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Search Results for " collagen-1 "
Targets Recommended: Others

50

抑制剂 & 化合物

11

天然产物

1781

重组蛋白

2

同位素标记化合物

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Cat. No. Product Name Target Signaling Pathways
T10861 Collagen proline hydroxylase inhibitor-1

Others Others
Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。
TP1643 Alpha 1(I) Collagen (614-639), human

This is a peptide inhibitor of collagen fibrillar matrix assembly.
T16886 Sinefungin

Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP

Others; Histone Methyltransferase; Antibiotic; Antifungal Chromatin/Epigenetic; Microbiology/Virology; Others
Sinefungin (Adenosyl-Ornithine) 是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9,通过抑制H3K4甲基化来改善肾纤维化。
T4283 SRI-011381

TGF-beta/Smad Stem Cells
SRI011381 是口服具有活力的 TGF-β信号通路的激活剂,具有神经保护活性。
T60303 Collagen-IN-1

Others Others
Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 effectively reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelets. This compound holds promise for research into platelet-related thrombosis diseases [1].
TP2452 Collagen type IV alpha1 (531-543)

Hep III peptide,Gefyfdlrlkgdk

Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of type IV collagen and plays a role in angiogenesis.
T5129 SRI-011381 hydrochloride

SRI-011381 hydrochloride [1629138-41-5(free base)]

TGF-beta/Smad Stem Cells
SRI-011381 hydrochloride 是口服具有活力的TGF-β信号通路的激活剂,具有神经保护活性。
T1606 Fasudil

HA-1077,AT877,法舒地尔

ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂,也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用,ROCK1 的 Ki 值为 0.33 μM,ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。
T3060 Fasudil hydrochloride

Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877

ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂,也抑制蛋白激酶,对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。
T38369 CAY10678

Prostaglandin Receptor; PD-1/PD-L1 Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation
CAY10678 是一种 mPGES-1抑制剂,抑制 PD-1。CAY10678 可减少胶原沉积和T细胞耗竭,可用于研究黑色素瘤。
T2386 Pirfenidone

S-7701,AMR-69,S-7701,AMR69,吡非尼酮

CCR; TGF-beta/Smad Immunology/Inflammation; Microbiology/Virology; Stem Cells
Pirfenidone (AMR69) 是一种抗纤维化剂,可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长,并能降低人胶质瘤细胞系中的TGF-β2蛋白水平,具有抗炎活性。
T24816 SP-100030

SP100030,SP 100030

NF-κB NF-κB
SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat 和其他T 细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。
T38294 4-Deoxypyridoxine hydrochloride

S1P Receptor GPCR/G Protein
4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解,与 S1P 一样,减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T27170 Diethyl pyimDC

Others Others
Diethyl pyimDC is an inhibitor of human collagen prolyl 4-hydroxylase 1 (CP4H1).
T80025 Bovine Type II Collagen

Collagen, Type II, Immunization Grade

Others Others
Type II collagen 是一种治疗骨关节炎的有效蛋白质。在减缓小鼠胶原性关节炎疼痛和炎症方面,Type II collagen 显示了显著的效果。
T26596 Allylpyrocatechol

Others Others
Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways.
T61697 GPVI antagonist 1

Others Others
GPVI antagonist 1 (compound 5) functions as an antagonist for the glycoprotein VI (GPVI) platelet receptor. It effectively inhibits collagen-induced platelet aggregation, demonstrating an IC50 value of 25.3 μM [1].
T74402 FAP-PI3KI1

Others Others
FAP-PI3KI1 是一种成纤维细胞活化蛋白 (FAP) 靶向 PI3K 抑制剂,可选择性靶向表达 FAP 的人特发性肺纤维化 (IPF)细胞并有效抑制胶原蛋白合成,减少胶原蛋白沉积。
T78030 GRGESP

GRGESP为胶原凝胶收缩抑制剂,能够抑制人成纤维细胞在胶原凝胶中的扩散,显著减少凝胶收缩,适用于结缔组织形态发生研究。
T35725 4-hydroxy Valsartan

Others Others
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.
T82467 Endotrophin (Mus musculus)

Endotrophin (Mus musculus) 为Col6的裂解产物,其上调可能导致纤维化和炎症基因表达增强。
TP2354 Tetrapeptide-11

Pro-pro-tyr-leu

Tetrapeptide-11 is the reaction product of Acetic Acid and tetrapeptide-11, containing leucine, proline, and tyrosine residues. It boosts cell growth, Syndecan-1, and Collagen XVII synthesis. Tetrapeptide-11 has a face and body anti-wrinkle and anti-aging
T36929 Pal-KTTKS (acetate)

Others Others
Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...
T80746 YYRADDA

YYRADDA是一种多肽,能够促进皮肤细胞外基质中胶原蛋白的生成,从而改善皮肤外观并促进受损皮肤的恢复。
TP2186 PalMitoyl Tripeptide-1

Others Others
PalMitoyl Tripeptide-1 对人体皮肤成纤维细胞中胶原蛋白、纤连蛋白和透明质酸的合成有影响,可用于制备抗衰老化妆品。
T61811 GPVI antagonist 3

Others Others
GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antago...
T36930 Palmitoyl Tetrapeptide-7 (acetate)

Others Others
Palmitoyl tetrapeptide-7 is a cosmeceutical peptide that stimulates type I collagen, fibronectin, and hyaluronic acid production in skin.1Formulations containing palmitoyl tetrapeptide-7 have been used in the treatment of photoaging, dark circles, and undereye puffiness. 1.Bucay, V.W., and Day, D.Adjunctive skin care of the brow and periorbital regionClin. Plast. Surg.40(1)225-236(2013)
T60557 TRAP-6-IN-1

Others Others
TRAP-6-IN-1 (Compound 8) 是胶原蛋白和TRAP-6的双重抑制剂,IC50值分别为 17.12 μM 和 11.88 μM。TRAP-6-IN-1 非竞争性抑制激动剂诱导的血小板聚集。
T81005 Tetrapeptide-4

Tetrapeptide-4,一种护肤产品中常用的肽,具备减少皱纹与增强胶原蛋白、弹性蛋白及纤连蛋白的功能,展现出显著的抗衰老特性。
TP2186L1 PalMitoyl Tripeptide-1 hydrochloride

PalMitoyl Tripeptide-1 hydrochloride(147732-56-7 Free base),棕榈酰三肽-1盐酸盐

Others Others
PalMitoyl Tripeptide-1 hydrochloride (PalMitoyl Tripeptide-1 hydrochloride (147732-56-7 Free base)) 对人体皮肤成纤维细胞中胶原蛋白、纤连蛋白和透明质酸的合成有影响,可用于制备抗衰老化妆品。
T82780 Caprooyl-tetrapeptide-3 acetate

Caprooyl-tetrapeptide-3 acetate 旨在减少细纹与皱纹。该化合物能够在皮质激素诱导的皮肤老化模型中刺激VII型胶原蛋白及层粘连蛋白5的表达。
T11729 JTE-952

Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse
T73770 Galactosylhydroxylysine hydrochloride

Others Others
Galactosylhydroxylysine hydrochloride, 一种羟基赖氨酸经糖基化转换后生成的骨胶原蛋白成分,该化合物在骨吸收过程中释放,其浓度在代谢性骨丢失疾病中会上升。
T61586 TGFβ-IN-2

Others Others
TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and p-Smad3, which are induced by TGF-β. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].
T41079 MMP13-IN-2

MMP13-IN-2

Others Others
MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
T80859 Vitronectin

Vitronectin为一类多功能糖蛋白,广泛分布于血液及细胞外基质。该蛋白质与糖胺聚糖、胶原蛋白、纤溶酶原及尿激酶受体发生结合,并对纤溶酶原激活抑制剂1的抑制构象起稳定作用。Vitronectin常用于促进伤口愈合和肿瘤进展研究领域。
T78219 Obtustatin triacetate

Integrin Cytoskeletal Signaling
Obtustatin triacetate 是一种从 Vipera lebetina obtusa 毒液中提取、含有 41 个残基的非 RGD 型解整合素。它作为整合素α1β1与 IV 型胶原蛋白粘附的高效且选择性抑制剂,能够抑制血管生成,因此在癌症研究中有应用。
T62250 GPVI antagonist 2

Others Others
GPVI antagonist 2 (Compound 1) 是一种潜在的 Glycoprotein VI (GPVI) 拮抗剂,能够作用于胶原蛋白 (IC50: 0.35 μM)、CRP (IC50: 0.80 μM)、convulxin (IC50: 195.2 μM)、凝血酶 (IC50: 81.38 μM)。其中糖蛋白 VI (GPVI) 是一种血小板主要胶原受体,是有效的、安全的抗血栓研究靶点。GPVI antagonist 2 是一种很有前途的抗血小板药物。
T78038 H-Pro-Gly-Pro-OH

H-Pro-Gly-Pro-OH 是胶原蛋白衍生物,在生物医学领域中以其嗜中性粒细胞趋化性而被研究。该分子诱使中性粒细胞在特定部位集聚,并促进局部细胞修复过程。此外,H-Pro-Gly-Pro-OH 还能激活缺血后脑部的神经营养因子及其受体的基因表达。
T74632 TP0556351

MMP Proteases/Proteasome
TP0556351是一种高效且选择性地抑制基质金属蛋白酶2 (MMP2) 的化合物,其IC50值为0.2 nM。在Bleomycin诱导的肺纤维化小鼠模型中,该化合物能显著减少肺部胶原蛋白的含量,适用于特发性肺纤维化(IPF)的研究。
T79260 MCI

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
MCI具有针对性地清除活性氧(ROS)并降低环氧合酶-2(COX-2)表达的功能,COX-2的IC50值为1.23μM。在胶原诱导的关节炎(CIA)模型中展现出的抗炎效果明显,适用于类风湿性关节炎(RA)的研究。
T36101 Psychotridine

Others Others
Psychotridine is an alkaloid that has been found inP. forsterianaand has diverse biological activities.1,2,3It inhibits ADP-, collagen-, or thrombin-induced aggregation of washed isolated human platelets with IC50values of 1.4, 1.4, and 3.9 μM, respectively.1Psychotridine (2.5 or 5 μM) is cytotoxic to HTC rat hepatocellular carcinoma cells.2It reduces paw licking induced by capsaicin in mice when administered at doses of 0.5, 2.5, or 5 mg/kg.3 1.Beretz, A., Roth-Georger, A., Corre, G., et al.Pol...
T69671 SR1903 TFA

Others Others
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-190...
T81592 Osteostatin

PTHrP (107–111)

Osteostatin为甲状旁腺激素相关蛋白(PTHrP) 107-111片段,该化合物在动物模型中促进骨缺损修复,预防炎症性关节炎引起的骨侵蚀,并抑制骨胶原诱导的关节炎及破骨细胞的吸收作用。Osteostatin主要应用于免疫炎症的研究领域。
T60854 ENMD-1068 hydrochloride

Others Others
ENMD-1068 hydrochloride 是一种选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。ENMD-1068 hydrochloride 可通过抑制TGF-β1/Smad 信号转导而减少肝星状细胞的活化和胶原蛋白的表达。ENMD-1068 hydrochloride 还能抑制子宫内膜细胞的增殖,并诱导病灶中上皮细胞的凋亡。ENMD-1068 hydrochloride 可用于子宫内膜异位症、肝纤维化的研究。
T35638 SR 1903

Others Others
SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 209 nM) but does not activate it. SR 1903 (10 μM) inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) in RAW 264.7 cells. It also inhibits LPS-induced expression of th...
T84443 Halofuginone hydrochloride

RU-19110 hydrochloride

Others Others
Halofuginone hydrobromid (RU-19110),Febrifugine的衍生物,作为脯氨酰-tRNA合成酶竞争性抑制剂,其Ki值为18.3 nM。该化合物特异性抑制I型胶原合成,并能通过降低TGF-β活性来减轻骨关节炎症状。同时,Halofuginone hydrobromid作为有效的肺血管扩张剂,通过激活Kv通道并阻断电压门控、受体操作与存储操作的Ca2+通道发挥作用。此外,它还具有抗疟疾、抗炎、抗癌及抗纤维化的多重生物活性。
T74142 Angiotensin II human TFA

Angiotensin II human (Angiotensin II) TFA 作为肾素/血管紧张素系统中关键的生物活性肽,扮演着血管收缩剂的角色并在调节人体血压中发挥中心作用。其主要通过与 G 蛋白偶联受体 (GPCRs)、血管紧张素 II 1型受体 (AT1R) 和血管紧张素 II 2型受体 (AT2R) 的相互作用来介导效应,包括刺激交感神经系统、增加醛固酮的生物合成和肾脏功能。此外,Angiotensin II human TFA 促进血管平滑肌细胞的生长和 I 型及 III 型胶原在成纤维细胞中的合成,导致血管壁与心肌增厚及纤维化,并诱导细胞凋亡。还通过LOX-1依赖的氧化还原敏感路径诱导内皮细胞中的毛细血管形成。
T36486 Benpyrine

Others Others
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...
T36717 RWJ-56110 dihydrochloride

Others Others
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

Collagen proline hydroxylase inhibitor-1
Cat.No: T10861
Synonym:
Target: Others
Alpha 1(I) Collagen (614-639), human
Cat.No: TP1643
Synonym:
Target:
Sinefungin
Cat.No: T16886
Synonym: Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP
Target: Others, Histone Methyltransferase, Antibiotic, Antifungal
SRI-011381
Cat.No: T4283
Synonym:
Target: TGF-beta/Smad
Collagen-IN-1
Cat.No: T60303
Synonym:
Target: Others
Collagen type IV alpha1 (531-543)
Cat.No: TP2452
Synonym: Hep III peptide,Gefyfdlrlkgdk
Target:
SRI-011381 hydrochloride
Cat.No: T5129
Synonym: SRI-011381 hydrochloride [1629138-41-5(free base)]
Target: TGF-beta/Smad
Fasudil
Cat.No: T1606
Synonym: HA-1077,AT877,法舒地尔
Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy
Fasudil hydrochloride
Cat.No: T3060
Synonym: Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877
Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy
CAY10678
Cat.No: T38369
Synonym:
Target: Prostaglandin Receptor, PD-1/PD-L1
Pirfenidone
Cat.No: T2386
Synonym: S-7701,AMR-69,S-7701,AMR69,吡非尼酮
Target: CCR, TGF-beta/Smad
SP-100030
Cat.No: T24816
Synonym: SP100030,SP 100030
Target: NF-κB
4-Deoxypyridoxine hydrochloride
Cat.No: T38294
Synonym:
Target: S1P Receptor
Diethyl pyimDC
Cat.No: T27170
Synonym:
Target: Others
Bovine Type II Collagen
Cat.No: T80025
Synonym: Collagen, Type II, Immunization Grade
Target: Others
Allylpyrocatechol
Cat.No: T26596
Synonym:
Target: Others
GPVI antagonist 1
Cat.No: T61697
Synonym:
Target: Others
FAP-PI3KI1
Cat.No: T74402
Synonym:
Target: Others
GRGESP
Cat.No: T78030
Synonym:
Target:
4-hydroxy Valsartan
Cat.No: T35725
Synonym:
Target: Others
Endotrophin (Mus musculus)
Cat.No: T82467
Synonym:
Target:
Tetrapeptide-11
Cat.No: TP2354
Synonym: Pro-pro-tyr-leu
Target:
Pal-KTTKS (acetate)
Cat.No: T36929
Synonym:
Target: Others
YYRADDA
Cat.No: T80746
Synonym:
Target:
PalMitoyl Tripeptide-1
Cat.No: TP2186
Synonym:
Target: Others
GPVI antagonist 3
Cat.No: T61811
Synonym:
Target: Others
Palmitoyl Tetrapeptide-7 (acetate)
Cat.No: T36930
Synonym:
Target: Others
TRAP-6-IN-1
Cat.No: T60557
Synonym:
Target: Others
Tetrapeptide-4
Cat.No: T81005
Synonym:
Target:
PalMitoyl Tripeptide-1 hydrochloride
Cat.No: TP2186L1
Synonym: PalMitoyl Tripeptide-1 hydrochloride(147732-56-7 Free base),棕榈酰三肽-1盐酸盐
Target: Others
Caprooyl-tetrapeptide-3 acetate
Cat.No: T82780
Synonym:
Target:
JTE-952
Cat.No: T11729
Synonym:
Target: Histamine Receptor
Galactosylhydroxylysine hydrochloride
Cat.No: T73770
Synonym:
Target: Others
TGFβ-IN-2
Cat.No: T61586
Synonym:
Target: Others
MMP13-IN-2
Cat.No: T41079
Synonym: MMP13-IN-2
Target: Others
Vitronectin
Cat.No: T80859
Synonym:
Target:
Obtustatin triacetate
Cat.No: T78219
Synonym:
Target: Integrin
GPVI antagonist 2
Cat.No: T62250
Synonym:
Target: Others
H-Pro-Gly-Pro-OH
Cat.No: T78038
Synonym:
Target:
TP0556351
Cat.No: T74632
Synonym:
Target: MMP
MCI
Cat.No: T79260
Synonym:
Target: Reactive Oxygen Species
Psychotridine
Cat.No: T36101
Synonym:
Target: Others
SR1903 TFA
Cat.No: T69671
Synonym:
Target: Others
Osteostatin
Cat.No: T81592
Synonym: PTHrP (107–111)
Target:
ENMD-1068 hydrochloride
Cat.No: T60854
Synonym:
Target: Others
SR 1903
Cat.No: T35638
Synonym:
Target: Others
Halofuginone hydrochloride
Cat.No: T84443
Synonym: RU-19110 hydrochloride
Target: Others
Angiotensin II human TFA
Cat.No: T74142
Synonym:
Target:
Benpyrine
Cat.No: T36486
Synonym:
Target: Others
RWJ-56110 dihydrochloride
Cat.No: T36717
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T6856 Halofuginone

卤夫酮,常山酮,Tempostatin,empostatin,RU-19110

Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells
Halofuginone (RU-19110) 是Febrifugine 的衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂,可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。
T3524 Halofuginone hydrobromide

卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐

Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。
T3S1944 Darutoside

Darutin,豯莶苷

Others Others
Darutoside (Darutin) 是一种二萜化合物,提取自Siegesbeckia 中。
TN6975 Cirsiumaldehyde

5,5’-oxydimethylenebis(2-furfural)

Platelet aggregation Others
Cirsiumaldehyde 是一种从Lobelia chinensis、Cornus officinalis 成熟果实和 Hippophae rhamnoides 果实中分分离出的化合物。Cirsiumaldehyde 在胶原蛋白存在下对 U46619 诱导(1~5 uM)的大鼠血小板聚集的抑制浓度为 0.8~1.0 ug/mL。
T2769 3-Aminopropionitrile fumarate (2:1)

Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate

Others Others
3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) 是一种能抑制胶原蛋白(collagen)交联的山黧豆素。
T4S0498 Glaucocalyxin A

蓝萼甲素,Wangzaozin B,Leukamenin F

Apoptosis; Akt; Caspase; PI3K Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。
T72798 Ganodermaones B

Others Others
Ganodermaones B 是一种肾纤维化抑制剂,抑制 TGF-β1诱导的 collagen I 和 fibronectin 的表达。
T79983 Flaccidoside II

Apoptosis Apoptosis
Flaccidoside II 是一种源自Anemone flaccida根茎的三萜皂苷,能抑制恶性周围神经鞘瘤(MPNST)细胞系增殖并诱导细胞凋亡(apoptosis)。此外,Flaccidoside II 亦能改善由胶原蛋白引发的小鼠关节炎症状。
TN4664 Norarmepavine

Others Others
N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa
T38330 Collinin

Others Others
Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...
T35624 Ajoene

Others Others
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Halofuginone
Cat.No: T6856
Synonym: 卤夫酮,常山酮,Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Halofuginone hydrobromide
Cat.No: T3524
Synonym: 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Darutoside
Cat.No: T3S1944
Synonym: Darutin,豯莶苷
Target: Others
Cirsiumaldehyde
Cat.No: TN6975
Synonym: 5,5’-oxydimethylenebis(2-furfural)
Target: Platelet aggregation
3-Aminopropionitrile fumarate (2:1)
Cat.No: T2769
Synonym: Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate
Target: Others
Glaucocalyxin A
Cat.No: T4S0498
Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F
Target: Apoptosis, Akt, Caspase, PI3K
Ganodermaones B
Cat.No: T72798
Synonym:
Target: Others
Flaccidoside II
Cat.No: T79983
Synonym:
Target: Apoptosis
Norarmepavine
Cat.No: TN4664
Synonym:
Target: Others
Collinin
Cat.No: T38330
Synonym:
Target: Others
Ajoene
Cat.No: T35624
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPY-01395 CTHRC1 Protein, Human, Recombinant (His)

collagen triple helix repeat containing 1

Human HEK293 Cells
CTHRC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q96CG8-1.
TMPY-02848 Adiponectin Protein, Human, Recombinant (hFc)

ADPN,adiponectin, C1Q and collagen domain ...

Human HEK293 Cells
Adiponectin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q15848.
TMPY-05556 Adiponectin Protein, Human, Recombinant (His)

ADPN,Adiponectin,APM1,adiponectin, C1Q and...

Human Baculovirus Insect Cells
Adiponectin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A8K660.
TMPJ-00948 Endostatin Protein, Mouse, Recombinant (His)

antiangiogenic agent,type XVIII,collagen α-1

Mouse HEK293 Cells
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End...
TMPJ-00921 COL8A1 Protein, Human, Recombinant (His)

Vastatin,Endothelial Collagen,Collagen Alp...

Human HEK293 Cells
Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium o...
TMPJ-00804 COL3A1 Protein, Mouse, Recombinant (His)

Col3a1,Collagen alpha-1(III) chai...

Mouse HEK293 Cells
Collagen alpha-1(III) chain(Col3a1) is a secreted protein and belongs to the fibrillar collagen family.It contains 1 fibrillar collagen NC1 domain and 1 VWFC domain. Collagen alpha-1(III) chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. The COL3A1 gene produces the components of type III collagen, called pro-alpha1(III) chains. Three copies of this chain combine to make a mole...
TMPY-04288 CTHRC1 Protein, Rat, Recombinant (His)

collagen triple helix repeat containing 1

Rat HEK293 Cells
CTHRC1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.8 kDa and the accession number is NP_001258229.1.
TMPY-06826 CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated

collagen triple helix repeat containing 1

Human HEK293 Cells
CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 26.33 kDa and the accession number is NP_612464.1.
TMPY-06775 CTHRC1 Protein, Human, Recombinant (hFc)

collagen triple helix repeat containing 1

Human HEK293 Cells
CTHRC1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.8 kDa and the accession number is NP_612464.1.
TMPJ-01281 COL21A1 Protein, Human, Recombinant (His)

collagen, type XXI, alpha 1,COL21...

Human HEK293 Cells
Collagen α-1(XXI) Chain (COL21A1) is a member of the fibril-associated collagens with interrupted helices (FACIT) family. COL21A1 is a secreted protein and contains six collagen-like domains, one TSP N-terminal (TSPN) domain, and one VWFA domain. COL21A1 is widely expressed in many tissues with the highest expression observed at the fetal stage. COL21A1 is stimulated by PDGF/platelet-derived growth factor. Type XXI collagen is localized to tissues containing type I collagen; it may serve to main...
TMPY-01860 Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His)

SEDC,collagen, type II, alpha 1,COL1

Human HEK293 Cells
COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of th...
TMPH-01113 COL8A1 Protein, Human, Recombinant (His & SUMO)

Endothelial collagen,C3orf7,COL8A1,Col...

Human E. coli
COL8A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-04015 COL9A1 Protein, Human, Recombinant (mFc)

DJ149L1.1.2,STL4,collagen

Human HEK293 Cells
COL9A1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 59.2 kDa and the accession number is P20849-3.
TMPY-03960 COL9A1 Protein, Human, Recombinant (His)

EDM6,collagen, type IX, α1,STL4,collag...

Human HEK293 Cells
COL9A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is P20849-3.
TMPY-02596 GLT25D2 Protein, Human, Recombinant (His)

GLT25D2,RP11-498P10.2,collage...

Human Baculovirus Insect Cells
Glycosyl transferase 25 domain 2 (GLT25D2) is a glucosyltransferase enzyme expressed only at low levels in the nervous system. Glycosyltransferases are enzymes that act as a catalyst for the transfer of a monosaccharide unit from an activated nucleotide sugar (also known as the "glycosyl donor") to a glycosyl acceptor molecule, usually an alcohol. Glycosyl transferases transfer glycosyl groups onto their substrate. Localization partially defines their function. Glt25D2 enzyme showed a strong gal...
TMPY-06795 CTHRC1 Protein, Mouse, Recombinant (His)

1110014B07Rik,collag...

Mouse HEK293 Cells
CTHRC1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.53 kDa and the accession number is Q9D1D6.
TMPH-01117 COL18A1 Protein, Human, Recombinant (GST)

COL18A1,Collagen alpha-1...

Human E. coli
COL18A1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 46.3 kDa and the accession number is P39060.
TMPH-01118 COL18A1 Protein, Human, Recombinant (His)

COL18A1,Collagen alpha-1...

Human P. pastoris (Yeast)
COL18A1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P39060.
TMPH-01111 COL4A1 Protein, Human, Recombinant (His & SUMO)

COL4A1,Collagen alpha-1(IV) chain

Human E. coli
COL4A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-01112 COL4A1 Protein, Human, Recombinant (GST)

COL4A1,Collagen alpha-1(IV) chain

Human E. coli
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. COL4A1 Protein, Human, Recombinant (GST) is expressed in E. coli expr...
TMPH-01115 COL15A1 Protein, Human, Recombinant (His)

Collagen alpha-1(XV) chain,COL15A...

Human E. coli
COL15A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02593 CTHRC1 Protein, Mouse, Recombinant (His & SUMO)

Collagen triple helix repeat-containing protein

Mouse E. coli
May act as a negative regulator of collagen matrix deposition.
TMPH-01114 COL12A1 Protein, Human, Recombinant (His)

Collagen alpha-1(XII) chain,COL12...

Human E. coli
COL12A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02588 COL12A1 Protein, Mouse, Recombinant (His)

Collagen alpha-1(XII) chain,COL12...

Mouse E. coli
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
TMPH-02592 CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His)

Collagen triple helix repeat-containing protein

Mouse HEK293 Cells
May act as a negative regulator of collagen matrix deposition.
TMPH-01123 CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc)

Collagen triple helix repeat-containing protein

Human HEK293 Cells
May act as a negative regulator of collagen matrix deposition. CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 52 kDa and the accession number is Q96CG8.
TMPH-02589 COL26A1 Protein, Mouse, Recombinant (His & Myc)

Col26a,Col26a1,Emu2,Emid2,Emilin and multimerin dom...

Mouse Baculovirus Insect Cells
N/A. COL26A1 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 47.7 kDa and the accession number is Q91VF6.
TMPH-02856 SAAL1 Protein, Mouse, Recombinant (His & Myc)

Synoviocyte proliferation-associated in collagen-in...

Mouse E. coli
Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
TMPH-02655 Ficolin 1/FCN1 Protein, Mouse, Recombinant (His)

Ficolin-1,Ficolin-alpha,Ficolin-A,M-ficolin,Fcn...

Mouse E. coli
Ficolin 1/FCN1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.5 kDa and the accession number is O70165.
TMPH-02061 SCARB1 Protein, Human, Recombinant (His & SUMO)

SCARB1,SR-BI,CD36 antigen-like 1,CD36 and ...

Human E. coli
SCARB1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 62.7 kDa and the accession number is Q8WTV0.
TMPH-01116 COL17A1 Protein, Human, Recombinant (His)

BP180,Bullous pemphigoid antigen 2,180 kDa...

Human E. coli
May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. COL17A1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.4 kDa and the accession number is Q9UMD9.
TMPH-00350 Adiponectin Protein, Feline, Recombinant

apM-1,30 kDa adipocyte complement-related protein,A...

Feline E. coli
Adiponectin Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24.9 kDa and the accession number is A4PB30.
TMPH-00219 Adiponectin Protein, Bovine, Recombinant (His)

ACRP30,Adipocyte complement-related 30 kDa protein,Adipose m...

Bovine P. pastoris (Yeast)
Adiponectin Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is Q3Y5Z3.
TMPJ-00995 Serpin H1 Protein, Human, Recombinant (His)

Arsenic-Transactivated Protein 3,SERPINH2,Rheumatoid Arthrit...

Human HEK293 Cells
Serpin H1 is a serine proteinase inhibitors Which belongs to the serpin family. Serpin H1 is induced by heat shock. Serpin H1 localizes to the endoplasmic reticulum lumen and binds specifically to collagen. Thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. Serpin H1 may be a marker for cancer and nucleotide polymorphisms in this gene may be associated with preterm ...
TMPY-02953 TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

ATR,TEM8,anthrax toxin receptor 1,GAPO

Human HEK293 Cells
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key pro...
TMPJ-01172 IL-17 Protein, Mouse, Recombinant (His)

CTLA8,IL-17,IL-17A,Interleukin-17...

Mouse HEK293 Cells
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato...
TMPY-00203 LOXL2 Protein, Mouse, Recombinant (His)

1110004B06Rik,4930526G1<...

Mouse HEK293 Cells
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act...
TMPH-02402 Zinc metalloproteinase Protein, Legionella pneumophila, Recombinant (His)

Zinc metalloproteinase,PEP1,PRO A

Legionella pneumophila E. coli
Cleaves collagen, gelatin, casein, alpha-1-antitrypsin, and bovine insulin. May play a role in the pathogenesis of legionnaires disease.
TMPJ-00605 GPVI Protein, Mouse, Recombinant (His)

Glycoprotein 6,GP6,glycoprotein VI (platelet),GPVI,GPIV,MGC<...

Mouse HEK293 Cells
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like...
TMPY-04671 MCP-5 Protein, Mouse, Recombinant (His)

chemokine (C-C motif) ligand 12,MCP-5,Scya1

Mouse P. pastoris (Yeast)
Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1). Both MCP-1 ...
TMPK-01390 Fibronectin Protein, Human, Recombinant (aa 32-602, His)

FNZ,ED-B,SMDCF,FN1,GFND,MSF,GFND2,LETS,FN,FINC,CIG

Human HEK293 Cells
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 32-602, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted m...
TMPK-01389 Fibronectin Protein, Human, Recombinant (aa 32-345, His)

MSF,ED-B,LETS,SMDCF,FN,GFND2,CIG,FNZ,FN1,GFND,FINC

Human HEK293 Cells
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 32-345, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted m...
TMPY-01826 Relaxin 1/RLN1 Protein, Human, Recombinant (His)

RLXH1,H1RLX,relaxin 1,bA1

Human HEK293 Cells
Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 8 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has impo...
TMPK-01190 GPVI Protein, Human, Recombinant (His)

Glycoprotein 6,Gp6,MGC138168,GPVI

Human HEK293 Cells
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands. ...
TMPH-02512 TEM8/ANTXR1 Protein, Mouse, Recombinant (His)

Tumor endothelial marker 8,Anthrax toxin receptor 1...

Mouse E. coli
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
TMPH-02813 Nidogen-1 Protein, Mouse, Recombinant (E. coli, His)

Nid1,Nidogen-1,Entactin

Mouse E. coli
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Nidogen-1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.3 kDa and the accession number is P10493.
TMPH-02513 TEM8/ANTXR1 Protein, Mouse, Recombinant (His & Myc)

Antxr1,Tumor endothelial marker 8,Anthrax toxin rec...

Mouse HEK293 Cells
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
TMPJ-00566 MFAP4 Protein, Human, Recombinant (His)

Microfibril-associated glycoprotein 4

Human HEK293 Cells
Microfibril-associated glycoprotein 4(MFAP4) is a secreted protein and contains 1 fibrinogen C-terminal domain, similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in calcium-dependent cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region.
TMPJ-01444 IL-17A Protein, Cynomolgus, Recombinant (His)

CTLA-8,CTLA8,IL17A,IL-17,IL-17A,C...

Cynomolgus HEK293 Cells
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synt...
TMPJ-01333 TEM8/ANTXR1 Protein, Human, Recombinant (His)

ATR,ANTXR1,TEM8,Tumor Endothelial Marker 8,Anthrax ...

Human HEK293 Cells
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton, it mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It ...
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重组蛋白

CTHRC1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01395
Species: Human
Expression System: HEK293 Cells
Adiponectin Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02848
Species: Human
Expression System: HEK293 Cells
Adiponectin Protein, Human, Recombinant (His)
Cat.No: TMPY-05556
Species: Human
Expression System: Baculovirus Insect Cells
Endostatin Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00948
Species: Mouse
Expression System: HEK293 Cells
COL8A1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00921
Species: Human
Expression System: HEK293 Cells
COL3A1 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00804
Species: Mouse
Expression System: HEK293 Cells
CTHRC1 Protein, Rat, Recombinant (His)
Cat.No: TMPY-04288
Species: Rat
Expression System: HEK293 Cells
CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06826
Species: Human
Expression System: HEK293 Cells
CTHRC1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-06775
Species: Human
Expression System: HEK293 Cells
COL21A1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01281
Species: Human
Expression System: HEK293 Cells
Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His)
Cat.No: TMPY-01860
Species: Human
Expression System: HEK293 Cells
COL8A1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01113
Species: Human
Expression System: E. coli
COL9A1 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-04015
Species: Human
Expression System: HEK293 Cells
COL9A1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03960
Species: Human
Expression System: HEK293 Cells
GLT25D2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02596
Species: Human
Expression System: Baculovirus Insect Cells
CTHRC1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06795
Species: Mouse
Expression System: HEK293 Cells
COL18A1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01117
Species: Human
Expression System: E. coli
COL18A1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01118
Species: Human
Expression System: P. pastoris (Yeast)
COL4A1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01111
Species: Human
Expression System: E. coli
COL4A1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01112
Species: Human
Expression System: E. coli
COL15A1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01115
Species: Human
Expression System: E. coli
CTHRC1 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02593
Species: Mouse
Expression System: E. coli
COL12A1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01114
Species: Human
Expression System: E. coli
COL12A1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02588
Species: Mouse
Expression System: E. coli
CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His)
Cat.No: TMPH-02592
Species: Mouse
Expression System: HEK293 Cells
CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc)
Cat.No: TMPH-01123
Species: Human
Expression System: HEK293 Cells
COL26A1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02589
Species: Mouse
Expression System: Baculovirus Insect Cells
SAAL1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02856
Species: Mouse
Expression System: E. coli
Ficolin 1/FCN1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02655
Species: Mouse
Expression System: E. coli
SCARB1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02061
Species: Human
Expression System: E. coli
COL17A1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01116
Species: Human
Expression System: E. coli
Adiponectin Protein, Feline, Recombinant
Cat.No: TMPH-00350
Species: Feline
Expression System: E. coli
Adiponectin Protein, Bovine, Recombinant (His)
Cat.No: TMPH-00219
Species: Bovine
Expression System: P. pastoris (Yeast)
Serpin H1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00995
Species: Human
Expression System: HEK293 Cells
TEM8/ANTXR1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02953
Species: Human
Expression System: HEK293 Cells
IL-17 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01172
Species: Mouse
Expression System: HEK293 Cells
LOXL2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00203
Species: Mouse
Expression System: HEK293 Cells
Zinc metalloproteinase Protein, Legionella pneumophila, Recombinant (His)
Cat.No: TMPH-02402
Species: Legionella pneumophila
Expression System: E. coli
GPVI Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00605
Species: Mouse
Expression System: HEK293 Cells
MCP-5 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04671
Species: Mouse
Expression System: P. pastoris (Yeast)
Fibronectin Protein, Human, Recombinant (aa 32-602, His)
Cat.No: TMPK-01390
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 32-345, His)
Cat.No: TMPK-01389
Species: Human
Expression System: HEK293 Cells
Relaxin 1/RLN1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01826
Species: Human
Expression System: HEK293 Cells
GPVI Protein, Human, Recombinant (His)
Cat.No: TMPK-01190
Species: Human
Expression System: HEK293 Cells
TEM8/ANTXR1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02512
Species: Mouse
Expression System: E. coli
Nidogen-1 Protein, Mouse, Recombinant (E. coli, His)
Cat.No: TMPH-02813
Species: Mouse
Expression System: E. coli
TEM8/ANTXR1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02513
Species: Mouse
Expression System: HEK293 Cells
MFAP4 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00566
Species: Human
Expression System: HEK293 Cells
IL-17A Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPJ-01444
Species: Cynomolgus
Expression System: HEK293 Cells
TEM8/ANTXR1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01333
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
TMIJ-0518 L-Kynurenine-d4-1

L-Kynurenine-d4-1 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T35695 Oleic Acid-13C

Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximate...

同位素标记化合物

L-Kynurenine-d4-1
Cat.No: TMIJ-0518
Synonym:
Target:
Oleic Acid-13C
Cat.No: T35695
Synonym:
Target:
TargetMol Loading
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