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Cat. No. | Product Name | ||
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L6140 | 糖类及苷类化合物库 | 595 compounds | |
595 种糖类或苷类的化合物,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2535 |
Ivabradine hydrochloride
盐酸伊伐布雷定,S 16257-2,Ivabradine HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Ivabradine hydrochloride (S 16257-2) 是一种可口服的,超极化激活的环核苷酸门控离子通道通道阻滞剂。 | |||
T23535L |
Xanthine amine congener trihydrochloride
Xanthine amine congener trihydrochloride (96865-92-8 Free base) |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Xanthine amine congener trihydrochloride 是一种有效的腺苷拮抗剂,可逆转由腺苷激动剂 N6-环己基腺苷产生的尿流量、钠排泄和心率的减少。 | |||
T28748 |
Selodenoson
RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Selodenoson (RG-14202) 是一种选择性腺苷 A1 受体激动剂,可用于减慢心房颤动患者的心率,治疗心律失常。 | |||
T61316 |
HTS07545
|
NADPH | Metabolism |
HTS07545 是一种有效的硫化物:醌氧化还原酶抑制剂(IC50: 30 nM)。HTS07545 可降低硫化氢 (H2S) 的分解速率。HTS07545 可用于研究心力衰竭。 | |||
T10364 |
Arbutamine
GP 21213 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Arbutamine (GP 21213) 是一种新型非选择性β-肾上腺素受体激动剂,具有α-1-拟交感神经活性。Arbutamine 促进心脏应激,增加心率、心脏收缩力。Arbutamine 可用于研究心脏应激和冠状动脉疾病。 | |||
T11879 |
LS-102
LS102 |
Ligand for E3 Ligase | PROTAC |
LS-102 是一种选择性的 E3 连接酶 synoviolin (Syvn1) 抑制剂,是 黄芪甲苷IV衍生物,通过抑制线粒体裂变来缓解心肌缺血再灌注损伤。LS-102 抑制 Syvn1 自泛素化,可改善阿霉咪唑诱导的心率减慢,有研究心血管疾病。 | |||
T0805 |
Quinapril hydrochloride
CI-906,PD-109452-2,盐酸喹那普利,Quinapril HCl |
RAAS | Endocrinology/Hormones |
Quinapril hydrochloride (PD-109452-2) 是一种血管紧张素转化酶(ACE) 抑制剂的原药。 | |||
T3126 |
Bethanechol chloride
(±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride |
AChR | Neuroscience |
Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂,是毒蕈碱型受体 (mAChR) 激动剂,通过直接刺激副交感神经系统的 mAChR 发挥作用。 | |||
T0207 |
Ranolazine dihydrochloride
盐酸雷诺嗪,雷诺嗪二盐酸盐,RS 43285,Ranolazine 2HCl |
Calcium Channel; Sodium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Ranolazine dihydrochloride (Ranolazine 2HCl) 是一种抗心绞痛和抗缺血剂,可通过抑制内向钠电流的后期作用来发挥功效,而不会影响心率或血压。它对 INa 和 IKr 的 IC50值分别为 6 μM 和 12 μM。它还是脂肪酸氧化的部分抑制剂。 | |||
TP1937L1 |
RFRP-1 (human) acetate(311309-25-8 free base)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂(NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM)。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量,并增加大鼠的血浆催乳素水平。 GnIH 同系物。 | |||
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T50008 |
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide
5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide |
Others | Others |
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) 是一种苯氧基家族化合物。它已被证明对神经系统具有刺激作用,包括神经元放电率的增加、突触传递的增加和神经递质释放的增加;还被证明对心血管系统有刺激作用,包括提高心率和血压。 | |||
T1613 |
Hydralazine hydrochloride
Hydralazine HCl,Apresoline,盐酸肼屈嗪 |
MAO; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂,可抗高血压。 | |||
TP1369L |
[Sar9,Met(O2)11]-Substance P acetate
[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) 是一种速激肽 NK1 受体选择性激动剂。它是一种选择性速激肽 NK1 受体激动剂。它和 septide(每只大鼠 10-100 pmol,i.c.v.)在增加平均动脉血压 (MAP) 和心率 (HR),但它们的时间进程不同。两种激动剂都以剂量依赖性方式增加洗脸和吸鼻,而它是一种产生美容效果的化合物。 | |||
T1056 |
Isoprenaline hydrochloride
NCI-c55630,Isoproterenol hydrochloride,Isoprenaline HCl,盐酸异丙肾上腺素 |
PI3K; Endogenous Metabolite; Adrenergic Receptor; PDE | GPCR/G Protein; Metabolism; Neuroscience; PI3K/Akt/mTOR signaling |
Isoprenaline hydrochloride (Isoproterenol hydrochloride) 是一种 β-肾上腺素能受体激动剂,具有非选择性和口服活性。Isoprenaline hydrochloride 可以扩张支气管,提高心率和心输出量,而不会收缩血管。 | |||
T71800 |
Metoprolol HCl
|
Others | Others |
Metoprolol is a selective β1 receptor blocker medication. It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines. | |||
T25237 |
Chloracyzine
Chloroacizine,Chloroacizin,Chlorazicine,Chloroacyzin |
Others | Others |
Chloracyzine can produce a decrease in myocardial oxygen consumption accompanied by a reduction in coronary blood flow preceded by transient coronary dilatation. It produced an insignificant increase in arterial pressure; heart rate increased slightly in | |||
T60393 |
Clobutinol
|
Others | Others |
Clobutinol 具有止咳作用。Clobutinol 影响心率和血压,可用于咳嗽的相关研究。 | |||
T39063 |
Azilsartan mepixetil
|
Others | Others |
Azilsartan mepixetil is a potent angiotensin II receptor antagonist with enhanced efficacy and prolonged duration of action. It exhibits more prominent and sustained effects in lowering blood pressure and heart rate, while maintaining a high level of safety. Furthermore, Azilsartan mepixetil demonstrates optimal protective efficacy for cardiovascular and renal functions. Hence, it holds promise for the research and treatment of hypertension, chronic heart failure, and diabetic nephropathy. | |||
T78523 |
Clobutinol hydrochloride
|
Potassium Channel | Membrane transporter/Ion channel |
Clobutinol hydrochloride是一种具有止咳作用的化合物,能够影响心率和血压,通常用于咳嗽相关的研究。 | |||
T69085 |
Mabuterol, (S)-
|
Others | Others |
Mabuterol, (S)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors. | |||
T69084 |
Mabuterol, (R)-
|
Others | Others |
Mabuterol, (R)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors. | |||
T68242 |
D-Mabuterol hydrochloride
|
Others | Others |
D-Mabuterol hydrochloride is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors. | |||
T80121 |
Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH2 是一种环状八肽,能够激活MC4R。该化合物能显著提高心率与血压。 | |||
TP1937 |
RFRP-1(human)
RFRP-1 (human) |
||
Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac out | |||
T75947 |
RFRP-1(human) TFA
|
||
RFRP-1(human) TFA, an endogenous NPFF receptor agonist, exhibits potent activity with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. It significantly diminishes the contractile function of isolated rat and rabbit cardiac myocytes. Moreover, it decreases heart rate, stroke volume, ejection fraction, and cardiac output, while elevating plasma prolactin levels in rats. | |||
T78657 |
Azilsartan mepixetil potassium
QR-01019K |
Others | Others |
Azilsartan mepixetil potassium (QR-01019K),是一种高效安全的血管紧张素 II 受体拮抗剂,展现出卓越的持久降压效应以及显著且持续的降心率功能,有望用于治疗高血压、慢性心力衰竭和糖尿病肾病。 | |||
T69232 |
Atropine Oxide Hydrochloride
|
Others | Others |
Atropine Oxide is a derivative of Atropine. Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surgery. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. It is classified as an anticholinergic drug (parasympatholytic). | |||
T81118 |
Spexin-2 (53-70), human,mouse,rat
NPQ 53-70 |
Others | Others |
Spexin-2 (53-70), human, mouse, rat (NPQ 53-70) 是一种在哺乳动物中保守的非酰胺化Spexin-2肽段,具备生物活性。作为新型肽激素proNPQ的一个片段,它在调节心血管与肾功能方面发挥关键作用。在大鼠体内,Spexin-2能有效降低心率并促进尿流量增加。 | |||
T23763 |
Atropine Oxide
NSC 72861,NSC72861,NSC-72861 |
Others | Others |
Atropine Oxide is a derivative of Atropine. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5. Atropine is a medication to treat certain types of nerve agents and pesticide poisonings as well as som | |||
T32426 |
KT 1
KT-1,KT1 |
Others | Others |
KT 1 decreased aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increased aortic blood flow, vertebral blood flow, coronary blood flow, peak posit | |||
T35839 |
3-Iodothyronamine (hydrochloride)
|
Others | Others |
3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output. It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-... | |||
TP1369 |
[Sar9,Met(O2)11]-Substance P TFA(110880-55-2,free)
[Sar9,Met(O2)11]-Substance P TFA |
||
[Sar9,Met(O2)11]-Substance P TFA is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissi | |||
T82567 |
Di-4-ANEPPS
|
||
Di-4-ANEPPS为膜电位电压敏感染料,时间分辨率达1 ms优于,并能够呈现每100 mV荧光变化高至10%。常用于描绘心脏电活动图,对兔离体心脏模型的自发心率和心室冲动传导显示出显著直接不可逆影响。 | |||
T82933 |
Auriculin A
|
||
Auriculin A是一种合成ANF,它对血液动力学具有显著效应。该化合物可阻断犬的肾血管收缩,并在兔子的后肢灌注压、心率及动脉血压的全身调节中发挥作用。 | |||
T72213 |
Efonidipine hydrochloride
NZ-105 hydrochloride |
Others | Others |
Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。 | |||
T60368 |
Benzoctamine
|
Others | Others |
Benzoctamine 是一种口服有效作用精神剂,具有镇静作用。Benzoctamine 增加儿茶酚胺的周转率。Benzoctamine 增强大鼠心脏中 [3H] 去甲肾上腺素的摄取。Benzoctamine 也可加速脑内注射 [3H] 去甲肾上腺素的消失。 | |||
T35543 |
Methyl Diethyldithiocarbamate
|
Others | Others |
Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Methyl diethyldithiocarbamate inhibits liver low Kmaldehyde dehydrogenase (ALDH) in rats (ID50= 15.5 mg/kg).1It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg. 1.Hart, B.W., Yourick, J.J., and... | |||
T63014 |
Ivabradine
|
Others | Others |
Ivabradine 是一种有效的、口服具有活力的 HCN (超极化激活的环核苷酸门控) 通道阻滞剂,能够抑制心脏起搏器电流 (If)。Ivabradine 以剂量依赖性的方式降低心率,且不改变血压。Ivabradine 具有抗惊厥、抗缺血和抗心绞痛作用。 | |||
T35871 |
Bopindolol (malonate)
|
Others | Others |
Bopindolol is a non-selective β-adrenergic receptor antagonist. In vivo, bopindolol decreases heart rate and blood pressure and attenuates ischemia-induced myocardial acidosis in dogs. Formulations containing bopindolol have been used to treat essential and renovascular hypertension. | |||
T36204 |
Methylatropine (nitrate)
|
Others | Others |
Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotin... | |||
T73610 |
Lipoprotein lipase
|
Others | Others |
Lipoprotein lipase 是来自于脂肪组织、心肌和骨骼肌、胰岛和巨噬细胞的多功能酶。Lipoprotein lipase 促进正常脂蛋白代谢、组织特异性底物的输送和利用。Lipoprotein lipase 催化脂质在血液循环的限速步骤。 | |||
T78540 |
α-CGRP (mouse, rat) TFA
|
CGRP Receptor | GPCR/G Protein; Neuroscience |
α-CGRP (mouse, rat) TFA 是神经系统中的一种活性神经肽,位于神经肌肉接合部,具有显著的血管舒张功能。适用于心血管疾病、炎症、偏头痛及代谢研究领域。 | |||
T75732 |
α-CGRP, rat TFA
|
Others | Others |
α-CGRP, rat TFA 是一种神经肽 (降钙素基因相关肽),主要表达于神经肌肉交界处,是一种有效的血管扩张剂量。α-CGRP, rat TFA 外周给药可使大鼠血压下降、心率升高,并使结肠平滑肌松弛。α-CGRP, rat TFA 可用于心血管、促炎、偏头痛和代谢相关的研究。 | |||
T76334 |
Cenderitide
|
||
Cenderitide 是一种有效的颗粒鸟酰基环化酶受体 (pGC) 激动剂。Cenderitide 是一种由 C 型利钠肽 (CNP) 与石斛利钠肽 (DNP) 的 C 端融合而成的利钠肽 (NP) 。Cenderitide 可激活 pGC-A 和 pGC-B,激活第二信使 cGMP,抑制醛固酮 (aldosterone),在不降低血压的情况下保持 GFR 。Cenderitide 可用于心力衰竭的研究。 | |||
T1203 |
Nadolol
Anabet,Corgard,Solgol,苯甲丁氮酮,纳多洛尔,SQ11725 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 | |||
T79358 |
PF-07247685
|
Endogenous Metabolite | Metabolism |
PF-07247685是一种BCKDC激酶(BDK)抑制剂,具有较强的活性(EC50=2.2 nM)。该化合物能有效稳定BDK与BCKDH E2核心亚基之间的相互作用,并阻断E1亚基的磷酸化过程。BCKDH的活性受到BDK介导的磷酸化调控,从而控制支链氨基酸(BCAA)降解的关键步骤。BCAA的代谢失调与心力衰竭(HF)、2型糖尿病(T2DM)、非酒精性脂肪肝病(NAFLD)及肥胖等多种疾病相关联,尤其在心脏代谢疾病中表现明显。PF-07247685在小鼠模型中对心脏代谢终点产生改善效果,并提升了葡萄糖耐量。 | |||
T79357 |
PF-07238025
|
Endogenous Metabolite | Metabolism |
PF-07238025是一种BCKDC激酶(BDK)抑制剂,具有EC50值为19 nM。它通过稳定BDK和BCKDH复合体中的E2亚基相互作用,阻碍E1亚基的磷酸化过程,从而抑制了BCKDH的活性。由于BDK的磷酸化作用是控制支链氨基酸(BCAA)降解过程中的限速步骤,PF-07238025的作用与包括心力衰竭(HF)、2型糖尿病(T2DM)、非酒精性脂肪肝病(NAFLD)及肥胖在内的多种代谢性疾病的发病机制相关。研究显示PF-07238025能在小鼠体内改善心脏代谢指标并提升葡萄糖耐量。 | |||
T40869 |
Moxonidine hydrochloride
BDF5895hydrochloride,盐酸莫索尼定 |
Others | Others |
Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Target: I1-R Moxonidine Hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). AGN192403, a selective ligand at I1-R, had no influence on the dose-response... | |||
T83721 |
Hexafluoropropylene Oxide Dimer Acid
FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA |
Others | Others |
Hexafluoropropylene oxide dimer acid (HFPO-DA)作为一种全氟烷基醚羧酸(PFECA),于HepG2细胞中以250 µM的浓度使用时,可诱导凋亡并增加活性氧种类(ROS)的水平。HFPO-DA以每个蛋4 mg/kg的剂量,会减少孵化鸡右心室壁厚度,增加心率,并诱导肝脏脂肪积累,这些效应可通过敲除过氧化物酶体增殖物激活受体α(Ppara)基因编码实现预防。它减少了斑马鱼胚胎的存活百分比(LC50 = 7,651 mg/L)。在孕妇大鼠给药下,HFPO-DA(250 mg/kg)降低了新生大鼠的平均出生体重、存活时间和血清葡萄糖水平,并增加了血清胆固醇和甘油三酯水平。它已经被发现污染海水和河水。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8183 |
Deslanoside
洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C |
ATPase; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,可抑制Na-K-ATPase 膜泵,导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常,并在研究慢性心房颤动时控制心室率。 | |||
T4S1518 |
Pseudoginsenoside RT1
拟人参皂苷 RT1,假人参皂苷RT1 |
Others | Others |
Pseudoginsenoside RT1 是分离自 Randia siamensis 中,具有鱼毒素作用。它可导致血压下降、心率加快和子宫自发收缩力增加。 | |||
TN1367 |
Alismol
泽泻醇 |
Potassium Channel; Calcium Channel; PI3K | Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. |
Cat. No. | Product Name | Species | Expression System |
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TMPY-02977 |
PDE1C Protein, Human, Recombinant (His & GST)
hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-... |
Human | Baculovirus Insect Cells |
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s... | |||
TMPY-01000 |
BVES Protein, Human, Recombinant (GST)
CARICK,LGMD2X,POP1,blood vessel epicardial substance,POPDC1,... |
Human | E. coli |
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi... | |||
TMPY-01204 |
SMYD2 Protein, Human, Recombinant (His)
ZMYND14,SET and MYND domain containing 2,HSKM-B,KMT3C |
Human | Baculovirus Insect Cells |
SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cell differentiation. SMYD2 mRNA is most highly exp... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T11692 |
Ivabradine-d3 hydrochloride
盐酸伊伐布雷定 D3,Ivabradine D3 Hydrochloride |
Others | Others |
Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine D3 Hydrochloride is the deuterium labeled Ivabradine hydrochloride. | |||
T11694 |
Ivabradine-d6 hydrochloride
盐酸伊伐布雷定 D6,Ivabradine D6 hydrochloride |
Others | Others |
Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine D6 hydrochloride is the deuterium labeled Ivabradine hydrochloride. | |||
TMIJ-0042 |
Metoprolol-d7 Hydrochloride
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Metoprolol-d7 Hydrochloride 是 Metoprolol Hydrochloride 的氘代化合物。Metoprolol Hydrochloride 的 CAS 号为 56392-18-8。Metoprolol 是一种选择性 β1 受体阻滞剂。Metoprolol 用于治疗高血压、因心脏血流不畅而引起的胸痛以及许多心率异常快的疾病。 | |||
T69598 |
Isoproterenol-d7 HCl
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Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom... | |||
TMID-0070 |
Amiodarone-d10 Hydrochloride
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Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
TMID-0069 |
Amiodarone-d4 HCl
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Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T71402 |
Nicorandil-d4
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Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =... | |||
TMIJ-0317 |
Nadolol-d9 (Mixture of Diastereomers)
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Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 |