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TMPY-02585
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Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
aSMase,ASM,Zn-SMase,A-SMase,sphingomyelin phosphodiesterase ...
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Mouse
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Baculovirus Insect Cells
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Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monome... |
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TMPH-00574
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Adenylate cyclase Protein, E. coli, Recombinant (His)
cyaA,EC:4.6.1.1,Adenylyl cyclase,ATP pyrophosphate-lyase
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E. coli
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E. coli
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Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own transcription again. |
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TMPH-01294
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EDNRA Protein, Human, Recombinant (His)
ET-A,Endothelin-1 receptor,hET-AR,ETA-R,ETRA,EDNRA,ETA
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Human
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P. pastoris (Yeast)
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Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
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TMPH-01663
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GRM5 Protein, Human, Recombinant (His & Myc)
Metabotropic glutamate receptor 5,GRM5
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Human
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E. coli
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G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
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TMPJ-00029
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CALM1 Protein, Human, Recombinant
Calmodulin,CAMIII,CAMC,CALM,CALML2,CALM2,CAM2,CALM3,CAM1,CAM...
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Human
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E. coli
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Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of Calmodulin. Once bound to Ca2+, Calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases. Calmodulin is a small, highly conserved protein that is 148 amino acid... |
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TMPH-01346
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FPR1 Protein, Human, Recombinant (GST & His & Myc)
FPR1,N-formylpeptide chemoattractant receptor,N-formyl pepti...
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Human
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E. coli
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High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. FPR1 Protein, Human, Recombinant (GST & H... |
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TMPH-02905
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TRPC1 Protein, Mouse, Recombinant (His)
Transient receptor protein 1,Short transient receptor potent...
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Mouse
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E. coli
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Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. TRPC1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 94.0 kDa and the accession number is Q61056. |
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TMPH-02147
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TACR1 Protein, Human, Recombinant (GST)
Substance-P receptor,Tachykinin receptor 1,NK-1 receptor,TAC...
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Human
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E. coli
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This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. TACR1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.1 kDa and the accession number is P25103. |
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TMPH-01065
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CCR4 Protein-VLP, Human, Recombinant (His)
CC-CKR-4,CCR4,CCR-4,CD194,C-C chemokine receptor type 4,K5-5...
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Human
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HEK293 Cells
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High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cel... |
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TMPJ-01117
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INPP5A Protein, Human, Recombinant (His)
INPP5A,Type I inositol 1,5-trisphosphate 5-phosphatase,Type ...
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Human
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HEK293 Cells
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Type I inositol 1,4,5-trisphosphate 5-phosphatase is a 412 amino acids protein that belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. It is expressed in brain and high level in Purkinje cells. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. |
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TMPH-03749
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CYSLTR1 Protein, Human, Recombinant (His)
Cysteinyl leukotriene receptor 1,G-protein coupled receptor ...
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Human
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E. coli
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Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. |
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TMPH-01064
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CCR4 Protein, Human, Recombinant (His & SUMO)
CMKBR4,CD194,K5-5,CCR-4,C-C chemokine receptor type 4,CC-CKR...
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Human
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E. coli
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High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expressio... |
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TMPH-02658
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FPR1 Protein, Mouse, Recombinant (GST & His & Myc)
Fpr1,N-formylpeptide chemoattractant receptor,N-formyl pepti...
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Mouse
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E. coli
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High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. FPR1 Protein, Mouse, Recombinant (GST & H... |
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TMPH-02675
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GCGR Protein, Mouse, Recombinant (GST)
Glucagon receptor,Gcgr
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Mouse
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E. coli
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G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. ... |
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TMPY-04058
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RGS5 Protein, Human, Recombinant (His)
MST106,MSTP032,MST092,regulator of G-protein signaling 5,MST...
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Human
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E. coli
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RGS5 is a member of the RGS superfamily and acts as a negative regulator of heterotrimeric G protein-mediated signalling through G protein-coupled receptors (GPCRs). The regulator of G-protein signaling (RGS) proteins have recently been identified as signal transduction molecules which have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. The messenger RNA of hRGS5 was abundantly expressed in heart, lung, skeletal muscle, and small intestine, and at l... |
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TMPJ-00190
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CD38 Protein, Mouse, Recombinant (hFc)
ADP-ribosyl cyclase 1,cyclic ADP-ribose hydrolase,T10,CD38
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Mouse
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HEK293 Cells
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CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Th... |
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TMPY-01557
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MAGOH Protein, Human, Recombinant (His)
MAGOHA,MAGOH1,mago-nashi homolog, proliferation-associated (...
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Human
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E. coli
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MAGOH (Mago Homolog, Exon Junction Complex Subunit) is a Protein Coding gene. MAGOH is the human homolog of Drosophila mago nashi, a protein that is required for normal germplasm development in the Drosophila embryo. In mammals, mRNA expression is not limited to the germplasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. The exon junction complex (EJCs) are deposited on messenger RNAs (mRNAs) during splicing and their core consi... |
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TMPY-00963
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ASAH2 Protein, Mouse, Recombinant (His)
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) ...
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Mouse
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HEK293 Cells
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ASAH2 (N-acylsphingosine amidohydrolase 2), also known as neutral ceramidase, is a type II integral membrane protein that can be cleaved to produce a soluble secreted protein. The enzyme is abundant in the brush border membranes of the intestine, and also expressed in several tissues such as kidney, brain and liver. The primary structure of ASAH2/neutral ceramidase is highly conserved from bacteria to humans, however, there is a clear difference in the molecular architecture. The murine ASAH2 po... |
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TMPJ-01074
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PKCE Protein, Human, Recombinant (His)
PRKCE,PKCE,nPKC-ε,nPKC-Epsilon,Protein Kinase C Epsilon Type...
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Human
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E. coli
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Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these domains: one AGC-kinase C-terminal domain, one C2 domain, one protein kinase domain and two phorbol-ester/DAG-type zinc fingers. Protein Kinase C Epsilon phosphorylate a variety of protein targets and has been identified to participate in diverse cellular signaling pathways. It has m... |
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TMPY-02402
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WTAP Protein, Human, Recombinant (GST)
Mum2,Wilms tumor 1 associated protein
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Human
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E. coli
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Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, ... |
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TMPY-02805
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GNGT1 Protein, Human, Recombinant (His)
guanine nucleotide binding protein (G protein), γ transducin...
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Human
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E. coli
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GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the ... |
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TMPY-02236
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PTH1R Protein, Human, Recombinant (His)
PFE,PTHR1,MGC138452,parathyroid hormone 1 receptor,PTHR,MGC1...
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Human
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HEK293 Cells
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Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase an... |
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TMPY-01770
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HAO1 Protein, Human, Recombinant (His)
GOX1,hydroxyacid oxidase (glycolate oxidase) 1,GOX,HAOX1
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Human
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E. coli
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Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1, and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 / GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with the concomitant production of H2O2. In H... |
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TMPY-02802
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GNG13 Protein, Human, Recombinant (His)
G(gamma)13,h2-35,G(γ)13,guanine nucleotide binding protein (...
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Human
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E. coli
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GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. Each G protein is composed of an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding... |
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TMPY-04423
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CAMKI gamma/CAMK1G Protein, Human, Recombinant (His & GST)
VWS1,RP1-272L16.2,calcium/calmodulin-dependent protein kinas...
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Human
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Baculovirus Insect Cells
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Calmodulin-Dependent Protein Kinase (CaM Kinase) is a kind of protein phosphorylate multiple downstream targets. Concentration of cytosolic calcium functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases referred to as CaM-kinases (CaMKs), such as CaMKI, CaMKII, CaMKIV and CaMKK. Calmodulin-dependent protein kinase CL3/CaMKIγ is a membera... |
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TMPY-04456
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PKC nu Protein, Human, Recombinant (GST)
PRKCN,nPKC-NU,PKC-NU,PKD3,EPK2,protein kinase D3
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Human
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Baculovirus Insect Cells
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Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD3 / PRKCN contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second ... |
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TMPH-01689
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PLD6 Protein, Human, Recombinant (His)
Mitochondrial phospholipase,Choline phosphatase 6,Protein zu...
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Human
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E. coli
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Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger sig... |
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