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Search Results for " invasive "

Targets Recommended: Antifungal

35

抑制剂 & 化合物

14

天然产物

2

化合物库

22

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L4500	抗真菌库		252 compounds
	252 个抗真菌活性化合物的独特集合，包含作用于真菌相关靶点的化合物和临床中用于真菌类疾病的药物，是相关疾病药物筛选的有效工具。
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

Cat.No: L4500

Compounds: 252

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

Cat. No.	Product Name	Target	Signaling Pathways
T3934	Isavuconazonium sulfate	Antifungal	Microbiology/Virology
	Isavuconazonium sulfate 是一种口服活性抗真菌药，是活性三唑类抗真菌药物 Isavuconazole 的前药，可用于侵袭性曲霉菌病和毛霉菌病。
T9211	Mito-LND Mito-Loidamine	OXPHOS; Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Mito-LND (Mito-Loidamine) 是一种有口服活性和靶向线粒体的氧化磷酸化抑制剂。它抑制线粒体生物能，刺激活性氧的形成，并诱导肺癌细胞自噬细胞死亡。
T5519	Bivalirudin BG-8967,比伐卢定,Hirulog-1	Thrombin	Proteases/Proteasome
	Bivalirudin (BG-8967) 是一种直接凝血酶(thrombin)抑制剂，是一种肽类抗凝剂，可在侵入性心脏病，特别是在经皮冠状动脉介入中用于抗凝。
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T25813	Milenperone R 34009,R-34009,R34009	Others	Others
	Milenperone (R 34009) 是一种新型抗侵袭化合物，可用于控制癫痫和酗酒患者行为障碍。
T34705	SR4554 SR 4554	Others	Others
	SR4554 是通过 19F 磁共振波谱（MRS）检测到的含氟 2-硝基咪唑无创肿瘤缺氧探针，用于检测肿瘤缺氧。
T1898	RKI-1447 RKI1447	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	RKI-1447 是一种高效的ROCK1和ROCK2的小分子抑制剂，IC50值分别为14.5和6.2 nM。
T21483	Tricaine methanesulfonate 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222	Others	Others
	Tricaine methanesulfonate (MS-222) 常用于固定鱼的标记和运输，并能抑制入侵过程中的感觉系统。
T17239	VU0155069 CAY10593	Phospholipase	Metabolism
	VU0155069 在 transwell 试验中强烈抑制几种癌细胞系的侵袭性迁移。 VU0155069 是一种选择性磷脂酶 D1 抑制剂（体外 IC50：46 nM）。
T25384	Erbulozole R-55104,R55104,R 55104	Microtubule Associated	Cytoskeletal Signaling
	Erbulozole (R 55104) 是一种有效的合成微管抑制剂，具有抗侵袭、抗肿瘤和放射增敏活性，可诱发 Wernicke 脑病样神经毒性。
T64695	IR-808 MHI-148
	IR-808 (MHI-148) 是一种近红外菁染料，可用于无创癌症成像、诊断和成像引导光热治疗。
T35368	N-butyl-N-(4-hydroxybutyl) nitrosamine 4-Hydroxybutylbutylnitrosamine,N-Nitrosobutylbutanolamine,OH-BBN,N-butyl-N-(4-hydroxybutyl) nitrosamine,BBN,N-Butyl-N-(4-hydroxybutyl)nitrosamine,4-(Butylnitrosamino)-1-butanol	Others	Others
	N-butyl-N-(4-hydroxybutyl) nitrosamine (N-Nitrosobutylbutanolamine) (BBN, OH-BBN) 是一种模型化合物，可诱导膀胱中的高级别侵袭性肿瘤。
TQ0223	Lusutrombopag 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Lusutrombopag (Mulpleta) 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。
T60952	Fluridone EL-171	Others	Others
	Fluridone (EL-171) 是一种有效的合成脱落酸 (ABA) 的抑制剂，抑制 AchnFAR 和 TF 基因的表达，减少伯醇的形成。Fluridone 常作为水生除草剂用于控制入侵植物，也被用来控制水螅和欧亚水螅等物种。
T9912	Trastuzumab	EGFR; ADC Antibody	Angiogenesis; Antibody-drug Conjugate/ADC Related; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Trastuzumab 属于人源化单克隆抗体，可以高亲和力与 HER2 选择性结合。Trastuzumab 具有抗肿瘤活性，可用于治疗 HER2 阳性肿瘤。Trastuzumab 可以诱导细胞周期阻滞，介导细胞毒性，抑制 DNA 损伤修复。
T30040	Amphocil Amphotericin B cholesteryl sulfate	Others	Others
	Amphocil is used to treat patients with invasive fungal infection.
T25925	p-DDAP pDDAP,p-Dodecylaminophenol	Others	Others
	p-DDAP is an anti-invasive agent that acts by significantly suppressing cell invasion, and the activity and mRNA expression of matrix metalloproteinase-9 (MMP-9).
T40861	Nerindocianine	Others	Others
	Nerindocianine is a hydrophilic, fluorescent diagnostic contrast agent that is predominantly metabolized by the kidneys, enabling non-invasive, intraoperative ureteral imaging.
T68425	Saracatinib difumarate	Others	Others
	Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.
T11325	Frondoside A	Others	Others
	possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,
T70703	DK-139	Others	Others
	DK-139 is an inhibitor of NF-kappaB-mediated GROalpha expression, suppressing the TNFalpha-induced invasive capability of MDA-MB-231 human breast cancer cells.
T69769	BDP8900	Others	Others
	BDP8900 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. BDP8900 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character.
T71965	KRIBB3	Others	Others
	KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27.
TD0087L	Sulfo-Cy5.5 Trifluoroacetate	Others	Others
	Sulfo-Cy5.5 Trifluoroacetate 是一种氰基染料，非常适用于无创体内近红外成像，适用于需要低荧光背景的应用。
T74959	Antifungal agent 41	Others	Others
	Antifungal agent 41 (compound B01) 是一种抗真菌剂。Antifungal agent 41 在体内外表现出对白假丝酵母菌的抗性。Antifungal agent 41 可以用于侵袭性真菌感染的研究。
T11314	Fosmanogepix APX001,E1211	Others	Others
	Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
T79789	DT-6	TGF-beta/Smad	Stem Cells
	DT-6为一有效TGF-β1抑制剂，能够抑制M2巨噬细胞诱导的上皮至间质转化(Epithelial-Mesenchymal Transition, EMT)及癌细胞侵袭性迁移，可用于癌症相关疾病研究。
T74956	Chitin synthase inhibitor 10	Others	Others
	Chitin synthase inhibitor 10为一种高效的几丁质合酶(CHS)抑制剂，具有0.11 mM的IC50，表现出显著的CHS抑制活性。作为抗真菌剂，该化合物对包括C. albicans和C. neoformans在内的耐药真菌变体有效，适合用于侵袭性真菌感染(IFI)研究。
T80591	Efungumab
	Efungumab为一种单克隆抗体，对抗真菌(fungal)活性。该化合物通过与HSP90结合，抑制对真菌生存必需的构象变化。Efungumab主要用于侵袭性念珠菌感染(IC)的研究。
T72569	Cathepsin L/S-IN-1	Others	Others
	CathepsinL/S-IN-1 是 Cathepsin L 和 Cathepsin S 的双重抑制剂，IC50分别为 4.10 μM 和 1.79 μM。CathepsinL/S-IN-1 对胰腺癌 BxPC-3 和 PANC-1 细胞具有显著的抗转移和侵袭作用。
T63077	Chitin synthase inhibitor 12	Others	Others
	Chitin synthase inhibitor 12 是一种几丁质合酶 (CHS) 抑制剂，具有优异的 CHS 抑制作用 (IC50: 0.16 mM)。Chitin synthase inhibitor 12 也是一种广谱抗真菌剂，对耐药真菌变体（如 C. albicans、C. neoformans）具有抗性。Chitin synthase inhibitor 12 能够用于研究侵袭性真菌感染 (IFIs)。
T69269	DMGF	Others	Others
	DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). MGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization DMGF may be further developed to...
T75363	Fluorescein Di-β-D-Glucuronide
	Fluorescein Di-β-D-Glucuronide 作为一款荧光探针，以其非侵入性的优势被广泛应用于裸鼠肠道细菌β-葡萄糖醛酸酶（βG）活性成像研究中。该探针通过成像技术有效揭示了肠道细菌β-葡萄糖醛酸酶在体内外的活性，进而为特定细菌β-葡萄糖醛酸酶抑制剂的药效学评估提供了重要工具。
T62090	(Rac)-Tanomastat	Others	Others
	Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂，能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中，Tanomastat 表现出抗侵袭和抗转移作用。
T30783	CDy9 CDy 9,CDy-9	Others	Others
	CDy9 is a highly selective fluorescent probe for the detection and isolation of mESC using fluorescence microscopy and flow cytometry. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities. CD

化合物

Isavuconazonium sulfate

Cat.No: T3934

Target: Antifungal

Cat.No: T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat.No: T5519

Synonym: BG-8967,比伐卢定,Hirulog-1

Target: Thrombin

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Cat.No: T25813

Synonym: R 34009,R-34009,R34009

Target: Others

Cat.No: T34705

Synonym: SR 4554

Target: Others

Cat.No: T1898

Synonym: RKI1447

Target: ROCK

Tricaine methanesulfonate

Cat.No: T21483

Synonym: 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222

Target: Others

Cat.No: T17239

Synonym: CAY10593

Target: Phospholipase

Cat.No: T25384

Synonym: R-55104,R55104,R 55104

Target: Microtubule Associated

Cat.No: T64695

Synonym: MHI-148

N-butyl-N-(4-hydroxybutyl) nitrosamine

Cat.No: T35368

Synonym: 4-Hydroxybutylbutylnitrosamine,N-Nitrosobutylbutanolamine,OH-BBN,N-butyl-N-(4-hydroxybutyl) nitrosamine,BBN,N-Butyl-N-(4-hydroxybutyl)nitrosamine,4-(Butylnitrosamino)-1-butanol

Target: Others

Cat.No: TQ0223

Synonym: 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta

Target: Thrombin, Thrombopoietin Receptor

Cat.No: T60952

Synonym: EL-171

Target: Others

Cat.No: T9912

Target: EGFR, ADC Antibody

Cat.No: T30040

Synonym: Amphotericin B cholesteryl sulfate

Target: Others

Cat.No: T25925

Synonym: pDDAP,p-Dodecylaminophenol

Target: Others

Cat.No: T40861

Target: Others

Saracatinib difumarate

Cat.No: T68425

Target: Others

Cat.No: T11325

Target: Others

Cat.No: T70703

Target: Others

Cat.No: T69769

Target: Others

Cat.No: T71965

Target: Others

Sulfo-Cy5.5 Trifluoroacetate

Cat.No: TD0087L

Target: Others

Antifungal agent 41

Cat.No: T74959

Target: Others

Cat.No: T11314

Synonym: APX001,E1211

Target: Others

Cat.No: T79789

Target: TGF-beta/Smad

Chitin synthase inhibitor 10

Cat.No: T74956

Target: Others

Cat.No: T80591

Cathepsin L/S-IN-1

Cat.No: T72569

Target: Others

Chitin synthase inhibitor 12

Cat.No: T63077

Target: Others

Cat.No: T69269

Target: Others

Fluorescein Di-β-D-Glucuronide

Cat.No: T75363

(Rac)-Tanomastat

Cat.No: T62090

Target: Others

Cat.No: T30783

Synonym: CDy 9,CDy-9

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5834	Myrcene	Others	Others
	Myrcene 是具有可挥发性的芳香族化合物，对 TNFα 诱导的 NF-κB 具有抑制作用，且具有抗侵袭的能力。
T13509	4-Vinylphenol	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Vinylphenol 是酒中乳酸菌对香豆酸和阿魏酸的代谢产物，在白花蛇舌草中发现。 4-Vinylphenol 在体内诱导细胞凋亡。
T8193	α-Thujone Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮	Apoptosis; Reactive Oxygen Species; GABA Receptor; AChR; Parasite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	α-Thujone 是一种从西方金钟柏精油中分离出来的单萜，可穿透血脑屏障。它是 GABAA 受体的可逆调节剂，在抑制 GABA 诱导的电流时，它的 IC50为 21 μM。它诱导 ROS 依赖性细胞毒性，还诱导细胞凋亡和自噬。它具有抗伤害，抗肿瘤、杀虫和驱虫活性。
T5S0689	Demethylwedelolactone 去甲蟛蜞菊内酯,去甲基蟛蜞内酯	Serine Protease	Proteases/Proteasome
	Demethylwedelolactone 是一种分离自 Eclipta alba 中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭，是一种有效的trypsin 抑制剂(IC50:3.0 μM)。
T13741	Isoviolanthin 异佛莱心苷,异佛来心苷	Others	Others
	Isoviolanthin 是一种黄酮类苷类化合物，提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力，对正常细胞没有毒性影响，对转移性肝癌晚期具有潜在的研究价值。
T2787	Picroside I 6'-Cinnamoylcatalpol,胡黄连苦苷I	MMP; STAT	JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物，是有肝脏保护作用的代谢成分，可用于哮喘研究，有减轻炎症作用，还下调 pSTAT6 和 GATA3 表达。
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T4S1551	Cinnamaldehyde Cinnamic Aldehyde,肉桂醛	HIF	Angiogenesis; Chromatin/Epigenetic
	Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生，发挥血管扩张和抗癌作用。它似乎是一种有希望的候选药物，可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。它在抑制黑色素瘤的发生和发展方面具有一定的作用，其作用机制可能表现为抑制VEGF 和HIF-α的表达，从而使血管模拟和黑色素瘤细胞新生血管的形成，促进肿瘤的生长。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T12403	Penitrem A	Others	Others
	Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
TN1867	Licoricidin	MMP; VEGFR; ROS	Angiogenesis; Immunology/Inflammation; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
TN1881	Lucidenic acid C 赤芝酸 C,赤芝酸C	MMP	Proteases/Proteasome
	Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells.
T16035	Meleagrin	Others	Others
	Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.

天然产物

Cat.No: T5834

Target: Others

Cat.No: T13509

Target: Apoptosis, Endogenous Metabolite

Cat.No: T8193

Synonym: Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Demethylwedelolactone

Cat.No: T5S0689

Synonym: 去甲蟛蜞菊内酯,去甲基蟛蜞内酯

Target: Serine Protease

Cat.No: T13741

Synonym: 异佛莱心苷,异佛来心苷

Target: Others

Cat.No: T2787

Synonym: 6'-Cinnamoylcatalpol,胡黄连苦苷I

Target: MMP, STAT

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T4S1551

Synonym: Cinnamic Aldehyde,肉桂醛

Target: HIF

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: T12403

Target: Others

Cat.No: TN1867

Target: MMP, VEGFR, ROS

Lucidenic acid C

Cat.No: TN1881

Synonym: 赤芝酸 C,赤芝酸C

Target: MMP

Cat.No: T16035

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05030	PCDH7 Protein, Human, Recombinant (His) BHPCDH	Human	Baculovirus Insect Cells
	PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cancer. The low PCDH7 expression is a potential prognostic biomarker for primary non-muscle invasive bladder cancer (NMIBC). PCDH7 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 94 kDa and the accession number...
TMPY-02030	CD82 Protein, Human, Recombinant (His) CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1...	Human	HEK293 Cells
	CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud...
TMPY-00117	FGF-16 Protein, Human, Cynomolgus, Recombinant fibroblast growth factor 16	Human,Cynomolgus	Baculovirus Insect Cells
	Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ...
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His) CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in...
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPY-05055	GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His) GGH/Glutamyl hydrolase γ,γ-glutamyl hydrolase (conjugase, fo...	Human	HEK293 Cells
	gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.
TMPH-01876	Plexin-B1 Protein, Human, Recombinant (mFc) Plexin-B1,Semaphorin receptor SEP,PLXNB1	Human	HEK293 Cells
	Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 83.2 kDa and the accession number is O43157.
TMPK-00030	LAIR2 Protein, Human, Recombinant (Avi & His) CD306,LAIR-2,LAIR2,MGC71634,XXbac-BCX535A19.6	Human	HEK293 Cells
	The leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) shows increased expression during pregnancy and its reduced expression is associated with pregnancy complications. Although LAIR2 was expressed in the human placenta villus and decidua in the first trimester of pregnancy, it was not expressed in mouse tissues. Knockdown of LAIR2 markedly improved cell viability and inhibited the invasive ability of HTR8/SVneo cells.
TMPY-00610	RAB2 Protein, Mouse, Recombinant (His) C80220,Rab2,RAB2A, member RAS oncogene family,9330148M11Rik	Mouse	E. coli
	RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness of breast cancer (BC) cell lines.RAB2A is amplified and elevated in human BC and is a powerful and independent predictor of disease recurrence in BC patients. Thus, RAB2A is a novel trafficking determinant essential for regulation of a mesenchymal invasive program of BC dissemination. At the cellular levels, RAB2A controls both canonical polarized Golgi-to-Plasma membrane traff...
TMPH-01875	Plexin-B1 Protein, Human, Recombinant (His) Semaphorin receptor SEP,PLXNB1,Plexin-B1	Human	E. coli
	Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 56.4 kDa and the accession number is O43157.
TMPY-01346	Psoriasin/S100A7 Protein, Human, Recombinant S100 calcium binding protein A7,PSOR1,S100A7c	Human	E. coli
	Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role...
TMPH-01226	CRMP1 Protein, Human, Recombinant ULIP3,Collapsin response mediator protein 1,CRMP1,Dihydropyr...	Human	E. coli
	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis. CRMP1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted mole...
TMPY-06762	PCDH7 Protein, Human, Recombinant (His & Avi), Biotinylated BHPCDH	Human	Baculovirus Insect Cells
	PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cancer. The low PCDH7 expression is a potential prognostic biomarker for primary non-muscle invasive bladder cancer (NMIBC). PCDH7 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in Baculovirus insect cells with His and Avi tag. The predicted molecular weight is 95....
TMPK-00720	Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated CD170,CD33 antigen-like 2,OBBP2,SIGLEC5,OB-BP2,CD33L2	Human	HEK293 Cells
	Group B Streptococcus (GBS) causes invasive infections in human newborns. the GBS β-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes.the polymorphism could influence the risk of prematurity among human fetuses of mothers colonized with GBS. This first functionally proven example of a paired receptor system in the Siglec family has multiple implications for regulation of host immunity.
TMPK-01070	LRRC15 Protein, Mouse, Recombinant (His) LIB,LRRC15	Mouse	HEK293 Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPK-00338	LRRC15 Protein, Human, Recombinant (His & Avi) LRRC15,LIB	Human	CHO Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPK-01309	LRRC15 Protein, Canine, Recombinant (His) LIB,LRRC15	Canine	HEK293 Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPY-02847	Moesin Protein, Human, Recombinant (aa 1-346, His) moesin,HEL70	Human	E. coli
	Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. It seems that ERM proteins function as cross-linkers between plasma membranes and actin-based cytoskeletons. The sole Drosophila ERM protein, moesin, functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking moesin lose epithelial characteristics and adopt invasi...
TMPK-01380	LRRC15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) LIB,EGM_11224,LRRC15	Cynomolgus,Rhesus	HEK293 Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPY-02497	S100A15 Protein, Mouse, Recombinant (His & MBP) S100a17l1,Gm1020,S100a15a,AY465109,S100A7f,S100A7L1,S100 cal...	Mouse	E. coli
	Koebnerisin is also known as protein S100-A7A (S100A7A), S100 calcium-binding protein A7-like 1 (S100A7L1) or S100 calcium-binding protein A15 (S100A15). Human S100A7A / S100A15 is a novel member of the S100 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesti...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) DAPK,death-associated protein kinase 1,ROCO3	Human	Baculovirus Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g...
TMPJ-00281	CADM1 Protein, Mouse, Recombinant (hFc) IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...	Mouse	HEK293 Cells
	Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in...

重组蛋白

PCDH7 Protein, Human, Recombinant (His)

Cat.No: TMPY-05030

Species: Human

Expression System: Baculovirus Insect Cells

CD82 Protein, Human, Recombinant (His)

Cat.No: TMPY-02030

Species: Human

Expression System: HEK293 Cells

FGF-16 Protein, Human, Cynomolgus, Recombinant

Cat.No: TMPY-00117

Species: Human,Cynomolgus

Expression System: Baculovirus Insect Cells

RON/CD136 Protein, Human, Recombinant (His)

Cat.No: TMPY-02028

Species: Human

Expression System: HEK293 Cells

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His)

Cat.No: TMPY-05055

Species: Human

Expression System: HEK293 Cells

Plexin-B1 Protein, Human, Recombinant (mFc)

Cat.No: TMPH-01876

Species: Human

Expression System: HEK293 Cells

LAIR2 Protein, Human, Recombinant (Avi & His)

Cat.No: TMPK-00030

Species: Human

Expression System: HEK293 Cells

RAB2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00610

Species: Mouse

Expression System: E. coli

Plexin-B1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01875

Species: Human

Expression System: E. coli

Psoriasin/S100A7 Protein, Human, Recombinant

Cat.No: TMPY-01346

Species: Human

Expression System: E. coli

CRMP1 Protein, Human, Recombinant

Cat.No: TMPH-01226

Species: Human

Expression System: E. coli

PCDH7 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06762

Species: Human

Expression System: Baculovirus Insect Cells

Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00720

Species: Human

Expression System: HEK293 Cells

LRRC15 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01070

Species: Mouse

Expression System: HEK293 Cells

LRRC15 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00338

Species: Human

Expression System: CHO Cells

LRRC15 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01309

Species: Canine

Expression System: HEK293 Cells

Moesin Protein, Human, Recombinant (aa 1-346, His)

Cat.No: TMPY-02847

Species: Human

Expression System: E. coli

LRRC15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-01380

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

S100A15 Protein, Mouse, Recombinant (His & MBP)

Cat.No: TMPY-02497

Species: Mouse

Expression System: E. coli

DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)

Cat.No: TMPY-04417

Species: Human

Expression System: Baculovirus Insect Cells

CADM1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00281

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0250	Lusutrombopag-d13
	Lusutrombopag-d13 是 Lusutrombopag 的氘代化合物。Lusutrombopag 的 CAS 号为 1110766-97-6。Lusutrombopag 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。

同位素标记化合物

Lusutrombopag-d13

Cat.No: TMIJ-0250

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