74
40
4
50
2
Cat. No. | Product Name | ||
---|---|---|---|
L5300 | 线粒体靶向库 | 812 compounds | |
812 种具有潜在或确定线粒体靶向活性的化合物,以促进针对线粒体的药物研究; | |||
L1120 | AMPK靶向分子库 | 80 compounds | |
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选; | |||
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7600 | 趋化因子抑制剂库 | 59 compounds | |
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1725 |
Y-27632 dihydrochloride
反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl |
ROCK; Apoptosis | Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Y-27632 dihydrochloride (Y-27632 2HCl) 是一种 ROCK-I 和 ROCK-II 抑制剂,具有口服有效性、ATP 竞争性。Y-27632 dihydrochloride 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。 | |||
T7340 |
5'-N-Ethylcarboxamidoadenosine
NECA,5'-N-乙基酰胺基腺苷 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
5'-N-Ethylcarboxamidoadenosine (NECA) 是腺苷受体的激动剂,可增加荧光素和低分子量葡聚糖的脑外渗,与血脑屏障调节无关。 | |||
T29170 |
XU1
Benzo[c][1,8]naphthyridin-6(5h)-One |
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
XU1(Benzo[c][1,8]naphthyridin-6(5h)-One) 是一种 Aurora 蛋白激酶抑制剂,用于治疗适合激酶信号转导抑制、调节或调节的疾病。 | |||
T22378 |
Nilotinib hydrochloride
AMN-107 HCl |
Bcr-Abl; Autophagy | Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Nilotinib hydrochloride(AMN-107 HCl) 是一种可口服的 Bcr-Abl 酪氨酸激酶抑制,具有抗肿瘤活性,可用于调节神经炎症和认知障碍,可用于研究慢性骨髓性白血病。 | |||
T30819 |
CGP 20376
CGP-20376,CGP20376 |
Others | Others |
CGP 20376 是一种苯并噻唑化合物,是一种驱虫剂,对嗜酸性粒细胞呼吸爆发的双重剂量依赖性调节体外作用,具有抗纤特性。 | |||
T60325 |
Viloxazine
Emovit,Viloxazin |
5-HT Receptor; Norepinephrine | GPCR/G Protein; Neuroscience |
Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2]. | |||
T62204 |
NR2F6 modulator-1
|
Others | Others |
NR2F6 modulator-1 是一种核受体亚族 2,F 组第 6 号成员 (NR2F6) 的有效调节剂。NR2F6 modulator-1 能够用于研究免疫调节和肿瘤干细胞活性的调节。 | |||
T3564 |
SHP099
SHP099 free base,SHP 099,SHP-099 |
Phosphatase; PERK | Apoptosis; Metabolism |
SHP099 (SHP099 free base) free base 是一种选择性的,有效的,有口服活性的 SHP2抑制剂,IC50=70 nM。 | |||
T0217L |
(+)-Dropropizine
(+)-Dropropizine,右羟丙哌嗪 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
(+)-Dropropizine 可以抑制组胺受体,抗过敏,并通过调节参与咳嗽反射的神经肽和干扰感觉神经末梢的刺激激活来减少咳嗽。 | |||
T21505 |
Suberoyl bis-hydroxamic acid
SBHA,软木肟酸,Suberohydroxamic acid |
Apoptosis; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Suberoyl bis-hydroxamic acid (SBHA) 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂,ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径,可研究甲状腺髓样癌。 | |||
T10760 |
Ceramides Mixture
神经酰胺混合物,神经酰胺 |
Telomerase | DNA Damage/DNA Repair |
Ceramides Mixture 是表皮渗透屏障的主要脂质成分,参与生长抑制,细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺,由含羟基和非羟基脂肪酸的神经酰胺组成。 | |||
T36520 |
COR659
|
Cannabinoid Receptor; GABA Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。 | |||
T16328 |
Nitroaspirin
2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物,与 Aspirin 结合可抑制环氧合酶=,可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白,显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡,具有抗血栓和抗血小板特性。 | |||
T4965L |
TCS-OX2-29 HCl
TCSOX 229,TCS-OX229,TCS OX229,TCS OX2 29,TCSOX-229,TCSOX229 |
Others | Others |
TCS-OX2-29 is a selective orexin-2 receptor antagonist (IC50 = 40 nM), which plays an important role in pain modulation. | |||
T36037 |
CBR-470-2
|
Others | Others |
CBR-470-2, a glycine-substituted analog, exhibits the capacity to activate NRF2 signaling, making it a valuable compound for investigating glycolysis modulation in scientific research [1]. | |||
T37896 |
AZ 1729
|
Others | Others |
FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro. Bolognini et al (2016) A novel... | |||
T68702 |
Photoregulin3
|
Others | Others |
Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation. | |||
T16505 | PF-4778574 | Others | Others |
PF-4778574 is a positive AMPA receptor allosteric modulation (EC50: 45 to 919 nM in different cells). | |||
T26788 |
BG48
BG-48,BG 48 |
Others | Others |
BG48 is a probe of chemo-optical modulation of epigenetically regulated transcription (COMET). It enables high-resolution, optical control of epigenetic mechanisms and photochromically inhibits human histone deacetylases using visible light. | |||
T26787 |
BG47
BG-47,BG 47 |
Others | Others |
BG47 is a probe for chemo-optical modulation of epigenetically regulated transcription (COMET). It enables high-resolution, optical control of epigenetic mechanisms and photochromically inhibits human histone deacetylases using visible light. | |||
T13550 |
AP5
|
Others | Others |
AP5 is a potent and selective agonist for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49 nM against the GPR40 receptor. | |||
T70971 |
VGD020
|
Others | Others |
VGD020 is a CD4 and sortilin inhibitor. It displayed activity for sortilin down-modulation and reduction of progranulin-induced breast cancer stem cell propagation. | |||
T61276 |
CB1R Allosteric modulator 2
|
Others | Others |
CB1R Allosteric modulator 2 (compound 18) is a potent allosteric modulator of the CB1R receptor. It exhibits negative modulation of the functional activity of orthosteric ligands (NAM) at CB1Rs, as demonstrated in previous studies [1]. | |||
T71472 |
LN6023
|
Others | Others |
LN6023 is a ACKR3/CXCR7 Superagonist for Platelet Degranulation Modulation. LN6023 effectively reduced P-selectin expression by up to 97%, suggesting to be a potential candidate for the treatment of platelet-mediated thrombosis. | |||
T26786 |
BG14
BG 14,BG-14 |
Others | Others |
BG14 is a probe for chemo-optical modulation of epigenetically regulated transcription (COMET). It enables high-resolution, optical control of epigenetic mechanisms and photochromically inhibits human histone deacetylases using visible light. | |||
T26596 |
Allylpyrocatechol
|
Others | Others |
Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways. | |||
T40778 |
Tyrosylleucine TFA
Tyr-Leu TFA |
||
Tyrosylleucine (Tyr-Leu, YL) TFA is a dipeptide compound with potent antidepressant-like activity. This orally active compound demonstrates effective modulation of depressive symptoms. | |||
T39413 |
ACAT-IN-8
|
Others | Others |
ACAT-IN-8 (example 206) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol modulation. This compound also possesses the ability to inhibit transcription mediated by NF-κB. | |||
T39694 |
GluN2B receptor modulator-1
GluN2B receptor modulator-1 |
Others | Others |
GluN2B receptor modulator-1 is a potent and selective allosteric modulator of the GluN2B receptor. It demonstrates negative modulation, inhibiting receptor activity, and exhibits high selectivity towards the GluN2B subunit, with an impressive IC50 value of 31 nM. | |||
T29151 |
WAY267464 HCl
WAY267464,WAY-267464,WAY 267,464 dihydrochloride,WAY-267,464 dihydrochloride,WAY 267464 dihydrochloride,WAY 267464 |
Others | Others |
WAY267464 is a nonpeptide small-molecule OT agonists with anxiolytic activity. WAY267464 may be used for modulation of potency, selectivity over the structurally similar vasopressin receptors, CNS penetration, and oral bioavailability. | |||
T15971 |
Mal-NH-ethyl-SS-propionic acid
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Mal-NH-ethyl-SS-propionic acid, a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1], plays a crucial role in the modulation of drug release from the conjugate. | |||
T37448 |
UZH1a
|
Others | Others |
UZH1a is a potent and selective inhibitor of METTL3, exhibiting an IC50 of 280 nM. It serves as a tool for epitranscriptomic modulation of cellular processes and possesses antitumor activity. Additionally, UZH1a functions as a chemical probe for the study of METTL3[1]. | |||
TP2407 |
Small cardioactive peptide A
SCPA |
||
Small cardioactive peptide A, as a neuropeptide that modulates neuromuscular synapsis in Aplysia, can also function as a neural cotransmitter in molluscs and exert a role in both the central and peripheral modulation of the control of feeding behavior. | |||
T75592 |
Odonthobuthus Doriae Venom
|
Others | Others |
Odonthobuthus Doriae Venom,一种从Odonthobuthus Doriae获得的蝎子毒液,通过调节离子通道产生神经毒性。 | |||
T72925 |
Naloxonazine
|
Others | Others |
Naloxonazine为高效选择性μ-1阿片类拮抗剂,亦可通过调控宿主编码功能作用于利什曼原虫。 | |||
T40354 |
IL-17A modulator-1
|
Others | Others |
IL-17A modulator-1 is an effective inhibitor of IL-17A activity, exhibiting a pIC 50 value of 8.2. This compound holds great promise for studying diseases and disorders that involve the modulation of IL-17A, such as immune-related diseases, autoimmune pathologies, cancer, and neurodegenerative disorders. | |||
T17903 |
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
E3 ligase Ligand-Linker Conjugates 49,Cereblon Ligand-Linker Conjugates 14 |
Others | Others |
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest. | |||
T40355 |
IL-17A modulator-2
|
Others | Others |
IL-17A modulator-2, exhibits inhibitory properties towards IL-17A, with a pIC50 of 8.3. Its effectiveness lies in attenuating the biological effects associated with IL-17A activity. IL-17A modulator-2 finds utility in the study of diseases and disorders characterized by dysregulated IL-17A modulation, such as those involving immune dysfunction, autoimmune pathology, cancer, and neurodegenerative conditions. | |||
T11359 | gamma-secretase modulator 2 | Others | Others |
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease .γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease. | |||
T3689L |
Ruboxistaurin mesylate
LY-333531,LY333531,LY 333531,LY-333531 Mesylate |
Others | Others |
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/ | |||
T70754 |
NMS-P953
|
Others | Others |
NMS-P953 is a JAK2 inhibitor, displaying significant tumor growth inhibition in SET-2 xenograft tumor model. NMS-P953 has a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile. | |||
T76271 |
Hepcidin-25 (human)
|
||
Hepcidin-25 (human) 是调节铁代谢的化合物,具有调控铁介导的氧化损伤功能,并表现出抗炎和抗菌活性。 | |||
TP2134 |
c-JUN peptide
|
||
Peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. Spec | |||
T80082 |
Hepcidin-25 (human) (acetate)
|
Endogenous Metabolite | Metabolism |
Hepcidin-25 (human) acetate 作为铁代谢调节剂,表现出抗炎和抗菌活性,其作用机制涉及调节铁介导的氧化剂损伤。 | |||
T83076 |
Anticancer agent 93
|
Others | Others |
Anticanceragent 93, 一种4-羟基香豆素衍生物,能够抑制肺癌细胞的侵袭与迁移,其机制为调节上皮间质转化(EMT)效应子的表达。 | |||
T80817 |
WAY-328127
|
Others | Others |
WAY-328127是一种活性分子,适用于生化反应研究。 | |||
T71852 |
Lig4-4
|
Others | Others |
Lig4-4 is a TREK-1 current inhibitor (IC50 = 2.06 μM) that has demonstrated potential for use as a protective agent against cerebral ischemia. It has been postulated that the neuroprotective effects of Lig4-4 against cerebral ischemia may be attributed to the modulation of Bcl-2 and cleaved-caspase-3 expression, leading to the inhibition of neuronal apoptosis. | |||
T82762 |
Cdc25A (80-93) (human)
|
||
Cdc25A (80-93) (human)为调控细胞周期蛋白D1及G1/S转换中相关蛋白表达,进而控制细胞增殖与肿瘤发生的多肽。该化合物在癌症研究中具应用价值。 | |||
T78534 |
NVOC cage-TMP-Halo
|
Others | Others |
NVOC cage-TMP-Halo是一种具有细胞渗透能力和光激活特性的蛋白质二聚化诱导剂。该化合物可对活细胞内蛋白质定位进行快速且可逆的控制,适用于研究动态细胞过程。 | |||
T39175 |
CSP1
|
||
CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the genetic transformation of S. pneumoniae through modulation of quorum sensing (QS). Additionally, CSP1 possesses antibacterial activity, further enhancing its potential as an effective antibacterial agent. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1836 |
Kudinoside D
|
LDL; AMPK; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Kudinoside D 是 Ilex kudingcha 中三萜皂苷的主要天然成分之一。它能够调节 3T3-L1 脂肪细胞中 AMPK 途径,并可抑制脂肪形成。 | |||
T3877 |
Esculentoside A
|
NF-κB; COX | Immunology/Inflammation; Neuroscience; NF-κB |
Esculentoside A 是一种三萜皂苷,从商陆根部分离得到。它在具有抗炎活性,对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。 | |||
T4S1869 |
12-Epinapelline
12-表欧乌头碱,12-表-欧乌头碱 |
Others | Others |
12-Epinapelline 是一种二萜生物碱,分离自Aconitum baikalense 中。它具有抗炎作用,能刺激成纤维细胞前体克隆的生长。 | |||
T6S1529 |
Cynarin
Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-,Cynarine,1,5-Dicaffeoylquinic acid,洋蓟素,金银花 |
Antioxidant; Antiviral; Influenza Virus; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction |
Cynarin (1,5-Dicaffeoylquinic acid) 是一种抗窒息剂,具有抗氧化、抗组胺和抗病毒等多种生物活性。 | |||
T14008 |
2,2,5,7,8-Pentamethyl-6-Chromanol
PMC |
Androgen Receptor | Endocrinology/Hormones |
2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) 是维生素 E (α-tocopherol) 的抗氧化部分,能够有效的调节雄激素受体 (androgen receptor) 信号,及抗前列腺癌细胞系的抗癌活性。 | |||
T27012 |
Chrysotoxine
Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol,鼓槌石斛素 |
NF-κB | NF-κB |
Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) 通过 NF-κB 调节和线粒体保护抑制 SH-SY5Y 细胞中 6-羟基多巴胺诱导的细胞凋亡。 | |||
TN1879 |
Lucideric acid A
Lucidenic acid A,赤芝酸A |
MMP; p38 MAPK; JNK | MAPK; Proteases/Proteasome |
Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物,可抑制 PMA 诱导的MMP-9活性,具有抵抗肝癌细胞侵袭的作用。 | |||
T3834 |
8-Epideoxyloganic acid
8-表去氧马钱酸 |
ROS; Immunology/Inflammation related | Immunology/Inflammation |
8-Epideoxyloganic acid 是从 Incarvillea delavayi 中分离得到的一种环烯醚萜苷。它具有微弱的缓解疼痛活性。 | |||
TN1966 |
N-(3-Methoxybenzyl)Oleamide
N-Benzyloleamide,MAC 18:1 |
Antioxidant | oxidation-reduction |
N-(3-Methoxybenzyl)Oleamide (MAC 18:1) 是一种从 Lepidium meyenii 中分离出来的玛瑙酰胺,对运动引起的疲劳具有药理作用,可能与调节能量代谢和改善抗氧化状态有关。 | |||
T8198 |
Visnagin
|
Others | Others |
Visnagin 是一种抗氧化剂呋喃香豆素衍生物。它具有预防Cerulein 诱导的急性胰腺炎的潜力。它在血管平滑肌中具有良好的血管扩张作用。它具有抗炎作用,可用于缓解疼痛的研究。 | |||
TL0001 |
dencichine
L-Dencichin,ODAP,Dencichin,三七素 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸,可抑制 HIF-prolyl hydroxylase-2 的活性。 | |||
T8184 |
Fucosterol
岩皂甾醇,岩藻甾醇 |
PARP; Endogenous Metabolite; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Fucosterol 是从藻类、海藻或硅藻中分离的一种甾醇,具有抗氧化、抗脂肪、降低血液胆固醇、抗糖尿病和抗癌活性。它通过抑制 PPARα和C/EBPα的表达调控脂肪生成,可用于抗肥胖试剂开发研究。 | |||
T5497 |
AMAROGENTIN
苦杏苷,苦龙胆酯苷 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Amarogentin 是要从 Swertia 和 Gentiana 根中提取的裂环烯醚萜苷,有抗氧化、抗肿瘤和抗糖尿病活性,具有保肝和免疫调节作用。它通过激活 AMPK 发挥有益的血管代谢作用。它促进细胞凋亡,阻止 G2/M 细胞周期和下调 PI3K/Akt/mTOR 信号通路。 | |||
T7033 |
Rosmanol
|
Antioxidant; COX | Immunology/Inflammation; Neuroscience; oxidation-reduction |
Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达,抑制低密度脂蛋白的氧化,并具有抗炎作用。 | |||
T3676 |
Sesamol
1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分,具有抗氧化和抗肿瘤活性。它是一种自由基清除剂,在 DPPH 实验中,IC50为 5.95±0.56 μg/mL。 | |||
T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
TN1922 |
Meranzin hydrate
|
ERK; Adrenergic Receptor | GPCR/G Protein; MAPK; Neuroscience |
Meranzin hydrate 是来源于中药柴胡疏肝散中的吸收的生物活性化合物,表现出抗抑郁和抗动脉粥样硬化活性。 | |||
T3767 |
Polygalacic acid
Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸 |
MMP; AChR; AChE | Neuroscience; Proteases/Proteasome |
Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜,可抑制 MMP 表达。它对认知障碍有显著的神经保护作用,PA 通过抑制乙酰胆碱酯酶活性,增加胆碱乙酰转移酶活性,提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。 它可以用于骨关节炎相关研究。 | |||
TN1557 |
Decursinol angelate
|
ERK; VEGFR; PKC; JNK | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors |
Decursinol angelate 是从朝鲜当归根部分离得到的一种天然产物,是 PKC 激酶的激活剂,有细胞毒性,抗肿瘤和抗炎活性。 | |||
T4429 |
Rauwolscine hydrochloride
Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) 是一种高选择性的 α2 adrenergic 受体拮抗剂,Ki=12 nM。 | |||
TN2080 |
Pinoresinol
松脂酚,松脂素,(+)-Pinoresinol |
Apoptosis; NF-κB; CDK; p53 | Apoptosis; Cell Cycle/Checkpoint; NF-κB |
Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素,具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调,抑制 NF-kappaB 和激活蛋白 1 。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
T3921 |
Punicalagin
安石榴甙,安石榴苷 |
SARS-CoV; HBV | Microbiology/Virology |
Punicalagin 是一种在石榴中发现的主要鞣花单宁,是可逆且非竞争性的 3CLpro 抑制剂。Punicalagin 具有抗氧化、抗炎和抗肿瘤活性。 | |||
T6S1699 |
Shogaol
[6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol |
Lipoxygenase; Autophagy | Autophagy; Metabolism |
6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物,具有抗癌、抗炎和抗氧化的多种生物活性。 | |||
T6S0735 |
Flavokawain B
黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone |
Apoptosis; Others | Apoptosis; Others |
Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中,分离出的查尔酮。它是一种凋亡诱导剂,可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成,具有抗血管生成活性。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
TN1236 |
3',4',7-Trihydroxyisoflavone
|
MAPK; JNK | MAPK |
3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物,是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂,具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用,可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能,可用于研究特应性皮炎。 | |||
T3S2016 |
Epoxylathyrol
|
Others | Others |
Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells. | |||
TN6704 |
Alisol A 23-acetate
|
||
Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways. | |||
T14317 |
ar-Turmerone
(+)-ar-Turmerone |
Others | Others |
ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on murine DCs, induces NSC proliferation. | |||
T4366 |
Quinovic acid
|
NF-κB; Caspase | Apoptosis; NF-κB; Proteases/Proteasome |
Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-κB. | |||
TN7350 |
Gynosaponin TN2
|
Others | Others |
Gynosaponin TN-2, demonstrating anti-Parkinsonian activity, mitigates L-DOPA (100 and 200 μM)-induced apoptotic cell death in pheochromocytoma 12 cells through the modulation of extracellular signal-regulated protein kinases 1 and 2 activation. | |||
TN4322 |
Isopulegol
|
ATPase; Potassium Channel; GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper... | |||
TN4648 |
Nepetoidin B
|
IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; Antibacterial; JNK; Antifection; Antifungal | Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB |
Nepetoidin B 具有抗真菌、抗细菌和抗炎作用,它可以抑制 LPS 刺激的 NO 生成,可能是通过调节 RAW 264.7 细胞中由 MKP-5/NF-κB 通路介导的 iNOS 。 | |||
TN7240 |
Erinacine A
|
ROS | Immunology/Inflammation |
Erinacine A 是一种可从猴头菇中提取出的抗癌化合物,能够通过活性氧类 (ROS) 的产生促使癌细胞死亡。Erinacine A 可能通过参与信号通路的调节从而发挥其抗癌活性。Erinacine A 具有抗癌、抗肿瘤和神经保护活性。 | |||
TN4223 |
Homopterocarpin
|
Antifection | Microbiology/Virology |
Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property | |||
TN3525 |
Boehmenan
|
ERK; Phosphatase; EGFR; PARP; MEK; Wnt/beta-catenin; Akt; Caspase; STAT; p53 | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell | |||
TN6501 |
Isololiolide
|
||
Isololiolide has phytotoxicity, it inhibited seedling growth of cress and barnyard grass. It also showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values of 32 μM and 40 μM, respectively. I | |||
TN5474 |
Bonducellin
|
||
Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac | |||
TN4778 |
Physalin H
|
gp120/CD4; Antifection; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05510 |
BDNF Protein, Mouse, Recombinant (His)
brain-derived neurotrophic factor |
Mouse | HEK293 Cells |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,... | |||
TMPY-00117 |
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16 |
Human,Cynomolgus | Baculovirus Insect Cells |
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... | |||
TMPY-01085 |
VLDLR Protein, Human, Recombinant (His)
VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein receptor,... |
Human | HEK293 Cells |
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ... | |||
TMPJ-01343 |
MYOZ2 Protein, Human, Recombinant (His)
C4orf5,FATZ-Related Protein 2,MYOZ2,Myozenin-2,Calsarcin-1 |
Human | E. coli |
Myozenin 2 (MYOZ2) is a 264 amino acid protein that belongs to the myozenin family. MYOZ2 binds to Calcineurin, a phosphatase that is involved in calcium-dependent signal transduction in diverse cell types. MYOZ2 is one of the sarcomeric proteins and plays an important role in myofibrillogenesis and the modulation of calcineurin signaling. It may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and plays ... | |||
TMPH-02576 |
TAFA1/FAM19A1 Protein, Mouse, Recombinant (His & Myc)
Tafa1,Chemokine-like protein TAFA-1 |
Mouse | E. coli |
Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation. | |||
TMPH-01714 |
CHRM1 Protein, Human, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229. | |||
TMPH-00581 |
ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His)
yljA,ATP-dependent Clp protease adapter protein ClpS,clpS |
E. coli | E. coli |
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16.2?kDa and the accession number is P0A8Q6. | |||
TMPH-02473 |
14-3-3 zeta/delta Protein, Mouse, Recombinant (His & SUMO)
Ywhaz,14-3-3 protein zeta/delta,SEZ-2,KCIP-1,Protein kinase ... |
Mouse | E. coli |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. 14-3-3 zeta/delta Prot... | |||
TMPK-01221 |
APLN Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
APEL,APJ endogenous ligand,Apelin |
Mouse | HEK293 Cells |
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. | |||
TMPK-01023 |
Complement factor I Protein, Mouse, Recombinant (His)
FIC3b-INA,I factor (complement),IF,C3B/C4B inactivator,C3BIN... |
Mouse | HEK293 Cells |
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 66.39 kDa and the accession number is Q61129. | |||
TMPH-01717 |
CHRM5 Protein, Human, Recombinant (His)
CHRM5,Muscarinic acetylcholine receptor M5 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is P08912. | |||
TMPH-00891 |
ADAMTSL5 Protein, Human, Recombinant (His & Myc)
THSD6,ADAMTS-like protein 5,Thrombospondin type-1 domain-con... |
Human | E. coli |
May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM). ADAMTSL5 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 56.0 kDa and the accession number is Q6ZMM2. | |||
TMPK-00776 |
Complement factor I Protein, Human, Recombinant (His)
FIC3b-INA,KAF,IF,CFI,I factor (complement),EC:3.4.21.45,C3B/... |
Human | HEK293 Cells |
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 64.58 kDa and the accession number is P05156. | |||
TMPH-01716 |
CHRM3 Protein, Human, Recombinant (B2M & His)
Muscarinic acetylcholine receptor M3,CHRM3 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM3 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 40.7 kDa and the accession number is P20309. | |||
TMPH-03338 |
CHRM1 Protein, Rat, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1 |
Rat | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482. | |||
TMPH-02528 |
SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar)
Slc7a10,Solute carrier family 7 member 10,Asc-type amino aci... |
Mouse | P. pastoris (Yeast) |
Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar) is expressed in yeast with N-His tag. The predicted molecular weight is 22.5 kDa and the accession number is P63115. | |||
TMPH-01663 |
GRM5 Protein, Human, Recombinant (His & Myc)
Metabotropic glutamate receptor 5,GRM5 |
Human | E. coli |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. | |||
TMPK-00476 |
CD200 Protein, Cynomolgus, Recombinant (His)
MOX1,CD200,MOX2,My033,OX-2,MRC,OX2 |
Cynomolgus | HEK293 Cells |
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models. CD200 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.66 kDa and the accession number is A0A2K5TQS2. | |||
TMPH-01032 |
Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO)
Calponin-2,Calponin H2, smooth muscle,Neutral calponin,CNN2 |
Human | E. coli |
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.6 kDa and the accession number is Q99439. | |||
TMPH-03550 |
EsxA Protein, S. aureus, Recombinant (His & SUMO)
esxA,Type VII secretion system extracellular protein A |
Staphylococcus aureus | E. coli |
Virulence factor that is important for the establishment of infection in the host. EsxA is required for EsxB synthesis as well as secretion. Modulates host cell apoptotic pathways and mediates together with EsxB the release of S.aureus from the host cell. By acting on apoptosis, plays a role in the modulation of dendritic cell-mediated immunity. EsxA Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 27.... | |||
TMPH-01715 |
CHRM2 Protein, Human, Recombinant (His)
CHRM2,Muscarinic acetylcholine receptor M2 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. CHRM2 Protein, Human, Recombinant (His) is expressed in E. col... | |||
TMPK-00733 |
CD200 Protein, Mouse, Recombinant (aa 31-232, His)
My033,OX2,MRC,OX-2,MOX1,CD200,MOX2 |
Mouse | HEK293 Cells |
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models. CD200 Protein, Mouse, Recombinant (aa 31-232, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.6 kDa and the accession number is O54901. | |||
TMPK-01222 |
APLN Protein, Mouse, Recombinant (hFc)
APJ endogenous ligand,APEL,Apelin |
Mouse | HEK293 Cells |
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Mouse, Recombinant (hFc) is expressed in HE... | |||
TMPJ-01098 |
PRDX4 Protein, Human, Recombinant (His)
Prx-IV,Thioredoxin-Dependent Peroxide Reductase A0372,PRDX4,... |
Human | E. coli |
Peroxiredoxin-4 (PRDX4) is a member of the AhpC/TSA family. PRDX4 is a cytoplasmic protein and contains one thioredoxin domain. PRDX4 exists in homodimer or heterodimer with PRDX1. PRDX4 reduces hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. In addition, PRDX4 is probably involved in redox regulation of the cell, regulating the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-... | |||
TMPK-00767 |
SLPI Protein, Human, Recombinant (hFc)
WFDC4,HUSI,SLPI,WAP4,MPI,BLPI,ALK1,HUSI-1,ALP |
Human | HEK293 Cells |
Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. SLPI Protein, Human, Recombinant (hFc) is express... | |||
TMPY-03285 |
PPIL1 Protein, Human, Recombinant (His)
CGI-124,PPIase,CYPL1,hCyPX,peptidylprolyl isomerase (cycloph... |
Human | E. coli |
PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 is a peptidylprolyl isomerase(PPIase). It increases the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of... | |||
TMPJ-01365 |
SLAMF8 Protein, Human, Recombinant (His)
CD353,SLAM family member 8,BCM-like membrane protein,B-lymph... |
Human | HEK293 Cells |
SLAM family member 8 (SLAMF8) is a single-pass type I membrane protein and contains 1 Ig-like C2-type domain. SLAMF8 is a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling... | |||
TMPK-00924 |
SLPI Protein, Mouse, Recombinant (hFc)
WAP4,BLPI,SLPI,HUSI-1,HUSI,MPI,ALP,WFDC4,ALK1 |
Mouse | HEK293 Cells |
Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. SLPI Protein, Mouse, Recombinant (hFc) is express... | |||
TMPK-01236 |
APLN Protein, Human, Recombinant (hFc)
APJ endogenous ligand,Apelin,APEL |
Human | HEK293 Cells |
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Human, Recombinant (hFc) is expressed in HE... | |||
TMPH-01428 |
TRAP1 Protein, Human, Recombinant (GST)
TNFR-associated protein 1,Tumor necrosis factor type 1 recep... |
Human | E. coli |
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. TRAP1 Protein, Human, Recombinant (GST) is expressed in E. coli expressi... | |||
TMPH-02907 |
Sialidase-3 Protein, Mouse, Recombinant (His)
Neu3,Membrane sialidase,Ganglioside sialidase,N-acetyl-alpha... |
Mouse | E. coli |
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with sig... | |||
TMPJ-00972 |
CDKN1B Protein, Human, Recombinant (His)
KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,Cyclin-Dep... |
Human | E. coli |
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ... | |||
TMPJ-00951 |
TXLNA Protein, Human, Recombinant (His)
α-Taxilin,Alpha-Taxilin,TXLN,TXLNA |
Human | E. coli |
α-Taxilin belongs to the taxilin family. α-Taxilin exists in almost all tissues, with higher expression levels observed in the heart, kidney, liver, and pancreas. α-Taxilin binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A, and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex. It is shown that α-Taxilin plays multiple roles in the generation and maintenanc... | |||
TMPJ-01214 |
ZNF100 Protein, Human, Recombinant (His)
Zinc Finger Protein 100,ZNF100 |
Human | E. coli |
Zinc Finger Protein 100 (ZNF100) is part of the krueppel C2H2-type zinc-finger protein family. ZNF100 contains 12 C2H2-type zinc fingers and 1 KRAB domain. ZNF100 is a DNA-binding protein domain consisting of zinc fingers. Zinc finger protein 100 occurs in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain. Zinc finger proteins have also found use in protein engineering due to their modularity and have prospects as components of tools for us... | |||
TMPH-02300 |
RAD23A Protein, Human, Recombinant (His)
UV excision repair protein RAD23 homolog A,RAD23A |
Human | E. coli |
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucle... | |||
TMPJ-00578 |
CEACAM21 Protein, Human, Recombinant (His)
Carcinoembryonic antigen-related cell adhesion molecule 21,C... |
Human | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 21 is a protein that in humans is encoded by the CEACAM21 gene. It belongs to the immunoglobulin superfamily. CEA family.containing 1 Ig-like C2-type (immunoglobulin-like) domain.It was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been a... | |||
TMPJ-00614 |
CD47 Protein, Rhesus macaque, Recombinant (His & Flag)
MER6,Integrin-Associated Protein,IAP,Leukocyte Surface Antig... |
Rhesus | HEK293 Cells |
CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain, five membrane-spanning regions with short intervening loops, and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important r... | |||
TMPJ-00785 |
FABP3 Protein, Human, Recombinant (His)
H-FABP,FABP11,Fatty Acid-Binding Protein Heart,MDGIMuscle Fa... |
Human | E. coli |
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to p... | |||
TMPJ-00020 |
IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated
白介素,Eosinophil differentiation factor,B-cell differentiation... |
Human | HEK293 Cells |
IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functi... | |||
TMPY-02391 |
SUMO1 Protein, Human, Recombinant (His)
small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,UBL1,SENP2... |
Human | E. coli |
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act... | |||
TMPY-02648 |
PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc)
adenylate cyclase activating polypeptide 1 (pituitary) recep... |
Human | HEK293 Cells |
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediated in part by plasma membrane G protein-dependent activation of adenylyl cyclase and downstream signaling cascades. Studies point to the potential role of the (pituitary) adenylate cyclase activating polypeptide receptor 1 (ADCYAP1R1) gene, which has been implicated in stress resp... | |||
TMPY-02025 |
CPLX2 Protein, Human, Recombinant (His)
CPX-2,Hfb1,921-L,complexin 2,CPX2 |
Human | E. coli |
Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target ... | |||
TMPY-04458 |
TRIB2 Protein, Human, Recombinant (His & GST)
TRIBBLE,tribbles pseudokinase 2,TRIB2,C5FW,FLJ57420,GS3955,T... |
Human | Baculovirus Insect Cells |
Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate the activation of some intracellular signalling pathways with roles e... | |||
TMPY-01204 |
SMYD2 Protein, Human, Recombinant (His)
ZMYND14,SET and MYND domain containing 2,HSKM-B,KMT3C |
Human | Baculovirus Insect Cells |
SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cell differentiation. SMYD2 mRNA is most highly exp... | |||
TMPY-01831 |
SLAMF8 Protein, Mouse, Recombinant (His)
Blame,SBBI42,SLAM family member 8,5830408F06Rik |
Mouse | HEK293 Cells |
The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associ... | |||
TMPY-02602 |
PTPMT1 Protein, Human, Recombinant (His)
protein tyrosine phosphatase, mitochondrial 1,MOSP,FLJ46081,... |
Human | E. coli |
PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an a... | |||
TMPJ-00353 |
ILDR2 Protein, Human, Recombinant (His)
Angulin-3,immunoglobulin-like domain containing receptor 2,D... |
Human | HEK293 Cells |
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23–25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic ce... | |||
TMPY-04562 |
GRK2 Protein, Human, Recombinant (His & GST)
β,adrenergic, beta, receptor kinase 1 |
Human | Baculovirus Insect Cells |
G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor... | |||
TMPY-00975 |
FSTL3 Protein, Mouse, Recombinant (His)
E030038F23Rik,Flrg,follistatin-like 3 (secreted glycoprotein... |
Mouse | HEK293 Cells |
Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall structure and activity profile similar to that of FST, including binding and neutralization of activin. FLRG/Fstl3 is expressed in a wide range of adult tissues, not detected in hematopoietic cells except in patients with a B cell chronic leukemia and a translocation. Isoform 1 or t... | |||
TMPH-02274 |
JAK2 Protein, Human, Recombinant (His)
JAK2,Janus kinase 2,Tyrosine-protein kinase JAK2 |
Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T27210 |
DRX-065
DRX 065,DRX065,deuterated R-enantiomer of pioglitazone |
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DRX-065 is a stabilized and deuterated R-enantiomer of pioglitazone. DRX-065 has pharmacological properties desirable for the treatment of NASH (mitochondrial function modulation, non-steroidal anti-inflammatory effects, and glucose lowering effects) with | |||
TMID-0115 |
Dehydroepiandrosterone-2,2,3,4,4,6-d6
DHEA-d6 |
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Dehydroepiandrosterone-2,2,3,4,4,6-d6 是 Dehydroepiandrosterone 的氘代化合物。Dehydroepiandrosterone 的 CAS 号为 53-43-0。Dehydroepiandrosterone 是一种类固醇激素。它通过多种信号传导途径介导其作用,并通过转化成雄激素和雌激素衍生物(例如,雄激素,雌激素,7α和7β DHEA (Prasterone),以及7α和7β表雄甾酮衍生物)在特异性受体上起作用。 |