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Search Results for " endonuclease "

Targets Recommended: Others

61

抑制剂 & 化合物

2

天然产物

11

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T63808	Cap-dependent endonuclease-IN-1	Others	Others
	Cap-dependent endonuclease-IN-1 是一种具有高效性和口服活性的帽依赖内切酶抑制剂，具有抗病毒活性，可用于研究流感病毒感染。
T61840	pUL89 Endonuclease-IN-2	Others	Others
	pUL89 Endonuclease-IN-2 (Compound 15k) is a highly effective inhibitor of the pUL89 endonuclease of human cytomegalovirus (HCMV). With an IC50 of 3.0 μM, it exhibits potent antiviral activities [1].
T60379	pUL89 Endonuclease-IN-1	Others	Others
	pUL89 Endonuclease-IN-1 (Compound 13d) 是人巨细胞病毒 (HCMV) pUL89 核酸内切酶的有效抑制剂，IC50值为 0.88 μM，具有抗病毒活性。
T63519	Cap-dependent endonuclease-IN-13	Others	Others
	Cap-dependent endonuclease-IN-13 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂，对流感病毒感染 (仅甲型流感) 表现出研究潜力。
T64138	Cap-dependent endonuclease-IN-16	Others	Others
	Cap-dependent endonuclease-IN-16 是一种吡啶酮多环衍生物，也是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-16 表现出潜力进行流感的研究。
T72124	Cap-dependent endonuclease-IN-7	Others	Others
	Cap-dependent endonuclease-IN-7 是一种有效的 cap-dependent 核酸内切酶 (CEN) 抑制剂。Cap-dependent endonuclease-IN-7 抑制病毒 mRNA 的合成并抑制病毒增殖。Cap-dependent endonuclease-IN-7 具有研究病毒感染 (包括甲型流感、乙型流感和丙型流感) 的潜力
T62208	Cap-dependent endonuclease-IN-6	Others	Others
	Cap-dependent endonuclease-IN-6 (compound 13) 是一种 Cap 依赖性内切酶 (CEN) 抑制剂，能够抑制流感病毒。
T63702	Cap-dependent endonuclease-IN-21	Others	Others
	Cap-dependent endonuclease-IN-21 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂，对流感病毒的复制具有抑制作用。Cap-dependent endonuclease-IN-21 对流感病毒感染 (流感 A) 表现出研究潜力。
T63946	Cap-dependent endonuclease-IN-14	Others	Others
	Cap-dependent endonuclease-IN-14 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂，能够抑制流感病毒的复制。Cap-dependent endonuclease-IN-14 对流感病毒引起的病毒感染表现出潜力。
T63703	Cap-dependent endonuclease-IN-23	Others	Others
	Cap-dependent endonuclease-IN-23 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂，对流感病毒的复制具有抑制作用。Cap-dependent endonuclease-IN-21 对流感病毒感染 (流感 A) 表现出研究潜力。
T63981	Cap-dependent endonuclease-IN-17	Others	Others
	Cap-dependent endonuclease-IN-17 是帽依赖性核酸内切酶 (CEN) 抑制剂。Cap-dependent endonuclease-IN-17 对流感病毒 A/Hanfang/359/95 (H3N2) 表现出抗病毒作用 (IC50: 1.29 μM)。
T64177	Cap-dependent endonuclease-IN-2	Others	Others
	Cap-dependent endonuclease-IN-2 是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-2 对流感病毒具有很好的抑制作用，且细胞毒性较低，具有较好的体内药剂动力学特性和体内药效学特性。Cap-dependent endonuclease-IN-2 能够明显的抑制甲型流感病毒 RNA 聚合酶活性。
T74294	Cap-dependent endonuclease-IN-12	Others	Others
	Cap-dependent endonuclease-IN-12 (EXP-35) 为一种高效的 Cap 依赖性核酸内切酶(CEN)抑制剂，展现出对H1N1的抑制活性，同时具备低细胞毒性特性。
T63673	Cap-dependent endonuclease-IN-10	Others	Others
	Cap-dependent endonuclease-IN-10 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-10 能够有效的抑制流感病毒，且细胞毒性较低、体内药代动力学和体内药效学特性较好以及肝微粒体稳定性较好。Cap-dependent endonuclease-IN-10 对病毒感染 (包括甲型流感、乙型流感和丙型流感) 表现出研究潜力。
T62150	Cap-dependent endonuclease-IN-25	Others	Others
	Cap-dependent endonuclease-IN-25 是一种大环吡啶并三嗪衍生物，也是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-25 具有潜力进行由 Orthomyxoviridae 家族病毒引起的病毒感染的研究。
T74295	Cap-dependent endonuclease-IN-22	Others	Others
	Cap-dependent endonuclease-IN-22 是一种 Cap 依赖性内切酶(CEN)抑制剂。
T72117	Cap-dependent endonuclease-IN-15	Others	Others
	Cap-dependent endonuclease-IN-15 是一种有效的 cap-dependent 核酸内切酶 (CEN) 抑制剂。Cap-dependent endonuclease-IN-15 抑制流感病毒的复制。Cap-dependent endonuclease-IN-15 具有研究流感病毒引起的病毒感染的潜力。
T64094	Cap-dependent endonuclease-IN-8	Others	Others
	Cap-dependent endonuclease-IN-8 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-8 能够抑制正粘病毒 (包括甲型流感、乙型流感和丙型流感) 的复制。
T63910	Cap-dependent endonuclease-IN-5	Others	Others
	Cap-dependent endonuclease-IN-5 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-5 具有很好的流感病毒抑制活性，和/或具有更低的细胞毒性、更好的体内药代动力学特性和体内药效学特性。
T72125	Cap-dependent endonuclease-IN-9	Influenza Virus	Microbiology/Virology
	Cap-dependent endonuclease-IN-9 是高效的 CEN 抑制剂，其对流感病毒具明显抑制作用，同时展现低细胞毒性、良好的体内药剂动力学及药效学特性。此化合物强力抑制 A 病毒 RNA 聚合酶活性。
T63073	Cap-dependent endonuclease-IN-19	Others	Others
	Cap-dependent endonuclease-IN-19 是一种螺环吡啶酮衍生物，是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-19 能够强效的抑制甲型流感病毒的 RNA 聚合酶活性。
T63680	Cap-dependent endonuclease-IN-11	Others	Others
	Cap-dependent endonuclease-IN-11 是 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-11 对病毒感染表现出研究潜力。
T61757	Cap-dependent endonuclease-IN-26	Others	Others
	Cap-dependent endonuclease-IN-26, a potent inhibitor of cap-dependent endonuclease (CEN) with an IC50 of 286 nM, exhibits significant antiviral activity against a broad spectrum of influenza A and B strains [1].
T64213	Cap-dependent endonuclease-IN-3	Others	Others
	Cap-dependent endonuclease-IN-3 是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-3 不仅能很好地抑制流感病毒，而且具有较低的细胞毒性、较好的体内药剂动力学特性和体内药效学特性。Cap-dependent endonuclease-IN-3 对甲型和乙型流感感染表现出研究潜力。
T8880	PFM01	Others	Others
	PFM01 是 MRE11核酸内切酶抑制剂，是 N-烷基化的 Mirin 衍生物。它可以通过非同源末端连接 (NHEJ) 和同源重组 (HR) 调节双链断裂修复 (DSBR)。
T14495	Baloxavir Baloxavir acid,S-033447	Influenza Virus	Microbiology/Virology
	Baloxavir (S-033447) 是衍生自前药 Baloxavir marboxil，是流感病毒聚合酶 PA 亚基的一流帽依赖性核酸内切酶抑制剂。它抑制病毒 RNA 的转录和复制，具有强大的抗病毒活性。
T15507	Hycanthone Etrenol(mesylate),Win 249-33,海恩酮	DNA/RNA Synthesis; Topoisomerase; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Hycanthone (Etrenol(mesylate)) 是 Lucanthone 的生物活性代谢产物，是一种抗血吸虫病药。它是一个噻吨酮类 DNA 嵌入剂，可抑制 RNA 合成以及 DNA 拓扑异构酶 I 和 II。它通过直接蛋白质结合来抑制核酸生物合成并抑制嘌呤内切核酸酶1，KD 为 10 nM。
T8545	FEN1-IN-4 FEN1 Inhibitor C2	Others	Others
	FEN1-IN-4 (FEN1 Inhibitor C2) 是人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。
T6456	CRT0044876 NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	CRT0044876 (7-NO2-ICA) 是一种高选择性的嘌呤/嘧啶核苷核酸内切酶 1 抑制剂，IC50约为 3 μM。它也是 APE1 所属的核酸外切酶 III 家族的特异性抑制剂，可抑制 APE1 的 AP 内切酶、3′-磷酸二酯酶和 3′-磷酸酶活性，可增强几种 DNA 碱基靶向化合物的细胞毒性。
T6823	E3330	HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活，可以抑制癌细胞的生长和迁移，具有抗癌活性。
T9743	FEN1-IN-SC13	Others	Others
	FEN1-IN-SC13 是有效的DNA 片段化核酸内切酶 1 抑制剂。
T6681	STF-083010 STF083010	IRE1	Cell Cycle/Checkpoint
	STF-083010 是一种 IRE1α 核酸内切酶的选择性抑制剂。
T10671	Candoxatril UK 79300	Neprilysin	Metabolism
	Candoxatril (UK 79300) 是具有口服活性的中性肽链内切酶 (NEP，EC 3.4.24.11) 抑制剂，可改善接受血管紧张素转换酶抑制的慢性心力衰竭患者的运动能力。
T66154	Paroxypropione	Others	Others
	It is an inhibitor of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)
T4569	Lucanthone Lucantona,Lucanthonum,硫坎酮,硫蒽酮	DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Lucanthone (Lucanthonum) 是一种 Apurinic 核酸内切酶-1 的抑制剂。
T78345	Ribonuclease A EC 3.1.27.5,RNase A
	Ribonuclease A (RNase A) 是一种有效的内切核糖核酸酶，可在dna和蛋白质的制备过程中去除RNA。
T9147	FEN1-IN-3	Others	Others
	FEN1-IN-3 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂，可使 hFEN1 稳定化，EC50为 6.8 μM。
T6195	Baloxavir marboxil S-033188	Influenza Virus	Microbiology/Virology
	Baloxavir marboxil (S-033188) 是一种新型的帽依赖性核酸内切酶抑制剂，用于治疗甲型和乙型流感病毒感染。
T60904	ERCC1-XPF-IN-2	Others	Others
	ERCC1-XPF-IN-2 在核苷酸切除修复、顺铂增强和 γH2AX 测定中具有活性。ERCC1-XPF-IN-2 是 ERCC1-XPF 核酸内切酶的有效抑制剂，IC50值为 0.6 μM。
T15274	FEN1-IN-1 LNT-1	Others	Others
	FEN1-IN-1 (LNT-1) 是一种FEN1的抑制剂，可绑定 FEN1 的活性位点，也可通过协调 Mg2+，进而表现出部分抑制作用。
T40931	FEN1-IN-2	Others	Others
	FEN1-IN-2 是一种具有选择性和有效性的瓣内切酶 1 (FEN1) 的抑制剂，抑制 FEN1 和 XPG，具有潜在的抗癌活性，可用于研究DNA损伤修复。
T8583	Tenilsetam 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone	Others	Others
	Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂；一种促智剂和晚期糖基化终产物 (AGE) 抑制剂，具有治疗阿尔茨海默病 (AD) 的潜力。
T39746	DNDI-6148	Parasite	Microbiology/Virology
	DNDI-6148 具有抗实验性皮肤利什曼病活性，通过抑制利什曼原虫裂解和多聚腺苷酸化特异性因子（CPSF3）核酸内切酶起作用，可用于研究内脏利什曼病。
T61487	APE1-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	APE1-IN-1 是一种可透过血脑屏障且有效的无嘌呤/嘧啶内切酶 1 (APE1) 抑制剂，具有潜在的抗肿瘤活性，可增强烷基化剂甲基甲烷磺酸盐对癌细胞的细胞毒性。
T31554	DNA-Spermidine DA-51,DA 51,DA51,DNA Spermidine	Others	Others
	DNA-spermidine influences the activity of restricted endonuclease from several bacterial species.
T12743	RO-7	Others	Others
	RO-7 is a next-generation polymerase (PA) endonuclease influenza A and B viruses inhibitor.
T69128	NSC-13755	Others	Others
	NSC-13755 is a human flap endonuclease 1 (FEN1) inhibitor.
T68449	JFD00950	Others	Others
	JFD00950 is a human flap endonuclease 1 (FEN1) inhibitor with in vitro inhibition of flap cleavage activity as well as cytotoxic activity against a colon cancer cell line, DLD-1.
T79134	FEN1-IN-6	FLAP	Immunology/Inflammation
	FEN1-IN-6（化合物9）是一种高效的Flap内切酶1（FEN1，IC50=10 nM）抑制剂，对哺乳动物细胞DNA损伤修复有关键作用。同时，FEN1-IN-6也针对相关酶，如XPG，表现出较强的抑制活性（IC50为23 nM）。
T75166	Influenza virus-IN-7	Others	Others
	Influenza virus-IN-7 (Example 16) 是一种口服活性的帽依赖性核酸内切酶抑制剂，适用于流感病毒感染疾病的研究。

化合物

Cap-dependent endonuclease-IN-1

Cat.No: T63808

Target: Others

pUL89 Endonuclease-IN-2

Cat.No: T61840

Target: Others

pUL89 Endonuclease-IN-1

Cat.No: T60379

Target: Others

Cap-dependent endonuclease-IN-13

Cat.No: T63519

Target: Others

Cap-dependent endonuclease-IN-16

Cat.No: T64138

Target: Others

Cap-dependent endonuclease-IN-7

Cat.No: T72124

Target: Others

Cap-dependent endonuclease-IN-6

Cat.No: T62208

Target: Others

Cap-dependent endonuclease-IN-21

Cat.No: T63702

Target: Others

Cap-dependent endonuclease-IN-14

Cat.No: T63946

Target: Others

Cap-dependent endonuclease-IN-23

Cat.No: T63703

Target: Others

Cap-dependent endonuclease-IN-17

Cat.No: T63981

Target: Others

Cap-dependent endonuclease-IN-2

Cat.No: T64177

Target: Others

Cap-dependent endonuclease-IN-12

Cat.No: T74294

Target: Others

Cap-dependent endonuclease-IN-10

Cat.No: T63673

Target: Others

Cap-dependent endonuclease-IN-25

Cat.No: T62150

Target: Others

Cap-dependent endonuclease-IN-22

Cat.No: T74295

Target: Others

Cap-dependent endonuclease-IN-15

Cat.No: T72117

Target: Others

Cap-dependent endonuclease-IN-8

Cat.No: T64094

Target: Others

Cap-dependent endonuclease-IN-5

Cat.No: T63910

Target: Others

Cap-dependent endonuclease-IN-9

Cat.No: T72125

Target: Influenza Virus

Cap-dependent endonuclease-IN-19

Cat.No: T63073

Target: Others

Cap-dependent endonuclease-IN-11

Cat.No: T63680

Target: Others

Cap-dependent endonuclease-IN-26

Cat.No: T61757

Target: Others

Cap-dependent endonuclease-IN-3

Cat.No: T64213

Target: Others

Cat.No: T8880

Target: Others

Cat.No: T14495

Synonym: Baloxavir acid,S-033447

Target: Influenza Virus

Cat.No: T15507

Synonym: Etrenol(mesylate),Win 249-33,海恩酮

Target: DNA/RNA Synthesis, Topoisomerase, Parasite

Cat.No: T8545

Synonym: FEN1 Inhibitor C2

Target: Others

Cat.No: T6456

Synonym: NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid

Target: DNA/RNA Synthesis

Cat.No: T6823

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

Cat.No: T9743

Target: Others

Cat.No: T6681

Synonym: STF083010

Target: IRE1

Cat.No: T10671

Synonym: UK 79300

Target: Neprilysin

Cat.No: T66154

Target: Others

Cat.No: T4569

Synonym: Lucantona,Lucanthonum,硫坎酮,硫蒽酮

Target: DNA/RNA Synthesis, Autophagy

Cat.No: T78345

Synonym: EC 3.1.27.5,RNase A

Cat.No: T9147

Target: Others

Baloxavir marboxil

Cat.No: T6195

Synonym: S-033188

Target: Influenza Virus

Cat.No: T60904

Target: Others

Cat.No: T15274

Synonym: LNT-1

Target: Others

Cat.No: T40931

Target: Others

Cat.No: T8583

Synonym: 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone

Target: Others

Cat.No: T39746

Target: Parasite

Cat.No: T61487

Target: DNA/RNA Synthesis

Cat.No: T31554

Synonym: DA-51,DA 51,DA51,DNA Spermidine

Target: Others

Cat.No: T12743

Target: Others

Cat.No: T69128

Target: Others

Cat.No: T68449

Target: Others

Cat.No: T79134

Target: FLAP

Influenza virus-IN-7

Cat.No: T75166

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TL0015	Pyromeconic acid 3-羟基-4氢-吡喃-4-酮,3-hydroxy-4H-pyran-4-one	Anti-infection	Microbiology/Virology
	Pyromeconic acid (3-hydroxy-4H-pyran-4-one) 及其衍生物是核酸内切酶的有效抑制剂
T70355	Flutimide	Others	Others
	Flutimide是一种针对流感病毒核酸内切酶的选择性抑制剂，具有3 μM的IC50值，表现出细胞培养中的抗病毒活性，适用于流感等急性传染性呼吸道疾病的研究。

天然产物

Pyromeconic acid

Cat.No: TL0015

Synonym: 3-羟基-4氢-吡喃-4-酮,3-hydroxy-4H-pyran-4-one

Target: Anti-infection

Cat.No: T70355

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01344	Flap endonuclease 1/FEN-1 Protein, Human, Recombinant (His & Myc) FEN1,DNase IV,Flap endonuclease 1,Flap structure-sp...	Human	E. coli
	Flap endonuclease 1/FEN-1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.0 kDa and the accession number is P39748.
TMPY-02798	NEIL1 Protein, Human, Recombinant (His) NEI1,nei endonuclease VIII-like 1 (E. coli),FPG1,hF...	Human	E. coli
	NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision r...
TMPJ-00464	APE Protein, Human, Recombinant APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-...	Human	E. coli
	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down...
TMPH-00600	RuvC Protein, E. coli, Recombinant (His & SUMO) Holliday junction resolvase RuvC,ruvC,Crossover junction end...	E. coli	E. coli
	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
TMPH-00598	Colicin-E5 Protein, E. coli, Recombinant (His & SUMO) Colicin-E5,col	E. coli	E. coli
	Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria. This colicin is an endonuclease. Colicin-E5 Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 24.8 kDa and the accession number is P18000.
TMPH-00605	CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) CDTB,Cytolethal distending toxin subunit B,Deoxyribonuclease...	E. coli	E. coli
	Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement. CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is Q46669.
TMPY-02433	APE1/APEX1 Protein, Human, Recombinant (His) APEX,HAP1,APX,APE,APEX nuclease (multifunctional DNA repair ...	Human	E. coli
	The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the...
TMPY-03180	Ribonuclease A Protein, Human, Recombinant (His) RNS1,ribonuclease, RNase A family, 1 (pancreatic),RIB1,RAC1	Human	HEK293 Cells
	RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) ...
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc) Fanconi-associated nuclease 1,Myotubularin-related protein 1...	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to e...
TMPH-01689	PLD6 Protein, Human, Recombinant (His) Mitochondrial phospholipase,Choline phosphatase 6,Protein zu...	Human	E. coli
	Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger sig...
TMPH-03712	Clp1 Protein, Xenopus laevis, Recombinant (His) clp1,Pre-mRNA cleavage complex II protein Clp1,Polyadenylati...	Xenopus laevis	E. coli
	Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the...

重组蛋白

Flap endonuclease 1/FEN-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01344

Species: Human

Expression System: E. coli

NEIL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02798

Species: Human

Expression System: E. coli

APE Protein, Human, Recombinant

Cat.No: TMPJ-00464

Species: Human

Expression System: E. coli

RuvC Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00600

Species: E. coli

Expression System: E. coli

Colicin-E5 Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00598

Species: E. coli

Expression System: E. coli

CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00605

Species: E. coli

Expression System: E. coli

APE1/APEX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02433

Species: Human

Expression System: E. coli

Ribonuclease A Protein, Human, Recombinant (His)

Cat.No: TMPY-03180

Species: Human

Expression System: HEK293 Cells

FAN1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02649

Species: Mouse

Expression System: E. coli

PLD6 Protein, Human, Recombinant (His)

Cat.No: TMPH-01689

Species: Human

Expression System: E. coli

Clp1 Protein, Xenopus laevis, Recombinant (His)

Cat.No: TMPH-03712

Species: Xenopus laevis

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0105	Baloxavir-d4
	Baloxavir-d4 是 Baloxavir 的氘代化合物。Baloxavir 的 CAS 号为 1985605-59-1。Baloxavir 是衍生自前药 Baloxavir marboxil，是流感病毒聚合酶 PA 亚基的一流帽依赖性核酸内切酶抑制剂。它抑制病毒 RNA 的转录和复制，具有强大的抗病毒活性。

同位素标记化合物

Cat.No: TMIH-0105

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