|
TMPY-04853
|
TSHR Protein, Human, Recombinant (His)
TSHR,hTSHR-I,TSH Receptor,LGR3,CHNG1
|
Human
|
Baculovirus Insect Cells
|
|
Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis. |
|
TMPY-03431
|
HDAC4 Protein, Human, Recombinant (aa 612-1084)
histone deacetylase 4,HA6116,HDAC-4,HD4,BDMR,HDAC-A,AHO3,HDA...
|
Human
|
Baculovirus Insect Cells
|
|
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th... |
|
TMPY-04396
|
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...
|
Human
|
Baculovirus Insect Cells
|
|
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... |
|
TMPJ-01407
|
FIS1 Protein, Human, Recombinant (His)
FIS1 Homolog,FIS1,Tetratricopeptide Repeat Protein 11,TPR Re...
|
Human
|
E. coli
|
|
Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FIS1 can induce cytochrome C discharge from the mitochondrion to the cytosol, eventually leading to apoptosis. In addition, FIS1 participates in peroxisomal growth and division. The C-terminus of FIS1 is required for mitochondrial or peroxisomal localization, while the N-terminus i... |
|
TMPH-02351
|
Influenza A H3N2 (strain A/Beijing/353/1989) Nucleoprotein/NP Protein (His & SUMO)
Nucleoprotein,NP,Nucleocapsid protein
|
H3N2
|
E. coli
|
|
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathw... |
|
TMPH-02352
|
Influenza A H3N2 (strain A/Kitakyushu/159/1993) Nucleoprotein/NP Protein (His)
Nucleocapsid protein,NP,Nucleoprotein
|
H3N2
|
E. coli
|
|
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathw... |
|
TMPH-02350
|
Influenza A H3N2 (strain A/Shanghai/16/1989) Nucleoprotein/NP Protein (His)
NP,Nucleocapsid protein,Nucleoprotein
|
H3N2
|
E. coli
|
|
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathw... |
|
TMPH-02354
|
Influenza A H1N1 (strain A/New Jersey/8/1976) Nucleoprotein/NP Protein (His & SUMO)
NP,Nucleocapsid protein,Nucleoprotein
|
H1N1
|
E. coli
|
|
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathw... |
|
TMPH-02355
|
Influenza A H3N2 (strain A/Port Chalmers/1/1973) Nucleoprotein/NP Protein (His & SUMO)
NP,Nucleoprotein,Nucleocapsid protein
|
H3N2
|
E. coli
|
|
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathw... |
|
TMPH-02353
|
Influenza A H1N1 (strain A/Fort Warren/1/1950) Nucleoprotein/NP Protein (His & SUMO)
Nucleocapsid protein,Nucleoprotein,NP
|
H1N1
|
E. coli
|
|
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathw... |
|
TMPH-00703
|
Pal Protein, E. coli, Recombinant (His & Myc)
Peptidoglycan-associated lipoprotein,pal,Tol-Pal system lipo...
|
E. coli
|
E. coli
|
|
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. The Tol-Pal system is also required for polar localization of chemoreceptors clusters. The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity. |
|
TMPK-00806
|
GHR/Growth Hormone R Protein, Human, Recombinant (His)
GHR/BP,GH receptor,GHBP,GHR
|
Human
|
HEK293 Cells
|
|
Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual functions based on its localization in the plasma membrane and nucleus. |
|
TMPH-00275
|
ITIH2 Protein, Bovine, Recombinant (His & KSI)
Inter-alpha-trypsin inhibitor heavy chain H2,ITIH2
|
Bovine
|
E. coli
|
|
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. ITIH2 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 21.3 kDa and the accession number is P56651. |
|
TMPH-01420
|
SAR1A Protein, Human, Recombinant (GST)
SAR1A,COPII-associated small GTPase,GTP-binding protein SAR1...
|
Human
|
E. coli
|
|
Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). SAR1A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 49.4 kDa and the accession number... |
|
TMPH-02106
|
SH3PXD2A Protein, Human, Recombinant (His & Myc)
SH3PXD2A,SH3 multiple domains protein 1,SH3 and PX domain-co...
|
Human
|
E. coli
|
|
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. |
|
TMPY-00587
|
GABARAP Protein, Human, Recombinant (His & MBP)
GABARAP-a,GABA(A) receptor-associated protein,ATG8A,MM46
|
Human
|
E. coli
|
|
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in vivo by delaying cell death and its associated immune-related response. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. GABARAPs as the first known direct interaction partners of Nef that are essential... |
|
TMPY-02311
|
AGO3 Protein, Human, Recombinant (His)
EIF2C3,argonaute RISC catalytic component 3
|
Human
|
Baculovirus Insect Cells
|
|
Argonaute (Ago) protein family plays a key role in the RNA interference (RNAi) process in different insects including Lepidopteran. AGO3 also coexists and interacts with Armitage in the mitochondrial fraction. Furthermore, AGO3 acts in conjunction with the mitochondria-associated protein Zucchini to control the dynamic subcellular localization of Armitage between mitochondria and nuage in a Slicer-dependent fashion. |
|
TMPH-03379
|
Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His)
p29,Synaptogyrin-1,Syngr1
|
Rat
|
E. coli
|
|
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation. Involved in the regulation of short-term and long-term synaptic plasticity. Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 31.7 kDa and the accession number is Q62876. |
|
TMPH-00811
|
Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc)
Small delta antigen,p24
|
HDV
|
P. pastoris (Yeast)
|
|
Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome. Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) is expressed in yeast with N-6xHi... |
|
TMPH-02285
|
USP6 Protein, Human, Recombinant (His & KSI)
Proto-oncogene TRE-2,Ubiquitin-specific-processing protease ...
|
Human
|
E. coli
|
|
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. |
|
TMPJ-01120
|
KPNB1 Protein, Human, Recombinant (His)
Nuclear factor p97,Importin subunit β-1,NTF97,Karyopherin su...
|
Human
|
E. coli
|
|
Importin subunit beta-1(KPNB1) is a member of the importin beta family. KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats. It is involved in nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Its functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by ac... |
|
TMPH-02730
|
ITIH2 Protein, Mouse, Recombinant (His & Myc)
Itih2,Inter-alpha-trypsin inhibitor heavy chain H2
|
Mouse
|
E. coli
|
|
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. ITIH2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 79.6 kDa and the accession number is Q61703. |
|
TMPH-01079
|
CLN5 Protein, Human, Recombinant (His)
CLN5,BMPS,Bis(monoacylglycero)phosphate synthase CLN5,S-depa...
|
Human
|
E. coli
|
|
Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. CLN5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 43.5 kDa and ... |
|
TMPH-01365
|
SNTG1 Protein, Human, Recombinant (His & Myc)
Syntrophin-4,Gamma-1-syntrophin,SNTG1
|
Human
|
E. coli
|
|
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. SNTG1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicte... |
|
TMPJ-00463
|
BDH2 Protein, Human, Recombinant (His)
Oxidoreductase UCPA,Dehydrogenase/Reductase SDR Family Membe...
|
Human
|
E. coli
|
|
3-Hydroxybutyrate Dehydrogenase Type 2 belongs to the short-chain dehydrogenases/reductases (SDR) family. 3-Hydroxybutyrate Dehydrogenase Type 2 may play an important role in the peripheral utilization of 3-hydroxybutyrate. The cytoplasmic localization with its high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters of 3-Hydroxybutyrate Dehydrogenase Type 2 make it suitable to conbert high levels of circulating 3-hydroxybutyrate into acetoacetate. |
|
TMPY-01270
|
PRMT3 Protein, Human, Recombinant (GST)
HRMT1L3,protein arginine methyltransferase 3
|
Human
|
E. coli
|
|
Protein arginine methyltransferase 3, also known as PRMT3, is one of four type I protein arginine methyltransferases (PRMT) that in humans is encoded by the PRMT3 gene. Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a small family of PRMTs. The modification appears to regulate protein functions and interactions that affect gene regulation, signalling and subcellular localization of proteins and nucleic acids. In human cells, the PRMT fam... |
|
TMPJ-01041
|
FGF-12 Protein, Human, Recombinant
FGF12B,Myocyte-Activating Factor,FHF-1,FGF12,Fibroblast Grow...
|
Human
|
E. coli
|
|
Fibroblast Growth Factor 12 (FGF-12) is a member of the fibroblast growth factor (FGF) family. FGF-12 is probably involved in nervous system development and function. FGF-12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfectedinto mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gen... |
|
TMPY-02761
|
Rack1 Protein, Human, Recombinant (His & MBP)
PIG21,Gnb2-rs1,H12.3,RACK1,HLC-7
|
Human
|
E. coli
|
|
The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin beta subunit cytoplasmic domains and to members of two kinase families (src and protein kinase C, PKC) that mediate integrin bidirectional signaling.Rack1 may link protein kinase C directly to integrins and participate in the regulation of integrin functions.Rack1 regulates the localization of an essential PCP protein and acts as a molecular switch to promote PCP signaling. |
|
TMPK-00879
|
CCR2b Protein-VLP, Human, Recombinant
C-C CKR-2,CCR2,MCP-1-R,CCR-2,CMKBR2
|
Human
|
HEK293 Cells
|
|
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane stru... |
|
TMPY-03604
|
VAMP3 Protein, Human, Recombinant (His)
vesicle-associated membrane protein 3,CEB
|
Human
|
E. coli
|
|
VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Because of VAMP3 gene's high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, VAMP3 was shown to be the human equivalent ... |
|
TMPH-00810
|
Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc)
p27,Large delta antigen
|
HDV
|
P. pastoris (Yeast)
|
|
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication. Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc) is expressed i... |
|
TMPY-00561
|
Neurotensin Protein, Human, Recombinant (hFc)
NMN-125,NTS1,NN,NT/N,neurotensin,NT
|
Human
|
HEK293 Cells
|
|
NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali... |
|
TMPH-01683
|
Tau-F Protein, Human, Recombinant (HEK293, His)
Microtubule-associated protein tau,Paired helical filament-t...
|
Human
|
HEK293 Cells
|
|
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ... |
|
TMPY-03286
|
hnRNP-R Protein, Human, Recombinant (His & GST)
hnRNP-R,HNRPR,heterogeneous nuclear ribonucleoprotein R,HNRN...
|
Human
|
Baculovirus Insect Cells
|
|
HNRNP R, also known as HNRNPR, is an RNA binding protein. HNRNP R gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). HnRNPs complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The ... |
|
TMPY-00371
|
STC1 Protein, Human, Recombinant (His)
stanniocalcin 1,STC
|
Human
|
HEK293 Cells
|
|
Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep e... |
|
TMPY-02924
|
RGS1 Protein, Human, Recombinant (His)
1R20,IER1,BL34,HEL-S-87,regulator of G-protein signaling 1,I...
|
Human
|
E. coli
|
|
RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type I diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs. RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new Multiple myeloma (MM) therapy. The markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that ... |
|
TMPY-02596
|
GLT25D2 Protein, Human, Recombinant (His)
GLT25D2,RP11-498P10.2,collagen β(1-O)galactosyltransferase 2...
|
Human
|
Baculovirus Insect Cells
|
|
Glycosyl transferase 25 domain 2 (GLT25D2) is a glucosyltransferase enzyme expressed only at low levels in the nervous system. Glycosyltransferases are enzymes that act as a catalyst for the transfer of a monosaccharide unit from an activated nucleotide sugar (also known as the "glycosyl donor") to a glycosyl acceptor molecule, usually an alcohol. Glycosyl transferases transfer glycosyl groups onto their substrate. Localization partially defines their function. Glt25D2 enzyme showed a strong gal... |
|
TMPY-00209
|
PSAP/Prosaposin Protein, Rat, Recombinant (His)
prosaposin
|
Rat
|
HEK293 Cells
|
|
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... |
|
TMPY-01710
|
IkB alpha/NFKBIA Protein, Human, Recombinant (His)
IkB α,IKBA,nuclear factor of kappa light polypeptide gene en...
|
Human
|
E. coli
|
|
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function... |
|
TMPY-04510
|
PSAP/Prosaposin Protein, Human, Recombinant (His)
prosaposin,SAP1,GLBA
|
Human
|
HEK293 Cells
|
|
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... |
|
TMPJ-00926
|
GCA Protein, Human, Recombinant (GST)
GCA,Grancalcin,GCL
|
Human
|
E. coli
|
|
Grancalcin (GCA) is a member of the penta EF hand subfamily which includes sorcin, calpain and ALG2. Grancalcin is highly expressed bone marrow and also can detected in neutrophils and macrophages. Grancalcin interacts with L-plastin which known to have actin bundling activity. It indicates that Grancalcin may play an important role in the adhesion of neutrophils to fibronectin. Furthermore, Grancalcin localization is dependent upon calcium and magnesium. It associates with both the granule and ... |
|
TMPY-02306
|
MAB21L2 Protein, Human, Recombinant (His & ZZ)
mab-21-like 2 (C. elegans),MCOPS14
|
Human
|
E. coli
|
|
MAB21L2 (Mab-21 Like 2) is a Protein Coding gene. It encodes a protein similar to C. elegans mab-21 cell fate-determining factor. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. MAB21L2 belongs to the mab-21 family. It is required for several aspects of embryonic development including normal development of the eye. It is thought that this gene may also be involved in neural development. The identification of MAB21L2 as a novel fact... |
|
TMPJ-01044
|
NCALD Protein, Human, Recombinant (His)
Neurocalcin-δ,Neurocalcin-Delta,NCALD
|
Human
|
E. coli
|
|
Neurocalcin-delta (NCALD) is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family. It expressed in mammalian brains. NCALD contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein possesses a Ca2+ /myristoyl switch. It is cytosolic at resting calcium levels. However, elevated intracellular calcium levels induce a conformational change which exposes the myristoyl group, resulting in protein association with membranes a... |
|
TMPJ-00798
|
ACYP1 Protein, Human, Recombinant (His)
ACYPE,Acylphosphate phosphohydrolase 1,erythrocyte isozyme,o...
|
Human
|
E. coli
|
|
ACYP1, also known as Acylphosphatase-1, Acylphosphatase, erythrocyte isozyme, Acylphosphatase, organ-common type isozyme, Acylphosphate phosphohydrolase 1 and ACYPE, is a small cytosolic enzyme which catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates.ACYP1 is a protein which belongs to the acylphosphatase family and contains 1 fibrinogen C-terminal domain. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of thei... |
|
TMPH-02669
|
GJA1 Protein, Mouse, Recombinant (His & Myc)
Gap junction 43 kDa heart protein,Gja1,Gap junction alpha-1 ...
|
Mouse
|
Baculovirus Insect Cells
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Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibi... |
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TMPY-04318
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GRIK2 Protein, Human, Recombinant (hFc)
GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...
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Human
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HEK293 Cells
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GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl... |
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TMPY-03658
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ETHE1 Protein, Human, Recombinant (His)
YF13H12,HSCO,ethylmalonic encephalopathy 1
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Human
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E. coli
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ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic en... |
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TMPY-02277
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Carbonic Anhydrase 7 Protein, Human, Recombinant (His)
CAVII,carbonic anhydrase VII
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Human
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E. coli
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Carbonic anhydrase 7, also known as carbonate dehydratase VII, carbonic anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to thealpha-carbonic anhydrase family. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, ... |
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TMPH-02697
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GNA12 Protein, Mouse, Recombinant (His & Myc)
Guanine nucleotide-binding protein subunit alpha-12,Gna12
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Mouse
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E. coli
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Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by ac... |
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TMPY-02117
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Marapsin Protein, Human, Recombinant (His)
UNQ1884/PRO4327,protease, serine 27,CAPH2,MPN
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Human
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HEK293 Cells
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The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most stro... |
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