74
23
1
4
27
4
Cat. No. | Product Name | ||
---|---|---|---|
L7000 | 活性脂质化合物库 | 385 compounds | |
385 种生物活性小分子化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0046 |
RIPA Lysis Buffer (Medium)
RIPA裂解液(中) |
Solution in bottle | |
C0045 |
RIPA Lysis Buffer (Strong)
RIPA裂解液(强) |
Solution in bottle | |
C0047 |
RIPA Lysis Buffer (Weak)
RIPA裂解液(弱) |
Solution in bottle | |
C0048 |
Deacetylase Inhibitor Cocktail (100× in 70% DMSO)
去乙酰化酶抑制剂 Cocktail(100× in 70% DMSO) |
Solution (100× in 70% DMSO) | Class I/II/III HDAC |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T41039 |
Gel filtration medium G-100
|
Others | Others |
Gel filtration medium G-100, a substance designed for protein purification, enables the separation and purification of proteins through gel filtration. | |||
T19376 |
Ioversol
MP-328,碘佛醇 |
Others | Others |
Ioversol (MP-328) 是一种非离子碘化造影剂 (CM),不损伤动物的血脑屏障 (BBB),可用于动物实验的 CT 扫描或 x-ray。 | |||
T16471 |
Perflubron
Perfluorooctyl bromide,全氟溴辛烷,PFOB |
Others | Others |
Perflubron (Perfluorooctyl bromide) 是一种用于磁共振成像和超声检查的造影剂,可以与卵磷脂(EYP)一起乳化,并表现出较迅速的排泄特性。 | |||
T8936 |
Proteinase K
proteinase K for tritirachium album,Protease K,蛋白酶 K |
Others | Others |
Proteinase K (proteinase K for tritirachium album) 是一种非特异性丝氨酸蛋白酶,可用于蛋白消化。它在有 SDS 或尿素存在的情况下,在很大 pH 值 (4-12)、盐浓度和温度单位内均有活性。 | |||
T19389 |
L-Ascorbic acid 2-phosphate magnesium
2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁 |
Phosphatase; Phosphorylase | Metabolism |
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物,能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。 | |||
T22225 |
4-Methylsalicylic acid
|
Others | Others |
4-Methylsalicylic acid 用于抑制中链酰基辅酶A 合成酶。 | |||
T19799 |
Ioxitalamic Acid
碘羟拉酸,Telebrix,Vasobrix,Acidum Joxitalamicum |
Others | Others |
Ioxitalamic Acid (Acidum Joxitalamicum) 是一种医用造影剂,可在医学成像中增强体内结构或流体的对比度。 | |||
T1576 |
Iopamidol
SQ-13396,Niopam,Iopamiron,Iopamiro,碘帕醇,B-15000,Isovue |
Others | Others |
Iopamidol (SQ-13396) 是一种 benzenedicarboxamide 化合物。它具有放射性不透明介质、环境污染物和异种生物的作用。 | |||
T3475 |
MD 39-AM
|
Others | Others |
MD 39-AM 的活性通过在含有激动素但不含抗细胞分裂素的培养基上 50% 的愈伤组织生长来评估。 | |||
T20637 |
Diatrizoate meglumine
Reno,Renografin,Renovist,泛影葡胺,Hypaque,Renocal,Sinografin |
Others | Others |
Diatrizoate meglumine (Renocal) 是泛影酸盐的葡甲胺盐,它是一种有机的、碘化的、不透射线的 X 射线造影剂,用于放射诊断。 | |||
T0503 |
Meglumine
Meglumin,Methylglucamin,葡甲胺,葡萄糖甲胺,Methylglucamine |
Others | Others |
Meglumine (Meglumin) 是一种氨基糖,来源于山梨糖醇。其中常在药物中用作赋形剂,并与碘代化合物葡甲胺和碘帕胺葡甲胺等造影剂中的碘化化合物一起使用。 | |||
T1395 |
Diatrizoic Acid
Diatrizoate,泛影酸,Amidotrizoic acid |
Apoptosis; Others | Apoptosis; Others |
Diatrizoic Acid (Amidotrizoic acid) 是一种有机碘化不透射线 X 射线造影剂,用于放射诊断,具有对气道进行放射照相成像的潜力。它通过钙失调诱导线粒体更新和氧化应激,激活细胞凋亡。 | |||
T22438 |
Tetramethylthiuram monosulfide
一硫化四甲基秋兰姆,TMTM |
Others | Others |
Tetramethylthiuram monosulfide 被广泛用作橡胶加工技术中的催化剂,它具有中等毒性,并在菌株 TA 100 和 TA 1535(鼠伤寒沙门氏菌 LT 2)中引起点突变。 | |||
T6198 |
Dolutegravir
S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Dolutegravir (GSK1349572) 是口服HIV 整合酶链转移高效抑制剂,抑制 HIV-1 病毒在外周血单个核细胞中的复制。它对耐拉替拉韦的特征突变体 Y143R、Q148K、N155H 和 G140S/Q148H 具有中等活性。 | |||
T8549 |
HEPES
|
Others | Others |
HEPES 是两性离子化学缓冲剂,在 pH 值为 6.8 至 8.2 时为有效的缓冲液,广泛应用于细胞培养。它是溶酶体生物发生的有效诱导剂。 | |||
T40545 |
MES
2-Morpholinoethanesulphonic acid,4-Morpholineethanesulfonic acid |
Others | Others |
MES (2-Morpholinoethanesulphonic acid) (2-Morpholinoethanesulphonic acid) 是一种两性离子缓冲液,在 pH 值 5.5-7.7 范围内有效。MES 作为一种 Good's 缓冲液,广泛应用于植物培养基、试剂溶液和生理实验中调节 pH 值。 | |||
T16499 |
Mardepodect
PF-2545920 |
PDE | Metabolism |
Mardepodect (PF-2545920) 是一种有效的、口服具有活性的、可透过血脑屏障的、选择性的 PDE10A 抑制剂,IC50=0.37 nM,比作用于其他 PDE 选择性高 1000 多倍。 | |||
T17197 |
UCL 2077
|
Others | Others |
UCL 2077 是癫痫相关 KCNQ 通道的亚型选择性阻滞剂,也是一种选择性慢后超极化通道阻滞剂,在培养的海马神经元中 IC50 为 500 nM,对 Ca2+ 通道、动作电位、输入电阻的影响小 ,以及超极化后的介质。 | |||
T16947 |
SU16f
3-substituted indolin-2-one 16f,SU-16F,SU 16F |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU16f (3-substituted indolin-2-one 16f) 是一种有效的,选择性 PDGFRβ 抑制剂,对 PDGFRβ,PDGFR1,PDGFR2 的 IC50 分别为 10 nM,140 nM,2.29 μM。SU16f 抑制 PDGFRβ 受体从而可以阻断胃癌来源的间充质干细胞 (GC-MSC) 条件培养基在胃癌细胞增殖和迁移中的促进作用。 | |||
T12610L |
3-Hydroxy Midostaurin
CGP52421 |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1]. | |||
T19375 |
Iotalamic acid
Iothalamic acid,碘他拉酸 |
Others | Others |
Lotalamic acid is a molecule used as a contrast medium. | |||
T33853 |
P 569
P569,P-569 |
Others | Others |
P 569 is an MRI contrast medium. | |||
T38232 |
Heptanoyl-L-carnitine (chloride)
|
Others | Others |
Heptanoyl-L-carnitine is a medium-chain acylcarnitine and derivative of L-carnitine . | |||
T32181 |
Iopydol
Jopydolum,Iopidolo,Iopidol,Iopydolum,EINECS 226-968-6 |
Others | Others |
Iopydol is a Diagnostic Aid used in Radiopaque Medium and Bronchographic. | |||
T32167 |
Iodamide
BRN 2175358,Iodamidum,Ametriiodic acid |
Others | Others |
Iodamide can be used as a contrast medium. | |||
T33322 |
Methiodal sodium
Abrodan,Abrodil,Diagnorenol,Conturex,Iodomethanesulfonic acid sodium salt,Abroden |
Others | Others |
Methiodal sodium is a crystalline salt used as a radiopaque contrast medium in intravenous urography. | |||
T16067 |
Metrizoic acid
甲泛影酸,Metrizoate |
Others | Others |
Metrizoic acid is an ionic contrast medium. Metrizoic acid displays high osmolality and has a risk of inducing allergic reactions. | |||
T34163 |
Propyliodone
NSC97103,NSC-97103,NSC 97103 |
Others | Others |
Proiodarone is a radiopaque medium used in bronchography that may induce hyperthyroidism. | |||
T32178 |
Ioglucomide
MP 8000,MP-8000 |
Others | Others |
Ioglucomide is an iodinated nonionic contrast medium directed primarily toward myelographic use. | |||
T26970 |
CD-349
CD 349,CD349 |
Others | Others |
CD-349 is a calcium channel antagonist. CD-349 inhibits the noradrenaline (NA)-induced contraction of aortas in Ca2(+)-free medium. | |||
T31507 |
Diodone
Iodopyracet |
Others | Others |
Diodone is an ionic monomeric contrast medium that was formerly used for a variety of diagnostic procedures. | |||
T32184 |
Iothalamate meglumine
Cysto-Conray,Methylglucamine iotalamate,EINECS 235-998-9,Meglumine conray |
Others | Others |
Iothalamate meglumine, known as radiopaque medium, can be used for urography, angiography, venography, and myelography. It is highly viscous and can bind to plasma proteins. | |||
T84451 |
1,2-Dilauroyl-sn-glycero-3-PA sodium
1,2-Dilauroyl-sn-glycero-3-phosphate |
Others | Others |
DLPA is a phosphatidic acid (PA) that incorporates the medium-chain lauric acid (12:0). | |||
T41038 |
Sephadex G 50
|
Others | Others |
Sephadex G 50 is a gel filtration medium commonly utilized in gel permeation chromatography for effective fractionation of glycopeptide mixtures. | |||
T32180 |
Iophendylate
Maiodil,Panthopaque,Iodophendylate,Ethiodan,Ioglunide |
Others | Others |
Iofendylate is a molecule used as a contrast medium. It is an absorbable iodized fatty acid of low viscosity used for roentgenography of the spinal cord, biliary tree, sinuses, and body cavities. | |||
T13728 |
Hydrocortisone buteprate
HBP,Hydrocortisone probutate |
Others | Others |
Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. | |||
T41036 |
Sephadex LH 20
|
Others | Others |
Sephadex LH 20 is a suitable medium for the isolation of natural compounds found in various sources, including red wine and pigments, aiding in their purification and extraction processes. | |||
T29592 |
Acetrizoate sodium
Reopak,Diaginol,MP1023,MP 1023,MP-1023 |
Others | Others |
Acetrizoate sodium 又称醋碘苯酸的钠盐,可用作高渗透压、水溶性、碘化的放射造影剂。 | |||
T37405 |
Octanoyl Coenzyme A (sodium salt)
|
Others | Others |
Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase. | |||
T38823 |
sulfo-DGN462 sodium
sulfo-DGN462 sodium |
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Sulfo-DGN462 sodium undergoes degradation to DGN462 when subjected to culture medium and plasma. DGN462, a highly effective DNA-alkylating agent, exhibits anti-tumor properties that are particularly active against acute myeloid leukemia (AML). | |||
T36751 |
Dihydroxy Melphalan
|
Others | Others |
Dihydroxy melphalan is an inactive degradation product of melphalan . It is formed by the hydrolysis of melphalan via the intermediate monohydroxy melphalan in aqueous solutions, including cell culture medium and human plasma. | |||
T37443 |
Aspochalasin D
|
Others | Others |
Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that was initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml. Aspochalasin D is more cytotoxic, via apoptosis, to Ba/F3-V12 cells in an IL-3-free medium than in an IL-3-containing medium (IC50s = 0.49 and 1.9 μg/ml, respectively). | |||
T38233 |
Hexanoyl-L-carnitine (chloride)
|
Others | Others |
Hexanoyl-L-carnitine is a medium-chain acylcarnitine. It has been used in the synthesis of acylcarnitine benzyl esters.1 1.Gong, X.-w., Li, J.-p., Wu, J.-f., et al.Synthesis of carnitine benzyl esters as prodrugsJ. Chem. Res.2008(6)327-330(2008) | |||
T36634 |
ZQ 16
|
Others | Others |
Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro. Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID:27326330 |Zhang et al (2016) Discovery and characte... | |||
T16113 | ML753286 | AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 μM). It is also stable in plasma across species. | |||
T21374 |
Clocortolone
Clocortolona,Clocortolonum,Cloderm |
Others | Others |
Clocortolone is a Corticosteroid Hormone Receptor Agonist. It is used in the form of an ester, clocortolone pivalate, and applied as a cream. clocortolone pivalate is used to treat dermatitis and is considered a medium-strength corticosteroid. | |||
T32171 |
Iodoalphionic acid
NSC 11854,NSC-11854,Pheniodolum,NSC11854,Tenamid |
Others | Others |
Iodoalphionic acid is the contrast medium for gallbladder examination. It is rarely found in the colon and can rarely masked the gallbladder. The density of the shadow from Iodoalphionic acid was greater than that produced by iodophthalein. It was reliabl | |||
T68805 |
PSB-1584
|
Others | Others |
PSB-1584 is a Potent Agonist of the Orphan G Protein-Coupled Receptor 84 (GPR84). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer. | |||
T73790 |
3-Hydroxysebacic acid
|
Others | Others |
3-Hydroxysebacic acid 是存在于尿中的内源代谢物,可用于研究中链酰基钴 A 脱氢酶缺乏症。 | |||
T40819 |
MES sodium salt
2-Morpholinoethanesulphonic acid sodium salt |
Others | Others |
MES (2-Morpholinoethanesulphonic acid) sodium salt, a zwitterionic buffer, is effective in the pH range of 5.5-7.7. MES sodium salt, as one of the Good’s buffers, is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3112 |
5-Heneicosylresorcinol
|
NADPH-oxidase; Antifection | Immunology/Inflammation; Microbiology/Virology |
5-Heneicosylresorcinol 对 RBL-2H3 细胞中 β-己糖胺酶的释放具有抑制作用,它还可以防止 3T3-L1 细胞中甘油三酯的积累。它对红线虫、秀丽隐杆线虫和松材线虫具有杀线虫活性,ED50 值分别为 80、30 和 180 ug/mL。 | |||
T2185 |
L-Ascorbic acid 2-phosphate trisodium
L-抗坏血酸-2-磷酸三钠盐(维生素C),L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐 |
Reactive Oxygen Species; c-Met/HGFR; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB; Tyrosine Kinase/Adaptors |
L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) 是长效的维生素 C 衍生物,能够刺激胶原蛋白的表达和形成。Sodium L-ascorbyl-2-phosphate 提高成骨细胞分化过程中 hASC 中的碱性磷酸酶活性和 runx2A 的表达,因此,能够促进人脂肪干细胞的成骨分化。 | |||
T7565 |
3-Hydroxycapric acid
|
Endogenous Metabolite | Metabolism |
3-Hydroxycapric acid 是有丝分裂抑制剂。 | |||
TN1800 |
Isosakuranin
|
Others | Others |
Isosakuranin 是一种提取自Paliurus ramosissimus果实中的天然产物,具有抗糖尿病作用。 | |||
T7481 |
2-Hydroxycaprylic acid
2-hydroxyoctanoic acid,2-羟基辛酸 |
Others | Others |
2-Hydroxyoctanoic acid 是中链酰基辅酶 A 合成酶抑制剂 (Ki:500 μM)。 | |||
T2944 |
Danshensu sodium salt
Sodium Danshensu,(±)-DanShenSu sodium salt,丹参素钠,(±)-DanShenSu sodium sal |
P450; Autophagy | Autophagy; Metabolism |
Danshensu sodium salt (Sodium Danshensu) 是从中国草本丹参中提取的一种天然产物,可以抑制去氧肾上腺素和CaCl2 在无Ca2+ 培养基中引起的血管收缩。 | |||
T6873 |
Lauric Acid
月桂酸,Dodecylic acid,dodecanoic acid,Vulvic acid,N-Dodecanoic acid |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
Lauric Acid (Dodecylic acid) 是一种有抗菌活性的中链脂肪酸,对P. acnes,S.aureus 和S. epidermidis 的 EC50值分别为 2,6,4 μg/mL。 | |||
T5S1989 |
Apiin
Apioside,芹菜苷 |
Others | Others |
Apiin (Apioside) 是Apium graveolens 叶片的一种主要成分,具有抗炎作用。它在体外抑制亚硝酸盐产生的IC50值为0.08 mg/mL,在 LPS 激活的 J774.A1 细胞中抑制 iNOS 的表达的IC50值为0.049 mg/ mL。 | |||
T5285 |
3-(Methylthio)propionic acid
3-Methylthiopropionate,3-甲基硫代丙酸,4-Thiapentanoic acid,3-Methylsulfanylpropionic acid |
Others; Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology; Others |
3-(Methylthio)propionic acid (4-Thiapentanoic acid) 是methionine 的代谢物,是中间体。 | |||
T3859 |
Isomucronulatol
7,2'-Dihydroxy-3',4'-dimethoxyisoflavan,7,2'-二羟基-3',4'-二甲氧基异黄烷,异短尖剑豆酚 |
Others | Others |
Isomucronulatol 是一种黄酮类化合物,分离自A. membranaceus根。它在体外对 LPS 刺激产生的 IL-12 p40 有抑制作用,具有潜在的抗炎作用。 | |||
T5803 |
D(-)-Tartaric acid
|
Others | Others |
D(-)-Tartaric acid 存在于许多植物中,特别是罗望子和葡萄,口服后通过与碳酸氢钠相互作用产生二氧化碳。二氧化碳会延伸胃部并在双造影射线照相期间提供负造影剂。 | |||
T4734 |
Suberic acid
Octanedioic acid,1,8-Octanedioic acid,辛二酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。 | |||
T5227 |
Tricaprin
Tridecanoin,Glyceryl tridecanoate,Glycerol Tridecanoate,TG(10:0/10:0/10:0),Glycerol tricaprate,甘油三癸酸酯,三癸酸甘油酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Glycerol Tridecanoate 是癸酸的一种口服具有活性前体 (DA precursor),能够被水解为癸酸。它是中链甘油三酸酯 (MCT) 的主要成分,具有抗雄激素和抗高血糖特性。 它能够用做食品,药品,化妆品中的添加剂。 | |||
T2O2707 |
D-(+)-Fucose
|
Others | Others |
D-(+)-Fucose 是一种 l-阿拉伯糖的非代谢类似物,也是 β-甲基半乳糖苷透皮酶诱导剂。它能够抑制 l-阿拉伯糖操纵子的诱导,阻断大肠杆菌 B/r 在矿物盐培养基上加 l-阿拉伯糖的生长。 | |||
T5215 |
N-(3-Phenylpropionyl)glycine
N-(3-苯基丙酰基)甘氨酸,Phenylpropionylglycine |
Others | Others |
N-(3-Phenylpropionyl)glycine (Phenylpropionylglycine) 是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。 | |||
T38373 |
2-heptyl-3-hydroxy-4(1H)-Quinolone
2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal |
Others | Others |
2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。 它增加了铜绿假单胞菌中lasB 基因的表达,增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌,以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时,它还会降低铜绿假单胞菌生长介质中的铁含量,并在硫酸铁溶液中充当一种铁螯合剂。 | |||
T3826 |
Polygalasaponin F
异牡荆苷,瓜子金皂苷己 |
NF-κB; TLR; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
T4947 |
3-Hydroxybutyric acid
Butanoic acid,3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。 | |||
T19120 |
3-Hydroxydodecanoic acid
|
Others | Others |
3-Hydroxydodecanoic acid is a medium-chain fatty acid commonly linked to fatty acid metabolic disorders. | |||
TN6041 |
Cyclo(L-Ala-L-Pro)
Cyclo(alanylprolyl) |
||
Cyclo(L-Ala-L-Pro) and cyclo(L-Val-L-Pro) inhibit aflatoxin production of Aspergillus parasiticus and Aspergillus flavus in liquid medium at concentrations of several hundred uM without affecting fungal growth. | |||
TN1903 |
Magnolignan A
厚朴木脂素A |
Others | Others |
Magnolignan A-2-O-beta-D-glucopyranoside has medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, and 46.4 microM, respectively. | |||
TN2841 | 2alpha,9alpha,11-Trihydroxy-6-oxodrim-7-ene | Others | Others |
2alpha,9alpha,11-Trihydroxy-6-oxodrim-7-ene is a natural product from the culture medium of the marine-derived fungus Aspergillus insuetus (OY-207). | |||
T69369 |
Cladosporin
|
Others | Others |
Cladosporin 是一种真菌代谢物,在 Cladosporium cladosporioid 的菌丝体中产生。含浓度 75 μg/mL Cladosporin 的琼脂培养基可完全抑制多种皮肤癣菌的生长。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00834 |
ACADM Protein, Human, Recombinant (His)
ACADM,Medium-Chain Specific Acyl-CoA Dehydrogenase ... |
Human | E. coli |
Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a ... | |||
TMPH-01760 |
NEFM Protein, Human, Recombinant (His & Myc)
Neurofilament 3,Neurofilament triplet M protein,160 kDa neur... |
Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. NEFM Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.8 kDa and the accession number is P07197. | |||
TMPH-03448 |
EHT1 Protein, S. cerevisiae, Recombinant (His)
EHT1,Ethanol hexanoyl transferase 1,Alcohol O-acetyltransfer... |
Saccharomyces cerevisiae | E. coli |
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification. EHT1 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 57.3 kDa and the accession number is P38295. | |||
TMPH-02716 |
HADH Protein, Mouse, Recombinant (His & SUMO)
Short-chain 3-hydroxyacyl-CoA dehydrogenase,Hydroxyacyl-coen... |
Mouse | E. coli |
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. HADH Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted... | |||
TMPY-02453 |
CROT Protein, Human, Recombinant (474 Leu/Val, His)
carnitine O-octanoyltransferase,COT |
Human | Baculovirus Insect Cells |
Carnitine octanoyltransferase (CROT or COT), also known as octanoyl-CoA: L-carnitine O-octanoyltransferase, medium-chain/long-chain carnitine acyltransferase, and carnitine medium-chain acyltransferase, is a carnitine acyltransferase belonging to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. Carnitine octanoyltransferase (CROT or COT) facilitate... | |||
TMPH-01410 |
GPR84 Protein, Human, Recombinant (hFc)
G-protein coupled receptor 84,GPR84,Inflammation-related G-p... |
Human | P. pastoris (Yeast) |
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. GPR84 Protein, Human, Recom... | |||
TMPH-03433 |
ACB1 Protein, S. cerevisiae, Recombinant (His)
Acyl-CoA-binding protein |
Saccharomyces cerevisiae | P. pastoris (Yeast) |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. ACB1 Protein, S. cerevisiae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 12.1 kDa and the accession number is P31787. | |||
TMPH-03173 |
OprF Protein, Pseudomonas aeruginosa, Recombinant (His)
Outer membrane porin F,oprF |
Pseudomonas aeruginosa | E. coli |
Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium. OprF Protein, Pseudomonas aeruginosa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.3 kDa and the accession number is P13794. | |||
TMPH-00406 |
ctfB Protein, Clostridium acetobutylicum, Recombinant (His & Myc)
Butyrate--acetoacetate CoA-transferase subunit B,ctfB,Coat B... |
Clostridium acetobutylicum | E. coli |
Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation. ctfB Protein, Clostridium acetobutylicum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.6 kDa and the accession number is P23673. | |||
TMPJ-01383 |
Serpin A10 Protein, Human, Recombinant (His)
PZI,Protein Z-Dependent Protease Inhibitor,Serpin A10,ZPI,PZ... |
Human | HEK293 Cells |
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis. | |||
TMPH-02142 |
ERR1 Protein, Human, Recombinant (GST)
Steroid hormone receptor ERR1,Estrogen receptor-like 1,Nucle... |
Human | E. coli |
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. | |||
TMPK-00039 |
TSLP Protein, Human, Recombinant (His & Avi), Biotinylated
TSLP,thymic stromal lymphopoietin |
Human | HEK293 Cells |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells. TSLP Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells ... | |||
TMPK-00037 |
TSLP Protein, Human, Recombinant (His & Avi)
TSLP,thymic stromal lymphopoietin |
Human | HEK293 Cells |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells. TSLP Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi... | |||
TMPH-01050 |
CPT2 Protein, Human, Recombinant (His & Myc)
Carnitine O-palmitoyltransferase 2, mitochondrial,CPT II,Car... |
Human | E. coli |
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters. CPT2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with ... | |||
TMPH-02492 |
DBI Protein, Mouse, Recombinant (His & Myc)
Endozepine (EP),Diazepam-binding inhibitor,DBI,Acyl-CoA-bind... |
Mouse | E. coli |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. DBI Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted ... | |||
TMPH-02825 |
ACOX1 Protein, Mouse, Recombinant (Myc)
AOX,Peroxisomal fatty acyl-CoA oxidase,EC:1.3.3.6,Peroxisoma... |
Mouse | E. coli |
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.; Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. | |||
TMPH-03235 |
DBI Protein, Rat, Recombinant (His & Myc)
Endozepine (EP),ACBP,DBI,Acyl-CoA-binding protein,Diazepam-b... |
Rat | E. coli |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. DBI Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted mo... | |||
TMPK-00040 |
TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi), Biotinylated
Thymic stromal lymphopoietin,TSLP |
Human | HEK293 Cells |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells. TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi), Biotinylated is expressed in HEK293 m... | |||
TMPH-00890 |
DBI Protein, Human, Recombinant (aa 2-104, His)
Acyl-CoA-binding protein,Diazepam-binding inhibitor,DBI,Endo... |
Human | E. coli |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. DBI Protein, Human, Recombinant (aa 2-104, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecul... | |||
TMPJ-00805 |
Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)
Apo-E,APOE,Apolipoprotein E |
Mouse | HEK293 Cells |
Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. ApoE is a major protein component of serum LDL, VLDL, HDL, and chylomicrons. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. APOE is usually secreted in plasma. Phosphorylation sites are present in the extracellular medium. | |||
TMPK-00482 |
TSLP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
thymic stromal lymphopoietin,TSLP |
Cynomolgus | HEK293 Cells |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells. TSLP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in... | |||
TMPK-00038 |
TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi)
thymic stromal lymphopoietin,TSLP |
Human | HEK293 Cells |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells. TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi) is expressed in HEK293 mammalian cells... | |||
TMPJ-00460 |
MECR Protein, Human, Recombinant (His)
Nuclear Receptor-Binding Factor 1,HsNrbf-1NRBF-1,MECR,NBRF1,... |
Human | HEK293 Cells |
Trans-2-Enoyl-CoA Reductase Mitochondrial (MECR) belongs to the zinc-containing alcohol dehydrogenase family. MECR localizes to the mitochondrion. It is highly expressed in skeletal and heart muscle and expressed at lower levels in the placenta, liver, kidney and pancreas, with weakly or no expression in the lung. MECR exists as a homodimer, which catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain... | |||
TMPJ-00953 |
ADH7 Protein, Human, Recombinant (His)
Retinol Dehydrogenase,Alcohol Dehydrogenase Class 4 μ/σ Chai... |
Human | HEK293 Cells |
Alcohol dehydrogenase class 4 mu/sigma chain (ADH7) is a cytoplasm enzyme which is a member of the alcohol dehydrogenase family. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members. ADH7 may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good subst... | |||
TMPY-01783 |
SMOC1 Protein, Human, Recombinant (His)
OAS,SPARC related modular calcium binding 1 |
Human | HEK293 Cells |
SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri... | |||
TMPY-01308 |
AGO1 Protein, Human, Recombinant (His)
EIF2C,GERP95,argonaute RISC catalytic component 1,EIF2C1,Q99 |
Human | Baculovirus Insect Cells |
Protein argonaute-1, also known as eukaryotic translation initiation factor 2C 1, EIF2C1, and AGO1, is a member of the argonaute family and ago subfamily. Protein argonaute-1 in humans is encoded by the EIF2C1 gene. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4. This genomic region is frequently lost in human cancers such as Wilms tumors, neuroblastoma, and carcinomas of the breast, liver, and colon. The human EIF... | |||
TMPY-01000 |
BVES Protein, Human, Recombinant (GST)
CARICK,LGMD2X,POP1,blood vessel epicardial substance,POPDC1,... |
Human | E. coli |
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35698 |
Octanoic Acid-13C
|
||
Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d... | |||
T19119 |
3-Hydroxy Midostaurin-D5
CGP52421-D5 |
Others | Others |
3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma). | |||
T35697 |
Lauric Acid-13C
|
||
Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2 | |||
T71328 |
Theobromine-d6
|
||
Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium.... |