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Search Results for " lactamase "

Targets Recommended: Antibacterial

124

抑制剂 & 化合物

3

天然产物

19

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T19206	β-Lactamase-IN-1 4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one,beta-lactamase-IN-1	Antibacterial	Microbiology/Virology
	β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) 是一种 β-Lactamase 抑制剂，针对淋病奈瑟菌的感染。
T35427	β-Lactamase-IN-2	Antibacterial	Microbiology/Virology
	β-Lactamase-IN-2 是 β-内酰胺酶的有效抑制剂。β-Lactamase-IN-2显示出抗菌活性。
T38476	Metallo β-lactamase ligand 1	Antibacterial	Microbiology/Virology
	Metallo β-lactamase ligand 1 是B 类β-内酰胺酶的抑制剂，具有抗菌活性。
T39865	β-Lactamase-IN-6	Others	Others
	β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.
T38955	β-Lactamase-IN-4	Others	Others
	β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.
T38956	β-Lactamase-IN-5	Others	Others
	β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections.
T60797	β-Lactamase-IN-7	Others	Others
	β-Lactamase-IN-7 (compound 14) 能够有效抑制肺炎克雷伯菌，它是 VIM 型金属 β 内酰胺酶的有效抑制剂，对VIM-1和VIM-4的Ki 值分别为 1.26 μM 和 0.54 μM。
T60387	β-Lactamase-IN-8	Others	Others
	β-Lactamase-IN-8 (compound 20) 是一种有效的、口服生物可利用的广谱环硼酸β- 内酰胺酶 (β-lactamase)抑制剂，可用于抗菌研究。
T60914	Metallo-β-lactamase-IN-8	Others	Others
	Metallo-β-lactamase-IN-8 (化合物 17) 是有效，可逆和竞争性的广谱金属-β-内酰胺酶 (MβLs)抑制剂，具有抗菌活性。Metallo-β-lactamase-IN-8 对L1，ImiS，IMP-1和VIM-2的IC50值分别为 1.3 μM，5.7 μM，9.8 μM。
T60694	Metallo-β-lactamase-IN-4	Others	Others
	Metallo-β-lactamase-IN-4 (compound 40) 是金属 -β- 内酰胺酶 (MBL) 的有效抑制剂，对VIM-1、NDM-1 和 IMP 的IC50值分别为 0.5 μM, 2.1 μM 和 3.3 μM。
T61173	Metallo-β-lactamase-IN-5	Others	Others
	Metallo-β-lactamase-IN-5 (compound 5c) is a powerful inhibitor of metallo-β-lactamases (MBLs). Its inhibitory activity against MBLs NDM-1 and VIM-1 has been demonstrated. With an IC50 value of 45 μg/mL, Metallo-β-lactamase-IN-5 effectively inhibits HUVECs. Additionally, when combined with Imipenem, Metallo-β-lactamase-IN-5 exhibits synergistic antimicrobial activity [1].
T60370	Metallo-β-lactamase-IN-2	Others	Others
	Metallo-β-lactamase-IN-4 (compound 40) 是一种有效的金属 -β- 内酰胺酶 (MBL) 抑制剂，其对于 VIM-1、NDM-1和 IMP-7的 IC50值分别为 0.1 μM, 1.3 μM 和 5.0 μM。
T60239	Metallo-β-lactamase-IN-6	Others	Others
	Metallo-β-lactamase-IN-6 is a highly effective inhibitor of VIM-Type metallo-β-lactamase, demonstrating IC 50 values of 0.56 μM, 29.50 μM, and 5.78 μM for VIM-2, VIM-1, and VIM-5, respectively. In addition, Metallo-β-lactamase-IN-6 exhibits potent synergistic antibacterial properties when combined with Meropenem, particularly against engineered Escherichia coli strains and clinically isolated Pseudomonas aeruginosa carrying the VIM-2 MBL gene [1].
T60282	Metallo-β-lactamase-IN-3	Others	Others
	Metallo-β-lactamase-IN-3 (compound 35) 是一种有效的金属 -β- 内酰胺酶 (MBL) 抑制剂，具有恢复现有 β-内酰胺类抗生素活性的潜力并为新抗生素的发现提供正交策略。Metallo-β-lactamase-IN-3 对 VIM-1和 NDM-1的活性较高，其 IC50值分别为 0.6 和 1.0 μM。Metallo-β-lactamase-IN-3 对 IMP-7 无抑制作用。
T79435	Metallo-β-lactamase-IN-11	Others	Others
	Metallo-β-lactamase-IN-11（化合物5f）是一种针对Metallo-β-lactamases（MBLs）的抑制剂，对CphA表现出较强的抑制活性（IC50=45 µM）。在10 µM浓度下，能分别抑制49%的NDM-1和61%的AIM-1。此化合物对于研究针对抗生素耐药性的策略具有潜在应用价值。
T60494	Metallo-β-lactamase-IN-7	Others	Others
	Metallo-β-lactamase-IN-7 是VIM 型金属 β-内酰胺酶的有效抑制剂，其对VIM-2、VIM-1和VIM-5 的IC50值分别为 0.019 μM、13.64 μM 和 0.38 μM。它还可以增强 Meropenem 对革兰氏阴性菌的抗菌活性。
T72261	Metallo-β-lactamase-IN-9	Others	Others
	Metallo-β-lactamase-IN-9 (Compound 23) 是一种高效的泛金属-β-内酰胺酶 (MBL) 抑制剂，其对 NDM-1、VIM-1 和 IMP-1 的抑制活性表现在 IC50 值上，分别为 35 nM、269 nM 和 369 nM。
T14979	Clavulanate lithium Clavulanic acid lithium,克拉维酸锂	Antibacterial	Microbiology/Virology
	Clavulanate lithium (Clavulanic acid lithium) 是一种β-lactamase 的高效抑制剂，可作抗生素。
T8620	piperacillin Pipril,Pipracil,哌拉西林,Pipercillin	Antibacterial	Microbiology/Virology
	Piperacillin (Pipercillin) 是半合成青霉素，可以作用于革兰氏阳性和革兰氏阴性需氧和厌氧菌。与其他青霉素相比，它对产生 β-内酰胺酶的菌类表现出更强的活性。
T1550	Thiamphenicol 甲砜霉素,Dextrosulphenidol,Thiophenicol	Antibacterial; Antibiotic	Microbiology/Virology
	Thiamphenicol (Dextrosulphenidol) 是 Chloramphenicol 的甲基磺酰基衍生物，是一种广谱抗菌类抗生素。它与 50S 核糖体亚基结合，抑制蛋白质合成并具有抑菌作用，特别针对革兰氏阴性，革兰氏阳性需氧和厌氧菌。
T1305	Ceftazidime GR20263,头孢他啶	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftazidime (GR20263) 是可静脉内或肌肉给药的第头孢菌素。它对革兰氏阳性和革兰氏阴性需氧细菌有体外活性。它对肠杆菌科特别有效，对大多数 β-内酰胺酶具有抗水解作用。
T2583	Cilastatin 西司他丁,MK0791	Proteasome; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I 抑制剂，IC50为 0.1 μM。它抑制细菌金属叶内酰胺酶CphA 的IC50为 178 μM，可用作抗菌辅助剂。
T1224	Cefuroxime sodium Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素，增加了对 β-内酰胺酶的稳定性。
T1031	Cloxacillin sodium monohydrate Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Cloxacillin sodium monohydrate (Cloxacillin Sodium) 有抗菌作用，对Staphylococcus aureus25923 的最小抑菌浓度为256 mg/L。
T4201	Avibactam sodium 阿维巴坦,AVE-1330A,阿维巴坦钠,NXL-104	Antibacterial; Antibiotic	Microbiology/Virology
	Avibactam sodium (NXL-104) 是一种可逆的 β-内酰胺酶抑制剂，抑制 TEM-1，P99和KPC-2 β-内酰胺酶，IC50分别为8、80和38 nM。
T5570	Cephalothin 头孢噻吩,Cephalotin acid	Antibacterial; Antibiotic	Microbiology/Virology
	Cephalothin 是一种 β-内酰胺抗生素，抑制 C 类 β-内酰胺酶活性的 Ki 值为 0.32 µM。
T5446	CIBACRON BLUE 3G-A	Others	Others
	Cibacron Blue 3G-A 是蒽醌染料，能够抑制 R46β-lactamase(Ki:1.2 uM)。
T1631	Sulbactam CP45899,舒巴坦,舒巴坦酸	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam (CP45899) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
T15047	Dacisteine N,S-Diacetyl-L-cysteine,达西司坦	Others	Others
	Dacisteine (N,S-Diacetyl-L-cysteine) 是 New Delhi metallo-beta-lactamase-1 (NDM-1) 的抑制剂 (IC50 = 1000 μM)。
T14081	Enmetazobactam AAI101	Antibacterial	Microbiology/Virology
	Enmetazobactam (AAI101) 是一种广谱β-lactamase 抑制剂，有抗耐药革兰氏阴性细菌。
T60454	NDM-1 inhibitor-3	Others	Others
	NDM-1 inhibitor-3 是一种广泛存在于自然界中的 New Delhi Metallo-β-lactamase-1 (NDM-1) 抑制剂（Ki ： 4 μM），与抗生素耐药有关。
T17210L1	(3R,6R)-Vaborbactam (3R,6R)-RPX7009,(3R,6R)-Vaborbactam (Iso-1360457-46-0)	Antibacterial	Microbiology/Virology
	(3R,6R)-Vaborbactam ((3R,6R)-Vaborbactam (Iso-1360457-46-0)) 是一种环状硼酸药效团 β-内酰胺酶 (β-lactamase) 抑制剂，具有潜在的抗菌活性。
T1143	Carbenicillin disodium BRL-2064,羧苄青霉素钠,Sodium carbenicillin	Cell wall; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology
	Carbenicillin disodium (BRL-2064) 作用于细菌细胞壁合成的最后阶段，是β-内酰胺青霉素衍生物。
T6685	Sulbactam sodium 舒巴坦钠,CP-45899-2	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam sodium (CP-45899-2) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂。它具有抗菌活性，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。
T0234	Methicillin sodium salt Methicillin sodium,Meticillin sodium,甲氧西林钠	Antibacterial; Antibiotic	Microbiology/Virology
	Methicillin sodium salt 是β-内酰胺抗生素，抑制参与肽聚糖合成的青霉素结合蛋白。
T13038	Sultamicillin	Antibacterial; Antibiotic	Microbiology/Virology
	Sultamicillin 是一种具有口服活性的氨苄西林/舒巴坦双前药。它是一种半合成 β-内酰胺酶抑制剂。
T1405	Cefditoren pivoxil 头孢妥仑匹酯,ME 1207,Cefditoren pivaloyloxymethyl ester,Cefditoren pivoxyl	Antibacterial; Antibiotic	Microbiology/Virology
	Cefditoren pivoxil (ME 1207) 是一种半合成、广谱、β-内酰胺酶耐药的第三代头孢菌素抗生素，具有杀菌活性。
T23858	WCK-5153 WCK 5153,WCK5153	Antibacterial	Microbiology/Virology
	WCK-5153 是 β-Lactamase 的增强剂和 PBP2 的抑制剂，对铜绿假单胞菌具有抗菌活性。 WCK-5153 可用于治疗由高度耐药的革兰氏阴性病原体引起的严重感染的研究。
T13395L	Zidebactam 齐德巴坦,WCK-5107	Antibacterial	Microbiology/Virology
	Zidebactam (WCK-5107) 是一种β-内酰胺酶抑制剂。它也是一种青霉素结合蛋白 2 抑制剂，IC50值为 0.26 μg/ml。
T1312	Nafcillin sodium monohydrate CL 8491,萘夫西林钠,nafcillin sodium	Antibacterial; Antibiotic	Microbiology/Virology
	Nafcillin sodium monohydrate (CL 8491) 是一种抗生素，是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。
T6268	Ceftiofur hydrochloride 头孢噻呋盐酸盐,Ceftiofur HCl,U-67279A,Excenel hydrochloride	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftiofur hydrochloride (U-67279A) 是头孢噻呋的盐酸盐形式，是一种β-内酰胺酶稳定的半合成广谱头孢菌素，具有抗菌活性。
T0868	Cefepime Dihydrochloride Monohydrate Cefepime HCl,头孢吡肟二盐酸盐一水合物	Antibacterial; Antibiotic; Antifection	Microbiology/Virology
	Cefepime Dihydrochloride Monohydrate (Cefepime HCl) 是一种广谱头孢菌素，对革兰氏阳性菌和革兰氏阴性菌有更高的覆盖率。
T60050	ANT3310	Antibacterial	Microbiology/Virology
	ANT3310 是一种广谱共价丝氨酸 β-内酰胺酶抑制剂，对 AmpC、CTX-M-15、TEM-1、OXA-48、OXA-23 和 KPC-2 的 IC50 范围为 1 nM 至 175 nM。 ANT3310 可用于细菌感染研究。
T17210L	Vaborbactam ammonium salt RPX7009 ammonium salt,Vaborbactam ammonium salt（1360457-46-0 Free base）	Antibacterial	Microbiology/Virology
	Vaborbactam ammonium salt 是一种 β-内酰胺酶抑制剂，可以恢复碳青霉烯类药物对 KPC 生产菌株的活性，常与其它药物连用来研究真菌感染。
T23801	WCK-4234 sodium WCK-4234,WCK4234,WCK 4234	Antibacterial	Microbiology/Virology
	WCK-4234 sodium (WCK 4234) 是一种 β-内酰胺酶抑制剂，可用于针对 MDR 感染的研究。 WCK-4234 sodium 抑制 A、C 和 D 类 β-内酰胺酶和 OXA 碳青霉烯酶。
T68137	Sanfetrinem GV104326	Antibiotic	Microbiology/Virology
	Sanfetrinem (GV104326) sodium 是一种新型可口服 β-内酰胺酶抗生素，对革兰氏阳性菌和革兰氏阴性菌显示出显著的抗菌活性，可用于研究细菌感染。
T12166	Nacubactam OP0595 free acid,那库巴坦	Antibacterial	Microbiology/Virology
	Nacubactam (OP0595 free acid) 是一种非 β-内酰胺-β-内酰胺酶抑制剂，对 A 类和 C 类 β-内酰胺酶具有活性。它作为青霉素结合蛋白 2 活性抗菌剂，并赋予 β-内酰胺酶非依赖性增强作用以靶向其他 PBP。
T13077	Taniborbactam dihydrochloride VNRX-5133 dihydrochloride,Taniborbactam 2HCl	Antibacterial; Antifungal	Microbiology/Virology
	Taniborbactam dihydrochloride (VNRX-5133 dihydrochloride) 是一种具有选择性和有效性的新型环硼酸β-内酰胺酶抑制剂，具有抗菌活性，对革兰氏阴性菌抑制作用显著。Taniborbactam dihydrochloride 抑制 KPC-2，AmpC，OXA-48 和 VIM-2 ，可以用于研究真菌感染。
T11125	Durlobactam sodium salt 杜巴坦,ETX2514 sodium salt,杜洛巴坦	Antibacterial	Microbiology/Virology
	Durlobactam sodium salt (ETX2514 sodium salt)是一种 β-内酰胺酶抑制剂，针对 A 类 KPC-2、C 类 AmpC 和 D 类 OXA-24，IC50 值分别为 4 nM、14 nM 和 190 nM。 Durlobactam sodium salt 可用于对包括鲍曼不动杆菌在内的耐药革兰氏阴性菌的研究。
T19860	Clavulanic Acid BRL 14151,MM-14151,MM 14151,RX-10100,MM14151,BRL14151,BRL-14151	Antibacterial; Antifungal	Microbiology/Virology
	Clavulanic Acid(RX-10100) 是一种由生物体克拉维链霉菌产生的主要β-内酰胺类抗生素，是一种强效的细菌 β-内酰胺酶抑制剂，用于研究细菌引起的感染。Clavulanic Acid 具有广谱的生物活性，对多种革兰氏阳性和革兰氏阴性细菌均有活性。

化合物

β-Lactamase-IN-1

Cat.No: T19206

Synonym: 4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one,beta-lactamase-IN-1

Target: Antibacterial

β-Lactamase-IN-2

Cat.No: T35427

Target: Antibacterial

Metallo β-lactamase ligand 1

Cat.No: T38476

Target: Antibacterial

β-Lactamase-IN-6

Cat.No: T39865

Target: Others

β-Lactamase-IN-4

Cat.No: T38955

Target: Others

β-Lactamase-IN-5

Cat.No: T38956

Target: Others

β-Lactamase-IN-7

Cat.No: T60797

Target: Others

β-Lactamase-IN-8

Cat.No: T60387

Target: Others

Metallo-β-lactamase-IN-8

Cat.No: T60914

Target: Others

Metallo-β-lactamase-IN-4

Cat.No: T60694

Target: Others

Metallo-β-lactamase-IN-5

Cat.No: T61173

Target: Others

Metallo-β-lactamase-IN-2

Cat.No: T60370

Target: Others

Metallo-β-lactamase-IN-6

Cat.No: T60239

Target: Others

Metallo-β-lactamase-IN-3

Cat.No: T60282

Target: Others

Metallo-β-lactamase-IN-11

Cat.No: T79435

Target: Others

Metallo-β-lactamase-IN-7

Cat.No: T60494

Target: Others

Metallo-β-lactamase-IN-9

Cat.No: T72261

Target: Others

Clavulanate lithium

Cat.No: T14979

Synonym: Clavulanic acid lithium,克拉维酸锂

Target: Antibacterial

Cat.No: T8620

Synonym: Pipril,Pipracil,哌拉西林,Pipercillin

Target: Antibacterial

Cat.No: T1550

Synonym: 甲砜霉素,Dextrosulphenidol,Thiophenicol

Target: Antibacterial, Antibiotic

Cat.No: T1305

Synonym: GR20263,头孢他啶

Target: Antibacterial, Antibiotic

Cat.No: T2583

Synonym: 西司他丁,MK0791

Target: Proteasome, Antibacterial, Antibiotic

Cefuroxime sodium

Cat.No: T1224

Synonym: Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin

Target: Antibacterial, Antibiotic

Cloxacillin sodium monohydrate

Cat.No: T1031

Synonym: Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物

Target: Antibacterial, Antibiotic

Avibactam sodium

Cat.No: T4201

Synonym: 阿维巴坦,AVE-1330A,阿维巴坦钠,NXL-104

Target: Antibacterial, Antibiotic

Cat.No: T5570

Synonym: 头孢噻吩,Cephalotin acid

Target: Antibacterial, Antibiotic

CIBACRON BLUE 3G-A

Cat.No: T5446

Target: Others

Cat.No: T1631

Synonym: CP45899,舒巴坦,舒巴坦酸

Target: Antibacterial, Antibiotic

Cat.No: T15047

Synonym: N,S-Diacetyl-L-cysteine,达西司坦

Target: Others

Cat.No: T14081

Synonym: AAI101

Target: Antibacterial

NDM-1 inhibitor-3

Cat.No: T60454

Target: Others

(3R,6R)-Vaborbactam

Cat.No: T17210L1

Synonym: (3R,6R)-RPX7009,(3R,6R)-Vaborbactam (Iso-1360457-46-0)

Target: Antibacterial

Carbenicillin disodium

Cat.No: T1143

Synonym: BRL-2064,羧苄青霉素钠,Sodium carbenicillin

Target: Cell wall, Antibacterial, Antibiotic

Sulbactam sodium

Cat.No: T6685

Synonym: 舒巴坦钠,CP-45899-2

Target: Antibacterial, Antibiotic

Methicillin sodium salt

Cat.No: T0234

Synonym: Methicillin sodium,Meticillin sodium,甲氧西林钠

Target: Antibacterial, Antibiotic

Cat.No: T13038

Target: Antibacterial, Antibiotic

Cefditoren pivoxil

Cat.No: T1405

Synonym: 头孢妥仑匹酯,ME 1207,Cefditoren pivaloyloxymethyl ester,Cefditoren pivoxyl

Target: Antibacterial, Antibiotic

Cat.No: T23858

Synonym: WCK 5153,WCK5153

Target: Antibacterial

Cat.No: T13395L

Synonym: 齐德巴坦,WCK-5107

Target: Antibacterial

Nafcillin sodium monohydrate

Cat.No: T1312

Synonym: CL 8491,萘夫西林钠,nafcillin sodium

Target: Antibacterial, Antibiotic

Ceftiofur hydrochloride

Cat.No: T6268

Synonym: 头孢噻呋盐酸盐,Ceftiofur HCl,U-67279A,Excenel hydrochloride

Target: Antibacterial, Antibiotic

Cefepime Dihydrochloride Monohydrate

Cat.No: T0868

Synonym: Cefepime HCl,头孢吡肟二盐酸盐一水合物

Target: Antibacterial, Antibiotic, Antifection

Cat.No: T60050

Target: Antibacterial

Vaborbactam ammonium salt

Cat.No: T17210L

Synonym: RPX7009 ammonium salt,Vaborbactam ammonium salt（1360457-46-0 Free base）

Target: Antibacterial

WCK-4234 sodium

Cat.No: T23801

Synonym: WCK-4234,WCK4234,WCK 4234

Target: Antibacterial

Cat.No: T68137

Synonym: GV104326

Target: Antibiotic

Cat.No: T12166

Synonym: OP0595 free acid,那库巴坦

Target: Antibacterial

Taniborbactam dihydrochloride

Cat.No: T13077

Synonym: VNRX-5133 dihydrochloride,Taniborbactam 2HCl

Target: Antibacterial, Antifungal

Durlobactam sodium salt

Cat.No: T11125

Synonym: 杜巴坦,ETX2514 sodium salt,杜洛巴坦

Target: Antibacterial

Clavulanic Acid

Cat.No: T19860

Synonym: BRL 14151,MM-14151,MM 14151,RX-10100,MM14151,BRL14151,BRL-14151

Target: Antibacterial, Antifungal

Cat. No.	Product Name	Target	Signaling Pathways
TN7257	β-LactaMase	Antibiotic	Microbiology/Virology
	β-LactaMase 是细菌产生的酶，可水解青霉素类等抗生素，活性可被乙二胺四乙酸（EDTA）所抑制。
T8261	Ceftazidime Pentahydrate 头孢他啶五水合物,头孢他啶	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftazidime pentahydrate 是一种β-内酰胺类抗菌剂，对革兰氏阳性和革兰氏阴性需氧细菌有广谱活性，可静脉内或肌肉给药。它对肠杆菌科特别有效，对大多数 β-内酰胺酶具有抗水解作用。
T15638	K-252c	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in human chronic myelogenous leukemia cancer cells.

天然产物

Cat.No: TN7257

Target: Antibiotic

Ceftazidime Pentahydrate

Cat.No: T8261

Synonym: 头孢他啶五水合物,头孢他啶

Target: Antibacterial, Antibiotic

Cat.No: T15638

Target: PKC

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00588	Beta-lactamase Protein, E. coli, Recombinant (His & SUMO) ampC,Cephalosporinase,ampA,Beta-lactamase	E. coli	E. coli
	This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
TMPH-02373	Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) Metallo-beta-lactamase type 2,B2 metallo-beta-l...	Klebsiella pneumoniae	E. coli
	Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
TMPH-03488	Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) Metallo-beta-lactamase type 2,BLA-IMP,Metallo-beta-...	Serratia marcescens	E. coli
	Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P52699.
TMPH-03165	Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) Beta-lactamase,ampC,ampA,Cephalosporinase	Pseudomonas aeruginosa	E. coli
	Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.7 kDa and the accession number is P24735.
TMPH-00584	Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) men1,Beta-lactamase MEN-1,Cefotaximase 1,Beta-l...	E. coli	E. coli
	Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
TMPH-03164	Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) Beta-lactamase OXA-10,bla,Beta-lactamase P...	Pseudomonas aeruginosa	E. coli
	Hydrolyzes both carbenicillin and oxacillin. Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.5 kDa and the accession number is P14489.
TMPH-00585	Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) Beta-lactamase MEN-1,Cefotaximase 1,bla,men1,Beta-<...	E. coli	P. pastoris (Yeast)
	Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
TMPH-03474	Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant bla,Beta-lactamase CTX-M-2,Cefotaximase 2	Salmonella typhimurium	E. coli
	Has cefotaxime-hydrolyzing activity. Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 28.4 kDa and the accession number is P74841.
TMPH-00586	Beta-lactamase TEM Protein, E. coli, Recombinant (His) IRT-4,Penicillinase,TEM-2,TEM-16/CAZ-7,Beta-lactamase	E. coli	P. pastoris (Yeast)
	TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lacta...
TMPH-00587	Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) IRT-4,TEM-16/CAZ-7,Penicillinase,Beta-lactamase TEM...	E. coli	E. coli
	TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lacta...
TMPH-02368	KPC Protein, Klebsiella oxytoca, Recombinant (His & SUMO) Carbapenem-hydrolyzing beta-lactamase KPC-2,Carbape...	Klebsiella oxytoca	E. coli
	Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency. KPC Protein, Klebsiella oxytoca, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.5 kDa and the accession number is Q848S6.
TMPJ-01157	LACTB2 Protein, Human, Recombinant (GST) β-Lactamase-Like Protein 2,LACTB2,Beta-Lactamas...	Human	E. coli
	β-Lactamase-like Protein 2 (LACTB2) is a number of the metallo-beta-lactamase superfamily.LACTB2 also belongs to the Glyoxalase II family. LACTB2 is 288 amino acids long with 8 zinc-binding domains. The LACTB2 gene is expressed at high levels and annotates structural defects or features in 4 cDNA clones. LACTB2 proteins are expected to have hydrolase activity and metal ion-binding functions. LACTB2 protein is found to localize in mitochondrion. Other functions of LACTB2 is yet unknown.
TMPH-00019	BlaNDM-1 Protein, Acinetobacter baumannii, Recombinant (His & SUMO) Class B carbapenemase NDM-1,NDM-1,NDM-1 metallo-beta-lac...	Acinetobacter baumannii	E. coli
	BlaNDM-1 Protein, Acinetobacter baumannii, Recombinant (His & SUMO) is expressed in E. coli with N-terminal 6xHis-SUMO tag. The predicted molecular weight is 22.0 kDa. Accession number: F8UNN7
TMPH-03602	BLIP Protein, S. clavuligerus, Recombinant (His & SUMO) Beta-lactamase inhibitory protein,BLIP	Streptomyces clavuligerus	E. coli
	Inhibits a wide variety of beta lactamases. BLIP Protein, S. clavuligerus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 33.5 kDa and the accession number is P35804.
TMPH-02370	SHV-3 Protein, Klebsiella pneumoniae, Recombinant (His) bla,Beta-lactamase SHV-3	Klebsiella pneumoniae	E. coli
	This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
TMPH-02371	SHV-5 Protein, Klebsiella pneumoniae, Recombinant (His & Myc) Beta-lactamase SHV-5,bla	Klebsiella pneumoniae	E. coli
	SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime. SHV-5 causes particularly high levels of resistance to aztreonam and ceftazidime.
TMPH-02369	SHV-1 Protein, Klebsiella pneumoniae, Recombinant (His) PIT-2,Beta-lactamase SHV-1,bla	Klebsiella pneumoniae	P. pastoris (Yeast)
	SHV-1 Protein, Klebsiella pneumoniae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 30.9 kDa and the accession number is P0AD64.
TMPY-02447	Shiga toxin II subunit B Protein, E. coli, Recombinant (His)	E. coli	E. coli
	E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic group of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli (EHEC). A total of 3222 outbreak cases (including 39 deaths) have been reported in northern Germany in May through June 2011. The outbreak strain was typed as an enteroaggregativ...
TMPY-02288	Glyoxalase II/HAGH Protein, Human, Recombinant (His) HAGH1,GLO2,GLX2,hydroxyacylglutathione hydrolase,GLXII	Human	E. coli
	HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathio...

重组蛋白

Beta-lactamase Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00588

Species: E. coli

Expression System: E. coli

Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His)

Cat.No: TMPH-02373

Species: Klebsiella pneumoniae

Expression System: E. coli

Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc)

Cat.No: TMPH-03488

Species: Serratia marcescens

Expression System: E. coli

Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)

Cat.No: TMPH-03165

Species: Pseudomonas aeruginosa

Expression System: E. coli

Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00584

Species: E. coli

Expression System: E. coli

Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)

Cat.No: TMPH-03164

Species: Pseudomonas aeruginosa

Expression System: E. coli

Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His)

Cat.No: TMPH-00585

Species: E. coli

Expression System: P. pastoris (Yeast)

Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant

Cat.No: TMPH-03474

Species: Salmonella typhimurium

Expression System: E. coli

Beta-lactamase TEM Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00586

Species: E. coli

Expression System: P. pastoris (Yeast)

Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00587

Species: E. coli

Expression System: E. coli

KPC Protein, Klebsiella oxytoca, Recombinant (His & SUMO)

Cat.No: TMPH-02368

Species: Klebsiella oxytoca

Expression System: E. coli

LACTB2 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01157

Species: Human

Expression System: E. coli

BlaNDM-1 Protein, Acinetobacter baumannii, Recombinant (His & SUMO)

Cat.No: TMPH-00019

Species: Acinetobacter baumannii

Expression System: E. coli

BLIP Protein, S. clavuligerus, Recombinant (His & SUMO)

Cat.No: TMPH-03602

Species: Streptomyces clavuligerus

Expression System: E. coli

SHV-3 Protein, Klebsiella pneumoniae, Recombinant (His)

Cat.No: TMPH-02370

Species: Klebsiella pneumoniae

Expression System: E. coli

SHV-5 Protein, Klebsiella pneumoniae, Recombinant (His & Myc)

Cat.No: TMPH-02371

Species: Klebsiella pneumoniae

Expression System: E. coli

SHV-1 Protein, Klebsiella pneumoniae, Recombinant (His)

Cat.No: TMPH-02369

Species: Klebsiella pneumoniae

Expression System: P. pastoris (Yeast)

Shiga toxin II subunit B Protein, E. coli, Recombinant (His)

Cat.No: TMPY-02447

Species: E. coli

Expression System: E. coli

Glyoxalase II/HAGH Protein, Human, Recombinant (His)

Cat.No: TMPY-02288

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0530	Sulbactam-d2
	Sulbactam-d2 是 Sulbactam 的氘代化合物。Sulbactam 的 CAS 号为 68373-14-8。Sulbactam是一种竞争性、不可逆的 β-内酰胺酶抑制剂，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
TMIJ-0182	Avibactam sodium salt-13C5
	Avibactam sodium salt-13C5 是 Avibactam sodium salt 的 13C 的标记化合物。Avibactam sodium salt 的 CAS 号为 1192491-61-4。Avibactam sodium 是一种可逆的 β-内酰胺酶抑制剂，抑制 TEM-1，P99和KPC-2 β-内酰胺酶，IC50分别为8、80和38 nM。

同位素标记化合物

Cat.No: TMIH-0530

Avibactam sodium salt-13C5

Cat.No: TMIJ-0182

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