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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2494 |
Cilengitide
西仑吉肽,EMD 121974 |
Integrin; Autophagy | Autophagy; Cytoskeletal Signaling |
Cilengitide (EMD 121974) 是一种有效的 αvβ3/5 受体整合素抑制剂,可抑制 ανβ3和 ανβ5与玻连蛋白结合,IC50值分别为 4 和 79 nM。 | |||
T21785 |
AG957
|
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Tyrphostin AG957 是一种酪氨酸激酶抑制剂,具有抗BCR/ABL 酪氨酸激酶活性。它能够抑制p210bcr/abl 酶活性 (IC50:2.9 μM)。 | |||
TQ0250 |
CWHM-12
|
Integrin | Cytoskeletal Signaling |
CWHM-12 是 αV 整合素的有效抑制剂,抑制αvβ8、αvβ3、αvβ6和αvβ1,IC50 为 0.2、0.8、1.5 和 1.8 nM。 | |||
T7566L1 |
GRGDSPK acetate
GRGDSPK acetate(111119-28-9 Free base) |
Beta Amyloid | Neuroscience |
GRGDSPK acetate 显示出对整合素-纤连蛋白结合的抑制活性,可用于研究整合素在骨形成和吸收中的作用。 | |||
T6966 |
RGD
RGD (Arg-Gly-Asp) Peptides,Arg-Gly-Asp,RGD Peptides |
Integrin | Cytoskeletal Signaling |
RGD (RGD (Arg-Gly-Asp) Peptides) 是一种细胞粘附基序,可以模拟细胞粘附蛋白并与整合素结合。 | |||
T2537 |
Tirofiban hydrochloride monohydrate
Tirofiban Hydrochloride,盐酸替罗非班水合物,MK-383 Hydrochloride,盐酸替罗非班 |
ATPase; Integrin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) 是一种非肽类糖蛋白IIb/IIIa 的拮抗剂。 | |||
T5310 |
TR-14035
MDK-1191 |
Integrin | Cytoskeletal Signaling |
TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7/α4β1整合素双重抑制剂,对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM,可用于炎症和自体免疫疾病的研究。 | |||
T4613 |
Arg-Gly-Asp TFA (99896-85-2(free base))
RGD Trifluoroacetate,RGD |
Integrin | Cytoskeletal Signaling |
Arg-Gly-Asp TFA (99896-85-2(free base)) (RGD Trifluoroacetate) 是一种三肽,可有效触发细胞粘附、定位某些细胞系并引发特定的细胞反应;与整合素结合。 | |||
T39933 |
Bexotegrast
PLN-74809 |
Integrin | Cytoskeletal Signaling |
Bexotegrast (PLN-74809)是一种具有口服活性和强效性的 αvβ6和αvβ1 整合素抑制剂,具有抗纤维化作用,抑制 αvβ6 和 αvβ1 诱导的 TGF-β 激活,可用于研究特发性肺纤维化(IPF)和非特异性间质性肺炎(NSIP)。 | |||
T26887 |
BOP
|
Others | Others |
BOP is anantagonist of alpha4beta1/alpha9beta1 integrins. BOP rapidly mobilizes long-term multi-lineage reconstituting hematopoietic stem cells (HSC). | |||
T69517 |
Bexotegrast HCl
|
Others | Others |
Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts. | |||
T16875 |
SF1126
|
Others | Others |
SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. SF1126 is an RGDS-conjugated LY294002 prodrug, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment. | |||
T16851 | SB-267268 | Others | Others |
SB-267268 inhibits human and mouse αvβ3 (IC50s: 0.68 and 0.29 nM, respectively). SB-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (Kis: 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respective | |||
T70083 |
Cilengitide hydrochloride
|
Others | Others |
Cilengitide hydrochloride sis the salt form of Cilengitide, a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. | |||
T80214 |
cRGDfK-thioacetyl ester
|
Integrin | Cytoskeletal Signaling |
cRGDfK-thioacetyl ester 为具选择性亲和力于整合素(integrins)之生物活性多肽。可应用于修饰NIR荧光探针,实现癌症靶向成像。 | |||
T38793 |
THI0019
THI0019 |
Others | Others |
THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem/progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins. | |||
T81283 |
RGD-targeted Proapoptotic Peptide
|
||
RGD-targeted Proapoptotic Peptide为一肽类化合物,其C端RGD-4C肽段(ACDCRGDCFC)能够特异性地与肿瘤新生血管的整合素结合位点优先结合。 | |||
T79792 |
αvβ1 integrin-IN-2
|
Integrin | Cytoskeletal Signaling |
αvβ1integrin-IN-2(compound 32)作为整合素ανβ1与α5β1的抑制剂,展现出高效性,其IC50值分别为0.9 nM和33 nM。此外,该化合物对其他整合素亦有抑制作用,其IC50分别为380 nM(ανβ3)、280 nM(ανβ5)、230 nM(ανβ6)、87 nM(ανβ8)。 | |||
TP1555 |
Fibronectin Active Fragment Control
|
||
Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins.In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin | |||
T82359 |
G-{d-Arg}-GDSP
|
||
G-{d-Arg}-GDSP为RGD多肽类似物,具有与整合素粘附受体结合的能力,能够抑制细胞对纤维连接蛋白的附着及破骨细胞的重吸收。 | |||
T41153 |
BOP-JF646
BOP-JF646 |
Others | Others |
BOP-JF646 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor®646. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 655 nm; emission maximum = 672 nm. | |||
T41149 |
BOP-JF549
BOP-JF549 |
Others | Others |
BOP-JF549 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor® 549. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 549 nm; emission maximum = 571 nm. | |||
T77154 | Etrolizumab | ||
Etrolizumab (rhuMAb Beta7) 是一种肠道选择性抗-β7整合素单克隆抗体。Etrolizuma b 是针对α4β7和 αEβ7 整合素的 β7 亚基的特异性靶向活性分子。Etrolizumab 可用于炎症性肠病 (IBD) 的研究。 | |||
T76255 |
Certepetide
|
||
Certepetide (CEND-1),即双功能环肽(a.k.a. iRGD),是一种具有穿透肿瘤功能的多肽。通过与α-V整联蛋白(alphav-integrins)的RGD motif相互作用,以及激活神经纤毛蛋白1(NRP-1),Certepetide能够将实体瘤微环境转化成临时的活性分子通道,从而在肿瘤中累积。该化合物在胰腺癌和其他实体瘤的研究中具有应用潜力。 | |||
T75765 |
GRGDSPK TFA
|
||
GRGDSPK TFA (EMD 56574 TFA) 是一种含有精氨酸-甘氨酸-天冬氨酸 (RGD) 序列的多肽。作为竞争性且可逆的抑制剂,它能够抑制整联蛋白与纤连蛋白的结合,用于探究整联蛋白在骨形成及吸收过程中的功能。 | |||
TP1343 |
RGD Trifluoroacetate
|
||
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.RGD Trifluoroacetate is the most effective and most often employed pept | |||
T36296 |
BIO5192 hydrate
|
Others | Others |
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days... | |||
T82379 |
FN-A208 fusion peptide
|
||
FN-A208 是源自鼠层粘连蛋白 a1 的 A208 与纤连蛋白 (GRGDS) 活性位点和甘氨酸间隔区融合形成的生物活性肽。该肽能形成淀粉样原纤维,并有助于促进肌动蛋白应力纤维的形成,进而介导成纤维细胞附着,显示出其在组织再生和工程生物粘合剂方面的应用潜力。FN-A208 与 IKVAV 受体和整合素发生相互作用,而在 EDTA 存在下,其活性则会被破坏。 | |||
T36291 |
Integrin modulator 1
|
Others | Others |
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1]. Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells[1].Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36295 |
Echistatin TFA
|
Others | Others |
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01009 |
TGFBI Protein, Human, Recombinant (His)
CDG2,CSD,EBMD,CSD1,CDGG1,CSD3,transforming growth factor, be... |
Human | HEK293 Cells |
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dys... | |||
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... | |||
TMPY-01806 |
CD9 Protein, Human, Recombinant (His)
BTCC-1,DRAP-27,TSPAN29,MRP-1,CD9 molecule,MIC3,TSPAN-29 |
Human | HEK293 Cells |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d... | |||
TMPH-03716 |
Invasin Protein, Yersinia enterocolitica, Recombinant (His & SUMO)
Invasin |
Yersinia enterocolitica | E. coli |
Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins. | |||
TMPJ-01433 |
Fibronectin Protein, Human, Recombinant (ED-B domain, Avi & His), Biotinylated
Fibronectin,FN1 |
Human | E. coli |
Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans. Fibronectin plays a major role in cell adhesion, growth, migration, and differentiation, and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression, degradation, an... | |||
TMPH-02731 |
ICAM4 Protein, Mouse, Recombinant (His & SUMO)
Intercellular adhesion molecule 4,Icam4 |
Mouse | E. coli |
Adhesion molecule that binds to leukocyte adhesion LFA-1 protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. Isoform 2 may modulate binding of membrane-associated ICAM4. ICAM4 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.1 kDa and the accession number is Q9ERM2. | |||
TMPY-02761 |
Rack1 Protein, Human, Recombinant (His & MBP)
PIG21,Gnb2-rs1,H12.3,RACK1,HLC-7 |
Human | E. coli |
The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin beta subunit cytoplasmic domains and to members of two kinase families (src and protein kinase C, PKC) that mediate integrin bidirectional signaling.Rack1 may link protein kinase C directly to integrins and participate in the regulation of integrin functions.Rack1 regulates the localization of an essential PCP protein and acts as a molecular switch to promote PCP signaling. | |||
TMPH-02758 |
LIMS1 Protein, Mouse, Recombinant (His)
LIM and senescent cell antigen-like-containing domain protei... |
Mouse | Baculovirus Insect Cells |
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. LIMS1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 39.6 kDa and the accession number is Q99JW4. | |||
TMPH-02187 |
Tenascin Protein, Human, Recombinant (E. coli, His)
GMEM,Glioma-associated-extracellular matrix antigen,Neuronec... |
Human | E. coli |
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. | |||
TMPH-03685 |
Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc)
Envelope glycoprotein L,gL |
HHV-3 | E. coli |
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The... | |||
TMPH-02571 |
CD9 Protein, Mouse, Recombinant (His)
CD9 antigen,CD9 |
Mouse | E. coli |
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and... | |||
TMPK-00644 |
CD47 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
CD47,OA3,IAP,CD47 molecule,CD47 glycoprotein,MER6 |
Cynomolgus,Rhesus | HEK293 Cells |
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. | |||
TMPH-02590 |
COL4A2 Protein, Mouse, Recombinant (His)
COL4A2,Collagen alpha-2(IV) chain |
Mouse | E. coli |
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptos... | |||
TMPY-00029 |
TM4SF2/TSPAN7 Protein, Rat, Recombinant (His)
tetraspanin 7 |
Rat | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-03862 |
TM4SF2/TSPAN7 Protein, Human, Recombinant (His)
TM4SF2,A15,MXS1,tetraspanin 7,TALLA-1,CCG-B7,CD231,DXS1692E,... |
Human | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-03871 |
TM4SF2/TSPAN7 Protein, Mouse, Recombinant (His)
AI323365,Tm4sf2,PE31,A15,R74651,TALLA,Mxs1,Cd231,1200014P11R... |
Mouse | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-02289 |
CIB2 Protein, Human, Recombinant (His)
DFNB48,calcium and integrin binding family member 2,USH1J,KI... |
Human | E. coli |
Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function a... | |||
TMPY-03833 |
TM4SF2/TSPAN7 Protein, Cynomolgus, Recombinant (His)
tetraspanin 7 |
Cynomolgus | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPH-03684 |
Varicella-zoster virus (strain Dumas) glycoprotein L/gL Protein (His & Myc)
gL,Envelope glycoprotein L |
HHV-3 | E. coli |
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Varicella-zoster virus (strain Dumas) glycoprotein L/gL Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predi... | |||
TMPJ-00159 |
EMMPRIN/CD147 Protein, Human, Recombinant (Avi & His), Biotinylated
Membrane glycoprotein gp42,Basigin,HT7 antigen,Bsg,Basic imm... |
Human | HEK293 Cells |
Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore... | |||
TMPY-03930 |
TM4SF2/TSPAN7 Protein, Cynomolgus, Recombinant (mFc)
tetraspanin 7 |
Cynomolgus | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-02404 |
ADAM9 Protein, Mouse, Recombinant (His)
mKIAA0021,AU020942,ADAM metallopeptidase domain 9,Mltng,MDC9 |
Mouse | HEK293 Cells |
ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential t... | |||
TMPJ-01355 |
SEMA4G Protein, Human, Recombinant (His)
Semaphorin-4G,SEMA4G,KIAA1619 |
Human | HEK293 Cells |
Semaphorin-4G is belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and ve... | |||
TMPJ-00111 |
CD9 Protein, Human, Recombinant (hFc)
CD9 molecule,TSPAN29,BTCC1,CD9 antigen,CD9,MIC3,MRP1,DRAP-27... |
Human | HEK293 Cells |
CD9, also known as Tspan29, 5H9 antigen, Leukocyte antigen MIC3 (MIC3), Motility-related protein, is a multi-pass membrane protein which belongs to the tetraspanin (TM4SF) family or the transmembrane 4 superfamily. CD9 is a cell surface glycoprotein with 4 hydrophobic domains that is described to complex with integrins and other transmembrane 4 superfamily members. The protein takes part in cellular signal transduction events and thus play a role in the regulation of cell development and activat... | |||
TMPJ-00361 |
Endoglin Protein, Human, Recombinant (Trx & His)
CD105,END,Endoglin,ENG |
Human | E. coli |
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins an... | |||
TMPJ-00157 |
CD82 Protein, Human, Recombinant (hFc)
Tetraspanin-27,KAI1,ST6,TSPAN27,TSPAN274F9,CD82 molecule,Tsp... |
Human | HEK293 Cells |
CD82 antigen, also known as Kai-1, is a widely expressed palmitoylated molecule of the tetraspanin superfamily. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signaling. CD82/Kai-1 is a component of the promiscuous TIMP-1 interacting protein complex on the cell surface of human adenocarcinoma cells and gives insight into tumorigenic metastatic potential. CD82/Kai-1... | |||
TMPJ-01177 |
NOV/CCN3 Protein, Mouse, Recombinant (His)
CCN family member 3,Nephroblastoma-overexpressed gene protei... |
Mouse | HEK293 Cells |
NOV, also called CCN3, is a secreted protein of CCN family members. CCN family members are highly conserved cysteine rich proteins sharing a common modular structure having 4 conserved domains, insulin-like growth factor-binding protein (IGFBP) domain, von Willebrand type C (VWC) domain, thrombospondin-1 (TSP-1) domain, and C-terminal (CT) domain (absent in CCN5). By specific interactions with these domains, CCN proteins modulate multiple signalling pathways including BMPs, Wnt, TGFs, Notch and ... | |||
TMPJ-00614 |
CD47 Protein, Rhesus macaque, Recombinant (His & Flag)
MER6,Integrin-Associated Protein,IAP,Leukocyte Surface Antig... |
Rhesus | HEK293 Cells |
CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain, five membrane-spanning regions with short intervening loops, and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important r... | |||
TMPJ-00952 |
SDF-1/CXCL12 Protein, Mouse, Recombinant
Sdf1,C-X-C motif chemokine 12,Thymic lymphoma cell-stimulati... |
Mouse | E. coli |
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scaven... | |||
TMPY-01212 |
ADAM12 Protein, Human, Recombinant (His)
ADAM metallopeptidase domain 12,MLTNA,MCMP,CAR10,MLTN,MCMPMl... |
Human | HEK293 Cells |
The ADAMs (a disintegrin and metalloprotease) comprise a family of multidomain proteins with metalloprotease, cell adhesion, and signaling activities. Human ADAM12, which is implicated in diseases such as cancer, is expressed in two splice forms, the transmembrane ADAM12-L and the shorter and soluble ADAM12-S. ADAM12, also known as and Meltrin alpha, is a member of the ADAM protein family, which contains one disintegrin domain, one EGF-like domain and one peptidase M12B domain. ADAM12 is synthes... | |||
TMPY-04391 |
Lyn Protein, Human, Recombinant (GST)
JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p... |
Human | Baculovirus Insect Cells |
Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif... |