53
2
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8239 |
Cromoglicic acid
|
Others | Others |
Cromoglicic acid 可防止肥大细胞释放炎性化学物质,例如组胺。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T0211 |
Azelastine
Azelastina,Astelin,Azelastinum,氮卓斯汀 |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine (Azelastinum) 是一种选择性组胺 1 拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T0118 |
Mizolastine
SL 850324,咪唑司汀,咪唑斯汀 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mizolastine (SL 850324) 是组胺 H1 受体拮抗剂,IC50为 47 nM。它用于治疗过敏反应,如花粉热和荨麻疹等。 | |||
T21404 |
Fluticasone furoate
Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate |
Glucocorticoid Receptor | Endocrinology/Hormones |
Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
T3185 |
R112
|
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
R112 是 ATP 竞争性的 Syk 激酶抑制剂,它能够抑制 Syk 激酶活性,Ki=6 nM,IC50=226 nM。 | |||
T6242 |
Rupatadine Fumarate
富马酸卢帕他定,Rinialer,Rupafin,Alergoliber |
PAFR; Autophagy; Histamine Receptor | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂,Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。 | |||
T0059 |
Diphenylpyraline hydrochloride
盐酸双苯比拉林,4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂,抑制多巴胺的吸收。它是可口服的抗组胺试剂,具有抗胆碱和抗过敏作用,可用于缓解过敏性疾病,如鼻炎、花粉热和瘙痒性皮肤疾病等。 | |||
T0211L |
Azelastine hydrochloride
Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine hydrochloride (Astelin) 是一种选择性组胺 1拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T1030 |
Triprolidine hydrochloride monohydrate
盐酸曲普利啶,盐酸曲普利啶一水合物,Triprolidine hydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Triprolidine hydrochloride monohydrate 是一种组胺 H1 拮抗剂,用于过敏性鼻炎、哮喘。 | |||
T1269 |
Tripelennamine hydrochloride
Pyribenzamine hydrochloride,去敏灵,Tripelennamine HCl,Pyribenzamine HCl,盐酸曲吡那敏 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) 是一种组胺 H1 拮抗剂,具有低镇静作用,但经常刺激胃肠道。 | |||
T2335 |
Ebastine
Ebastel,依巴斯汀,LAS-W 090,Ebastin,Kestine,RP64305 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Ebastine (Kestine) 是一种可口服的组胺 H1 受体拮抗剂,用于过敏性鼻炎的症状和慢性特发性荨麻疹的研究。 | |||
T0188 |
Fluticasone (propionate)
丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate |
Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Endocrinology/Hormones; Metabolism; Microbiology/Virology |
Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂,是一种局部抗炎激素,亲和力KD 为 0.5 nM。具有抗病毒活性。 | |||
T0205 |
Brompheniramine maleate
Dimotane,马来酸溴苯那敏,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Brompheniramine maleate (Dimotane) 是一种可口服的丙胺类抗组胺剂,具有抗胆碱能和抗抑郁作用,可用于过敏性鼻炎和缓解疼痛的研究。它是一种选择性组胺 H1 受体拮抗剂,Kd 为 6.06 nM。 | |||
T0089 |
Cetirizine dihydrochloride
盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物,是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性,抑制过敏反应期间嗜酸性粒细胞趋化,可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。 | |||
T1553 |
Chlorpheniramine maleate
马来酸氯苯那敏,NCI-C55265,Chlorphenamine maleate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Chlorpheniramine maleate (NCI-C55265) 是一种组胺 H1 拮抗剂,IC50为12 nM,用于过敏反应、花粉热、鼻炎、荨麻疹和哮喘。 | |||
T6660 |
SB-705498
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
SB705498 是一种口服有效的 TRPV1选择性拮抗剂,pIC50值为 7.1。 | |||
T1531 |
Mometasone furoate
糠酸莫美他松,糠酸莫米松,Sch32088 |
Glucocorticoid Receptor | Endocrinology/Hormones |
Mometasone furoate (Sch32088) 是糖皮质激素受体激动剂,具有抗炎和抗过敏作用。它是皮质固醇类试剂,动物模型中,可局部应用于气道炎症、慢性皮肤湿疹、哮喘。 | |||
T16476 |
PF-03654746
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
PF-03654746 是组胺 H3 受体的选择性拮抗剂。 PF-03654746 提高了阿尔茨海默病的认知功效和疾病改善作用。 PF-03654746 可用于治疗过敏性鼻炎的研究。 | |||
T77426 |
Pascolizumab
SB-240683 |
IL Receptor | Immunology/Inflammation |
Pascolizumab (SB-240683) 是一种人源化抗 IL-4 单克隆抗体。Pascolizumab 具有哮喘作用,可用于研究过敏性鼻炎。 | |||
T1470 |
Fexofenadine hydrochloride
Terfenidine carboxylate hydrochloride,MDL-16455 hydrochloride,盐酸非索非那定,Telfast,Fexofenadine HCl,Allegra,MDL 16455A |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) 是一种抗组胺药,用于治疗过敏性鼻炎、血管性水肿和慢性荨麻疹。 | |||
T1278 |
Astemizole
Laridal,Histaminos,Paralergin,阿司咪唑 |
Potassium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Astemizole (Laridal) 是一种长效、非镇静抗组胺药,用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂,IC50值为 4 nM,还阻断 hERG K+通道,IC50值为 0.9 nM,具有抗胆碱能和止痒作用。 | |||
T2270 |
Trans-Tranilast
Tranilast trans-,反式-曲尼司特,反-曲尼司特 |
RAAS | Endocrinology/Hormones |
Trans-Tranilast 是抗过敏剂,可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。 | |||
T2392 |
Nafamostat mesylate
甲磺酸萘莫司他,FUT-175 |
Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease | Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂,血管舒缓素抑制剂,能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性,可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。 | |||
T2396 |
Ramatroban
BAY u3405,雷马曲班 |
GPR; Prostaglandin Receptor; PPAR | DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
Ramatroban (BAY u3405) 是一种血栓素 A(2) (TxA(2)) 拮抗剂,IC50为 14 nM。它还通过抑制PGD2结合从而拮抗CRTH2,IC50为113 nM。它用于治疗过敏性鼻炎,可用于治疗哮喘的研究。 | |||
T22354 |
Levocetirizine Dihydrochloride
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria. | |||
T1097 |
Loratadine
氯雷他定,SCH 29851,Loratidine |
Influenza Virus; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Loratadine (SCH 29851) 是一种组胺 H1受体反向激动剂,IC50>32 μM。它抑制炎症介质的免疫释放,具有抗登革热病毒的活性。 | |||
T4563 |
Thonzylamine
neohetramine,松齐拉敏 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂,具有抗组胺和抗过敏特性,可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。 | |||
T21112 |
Triprolidine hydrochloride
295 C 51,Pro-Entra,Entra,盐酸曲普利啶,Actidilat,Triprolidine hydrochloride anhydrous,Actidil,Pro-Actidil |
Others | Others |
Triprolidine hydrochloride anhydrous, a Histamine H1 antagonist, is used in asthma, allergic rhinitis, and urticaria. | |||
T10437 |
AZD8848
|
TLR | Immunology/Inflammation |
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis. | |||
T69737 |
SCH-79687
|
Others | Others |
SCH-79687 is a histamine antagonist selective for the H3 subtype. This H3 antagonist may play a role in allergic rhinitis. | |||
T29951 |
Ambicromil
|
Others | Others |
Ambicromil is used for allergic rhinitis. | |||
T0785L |
Dexchlorpheniramine free base
Polaramine,Dexchlorpheniramine Maleate,Mylaramine |
Others | Others |
Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus. | |||
T27556 |
HSR-609
HSR609,FY609,FY-609,FY 609 |
Others | Others |
HSR-609, a histamine H1 receptor antagonist, is used potentially for the treatment of allergic rhinitis. | |||
T27445 |
GSK-1004723
GSK 1004723 |
Others | Others |
GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis. | |||
T21247 |
Carbinoxamine
Allergefon,(+-)-Carbinoxamine,Paracarbinoxamine |
Others | Others |
Carbinoxamine, an anticholinergic and antihistamine agent, is used for hay fever, angioedema, vasomotor rhinitis, mild urticaria, dermatographism and allergic conjunctivitis. It is a histamine antagonist, specifically an H1-antagonist. | |||
T68280 |
Adriforant
|
Others | Others |
Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies. | |||
T37386 |
Dihydro Montelukast
|
Others | Others |
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing montelukast are used for the treatment of asthma as well as for the symptoms associated with allergic rhinitis. | |||
T74646 |
PM-81I
|
Others | Others |
PM-81I为一种高效STAT6抑制剂(针对SH2结构域),可显著减少STAT6的磷酸化水平。适用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。 | |||
T73972 |
Fexofenadine Impurity F
|
Others | Others |
Fexofenadine Impurity F 是 Fexofenadine 的杂质。 Fexofenadine 是一种H1R 拮抗剂,可用于研究季节性过敏性鼻炎和慢性特发性荨麻疹。 | |||
T60514 |
Triprolidine
|
Others | Others |
Triprolidine 是一种口服活性的组胺H1受体拮抗剂,可用于过敏性鼻炎的研究 。Triprolidine 具有脊髓运动和知觉阻止的作用。 | |||
T60392 |
Tripelennamine
|
Others | Others |
Tripelennamine 是一种乙二胺衍生物,是一种有效的组胺 H1受体拮抗剂,可减轻由组织胺引起的机体过敏反应。Tripelennamine 可用于鼻炎、结膜炎、过敏性和过敏性反应的研究。 | |||
T73129 |
STAT6-IN-1
|
Others | Others |
STAT6-IN-1(化合物19a)是一种针对STAT6的SH2结构域表现出较高亲和力(IC50=0.028 µM)的STAT6抑制剂。该化合物主要用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。 | |||
T62669 |
Tripelennamine citrate
|
Others | Others |
Tripelennamine citrate 是一种乙二胺衍生物,是一种有效的组胺 H1 受体拮抗剂。Tripelennamine citrate 能够减少组织胺引起的机体过敏反应。Tripelennamine citrate 能够用于研究鼻炎、结膜炎、过敏性和过敏性反应。 | |||
T26770 |
Bencycloquidium Bromide
BCQB |
Others | Others |
Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M(1) pKi=7.86, M(2) pKi=7.21, M(3) pKi=8.21); pA(2)=8.85, 8.71 and 8.57 in methacholine-induced contraction of trachea, ileum and urinary bladder, 8.19 in methacholine-induced bradycardia of right atrium in vitro, respectively.This compound is un... | |||
T61213 |
PF-03654764
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
PF-03654764 是一种具有口服活性、高效性和选择性的组胺 H3 受体拮抗剂,对人 H3 和大鼠 H3 具有抑制作用, Ki 值分别为 1.2 nM 和 7.9 nM。PF-03654764 常与 Fexofenadine 一起联合用药来治疗过敏性鼻炎。 | |||
T69918 |
Adriforant tartrate hydrate
|
Others | Others |
Adriforant tartrate hydrate, also known as ZPL-3893787 tartrate hydrate, PF-3893787 tartrate hydrate and ZPL-389 tartrate hydrate, is a novel histamine H4 receptor antagonist. Adriforant tartrate hydrate shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies. | |||
T38350 |
TAS 205
|
Others | Others |
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens... | |||
T84604 |
11(S)-HETE
11(S)-Hydroxyeicosatetraenoic Acid |
Others | Others |
11(S)-HETE, an (S) enantiomer of 11(R)-HETE and a type of oxylipin, is non-enzymatically synthesized from arachidonic acid. Compared to its counterpart, 11(S)-HETE levels are found to be elevated in both isolated human plasma and serum, as well as in LPS-stimulated isolated human plasma. Notably, patients with allergic rhinitis exhibit a decrease in 11(S)-HETE levels in their serum following one year of double-mite subcutaneous immunotherapy (DM-SCIT), correlating with an enhanced quality of lif... | |||
T60843 |
Brompheniramine
|
Others | Others |
Brompheniramine ((±)-Brompheniramine) 是具有口服活性的烷基胺类抗组胺药。Brompheniramine 是组胺 H1 受体的选择性拮抗剂 (Kd = 6.06 nM)。Brompheniramine 可用于过敏性鼻炎,它具有抗胆碱能、抗抑郁和麻醉作用。Brompheniramine 可阻断钙离子通道、钠离子通道和 hERG 通道,IC50分别为 16.12 μM, 21.26 μM 和 0.90 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0878 |
Prunetin
樱黄素,Prunusetin |
ERK; Dehydrogenase; NF-κB | MAPK; Metabolism; NF-κB |
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。 | |||
T4038 |
Ectoine
THP(B),L-Ectoine,四氢甲基嘧啶羧酸 |
Others; Antibacterial | Microbiology/Virology; Others |
Ectoine (L-Ectoine) 是生活在极其恶劣环境中的细菌所产生的氨基酸衍生物,是一种天然的细胞保护剂。它具有良好的安全性,可研究过敏性鼻炎。它用作渗透调节相容性溶质,可增加皮肤表面的水合作用并稳定脂质层,常用于皮肤护理。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0328 |
Mometasone furoate-d3
|
||
Mometasone furoate-d3 是 Mometasone furoate 的氘代化合物。Mometasone furoate 的 CAS 号为 83919-23-7。Mometasone furoate 是糖皮质激素受体激动剂,具有抗炎和抗过敏作用。它是皮质固醇类试剂,动物模型中,可局部应用于气道炎症、慢性皮肤湿疹、哮喘。 | |||
TMIJ-0498 |
Fluticasone Propionate-d5
|
||
Fluticasone Propionate-d5 是 Fluticasone Propionate 的氘代化合物。Fluticasone Propionate 的 CAS 号为 80474-14-2。Fluticasone propionate 是一种选择性糖皮质激素受体激动剂,是一种局部抗炎激素,绝对亲和力KD为 0.5 nM。具有抗病毒活性。 | |||
TMIJ-0200 |
Loratadine-d5
|
||
Loratadine-d5 是 Loratadine 的氘代化合物。Loratadine 的 CAS 号为 79794-75-5。Loratadine是一种组胺 H1受体反向激动剂,IC50>32 μM。它抑制炎症介质的免疫释放,具有抗登革热病毒的活性。 | |||
TMIJ-0505 |
Fluticasone Furoate-d3
|
||
Fluticasone Furoate-d3 是 Fluticasone Furoate 的氘代化合物。Fluticasone Furoate 的 CAS 号为 397864-44-7。Fluticasone furoate 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 |