首页工具

登录

搜索结果

Search Results for " complications "

Targets Recommended: Others

26

抑制剂 & 化合物

16

天然产物

2

化合物库

19

重组蛋白

3

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L1900	抗糖尿病库		683 compounds
	683 种生物活性小分子化合物；
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；

化合物库

抗糖尿病库

Cat.No: L1900

Compounds: 683

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

Cat. No.	Product Name	Target	Signaling Pathways
T1129	Benfotiamine Benzoylthiamine monophosphate,S-Benzoylthiamine O-monophosphate,苯磷硫胺	Others	Others
	Benfotiamine (S-Benzoylthiamine O-monophosphate) 是维生素 B1 的类似物，其吸收率和生物利用度比维生素B1高，具有直接抗氧化能力，可防止DNA 损伤。它常用作糖尿病并发症的食品补充剂。
T28009	ME-3221 ME 3221,ME3221	RAAS	Endocrinology/Hormones
	ME-3221是一种血管紧张素AT1受体拮抗剂，可预防老年中风易发性高血压大鼠的高血压并发症。
T16910	Sorbinil	Reductase	Endocrinology/Hormones; Metabolism
	Sorbinil 是一种醛糖还原酶抑制剂，在糖尿病及其并发症方面发挥治疗作用。
T3977L	Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra	Others	Others
	Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel
T77523	ALR2-IN-1	Reductase	Endocrinology/Hormones; Metabolism
	ALR2-IN-1 是一种有效的且具有选择性的 ALR2 抑制剂，IC50值为1.42 μM。ALR2-IN-1 具有抗糖和抗氧化活性，可用于研究糖尿病并发症。
T15756	Lidorestat IDD-676	Reductase	Endocrinology/Hormones; Metabolism
	Lidorestat (IDD-676) 是一种醛糖还原酶抑制剂(IC50: 5 nM)，具有有效性，选择性和口服活性。Lidorestat 改善神经传导，减少白内障的形成。Lidorestat 可用于治疗慢性糖尿病并发症。
T0688	Ganciclovir BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog; Others; Antibiotic; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物，对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
T34268	Raxofelast IRFI016,IRFI-016,IRFI 016	Others	Others
	Raxofelast (IRFI-016) 具有治疗糖尿病并发症和动脉粥样硬化的潜力
T10393	AT-007	Reductase	Endocrinology/Hormones; Metabolism
	AT-007 是口服有效的，中枢神经系统渗透性醛糖还原酶的高效抑制剂， IC50为 100 pM。在 GALT 缺失大鼠中，它降低了有毒的半乳糖醇水平并预防了疾病并发症。
T36619	Aligeron	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aligeron 是一种非选择性的prostaglandin (PG)拮抗剂，对PGF2α和PGE2诱导的猫血压下降有抑制作用，可用于抑制PGF2α诱导的小鼠腹泻和PGE2诱导的大鼠爪水肿。Aligeron 对血管并发症具有抗氧化保护作用。
T21327	Uridine triacetate RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate	Others	Others
	Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性，或早发性心脏或中枢神经系统 (CNS) 毒性。
T24808	SMI-6860766 TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766	Others	Others
	SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice.
T70679	Spr 210	Others	Others
	Spr 210 is an aldose reductase (AR) inhibitor with potential uses as a therapeutic agent for preventing and improving some diabetic complications.
T27247	EGFR-IN-542	Others	Others
	EGFR-IN-542 is a novel EGFR inhibitor. EGFR-IN-542 significantly reduces myocardial inflammation, fibrosis, apoptosis and dysfunction. It shows promise for use in the treatment of obesity-induced cardiac complications.
T68929	Lidorestat monohydrate	Others	Others
	Lidorestat monohydrate is an aldose reductase inhibitor potentially for the treatment of diabetic neuropathy and diabetic complications.
T61706	α-Amylase/α-Glucosidase-IN-2	Others	Others
	α-Amylase/α-Glucosidase-IN-2 (compound 5) exhibits strong inhibition activity towards both α-amylase and α-glucosidase enzymes, with IC 50 values of 13.02 μM and 13.09 μM, respectively. This compound shows promise for investigating diabetic complications [1].
T38828	Mesdopetam IRL790	Others	Others
	Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of motor and psychiatric complications associated with Parkinson's disease.
T73240	PDE5-IN-4	Others	Others
	PDE5-IN-4为磷酸二酯酶5（PDE5）抑制剂，应用于急性心肌梗死及再灌注损伤、消化系统疾病、糖尿病相关损害及肝功能衰竭的研究。
T28414	Piclozotan SUN-N-4057,SUN4057,SUNN-4057,SUN-4057,SUNN4057	5-HT Receptor	GPCR/G Protein; Neuroscience
	Piclozotan (anhydrous) 是一种 5-HT1A 受体激动剂，在短暂的大脑中动脉闭塞（t-MCAO）模型中表现出显着的神经保护活性,可以改善晚期帕金森病患者的运动并发症。
T73305	ALR2-IN-3	Others	Others
	ALR2-IN-2 是一种有效的醛糖还原酶 (ALR2) 抑制剂，抑制大鼠 ALR2和 ALR1的 IC50值分别为为 22 nM 和 116 nM。ALR2-IN-2 可用于研究糖尿病并发症。
T60897	Aldose reductase-IN-5	Others	Others
	Aldose reductase-IN-5 是一种醛糖还原酶（ALR2）抑制剂，可增强抑制性兴奋性和抗氧化能力的组合，从而延缓糖尿病并发症的进程。
T73304	ALR2-IN-2	Others	Others
	ALR2-IN-2, 作为一种高效的醛糖还原酶 (ALR2) 抑制剂，对大鼠ALR2的IC50值为27 nM，对ALR1的IC50值为228 nM。此化合物适用于糖尿病并发症的研究。
T60731	Mitobronitol	Others	Others
	Mitobronitol (Myelobromol; DBM) 是甘露醇的溴化类似物。Mitobronitol 是被归类为烷化剂的抗癌剂。Mitobronitol 具有骨髓抑制作用，可显著降低加速慢性粒细胞白血病异体骨髓移植的几种并发症的风险。
T60640	SSAO inhibitor-2	Others	Others
	SSAO inhibitor-2 (Compound 1) 可用于动脉粥样硬化、糖尿病及其并发症、肥胖、中风、慢性肾病、视网膜病变、慢性阻塞性肺病 (COPD)、自身免疫性疾病、多发性硬化等的研究。SSAO inhibitor-2 是氨基脲敏感性胺氧化酶 (SSAO) 抑制剂，其对人 SSAO 和 MAO-A 的IC50分别为 <10 nM 和 10-100 μM。
T60909	SSAO inhibitor-3	Others	Others
	SSAO inhibitor-3 (Compound 2) 可用于研究动脉粥样硬化、糖尿病及其并发症、肥胖症、中风、慢性肾病、视网膜病变、慢性阻塞性肺病 (COPD)、自身免疫性疾病、多发性硬化等。SSAO inhibitor-3 是一种氨基脲敏感性胺氧化酶 (SSAO) 的抑制剂，对人 AOC1 和SSAO 的IC50分别为 0.1-10 μM 和 <10 nM 。
T72034	LI-2242	Others	Others
	LI-2242是一种强效肌醇六磷酸激酶（IP6K）抑制剂，对 IP6K1、IP6K2、IP6K3和 IPMK 的 IC50s 分别为31 nM、42 nM、8.7 nM 和1944 nM。LI-2242通过减少增强脂质吸收、脂质稳定和脂肪生成的基因的表达，改善了肝脏脂肪变性，增强体外脂肪细胞和肝细胞的线粒体耗氧率（OCR）和胰岛素信号传导。 LI-2242可改善饮食诱导的小鼠肥胖症、高血糖症和肝脂肪变性。LI-2242可用于研究 II 型糖尿病、肥胖症、代谢并发症、静脉血栓和精神疾病。

化合物

Cat.No: T1129

Synonym: Benzoylthiamine monophosphate,S-Benzoylthiamine O-monophosphate,苯磷硫胺

Target: Others

Cat.No: T28009

Synonym: ME 3221,ME3221

Target: RAAS

Cat.No: T16910

Target: Reductase

Lifitegrast sodium

Cat.No: T3977L

Synonym: SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra

Target: Others

Cat.No: T77523

Target: Reductase

Cat.No: T15756

Synonym: IDD-676

Target: Reductase

Cat.No: T0688

Synonym: BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine

Target: Nucleoside Antimetabolite/Analog, Others, Antibiotic, Antifection, HSV

Cat.No: T34268

Synonym: IRFI016,IRFI-016,IRFI 016

Target: Others

Cat.No: T10393

Target: Reductase

Cat.No: T36619

Target: Prostaglandin Receptor

Uridine triacetate

Cat.No: T21327

Synonym: RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate

Target: Others

Cat.No: T24808

Synonym: TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766

Target: Others

Cat.No: T70679

Target: Others

Cat.No: T27247

Target: Others

Lidorestat monohydrate

Cat.No: T68929

Target: Others

α-Amylase/α-Glucosidase-IN-2

Cat.No: T61706

Target: Others

Cat.No: T38828

Synonym: IRL790

Target: Others

Cat.No: T73240

Target: Others

Cat.No: T28414

Synonym: SUN-N-4057,SUN4057,SUNN-4057,SUN-4057,SUNN4057

Target: 5-HT Receptor

Cat.No: T73305

Target: Others

Aldose reductase-IN-5

Cat.No: T60897

Target: Others

Cat.No: T73304

Target: Others

Cat.No: T60731

Target: Others

SSAO inhibitor-2

Cat.No: T60640

Target: Others

SSAO inhibitor-3

Cat.No: T60909

Target: Others

Cat.No: T72034

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6774	Emodin 6-O-β-D-glucoside 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin	Others	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性，可用于研究动脉粥样硬化及糖尿病并发症。
T2755	Rhoifolin 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others; p38 MAPK; NF-κB; transporter; IGF-1R; Autophagy	Autophagy; MAPK; Metabolism; NF-κB; Others; Tyrosine Kinase/Adaptors
	Rhoifolin (Apigenin 7-O-neohesperidoside) 是从琯溪蜜柚叶子分离的一种黄酮糖苷。它通过 RANKL 诱导的NF-κB 和MAPK 途径改善钛颗粒刺激的骨溶解并减少破骨细胞生成。它通过增强脂联素分泌，胰岛素受体-β的酪氨酸磷酸化和GLUT4易位有助于治疗糖尿病并发症。
T4S0295	Apigenin 7-glucoside 波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Apigenin 7-glucoside (Cosmosiin) 是一种 ROS 清除剂，具有抗增殖、抗氧化作用。
T1273	Diacerein 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein	IL Receptor; Interleukin	Immunology/Inflammation
	Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。
T5528	Cyanidin Chloride	Antioxidant	oxidation-reduction
	Cyanidin Chloride 是一种花青素的亚类，具有抗氧化和抗癌活性。它能够抑制破骨细胞形成，羟基磷灰石吸收和 NF-κB 配体 (RANKL) 诱导的破骨细胞标记基因表达的受体激活。
TN2165	Rubrofusarin gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside,红链霉素-龙胆二糖苷,芸苔红素龙胆苷	ERK; NF-κB; TGF-beta/Smad	MAPK; NF-κB; Stem Cells
	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) 一种分离自决明子的、具有清除自由基作用的化合物。
T21418	Lisinopril Linopril,赖诺普利,Zestril,Prinivil,Lisipril	RAAS	Endocrinology/Hormones
	Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂，能够作用于高血压，充血性心力衰竭和心脏病等。
T4721	β-Nicotinamide mononucleotide NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸	Others; Endogenous Metabolite	Metabolism; Others
	β-nicotinamide mononucleotide 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。
T5S0384	Rhapontin Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis; Others	Apoptosis; Others
	Rhapontin (Ponticin) 是药用大黄的一种成分，可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性，改善血糖和血脂，表明其具有显着的降糖作用，有望成为治疗2型糖尿病及其并发症的新药。
TN1042	Chebulic acid	Others	Others
	Chebulic acid 是一种分离自Terminalia chebula 中的酚羧酸化合物，具有显著的抗氧化作用，它能够打破由晚期糖基化终产物 (AGEs) 诱导的蛋白质交联，阻碍 AGEs 的形成。它能够有效控制代谢参数升高、氧化应激和肾损害，支持其在糖尿病肾病中的有益作用。
T5S1988	Isorhamnetin-3-O-glucoside Isorhamnetin-3-O-beta-D-Glucoside,异鼠李素-3-O-葡萄糖苷	Others	Others
	Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) 是一种天然化合物，广泛存在于蔬菜和水稻中，经消化后可在肠道菌群中代谢。
T3851	Vicenin 2 Vicenin -2,维采宁 2,新西兰牡荆苷	RAAS	Endocrinology/Hormones
	Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50=43.83 μM。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
T3839	Cycloolivil Isoolivil,环橄榄树脂素	Free radical scavengers; Others; Platelet aggregation	Others; oxidation-reduction
	Cycloolivil (Isoolivil) 是一种天然多酚化合物，在橄榄树中具有显着的自由基清除活性。 Cycloolivil 具有抗氧化活性，它可以预防与血小板过度聚集相关的血栓并发症，是开发抗聚集治疗策略的基础。
TN5942	Dammarenediol II 达玛烯二醇II,Dammar-24-ene-3,20-diol
	Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber forma

天然产物

Emodin 6-O-β-D-glucoside

Cat.No: TN6774

Synonym: 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin

Target: Others

Cat.No: T2755

Synonym: 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside

Target: Others, p38 MAPK, NF-κB, transporter, IGF-1R, Autophagy

Apigenin 7-glucoside

Cat.No: T4S0295

Synonym: 波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin

Target: Reactive Oxygen Species, HIV Protease

Cat.No: T1273

Synonym: 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein

Target: IL Receptor, Interleukin

Cyanidin Chloride

Cat.No: T5528

Target: Antioxidant

Rubrofusarin gentiobioside

Cat.No: TN2165

Synonym: Rubrofusarin-6-O-beta-D-gentiobioside,红链霉素-龙胆二糖苷,芸苔红素龙胆苷

Target: ERK, NF-κB, TGF-beta/Smad

Cat.No: T21418

Synonym: Linopril,赖诺普利,Zestril,Prinivil,Lisipril

Target: RAAS

β-Nicotinamide mononucleotide

Cat.No: T4721

Synonym: NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸

Target: Others, Endogenous Metabolite

Cat.No: T5S0384

Synonym: Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside

Target: Apoptosis, Others

Cat.No: TN1042

Target: Others

Isorhamnetin-3-O-glucoside

Cat.No: T5S1988

Synonym: Isorhamnetin-3-O-beta-D-Glucoside,异鼠李素-3-O-葡萄糖苷

Target: Others

Cat.No: T3851

Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷

Target: RAAS

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

Cat.No: T3839

Synonym: Isoolivil,环橄榄树脂素

Target: Free radical scavengers, Others, Platelet aggregation

Dammarenediol II

Cat.No: TN5942

Synonym: 达玛烯二醇II,Dammar-24-ene-3,20-diol

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00071	EPO/Erythropoietin Protein, Human, Recombinant (His) Erythropoietin,EPO,红细胞生长素,Epoetin	Human	HEK293 Cells
	Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP...
TMPK-01031	MAdCAM-1 Protein, Mouse, Recombinant (His) MACAM1,MADCAM1,MAdCAM-1	Mouse	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...
TMPK-00030	LAIR2 Protein, Human, Recombinant (Avi & His) CD306,LAIR-2,LAIR2,MGC71634,XXbac-BCX535A19.6	Human	HEK293 Cells
	The leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) shows increased expression during pregnancy and its reduced expression is associated with pregnancy complications. Although LAIR2 was expressed in the human placenta villus and decidua in the first trimester of pregnancy, it was not expressed in mouse tissues. Knockdown of LAIR2 markedly improved cell viability and inhibited the invasive ability of HTR8/SVneo cells.
TMPK-00965	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) MADCAM1,MACAM1,MAdCAM-1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) is expressed in HEK293 mammalian cells with C-hFc ta...
TMPK-00964	MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated MADCAM1,MAdCAM-1,MACAM1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with...
TMPK-00966	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His) MACAM1,MADCAM1,MAdCAM-1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His) is expressed in HEK293 mammalian cells with C-His ta...
TMPK-00526	LRG1 Protein, Cynomolgus, Recombinant (His) Leucine-rich α-2-glycoprotein,LRG1,LRG,Leucine-rich alpha-2-...	Cynomolgus	HEK293 Cells
	Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ma...
TMPK-01236	APLN Protein, Human, Recombinant (hFc) APJ endogenous ligand,Apelin,APEL	Human	HEK293 Cells
	Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Human, Recombinant (hFc) is expressed in HE...
TMPJ-00104	SOD2 Protein, Human, Recombinant (E. coli, His) SOD2,Superoxide Dismutase [Mn] Mitochondrial	Human	E. coli
	Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6), idiopathic cardiomyopathy (IDC), sporadic motor neuron dis...
TMPK-01222	APLN Protein, Mouse, Recombinant (hFc) APJ endogenous ligand,APEL,Apelin	Mouse	HEK293 Cells
	Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Mouse, Recombinant (hFc) is expressed in HE...
TMPK-01128	LRG1 Protein, Mouse, Recombinant (His) Leucine-rich α-2-glycoprotein,Leucine-rich alpha-2-glycoprot...	Mouse	HEK293 Cells
	Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammali...
TMPJ-00022	LGALS7 Protein, Human, Recombinant Galectin-7,Gal-7,LGALS7,PI7,PIG1,LGALS7B,p53-Induced Gene 1 ...	Human	E. coli
	The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide; they can be secreted ...
TMPY-03499	CARHSP1 Protein, Human, Recombinant (His) CSDC1,calcium regulated heat stable protein 1, 24kDa,CRHSP-2...	Human	E. coli
	CARHSP1 is a biomarker for diabetic complications. Adenovirus-mediated CARHSP1 overexpression and siRNA-mediated knockdown experiments were performed to characterize the role of CARHSP1 in the regulation of gluconeogenic gene expression. CARHSP1 is regulated by nutrient status in the liver and functions at the transcriptional level to negatively regulate gluconeogenic genes, including the glucose-6-phosphatase catalytic subunit (G6Pc) and phosphoenolpyruvate carboxykinase 1 (PEPCK1). In add...
TMPY-00540	ANXA5 Protein annexin A5
	The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. The association found between the...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His) ALDR1,AR,ADR,aldo-keto reductase family 1, member B1 (aldose...	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the c...
TMPJ-00505	Serpin A1 Protein, Human, Recombinant (aa 25-418, His) Alpha-1-Antiproteinase,α-1-Antiproteinase,SERPINA1,Serpin A1...	Human	HEK293 Cells
	Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants re...
TMPY-02461	AKR1A1 Protein, Human, Recombinant (His) DD3,ALDR1,HEL-S-6,aldo-keto reductase family 1, member A1 (a...	Human	E. coli
	Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fo...
TMPJ-00379	AOC3 Protein, Human, Recombinant (hFc) SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas...	Human	HEK293 Cells
	Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam...
TMPJ-00654	LGALS8 Protein, Human, Recombinant Prostate Carcinoma Tumor Antigen 1,Po66-CBP,Galectin-8,PCTA-...	Human	E. coli
	The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be...

重组蛋白

EPO/Erythropoietin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00071

Species: Human

Expression System: HEK293 Cells

MAdCAM-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01031

Species: Mouse

Expression System: HEK293 Cells

LAIR2 Protein, Human, Recombinant (Avi & His)

Cat.No: TMPK-00030

Species: Human

Expression System: HEK293 Cells

MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc)

Cat.No: TMPK-00965

Species: Human

Expression System: HEK293 Cells

MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00964

Species: Human

Expression System: HEK293 Cells

MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His)

Cat.No: TMPK-00966

Species: Human

Expression System: HEK293 Cells

LRG1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00526

Species: Cynomolgus

Expression System: HEK293 Cells

APLN Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01236

Species: Human

Expression System: HEK293 Cells

SOD2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-00104

Species: Human

Expression System: E. coli

APLN Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01222

Species: Mouse

Expression System: HEK293 Cells

LRG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01128

Species: Mouse

Expression System: HEK293 Cells

LGALS7 Protein, Human, Recombinant

Cat.No: TMPJ-00022

Species: Human

Expression System: E. coli

CARHSP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03499

Species: Human

Expression System: E. coli

Cat.No: TMPY-00540

Expression System:

AKR1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02438

Species: Human

Expression System: E. coli

Serpin A1 Protein, Human, Recombinant (aa 25-418, His)

Cat.No: TMPJ-00505

Species: Human

Expression System: HEK293 Cells

AKR1A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02461

Species: Human

Expression System: E. coli

AOC3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00379

Species: Human

Expression System: HEK293 Cells

LGALS8 Protein, Human, Recombinant

Cat.No: TMPJ-00654

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0306	Ganciclovir-d5
	Ganciclovir-d5 是 Ganciclovir 的氘代化合物。Ganciclovir 的 CAS 号为 82410-32-0。Ganciclovir是核苷类似物和口服抗病毒药物，对CMV具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
TMIJ-0052	Propionicacid-d5
	Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。
TMIJ-0054	Propionic-2,2-d2 acid
	Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。

同位素标记化合物

Cat.No: TMIJ-0306

Propionicacid-d5

Cat.No: TMIJ-0052

Propionic-2,2-d2 acid

Cat.No: TMIJ-0054

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼