降低急性肾损伤中（Cisplatin）以及缺血/再灌注（I/R）引起的肾脏损伤、炎症及坏死性凋亡现象。
T71998	673-A	Others	Others
	673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). 673-A also overcomes chemotherapy resistance in vivo.
T84727	Necrostatin-1 (inactive control) Nec-1 (inactive control)	Others	Others
	Necrostatin-1(Nec-1)（inactive control）为Necrostatin-1的非活性类似物，后者为一种高效的坏死性凋亡抑制剂。
T80052	Cathepsin B
	Cathepsin B为一种半胱氨酸蛋白酶，涉及多种程序性细胞死亡（包括细胞凋亡、焦亡、铁亡、坏死亡及自噬性细胞死亡）。
T62723	RIPK1-IN-12
	RIPK1-IN-12 是一种 RIPK1 的有效抑制剂。RIPK1-IN-12 对人和小鼠细胞的坏死性凋亡表现出抑制作用，EC50 值分别为 1.6 和 2.9 nM.
T81268	RIPK1-IN-17	RIP kinase	Apoptosis; NF-κB
	RIPK1/3-IN-1（Compound 10）是RIPK1与RIPK3的抑制剂，其通过抑制RIPK1、RIPK3及MLKL的磷酸化作用，特异性地抑制坏死性凋亡。
T79369	ZMF-23	PAK	Cytoskeletal Signaling
	ZMF-23 是一种针对PAK1和HDAC6的双重抑制剂，能够抑制这两种酶控制的有氧糖酵解过程和细胞迁移。它促使TNF-α 介导的坏死性凋亡（necroptosis），并增强细胞凋亡（apoptosis）。ZMF-23 还可作为研究三阴性乳腺癌（TNBC）的工具，因其能够抑制Warburg效应及细胞迁移。
T78784	RIPK3-IN-3	Others	Others
	RIPK3-IN-3（化合物20）是一种针对受体相互作用蛋白激酶RIPK3的选择性抑制剂，其IC50为10 nM。它通过抑制p-MLKL的寡聚化作用来阻止RIPK3介导的MLKL磷酸化以及随后的坏死性凋亡。此外，RIPK3-IN-3还能降低CXCL5的分泌，并抑制AsPC-1细胞的迁移和侵袭。
T9429	ZZW-115	Others	Others
	ZZW-115 是一种有效的 NUPR1抑制剂，Kd 为 2.1 μM。ZZW-115是三氟拉嗪(TFP)的衍生物。ZZW-115显示出剂量依赖性肿瘤消退，无神经系统副作用，主要通过坏死和凋亡诱导细胞死亡。
T74681	NecroIr2	Others	Others
	NecroIr2 是一种铱 (III) 复合物，是顺铂 (Cisplatin) 耐药肺癌细胞 (A549R) 的坏死诱导剂。NecroIr2 选择性积累在线粒体中，导致氧化应激和线粒体膜电位 (MMP) 的损失。NecroIr2 能够激活受体相互作用的丝氨酸苏氨酸激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL)，调节CDK4表达。
T79831	PROTAC MLKL Degrader-1	Others	Others
	PROTACMLKL Degrader-1 (Compound 36) 为MLKL的PROTAC靶向降解剂，具有超过90%的Dmax效率。该化合物构成包含了修饰后的CRBN配体、linker 及 Lenalidomide 接头片段，能有效消除TSZ坏死模型中的细胞死亡。
T74680	NecroIr1	Others	Others
	NecroIr1 是一种铱 (III) 复合物，是顺铂 (Cisplatin) 耐药肺癌细胞 (A549R) 的坏死诱导剂。NecroIr1 选择性积累在线粒体中，导致氧化应激和线粒体膜电位 (MMP) 的损失。NecroIr1 能够激活受体相互作用的丝氨酸苏氨酸激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL)，调节CDK4表达。
T37851	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)	Others	Others
	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging...
T73382	SZM-1209	RIP kinase	Apoptosis; NF-κB
	SZM-1209是一种口服活性且特异性RIPK1抑制剂，具有85 nM的Kd值。该化合物展现出对抗坏死性凋亡（necroptosis）高效活性（EC50=22.4 ± 8.1 nM），并能抵抗SIRS（全身炎症反应综合征）及ALI（急性肺损伤）。

化合物

Necroptosis-IN-1

Cat.No: T9305

Target: RIP kinase

Necroptosis-IN-3

Cat.No: T64349

Synonym: Cyclohexanecarboxamide, N-(2-thienylmethyl)-

Target: Necroptosis

ZZW-115 hydrochloride

Cat.No: T9465

Target: Apoptosis, Others

Cat.No: T9079

Synonym: Apt-1

Target: Others

Cat.No: T9095

Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Target: RIP kinase

Necrostatin 2 racemate

Cat.No: T7504

Synonym: 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate

Target: RIP kinase

Cat.No: T13603

Target: Necroptosis

Cat.No: T11520

Target: MLK, VEGFR

Necrosulfonamide

Cat.No: T6904

Synonym: (E)-Necrosulfonamide

Target: MLK

Cat.No: T37558

Synonym: Nec-5

Target: RIP kinase, Necroptosis

Cat.No: T73279

Target: Others

Cat.No: T81269

Target: RIP kinase

Anticancer agent 15

Cat.No: T40330

Target: Others

Cat.No: T12203L

Target: Others

Anticancer agent 146

Cat.No: T79347

Target: Necroptosis

Cat.No: T81267

Target: RIP kinase

Cat.No: T71998

Target: Others

Necrostatin-1 (inactive control)

Cat.No: T84727

Synonym: Nec-1 (inactive control)

Target: Others

Cat.No: T80052

Cat.No: T62723

Cat.No: T81268

Target: RIP kinase

Cat.No: T79369

Target: PAK

Cat.No: T78784

Target: Others

Cat.No: T9429

Target: Others

Cat.No: T74681

Target: Others

PROTAC MLKL Degrader-1

Cat.No: T79831

Target: Others

Cat.No: T74680

Target: Others

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Cat.No: T37851

Target: Others

Cat.No: T73382

Target: RIP kinase

Cat. No.	Product Name	Target	Signaling Pathways
T5136	Kongensin A
	Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.
TN1837	Kuguaglycoside C 苦瓜皂苷 C	PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.

天然产物

Cat.No: T5136

Kuguaglycoside C

Cat.No: TN1837

Synonym: 苦瓜皂苷 C

Target: PARP, Caspase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His) Cell death protein RIP,Receptor-interacting protein 1,Ripk1,...	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i...
TMPH-01694	MLKL Protein, Human, Recombinant (E. coli, His) MLKL,Mixed lineage kinase domain-like protein	Human	E. coli
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZB...

重组蛋白

RIPK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02876

Species: Mouse

Expression System: E. coli

MLKL Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01694

Species: Human

Expression System: E. coli

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