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Search Results for " myelogenous "

Targets Recommended: Nucleoside Antimetabolite/Analog HCV Protease DNA/RNA Synthesis

33

抑制剂 & 化合物

3

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15235	Enocitabine	Nucleoside Antimetabolite/Analog; HCV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Enocitabine 是一种核苷类似物，抑制 DNA 复制剂。Enocitabine 抑制人巨细胞病毒的复制，显示出抗白血病和抗病毒活性。
T1803	GNF-5 GNF 5	SARS-CoV; Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	GNF-5是 Bcr-Abl 的特异性非 ATP 竞争性抑制剂，IC50为0.22uM。它是 GNF-2 的类似物，具有改进的药代动力学特性。
T13186	TL02-59	Apoptosis; Src; Hck	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	TL02-59 是 Src 家族激酶中 Fgr 的特异性抑制剂 (IC50 = 0.03 nM)。 TL02-59 抑制 Lyn 和 Hck，IC50 分别为 0.1 nM 和 160 nM。 TL02-59 有效抑制急性髓性白血病细胞的生长。
T3196	GNF-7 GNF7	Bcr-Abl; ACK; AChR	Angiogenesis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors
	GNF-7 是一种多重激酶抑制剂。它对ACK1和GCK 具有抑制活性，IC50分别为 25 nM 和 8 nM。它是一种 Bcr-Abl 的抑制剂，对 Bcr-AblWT 和 Bcr-AblT315I 作用的IC50值分别为 133 nM 和 61 nM。它可用于研究血液恶性肿瘤。
T21785	AG957	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG957 是一种酪氨酸激酶抑制剂，具有抗BCR/ABL 酪氨酸激酶活性。它能够抑制p210bcr/abl 酶活性 (IC50:2.9 μM)。
T14871	Carboxyamidotriazole Orotate L-651582 Orotate,CAI Orotate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Carboxyamidotriazole Orotate (L-651582 Orotate) 是一种可口服的信号转导抑制剂，是Carboxyamidotriazole (CAI) 的乳清酸盐形式。它是一种非电压性钙通道和钙通道介导的信号通路的细胞抑制剂，具有抗癌、抗炎活性和抗血管生成作用。
T22553	Adaphostin 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Adaphostin (NSC-680410) 是 AG957 金刚烷酯，是一种 p210bcr/abl 抑制剂，可诱导 T 淋巴细胞白血病细胞系凋亡。它增加了 CLL B 细胞内活性氧的水平，对慢性和急性髓系白血病细胞具有显著的选择性活性。
T16545	Pivanex Pivalyloxymethyl butyrate,AN-9	Apoptosis; HDAC; Bcr-Abl	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物，是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。
T1667	Tandutinib MLN518,CT53518,NSC726292,坦度替尼	Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tandutinib (CT53518) 是一种选择性 FLT3抑制剂，其 IC50为 0.22 μM。它还抑制c-Kit 和PDGFR，其IC50分别为 0.17 μM 和 0.20 μM。它可穿透血脑屏障，用于急性骨髓性白血病。
T6018	Zosuquidar trihydrochloride 唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp	Membrane transporter/Ion channel; Neuroscience
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) 是一种P-糖蛋白抑制剂，Ki 值为 59 nM。
T26625	AN-019 NRC-AN-019,NRC-019	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	AN-019 (NRC-019) 是一种 Bcr-Abl 激酶抑制剂，具有抗肿瘤活性，可用于研究慢性粒细胞白血病（CML）和乳腺癌。
T5820	Amsacrine hydrochloride acridinyl anisidide hydrochloride,盐酸胺苯吖啶,m-AMSA hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Amsacrine hydrochloride (acridinyl anisidide hydrochloride) 是一种拓扑异构酶 II 抑制剂，用于治疗急性髓细胞性白血病。
T27695	JTE-607 JTE-607 dihydrochloride,JTE-607 HCl,甲氧番荔枝碱	Cysteine Protease	Proteases/Proteasome
	JTE-607 HCl 是高选择性的炎性细胞因子合成抑制剂，可保护小鼠免受内毒素休克。它作用于 LPS 刺激的人 PBMC，抑制TNF-α(IC50:11 nM)、IL-1β(IC50:5.9 nM)、IL-6(IC50:8.8 nM)、IL-8(IC50:7.3 nM)和IL-10(IC50:9.1 nM)。
T22378	Nilotinib hydrochloride AMN-107 HCl	Bcr-Abl; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Nilotinib hydrochloride(AMN-107 HCl) 是一种可口服的 Bcr-Abl 酪氨酸激酶抑制，具有抗肿瘤活性，可用于调节神经炎症和认知障碍，可用于研究慢性骨髓性白血病。
T11299	FLT3-IN-4 FLT3 inhibitor 9u	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	FLT3-IN-4 (FLT3 inhibitor 9u) 是一种口服有效的 Fms 样酪氨酸受体激酶 3 (FLT3; IC50= 7 nM) 抑制剂，可用于急性髓性白血病的研究。
T24212	XX-650-23 XX65023,XX 650 23	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	XX-650-23 是一种小分子 CREB 抑制剂，阻断 CREB 与其所需的共激活因子 CBP（CREB 结合蛋白）之间的关键相互作用，诱导AML细胞凋亡和细胞周期停滞，可用于研究急性髓系白血病（AML）。
T23128	PD180970 PD 180970	Bcr-Abl; Src; c-Kit	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PD180970 是一种 Bcr-Abl 抑制剂，对于 p210Bcr-Abl、Src 和 Kit 的自磷酸化，IC50 分别为 5 nM、0.8 nM 和 50 nM。 PD180970 可用于慢性粒细胞白血病的研究。
T72958	BCR-ABL-IN-7	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	BCR-ABL-IN-7 是一种 WT 和 T315I 突变体 ABL 激酶抑制剂。BCR-ABL-IN-7 有效抑制 WT 和 T315I 突变体 ABL 激酶的活性。BCR-ABL-IN-7 可以用于慢性髓系白血病 (CML) 的研究。
T68151L	Tallimustine HCl Tallimustine HCl(115308-98-0 Free base)	DNA	DNA Damage/DNA Repair
	Tallimustine HCl 是一种DNA 抑制剂，是二霉素的AT 特异性烷化抗肿瘤衍生物。Tallimustine HCl 可用于成人骨髓性白血病的严重联合免疫缺陷小鼠模型，可用于治疗白血病。
T10488	BCR-ABL-IN-1	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.
T71144	Nilotinib N-oxide	Others	Others
	Nilotinib N-oxide is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia.
T71068	Nilotinib dihydrochloride dihydrate	Others	Others
	Nilotinib dihydrochloride dihydrate is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia.
T68338	Nilotinib hydrochloride dihydrate	Others	Others
	Nilotinib hydrochloride dihydrate is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia.
T22859	Imatinib hydrochloride	Others	Others
	Imatinib is a multi-target inhibitor of v-Abl, c-Kit, and PDGFR (IC50: 0.6 μM, 0.1 μM, and 0.1 μM, respectively). Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs), and a number of other malignancies.
T60927	Ranimustine	Others	Others
	Ranimustine (MCNU) 是一种可用于真性红细胞增多症和慢性粒细胞白血病研究的亚硝基脲烷基化剂。
T6018L	Zosuquidar	Others	Others
	Zosuquidar (LY335979) 是 P-糖蛋白 (P-glycoprotein) 抑制剂，Ki 值为 59 nM。Zosuquidar 具有抗肿瘤活性，可用于急性髓性白血病 (AML) 研究。
T9634	Bomedemstat	Others	Others
	Bomedemstat (IMG-7289) 是一种有效的，具有口服活性的且不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，具有表观遗传活性。Bomedemstat 具有抗癌活性，可用于急性髓性白血病 (AML) 和骨髓纤维化 (MF) 的研究。
T64226	Tandutinib hydrochloride	Others	Others
	Tandutinib hydrochloride (MLN518 hydrochloride) 是一种有效和选择性的FLT3的抑制剂，其IC50为 0.22 μM，并且还抑制c-Kit 和PDGFR，其IC50分别为 0.17 μM 和 0.20 μM。Tandutinib hydrochloride 可用于急性骨髓性白血病，并具有穿越血脑屏障的能力。
T78904	Anticancer agent 110	Apoptosis	Apoptosis
	Anticanceragent 110 是抗癌化合物，表现出体外抗肿瘤活性和对抗白血病的卓越效力。该化合物在 K-562 慢性粒细胞白血病细胞系中展示了显著的纳摩尔级别细胞毒性，并能引发 DNA 损伤和细胞凋亡(apoptosis)。
T71313	BVB-808	Others	Others
	BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning int...
T64277	ODN 1585	Others	Others
	ODN 1585 是一种有效的 IFN 和 TNFα 产生诱导剂，也是一种 NK (natural killer) 的有效刺激剂，可用做疫苗佐剂。ODN 1585 能够增强 CD8+ T 细胞的功能，包括 CD8+ T 细胞介导的 IFN-γ 的产生。ODN 1585 可以诱导小鼠已建立的黑色素瘤消退，对小鼠的疟疾也表现出完全的保护作用。ODN 1585 能够用于研究急性骨髓性白血病 (AML) 和疟疾。
T68389	LY2457546	Others	Others
	LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...
T35435	β-D-Ribofuranose 1,2,3,5-tetraacetate	Others	Others
	β-D-Ribofuranose 1,2,3,4-tetraacetate is a precursor in the synthesis of nucleosides with antiproliferative activity against cancer cells.1,2 1.Furukawa, Y., and Honjo, M.A novel method for the synthesis of purine nucleosides using Friedel-Crafts catalystsChem. Pharm. Bull. (Tokyo)16(6)1076-1080(1968) 2.Wicke, L., Engels, J.W., Gambari, R., et al.Synthesis and antiproliferative activity of quinolone nucleosides against the human myelogenous leukemia k-562 cell lineArch. Pharm. (Weinheim)346(10)7...

化合物

Cat.No: T15235

Target: Nucleoside Antimetabolite/Analog, HCV Protease, DNA/RNA Synthesis

Cat.No: T1803

Synonym: GNF 5

Target: SARS-CoV, Bcr-Abl

Cat.No: T13186

Target: Apoptosis, Src, Hck

Cat.No: T3196

Synonym: GNF7

Target: Bcr-Abl, ACK, AChR

Cat.No: T21785

Target: Bcr-Abl

Carboxyamidotriazole Orotate

Cat.No: T14871

Synonym: L-651582 Orotate,CAI Orotate

Target: Calcium Channel

Cat.No: T22553

Synonym: 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410

Target: Bcr-Abl

Cat.No: T16545

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Cat.No: T1667

Synonym: MLN518,CT53518,NSC726292,坦度替尼

Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit

Zosuquidar trihydrochloride

Cat.No: T6018

Synonym: 唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride

Target: P-gp

Cat.No: T26625

Synonym: NRC-AN-019,NRC-019

Target: Bcr-Abl

Amsacrine hydrochloride

Cat.No: T5820

Synonym: acridinyl anisidide hydrochloride,盐酸胺苯吖啶,m-AMSA hydrochloride

Target: Topoisomerase, Autophagy

Cat.No: T27695

Synonym: JTE-607 dihydrochloride,JTE-607 HCl,甲氧番荔枝碱

Target: Cysteine Protease

Nilotinib hydrochloride

Cat.No: T22378

Synonym: AMN-107 HCl

Target: Bcr-Abl, Autophagy

Cat.No: T11299

Synonym: FLT3 inhibitor 9u

Target: FLT

Cat.No: T24212

Synonym: XX65023,XX 650 23

Target: Apoptosis, Epigenetic Reader Domain

Cat.No: T23128

Synonym: PD 180970

Target: Bcr-Abl, Src, c-Kit

Cat.No: T72958

Target: Bcr-Abl

Tallimustine HCl

Cat.No: T68151L

Synonym: Tallimustine HCl(115308-98-0 Free base)

Target: DNA

Cat.No: T10488

Target: Bcr-Abl

Nilotinib N-oxide

Cat.No: T71144

Target: Others

Nilotinib dihydrochloride dihydrate

Cat.No: T71068

Target: Others

Nilotinib hydrochloride dihydrate

Cat.No: T68338

Target: Others

Imatinib hydrochloride

Cat.No: T22859

Target: Others

Cat.No: T60927

Target: Others

Cat.No: T6018L

Target: Others

Cat.No: T9634

Target: Others

Tandutinib hydrochloride

Cat.No: T64226

Target: Others

Anticancer agent 110

Cat.No: T78904

Target: Apoptosis

Cat.No: T71313

Target: Others

Cat.No: T64277

Target: Others

Cat.No: T68389

Target: Others

β-D-Ribofuranose 1,2,3,5-tetraacetate

Cat.No: T35435

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T25476	Gypsogenin 丝石竹皂苷元	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Gypsogenin (639-14-5) 是一种天然存在的生化物质，具有明显的抗血管生成活性和对 H460 的细胞毒性，拥有抗 ABL1 激酶和抗慢性骨髓性白血病作用。
TN5358	Eupahualin C
	Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).
T15638	K-252c	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in human chronic myelogenous leukemia cancer cells.

天然产物

Cat.No: T25476

Synonym: 丝石竹皂苷元

Target: Bcr-Abl

Cat.No: TN5358

Cat.No: T15638

Target: PKC

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04458	TRIB2 Protein, Human, Recombinant (His & GST) TRIBBLE,tribbles pseudokinase 2,TRIB2,C5FW,FLJ57420,GS3955,T...	Human	Baculovirus Insect Cells
	Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate the activation of some intracellular signalling pathways with roles e...
TMPY-01480	LTC4S Protein, Human, Recombinant (His) LTC4S,MGC33147,leukotriene C4 synthase	Human	Baculovirus Insect Cells
	Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells, and platelets. LTC4S is essential for the production of cysteinyl leukotrienes (Cys...

重组蛋白

TRIB2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04458

Species: Human

Expression System: Baculovirus Insect Cells

LTC4S Protein, Human, Recombinant (His)

Cat.No: TMPY-01480

Species: Human

Expression System: Baculovirus Insect Cells

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