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Search Results for " atrial "

80

抑制剂 & 化合物

4

天然产物

2

化合物库

13

重组蛋白

8

同位素标记化合物

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Cat. No.	Product Name
L6140	糖类及苷类化合物库		595 compounds
	595 种糖类或苷类的化合物，可用于高通量筛选和高内涵筛选；
L6750	活血化瘀中药单体库		580 compounds
	580种来源于常见活血化瘀中药的单体化合物，是药物开发、药理研究等领域的有效工具。

化合物库

糖类及苷类化合物库

Cat.No: L6140

Compounds: 595

活血化瘀中药单体库

Cat.No: L6750

Compounds: 580

Cat. No.	Product Name	Target	Signaling Pathways
T41065	Atrial natriuretic factor (1-28) (human, porcine) Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28)
	Atrial natriuretic factor (1-28) from both human and porcine sources is a powerful suppressor of pro-opiomelanocortin (POMC) mRNA, while it only has a modest inhibition effect on βEP-LI release.
TP1219	Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate ANP (1-28), human, porcineANP(1-28)
	Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 是颗粒鸟苷酸环化酶的刺激剂，已被发现通过增加环鸟苷单磷酸的合成来保护分离的心肌细胞免受复氧诱导的高收缩。Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 也有助于在反复运动期间刺激脂解，并在运动期间控制脂解。
TP1221	Atrial Natriuretic Peptide (ANP) (1-28), rat Atrial natriuretic factor (1-28) (rat)
	Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.
TP1218	Atrial natriuretic factor (1-28) (rat) TFA Atrial Natriuretic Peptide (ANP) (1-28), rat TFA
	Atrial Natriuretic Peptide (ANP) (1-28),rat (TFA) is the main circulating forms of Atrial Natriuretic Peptide (ANP) in rats, which strongly inhibit the secretion of Ang II - stimulated endothelin-1.
TP2221L	ANP (1-11), rat acetate Atrial natriuretic factor (1-11) acetate,ANP (1-11), rat醋酸盐,Atriopeptide (1-11) acetate	Others	Others
	ANP (1-11), rat acetate (Atrial natriuretic factor (1-11) acetate) 是心房利钠因子之一，是 CRF 刺激的 ACTH 分泌的抑制剂。
T39244	Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled
	Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, is one of three mammalian natriuretic peptides (NPs) that exerts endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide holds promise for cardiovascular diseases research.
TP1220L	ANP(1-28) Acetate (human, porcine) 醋酸卡培立肽,Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate	Endothelin Receptor	GPCR/G Protein
	Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate) 是一种由 28 个氨基酸组成的激素，由心脏产生并分泌，以响应心脏损伤和机械拉伸。Carperitide acetate 抑制内皮素-1 (endothelin-1) 分泌。
T80438	Atrial natriuretic peptide (3-28) (human) ANP (3-28) (human)	Endothelin Receptor	GPCR/G Protein
	Atrial natriuretic peptide (3-28) (human) 是由心房心肌细胞合成并分泌的肽类激素，主要在调节血压、体液平衡及电解质稳态方面发挥作用。
TP1220	Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine
	Carperitide, a 28-amino acid hormone known as Atrial Natriuretic Peptide (ANP) (1-28), is naturally synthesized and released by the human heart in reaction to cardiac injury and mechanical stretch. This compound effectively suppresses endothelin-1 secretion in a dose-dependent manner.
T81407	Prepro-Atrial Natriuretic Factor (26-55) (human)
	Prepro-Atrial Natriuretic Factor (26-55) (human) 为促进肾皮质与髓质循环GMP水平上升的多肽，同时也增强肾腺苷酸环化酶的活性。
T82932	Auriculin B Atrial natriuretic peptide(126-150)(rat),ANP (126-150) (Rat)
	Auriculin B (ANP (126-150) (Rat)) 是源自大鼠的心房钠尿肽，具备显著的血管舒张与利尿作用。
T0142	Brinzolamide 布林佐胺,AL-4862	Carbonic Anhydrase	Metabolism
	Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。
T0389	Dabigatran etexilate 达比加群酯,BIBR 1048	Thrombin	Proteases/Proteasome
	Dabigatran etexilate (BIBR 1048) 是一种 Dabigatran 前药，具有口服活性。它具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T7811	Pilsicainide HCl SUN 1165,盐酸吡西卡呢	Sodium Channel	Membrane transporter/Ion channel
	Pilsicainide HCl (SUN 1165) 是一种纯钠通道阻滞剂。
T5133	Dabigatran Etexilate Mesylate 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate	Thrombin	Proteases/Proteasome
	Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药，具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T1320	Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平	Potassium Channel; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流，延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。
T15207	Eleclazine hydrochloride GS 6615 hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Eleclazine hydrochloride (GS 6615 hydrochloride) 是新型 Na+电流抑制剂，IC50是0.7 uM。
T30520	BMS-394136 BMS394136,BMS 394136,BMS394136;UNII-M694U7167K	Potassium Channel	Membrane transporter/Ion channel
	BMS-394136 (BMS 394136) 是一种 KV1.5 拮抗剂，可用于治疗心律失常、心房颤动等心血管疾病。
T68038	Celivarone	Potassium Channel	Membrane transporter/Ion channel
	Celivarone 是一种钾离子通道阻滞剂，可用于研究心律失常、心房扑动和心房颤动。
T26689	AVE-0118 AVE 0118,AVE0118	Potassium Channel	Membrane transporter/Ion channel
	AVE-0118 是一种钾通道阻滞剂，可抑制持续性心房颤动。
T30544	BMS-919373 BMS919373,BMS 919373	Potassium Channel	Membrane transporter/Ion channel
	BMS-919373是的钾通道Kv1.5（KCNA5）抑制剂，可用于心房颤动和急性冠状动脉综合征。
T6955	Propafenone hydrochloride Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol	Sodium Channel	Membrane transporter/Ion channel
	Propafenone hydrochloride (Arythmol8) 具有抗心律不齐的功效，可用于心房和心室性心律不齐。
T68730	AVE1231	Potassium Channel	Membrane transporter/Ion channel
	AVE1231 是一种 TASK-1 通道阻滞剂，抑制 TASK-1 ，可用于研究心房颤动。
T28748	Selodenoson RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Selodenoson (RG-14202) 是一种选择性腺苷 A1 受体激动剂，可用于减慢心房颤动患者的心率，治疗心律失常。
T1073	Dronedarone hydrochloride Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆	Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Dronedarone hydrochloride (SR33589) 是一种胺碘酮类似物，可抑制 Na+,K+andCa2+的电流，有可能治疗心房颤动。
T61913	Cavutilide	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Cavutilide具有抗心律失常活性，抑制 hERG K（+）通道，可用于研究心力衰竭和持续性心房颤动。
T14077	A-935142	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	A-935142是一种人类醚-a-go-go 相关基因（hERG，Kv 11.1）通道激活剂。A-935142通过减慢失活、促进激活、减少失活、缩短心房和心室复极化，并通过一种复杂的方式增强 hERG 电流。
T83979	Sulcardine 2HCl Sulcardine 2HCl（343935-60-4 Free base）,HBI-3000 2HCl	HER; Sodium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Sulcardine 2HCl 是一种多离子通道阻滞剂，具有抗心律失常作用，可阻断 hERG 和hNav1.5通道的特性，可用于研究心房颤动和室性心律失常。
T6295	Dabigatran BIBR 953,BIBR 953ZW,达比加群	Thrombin	Proteases/Proteasome
	Dabigatran (BIBR 953ZW) 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
T27753	KT-362 fumarate KT 362,KT362,KT-362	Potassium Channel; Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	KT-362 fumarate 是一种新型化合物，可作为钙通道、钾通道和钠通道的拮抗剂.KT-362 fumarate 通过影响心房肌肉细胞内钙动员导致血管舒张。KT-362 fumarate 对兔子的股动脉和基底动脉条有放松作用。
T6476	Dofetilide UK 68789,UK-68798,Tikosyn,多非利特	Potassium Channel	Membrane transporter/Ion channel
	Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂，作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。
T3574	Sematilide hydrochloride 司美利特,CK-1752A,CK-1752,Sematilide HCl	Potassium Channel	Membrane transporter/Ion channel
	Sematilide hydrochloride (CK-1752) 是一种选择性的 IKr 通道阻滞剂。Sematilide 以浓度依赖性抑制延迟整流钾通道 (K+current)，IC50为 25 μM。Sematilide 是一种 III 类抗心律不齐剂。
T30249	AZD 7009 AZD-7009,AZD7009	Sodium Channel	Membrane transporter/Ion channel
	AZD 7009是一种新型抗心律失常化合物，对CHO K1细胞中 hNav1.5的钠电流具有抑制作用，IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用，对e -4031诱导的动作电位持续时间延长具有抑制作用，促使浦肯野纤维的早期后去极化(EADs)。
T1496	Amiodarone hydrochloride 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone	Potassium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
T6541	Ibutilide Fumarate Corvert Fumarate,U70226E,富马酸伊布利特	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物，可作用于急性心梗阻塞。
T4200	Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt	Neprilysin	Metabolism
	Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T0815L	Warfarin sodium	Others	Others
	Warfarin sodium 是一种抗凝血剂，通过抑制维生素 K 依赖性凝血因子的合成起作用。华法林适用于预防和/或治疗静脉血栓形成及其延伸、肺栓塞和房颤栓塞。它还用作预防心肌梗塞后全身性栓塞的辅助剂。华法林也用作杀鼠剂。
T26437	A 71915 A-71915,A71915
	A 71915, an atrial natricuretic factor receptor antagonist, blocks physiological effects of angiotensin.
T27637	ISQ-1 HCl ISQ-1,ISQ1,ISQ 1	Others	Others
	ISQ-1 HCl is an isoquinolinone (IKur) blocker with possible atrial arrhythmia activity.
T30701	Candoxatrilat UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578	Others	Others
	Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation.
T19331	F 16915	Others	Others
	F 16915 can prevent heart failure-induced atrial fibrillation.F 16915 is a docosahexaenoic acid derivative.
T37821	AP 14145 hydrochloride	Others	Others
	KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model. Diness et al (2017) Termination of vernakalant-resistant atrial fibrillation by inhibition of small-conductance Ca2+-activated K+...
T21373	Aprindine hydrochloride Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil	Others	Others
	Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.
T81891	M65
	M65为PAC1受体特异性拮抗剂，可抑制ANP释放。
T62207	KVI-020	Others	Others
	KVI-020 是一种选择性的、口服具有活力的心房钾通道 Kv1.5 阻滞剂 (IC50: 480 nM)。KVI-020 对 hERG 表现出抑制作用 (IC50: 15100 nM)。 KVI-020 是一种有效的抗心律失常剂 (antiarrhythmic)，能够用于研究房颤 (AF)。
T30678	C1-resveratrol C1resveratrol,C1 resveratrol	Others	Others
	C1 resveratrol is a novel multifunctional derivative of resveratrol, which is used to treat atrial fibrillation.
T29501	A 68828 A68828,A-68828	Others	Others
	A 68828 is an analog of the atrial natrium factor. It improves kidney function and reduces tissue damage.
TP1872	Vasonatrin Peptide (VNP) Vasonatrin Peptide VNP
	Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activity.
T68893	Vanoxerine free base	Others	Others
	Vanoxerine, also known as GBR-12909; I-893, is a dopamine ruptake inhibitor potentially for the treatment of atrial fibrillation.
T5336L	Zacopride Racemic zacopride	Others	Others
	Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias.

化合物

Atrial natriuretic factor (1-28) (human, porcine)

Cat.No: T41065

Synonym: Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28)

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

Cat.No: TP1219

Synonym: ANP (1-28), human, porcineANP(1-28)

Atrial Natriuretic Peptide (ANP) (1-28), rat

Cat.No: TP1221

Synonym: Atrial natriuretic factor (1-28) (rat)

Atrial natriuretic factor (1-28) (rat) TFA

Cat.No: TP1218

Synonym: Atrial Natriuretic Peptide (ANP) (1-28), rat TFA

ANP (1-11), rat acetate

Cat.No: TP2221L

Synonym: Atrial natriuretic factor (1-11) acetate,ANP (1-11), rat醋酸盐,Atriopeptide (1-11) acetate

Target: Others

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled

Cat.No: T39244

ANP(1-28) Acetate (human, porcine)

Cat.No: TP1220L

Synonym: 醋酸卡培立肽,Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

Target: Endothelin Receptor

Atrial natriuretic peptide (3-28) (human)

Cat.No: T80438

Synonym: ANP (3-28) (human)

Target: Endothelin Receptor

Cat.No: TP1220

Synonym: Atrial Natriuretic Peptide (ANP) (1-28), human, porcine

Prepro-Atrial Natriuretic Factor (26-55) (human)

Cat.No: T81407

Cat.No: T82932

Synonym: Atrial natriuretic peptide(126-150)(rat),ANP (126-150) (Rat)

Cat.No: T0142

Synonym: 布林佐胺,AL-4862

Target: Carbonic Anhydrase

Dabigatran etexilate

Cat.No: T0389

Synonym: 达比加群酯,BIBR 1048

Target: Thrombin

Pilsicainide HCl

Cat.No: T7811

Synonym: SUN 1165,盐酸吡西卡呢

Target: Sodium Channel

Dabigatran Etexilate Mesylate

Cat.No: T5133

Synonym: 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate

Target: Thrombin

Cat.No: T1320

Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平

Target: Potassium Channel, Sodium Channel, AChR

Eleclazine hydrochloride

Cat.No: T15207

Synonym: GS 6615 hydrochloride

Target: Sodium Channel

Cat.No: T30520

Synonym: BMS394136,BMS 394136,BMS394136;UNII-M694U7167K

Target: Potassium Channel

Cat.No: T68038

Target: Potassium Channel

Cat.No: T26689

Synonym: AVE 0118,AVE0118

Target: Potassium Channel

Cat.No: T30544

Synonym: BMS919373,BMS 919373

Target: Potassium Channel

Propafenone hydrochloride

Cat.No: T6955

Synonym: Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol

Target: Sodium Channel

Cat.No: T68730

Target: Potassium Channel

Cat.No: T28748

Synonym: RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009

Target: Adenosine Receptor

Dronedarone hydrochloride

Cat.No: T1073

Synonym: Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆

Target: Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, Autophagy

Cat.No: T61913

Target: EGFR

Cat.No: T14077

Target: EGFR

Sulcardine 2HCl

Cat.No: T83979

Synonym: Sulcardine 2HCl（343935-60-4 Free base）,HBI-3000 2HCl

Target: HER, Sodium Channel

Cat.No: T6295

Synonym: BIBR 953,BIBR 953ZW,达比加群

Target: Thrombin

KT-362 fumarate

Cat.No: T27753

Synonym: KT 362,KT362,KT-362

Target: Potassium Channel, Calcium Channel, Sodium Channel

Cat.No: T6476

Synonym: UK 68789,UK-68798,Tikosyn,多非利特

Target: Potassium Channel

Sematilide hydrochloride

Cat.No: T3574

Synonym: 司美利特,CK-1752A,CK-1752,Sematilide HCl

Target: Potassium Channel

Cat.No: T30249

Synonym: AZD-7009,AZD7009

Target: Sodium Channel

Amiodarone hydrochloride

Cat.No: T1496

Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Target: Potassium Channel, Adrenergic Receptor, Autophagy

Ibutilide Fumarate

Cat.No: T6541

Synonym: Corvert Fumarate,U70226E,富马酸伊布利特

Target: Calcium Channel, Sodium Channel

Sacubitril hemicalcium salt

Cat.No: T4200

Synonym: AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt

Target: Neprilysin

Warfarin sodium

Cat.No: T0815L

Target: Others

Cat.No: T26437

Synonym: A-71915,A71915

Cat.No: T27637

Synonym: ISQ-1,ISQ1,ISQ 1

Target: Others

Cat.No: T30701

Synonym: UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578

Target: Others

Cat.No: T19331

Target: Others

AP 14145 hydrochloride

Cat.No: T37821

Target: Others

Aprindine hydrochloride

Cat.No: T21373

Synonym: Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil

Target: Others

Cat.No: T81891

Cat.No: T62207

Target: Others

Cat.No: T30678

Synonym: C1resveratrol,C1 resveratrol

Target: Others

Cat.No: T29501

Synonym: A68828,A-68828

Target: Others

Vasonatrin Peptide (VNP)

Cat.No: TP1872

Synonym: Vasonatrin Peptide VNP

Vanoxerine free base

Cat.No: T68893

Target: Others

Cat.No: T5336L

Synonym: Racemic zacopride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T41358	2-Hydroxybenzylamine	Others	Others
	2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂，可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。
T7056	Dronedarone 决奈达隆,SR 33589	P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Dronedarone (SR 33589) 是一种胺碘酮类似物，对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂，通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
T4550	Ajmaline Cardiorythmine,Raugalline,阿义吗啉,阿义马林,Tachmalin,(+)-Ajmaline	Sodium Channel	Membrane transporter/Ion channel
	Ajmaline (Cardiorythmine) 是一种钠通道阻断剂，属于1A 类抗心律失常剂。Ajmaline 阻断 HERG 电流，在 HEK 细胞的 IC50为 1 μM，爪蟾卵母细胞的IC50为 42.3 μM。Ajmaline 在室性心动过速方面具有研究价值。

天然产物

2-Hydroxybenzylamine

Cat.No: T41358

Target: Others

Cat.No: T7056

Synonym: 决奈达隆,SR 33589

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

Cat.No: T4550

Synonym: Cardiorythmine,Raugalline,阿义吗啉,阿义马林,Tachmalin,(+)-Ajmaline

Target: Sodium Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03250	NPR3 Protein, Rat, Recombinant (His & SUMO) Npr3,Atrial natriuretic peptide receptor 3,Atri...	Rat	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system wi...
TMPH-00984	NPR2 Protein, Human, Recombinant (His) Atrial natriuretic peptide receptor 2,Atrial	Human	E. coli
	NPR2 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-00985	NPR3 Protein, Human, Recombinant (His) Atrial natriuretic peptide receptor type C,Atri...	Human	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-...
TMPH-00982	NPR1 Protein, Human, Recombinant (E. coli, His) Guanylate cyclase A,Atrial natriuretic peptide rece...	Human	E. coli
	NPR1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli.
TMPH-00983	NPR1 Protein, Human, Recombinant (His) Guanylate cyclase A,Atrial natriuretic peptide rece...	Human	P. pastoris (Yeast)
	NPR1 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-00986	CORIN Protein, Human, Recombinant (His) TMPRSS10,Pro-ANP-converting enzyme,Heart-specific serine pro...	Human	E. coli
	CORIN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.0 kDa and the accession number is Q9Y5Q5.
TMPY-04544	MEK2 Protein, Human, Recombinant (GST) mitogen-activated protein kinase kinase 2,FLJ26075,MKK2,CFC4...	Human	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ...
TMPJ-00878	NPR3 Protein, Human, Recombinant (hFc) ANPRC,ANPR-C,C5orf23,NPR-C,NPRC,NPR3,ANP-C	Human	HEK293 Cells
	Atrial Natriuretic Peptide Receptor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic peptide receptors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for N...
TMPJ-00874	NT-proBNP Protein, Human, Recombinant (His & Flag) γ-brain natriuretic peptide,Gamma-brain natriuretic peptide,...	Human	E. coli
	Brain-type Natriuretic Peptide (BNP) is a nonglycosylated peptide that is produced predominantly by ventricular myocytes and belongs to the natriuretic peptide family. Proteolytic cleavage of the 12 kDa BNP precursor gives rise to N-terminal Pro BNP (NT-proBNP) and mature BNP. N-terminal proB-type natriuretic peptide (NT-proBNP), a useful marker of heart failure (HF), is considered to be secreted mainly from the ventricle, increased serum NT-proBNP levels are also encountered in conditions such ...
TMPJ-00504	Serpin A8 Protein, Human, Recombinant (His) AGT and SERPINA8,Angiotensinogen,Serpin A8	Human	HEK293 Cells
	Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
TMPY-04327	VEGFB Protein, Human, Recombinant (hFc) VRF,血管内皮生长因子,vascular endothelial growth factor B,VEGFL	Human	HEK293 Cells
	Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang I...
TMPU-00002	SOS1-Cat Protein, Human, Recombinant (His) SOS-1,Son of sevenless homolog 1	Human	E. coli
	Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incid...
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His) phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C...	Human	Baculovirus Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ...

重组蛋白

NPR3 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03250

Species: Rat

Expression System: E. coli

NPR2 Protein, Human, Recombinant (His)

Cat.No: TMPH-00984

Species: Human

Expression System: E. coli

NPR3 Protein, Human, Recombinant (His)

Cat.No: TMPH-00985

Species: Human

Expression System: E. coli

NPR1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-00982

Species: Human

Expression System: E. coli

NPR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00983

Species: Human

Expression System: P. pastoris (Yeast)

CORIN Protein, Human, Recombinant (His)

Cat.No: TMPH-00986

Species: Human

Expression System: E. coli

MEK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04544

Species: Human

Expression System: Baculovirus Insect Cells

NPR3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00878

Species: Human

Expression System: HEK293 Cells

NT-proBNP Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00874

Species: Human

Expression System: E. coli

Serpin A8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00504

Species: Human

Expression System: HEK293 Cells

VEGFB Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04327

Species: Human

Expression System: HEK293 Cells

SOS1-Cat Protein, Human, Recombinant (His)

Cat.No: TMPU-00002

Species: Human

Expression System: E. coli

PDE2A Protein, Human, Recombinant (aa 215-900, His)

Cat.No: TMPY-02081

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0503	Digoxin-d3
	Digoxin-d3 是 Digoxin 的氘代化合物。Digoxin 的 CAS 号为 20830-75-5。Digoxin是Na+/K+-ATPase有效抑制剂，用于治疗各种心脏疾病。
TMIJ-0138	Dronedarone-d6 HCl
	Dronedarone-d6 HCl 是 Dronedarone HCl 的氘代化合物。Dronedarone HCl 的 CAS 号为 141625-93-6。Dronedarone Hydrochloride 是一种胺碘酮类似物，可抑制Na+,K+andCa2+的电流，有可能治疗心房颤动。
TMIJ-0501	Propafenone-d5 HCl
	Propafenone-d5 HCl 是 Propafenone HCl 的氘代化合物。Propafenone HCl 的 CAS 号为 34183-22-7。Propafenone HCl 具有抗心律不齐的功效，可用于心房和心室性心律不齐。
TMIJ-0003	Dabigatran-13C-d3
	Dabigatran-13C-d3 是 Dabigatran 的 13C 和氘代化合物。Dabigatran 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
TMIJ-0002	Dabigatran-13C6
	Dabigatran-13C6 是 Dabigatran 的 13C 的标记化合物。Dabigatran 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
TMIH-0173	Dabigatran-d4 HCl
	Dabigatran-d4 HCl 是 Dabigatran HCl 的氘代化合物。Dabigatran HCl 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
TMID-0070	Amiodarone-d10 Hydrochloride
	Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
TMID-0069	Amiodarone-d4 HCl
	Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。

同位素标记化合物

Cat.No: TMIJ-0503

Dronedarone-d6 HCl

Cat.No: TMIJ-0138

Propafenone-d5 HCl

Cat.No: TMIJ-0501

Dabigatran-13C-d3

Cat.No: TMIJ-0003

Dabigatran-13C6

Cat.No: TMIJ-0002

Dabigatran-d4 HCl

Cat.No: TMIH-0173

Amiodarone-d10 Hydrochloride

Cat.No: TMID-0070

Amiodarone-d4 HCl

Cat.No: TMID-0069

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