45
9
3
35
2
Cat. No. | Product Name | ||
---|---|---|---|
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; | |||
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; | |||
L1310 | 细胞骨架化合物库 | 759 compounds | |
759 种细胞骨架相关的化合物,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60043 |
DPTIP
|
Phospholipase | Metabolism |
DPTIP 是一种有效的中性鞘磷脂酶 2 抑制剂,IC50 值为 30 nM。 | |||
T77579 |
JC2-11
|
IL Receptor; Dehydrogenase; ROS; Caspase; NOD-like Receptor (NLR); AIM2 | Apoptosis; Immunology/Inflammation; Metabolism; Proteases/Proteasome |
JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用,通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。 | |||
TF0112 |
DPPS
12-Dipalmitoyl-sn-glycero-3-PS sodium salt,DPPS-Na |
Others | Others |
DPPS (12-Dipalmitoyl-sn-glycero-3-PS sodium salt) 是一种阴离子二酰基磷脂,是磷脂酰丝氨酸(PS)的一种形式,是一种位于细胞膜内小叶的带负电荷的磷脂。DPPS 被用来制作阳离子囊泡和脂质体。 | |||
T3534 |
Tetrabenazine Racemate
Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE |
Monoamine Transporter | Membrane transporter/Ion channel |
Tetrabenazine Racemate (Rubigen) 是一种选择性和可逆的囊泡单胺转运蛋白 2(VMAT-2) 抑制剂。它阻断神经递质吸收到肾上腺素能储存囊泡中,并已被用作囊泡运输系统的高亲和力标记。 | |||
T0719 |
Tetrabenazine
Xenazine,丁苯那嗪,Ro 1-9569 |
Others; Dopamine Receptor; Monoamine Transporter | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Others |
Tetrabenazine (Ro 1-9569) 是 VMAT 抑制剂,用作抗精神病药和治疗各种运动障碍。 | |||
T5850 |
Benzamil
Benzamil (hydrochloride) |
Na+/Ca2+ Exchanger; Sodium Channel | Membrane transporter/Ion channel |
Benzamil 是 Amiloride 类似物,是 Na+/Ca2+交换体抑制剂,抑制 TRPP3 介导的 Ca2+激活电流,IC50为 1.1 μM。它也是一种非选择性上皮钠通道 (ENaC) 阻滞剂,能增强肌源性血管收缩。 | |||
T6887 |
MCC950 sodium
CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950 |
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
MCC950 sodium (CP-456773 sodium) 是一种炎症小体 NLRP3 的抑制剂 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs),具有高效选择性。MCC950 sodium 对其他炎症小体,如 AIM2、 NLRC4 或 NLRP1 没有作用。 | |||
T3230 |
NLRP3-IN-2
5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I |
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物,对心肌细胞中NLRP3炎症小体的形成具有抑制作用,在小鼠心肌缺血/再灌注后限制梗死面积,且对代谢无影响。 | |||
T2556 |
Nandrolone decanoate
癸酸诺龙,19-Nortestosterone decanoate |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素,通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。 | |||
T13133 |
Tetrabenazine Metabolite
(-)-β-Dihydrotetrabenazine,(-)-β-HTBZ |
Monoamine Transporter | Membrane transporter/Ion channel |
Tetrabenazine Metabolite ((-)-β-HTBZ) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂,是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 对 VMAT2 具有高亲和力,其Ki 为13.4 nM。Tetrabenazine Metabolite 常常被用于研究与亨廷顿氏病和其他多动障碍相关的舞蹈病。 | |||
TP1902L1 |
G-Protein antagonist peptide acetate
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
G-Protein antagonist peptide acetate 是一种 substance P 相关肽,可抑制 G 蛋白与其受体的结合。G-Protein antagonist peptide acetate 竞争性和可逆性地抑制毒蕈碱型乙酰胆碱受体 M2 (M2 muscarinic receptor) 对 Gi 或 Go 的激活,并通过 β-肾上腺素受体抑制 Gs 的激活。 | |||
T35606 |
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt) |
Others | Others |
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium (1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)) 可与 DOPC 和 DOPE 一起用于脂质混合物中,作为有效的无毒和非病毒 DNA 载体。 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium 已用于单层囊泡的形成,以研究曲率对膜结构的影响,并用于支持脂质双层的形成,以研究各种支持膜小叶之间脂质重新分布的材料。 | |||
T23709 |
alphaSYN-IN-NAB2
alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2 |
Others | Others |
alphaSYN-IN-NAB2 是一种神经元保护剂,是一种由 NAB2基因编码的蛋白质。NAB2 高效且具有选择性地保护多种细胞免受 α-syn 毒性。NAB2 对依赖于 E3 泛素连接酶 Rsp5/Nedd4 的内体转运具有促进作用。NAB2 确定 α-syn 生物学中的一个可活性分子节点,该节点可以纠正其潜在病理学的多个方面,包括功能失调的内体和内质网到高尔基体囊泡的运输。NAB2参与细胞分化、凋亡和应激反应等细胞过程,可用来研究癌症、神经发育和神经元活动。 | |||
TP2460 |
Lys-phe-phe-phe-ile-ile-trp-och3
|
||
Lys-phe-phe-phe-ile-ile-trp-och3 is a hydrophobic peptide which reacts with lipid vesicles. | |||
T30290 |
Bam 1745
Bam1745,Pyroglutamyl peptide bam-1745,Bam-1745 |
Others | Others |
Bam 1745 is a significant adrenomedullary secretory vesicles component. | |||
T68886 |
FLA-365
|
Others | Others |
FLA-365 is a biochemical that has been shown to inhibit ryanodine-enhanced calcium release from skeletal SR vesicles in a dose-dependent manner. | |||
T85121 |
4-palmitamido TEMPO
C16-amido TEMPO |
Others | Others |
4-palmitamido TEMPO is a lipid-soluble spin label that integrates into vesicles and cell membranes. It is utilized to examine the encapsulation of molecules within phosphatidylcholine vesicles. | |||
T26260 |
Tetrabenazine methanesulfonate
NSC169886,NSC 169886,NSC-169886 |
Others | Others |
Tetrabenazine methanesulfonate is a medicine formerly utilized as an antipsychotic and therapy for various movement disorders. Tetrabenazine methanesulfonate blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high-affin | |||
T24934 |
Vesamicol
AH-5183,AH 5183,AH5183 |
Others | Others |
Vesamicol is an experimental drug. It acting presynaptically by inhibiting acetylcholine uptake into synaptic vesicles and reducing its release. | |||
T74759 |
18:0,18:1 PS sodium
|
Others | Others |
18:0,18:1 PS sodium 是突触囊泡和胆固醇的脂质组成成分,可用于代谢研究。 | |||
T40438 |
PEG-8 laurate
|
Others | Others |
PEG-8 laurate is a monofunctional surfactant and skin penetration enhancer. It disrupts the skin barrier and facilitates the formation of elastic vesicles when synthesized. | |||
T75360 |
Oxonol VI
|
||
Oxonol VI 是一种膜电位的光学指示剂,在脂质囊泡中发挥作用。它能用于监测重组囊泡中与 (Na++K+)-ATPase 活性相关的膜电位变化。 | |||
T74242 |
(Rac)-POPC
|
Others | Others |
(Rac)-POPC 是制备巨囊泡 (GV) 的模型磷脂。 | |||
T68260 |
Calmidazolium (cation)
|
Others | Others |
Calmidazolium (cation) is a powerful inhibitor of or red blood cell Ca -ATPase & Ca transport into inside-out red blood cell vesicles; an antagonist of calmodulin. | |||
T74306 |
Chol-PEG
|
Others | Others |
Chol-PEG 是一种非离子表面活性剂囊泡,可用于血液持续给药系统。 | |||
T84569 |
Thromboxane B3
Δ17-TXB2 |
Others | Others |
Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues. | |||
T74290 |
16:0 TAP
|
Others | Others |
16:0 TAP 是一种脂质产品。16:0 TAP 可用于制备巨大的单层囊泡运送活性分子。 | |||
T74758 |
18:0,22:6 PS sodium
|
Others | Others |
18:0,22:6 PS sodium 是突触囊泡和胆固醇的脂质组成成分,可用于代谢研究。 | |||
T41088 |
Diadenosine pentaphosphate pentalithium
|
Others | Others |
Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide, isolated from thrombocytes. It is a member of the diadenosine polyphosphates (ApnA, n=2–7) and is found in secretory vesicles of platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes. | |||
T37309 |
Diadenosine pentaphosphate pentaammonium
|
Others | Others |
Diadenosine pentaphosphate pentaammonium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, is one component of the diadenosine polyphosphates (ApnA, n=2-7) family. These compounds are found in secretory vesicles, including those in platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes[1][2]. | |||
T10191 |
7-Chlorokynurenic acid sodium salt
7-CKA sodium salt |
Others | Others |
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μ | |||
T37310 |
Diadenosine pentaphosphate pentasodium
|
Others | Others |
Diadenosine pentaphosphate pentasodium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, serves as a key component of secretory vesicles in platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes. This compound, along with other diadenosine polyphosphates (ApnA, n=2-7), plays a crucial role in physiological processes[1][2]. | |||
T80685 |
γ-Bag cell peptide
|
||
γ-袋细胞肽,一种肽类化合物,靠近卵激素原N末端区域定位,能在胰岛素促进下释放其囊泡内容。该肽在中枢及周围神经系统研究中具有应用价值。 | |||
T74875 |
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate
|
Others | Others |
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate 是脂质化合物,主要用于提高磷脂囊泡包封蛋白质的效率。 | |||
T61663 |
SBI-581
|
Others | Others |
SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5α at RAB11-positive vesicles and inhibits the formation of invadopodia. Additionally, SBI-581 exhibits reasonable pharmacokinetics in mice when administered via IP injection, demonstrating significant antitumor activity [1]. | |||
T81286 |
RG33 Peptide
|
||
"RG33 Peptide 是抗 2 型糖尿病 (T2D) 的化合物,它显著增强了胰岛素抵抗小鼠的葡萄糖清除效率。此外,该肽还能高效溶解脂质囊泡,并在培养的巨噬细胞中促进胆固醇排泄。RG33 Peptide 主要用于 2 型糖尿病的研究领域。" | |||
T41193 |
FFN 270
|
Others | Others |
FFN 270 is a fluorescent false neurotransmitter (FFN). Fluorescent substrate for NET and VMAT2. Labels noradrenergic neurons and their synaptic vesicles, and enables imaging of synaptic vesicle content release from specific axonal sitesin vivo. Selectively labels NA neurons over other monoamine and CNS targets. Exhibits two resolved absorption/excitation maxima depending on solvent pH (excitation maxima: 320 nm or 365 nm, emission maxima: 475 nm). | |||
T84529 |
Δ17-6-keto Prostaglandin F1α
ω-3 6-keto PGF2α |
Others | Others |
Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α), a cyclooxygenase (COX) metabolite produced from eicosapentaenoic acid (EPA) in a variety of tissues including seminal vesicles, lungs, polymorphonuclear leukocytes, and ocular tissues, alongside other 3-series COX products from EPA such as PGF3α, PGE3, and thromboxane B3, is potentially linked to a lower occurrence of glaucoma in individuals consuming a marine-rich (EPA-rich) diet. | |||
T76315 |
HKPao
|
||
HKPao (Hunter-killer peptide ao) 是一种具有抗肥胖和抗肿瘤促凋亡活性的生物活性肽,能够促使细胞释放囊泡中的细胞色素 c。 | |||
T77276 |
DOPE-mPEG (MW 2000)
|
Others | Others |
DOPE-mPEG (MW 2000),一种磷脂多分散PEG(亦称DOPE脂质体),广泛应用于制备靶向给药脂质体及巨大单层囊泡(GUVs)。此化合物能显著降低脂质体对pH的敏感性,其作用具浓度依赖性。 | |||
T37236 |
(±)17(18)-DiHETE
|
Others | Others |
Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE is one of the major metabolites produced when eicosapentaenoic acid (EPA) is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of (±)17(18)-DiHETE likely proceeds through cytochrome P450-catalyzed epoxidation at the ω-3 double bond followed by conversion to the vicinal diols by epoxide hydrolase. EPA is also metabolized preferentially by... | |||
T85045 |
22-NBD Cholesterol
|
Others | Others |
22-NBD cholesterol, a fluorescent cholesterol analog featuring a nitrobenzoxadiazole (NBD) group, serves multiple research purposes in both in vitro and in vivo settings. Its applications span the analysis of steroid uptake and esterification, the study of intracellular localization and targeting, cholesterol metabolism in mammalian and bacterial cells, and examining cholesterol intestinal absorption in hamsters. This compound showcases excitation/emission maxima at 472/540 nm when integrated in... | |||
T83757 |
RG33 TFA
|
||
RG33是一种33个氨基酸的合成肽,与apolipoprotein A1 (ApoA1)的C-末端域中两个Y类螺旋的209-219和220-241氨基酸相对应。它能溶解含有1,2-dimyristoyl-sn-glycero-3-PC (DMPC)的多层囊泡(MLVs),形成重组HDL。与脂质结合的RG33在J774巨噬细胞中诱导胆固醇外流。RG33 (12 mg/kg)可降低胰岛素抵抗性小鼠的血糖水平。 | |||
T37743 |
N-octadecanoyl-L-Homoserine lactone
|
Others | Others |
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37741 |
N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
Others | Others |
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7917 |
4'-Hydroxychalcone
4-羟基查耳酮,4′-羟基查耳酮,2-Benzal-4-Hydroxyacetophenone |
Proteasome | Proteases/Proteasome; Ubiquitination |
4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) 是从甘草根中分离的一种查尔酮,具有保护肝脏的作用。它能诱导大鼠离体肝线粒体囊泡快速释放钾,并引起其线粒体呼吸控制和氧化磷酸化衰退。它能通过抑制蛋白酶体 (proteasome),抑制TNFα 诱导的 NF-κB 活性。 | |||
T19554 |
L-Aspartic aicd sodium
L-Aspartic acid sodium,Sodium L-aspartate |
Others; Sodium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Others |
L-Aspartic aicd sodium (Sodium L-aspartate) 是一种氨基酸,是一种结肠特异性活性分子输送的前体活性分子,可促进大鼠前脑膜囊泡的 Na+外排。 | |||
T4969 |
Guanosine 5'-triphosphate trisodium salt
鸟苷-5'-三磷酸三钠盐,GTP Trisodium salt,5'-GTP trisodium salt |
Endogenous Metabolite | Metabolism |
Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) 为G蛋白(G proteins)信号转导过程中的活化剂。 | |||
T10191L |
7-Chlorokynurenic acid
7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA |
GluR; NMDAR | Neuroscience |
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂,对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中,Ki 为 0.59 μM,并在神经轴输送后显示出镇痛作用。 | |||
T0791 |
Reserpine
利血平,Serpalan,Serpasil,Serpivite |
Others; Potassium Channel; MRP; Monoamine Transporter; Autophagy | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Others |
Reserpine (Serpalan) 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中,导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。 | |||
T8270 |
Deserpidine
地舍平,Harmonyl |
RAAS | Endocrinology/Hormones |
Deserpidine (Harmonyl) 是从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 与 Reserpine 相关。Deserpidine 是竞争性血管紧张素转化酶抑制剂,可以被用作抗高血压药以及镇定剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。 | |||
T33342L |
Methyl reserpate
NSC81464,NSC 81464,NSC-81464,Me reserpate |
Norepinephrine | Neuroscience |
Methyl reserpate (NSC 81464) 是一种从 Rauwolfia vomitoria 的根和叶中提取出来的育亨宾 (Yohimbine) 型生物碱,抑制去甲肾上腺素转运到嗜铬囊泡中。 | |||
TN4374 |
Kaerophyllin
(-)-Kaerophylin |
Apoptosis | Apoptosis |
Kaerophyllin ( (-)-Kaerophylin) 是一种从中药柴胡中分离出的木酚素,抑制肝细胞凋亡小体激活肝星状细胞,通过抑制肝脏炎症和抑制 HSC 活化来保护大鼠肝脏免受 TAA 引起的损伤和纤维化。 | |||
T21772 |
Reserpine hydrochloride
|
||
Reserpine hydrochloride 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中,导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03399 |
VAMP2 Protein, Rat, Recombinant (His)
Vesicle-associated membrane protein 2,Vamp2,Synaptobrevin-2 |
Rat | E. coli |
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. VAMP2 Protein, Rat, Recombina... | |||
TMPH-03381 |
Synaptoporin/SYNPR Protein, Rat, Recombinant (His)
Synaptoporin,Synpr |
Rat | E. coli |
Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein. Synaptoporin/SYNPR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 35.2 kDa and the accession number is P22831. | |||
TMPH-02161 |
Synapsin-1 Protein, Human, Recombinant (GST)
SYN1,Brain protein 4.1,Synapsin I,Synapsin-1 |
Human | E. coli |
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. | |||
TMPH-00083 |
Dehydrin ERD14 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
ERD14,Dehydrin ERD14 |
Arabidopsis thaliana | E. coli |
Intrinsically disordered protein acting as a chaperone. Prevents heat-induced aggregation and/or inactivation of various substrates. Binds to acidic phospholipid vesicles without affecting membrane fluidity. Dehydrin ERD14 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.1 kDa and the accession number is P42763. | |||
TMPH-03380 |
Synaptophysin/SYP Protein, Rat, Recombinant (His)
Major synaptic vesicle protein p38,Synaptophysin,Syp |
Rat | E. coli |
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin/SYP Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 34.8 kDa and the accession number is P07825. | |||
TMPH-01100 |
CLINT1 Protein, Human, Recombinant (His)
KIAA0171,Epsin-related protein,ENTH,CLINT1,Clint,EpsinR,EPN4... |
Human | E. coli |
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. CLINT1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 72.3 kDa and the accession number is Q14677. | |||
TMPH-02249 |
TRIM72 Protein, Human, Recombinant (E. coli, His & Myc)
Mitsugumin-53,Tripartite motif-containing protein 72,TRIM72 |
Human | E. coli |
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch fo... | |||
TMPH-00304 |
SV2A Protein, Bovine, Recombinant (His & Myc)
Synaptic vesicle glycoprotein 2A,p87,SV2A |
Bovine | HEK293 Cells |
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. SV2A Protein, Bovine, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 22.8 kDa and the accession number is Q29397. | |||
TMPH-01099 |
CLTCL1 Protein, Human, Recombinant (His)
CLH-22,CLTD,CLTCL,CLTCL1,CLH22,Clathrin heavy chain on chrom... |
Human | E. coli |
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. CLTCL1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P53675. | |||
TMPH-02323 |
SLC30A8 Protein, Human, Recombinant (His)
Zinc transporter 8,Proton-coupled zinc antiporter SLC30A8,SL... |
Human | E. coli |
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.6 kDa and the accession number is Q8IWU4. | |||
TMPH-02979 |
SLC30A8 Protein, Mouse, Recombinant (His)
Slc30a8,Proton-coupled zinc antiporter SLC30A8,Zinc transpor... |
Mouse | E. coli |
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.0 kDa and the accession number is Q8BGG0. | |||
TMPH-03446 |
SSA1 Protein, S. cerevisiae, Recombinant (His & Myc)
Heat shock protein YG100,Heat shock protein SSA1,SSA1 |
Saccharomyces cerevisiae | E. coli |
May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA1 can participate in the ATP-dependent disassembly of clathrin-coated vesicles. SSA1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.3 kDa and the accession number is P10591. | |||
TMPY-02217 |
HSC70 Protein, Human, Recombinant (His)
HSP73,HSC54,HSP71,NIP71,LAP-1,HEL-33,HSPA10,HSC71,LAP1,HEL-S... |
Human | E. coli |
HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent ... | |||
TMPH-00317 |
BipD Protein, Burkholderia pseudomallei, Recombinant (His & Myc)
Translocator protein BipD,bipD |
Burkholderia pseudomallei | E. coli |
Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation. Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane. BipD Protein, Burkholderia pseudomallei, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.4 kDa and the accession number is Q3JL26. | |||
TMPH-03400 |
SLC17A6 Protein, Rat, Recombinant (His)
Slc17a6,Vesicular glutamate transporter 2,Solute carrier fam... |
Rat | P. pastoris (Yeast) |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vessel regression during postnatal development. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. SLC17A6 Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 11.1 kDa an... | |||
TMPH-01209 |
DENND1A Protein, Human, Recombinant (His & SUMO)
KIAA1608,Connecdenn 1,DENN domain-containing protein 1A,DENN... |
Human | E. coli |
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P. DENND1A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6... | |||
TMPK-00659 |
LAMP5 Protein, Cynomolgus, Recombinant (His)
C20orf103,BAD-LAMP,BADLAMP,LAMP-5,UNC-43,dJ1119D9.3 |
Cynomolgus | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK2... | |||
TMPK-01233 |
LAMP5 Protein, Human, Recombinant (hFc)
BADLAMP,C20orf103,LAMP-5,dJ1119D9.3,UNC-43,BAD-LAMP |
Human | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Human, Recombinant (hFc) is expressed in HEK293 ma... | |||
TMPK-01161 |
LAMP5 Protein, Mouse, Recombinant (hFc)
C20orf103,BADLAMP,dJ1119D9.3,LAMP-5,UNC-43,BAD-LAMP |
Mouse | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Mouse, Recombinant (hFc) is expressed in H... | |||
TMPK-01234 |
LAMP5 Protein, Human, Recombinant (His)
BAD-LAMP,BADLAMP,C20orf103,UNC-43,dJ1119D9.3,LAMP-5 |
Human | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Human, Recombinant (His) is expressed in H... | |||
TMPH-02334 |
RAB12 Protein, Human, Recombinant (His & Myc)
Ras-related protein Rab-12,RAB12 |
Human | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degrada... | |||
TMPH-02873 |
RAB10 Protein, Mouse, Recombinant (His & SUMO)
Ras-related protein Rab-10,Rab10 |
Mouse | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, f... | |||
TMPH-02183 |
CCT2 Protein, Human, Recombinant (His & SUMO)
CCT2,99D8.1,CCT-beta,TCP-1-beta,CCTB,T-complex protein 1 sub... |
Human | E. coli |
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. CCT2 Protein, Human, Recombinant (His & S... | |||
TMPY-03604 |
VAMP3 Protein, Human, Recombinant (His)
vesicle-associated membrane protein 3,CEB |
Human | E. coli |
VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Because of VAMP3 gene's high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, VAMP3 was shown to be the human equivalent ... | |||
TMPY-03852 |
Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)
dopamine β-hydroxylase (dopamine β-monooxygenase),Dopamine β... |
Human | HEK293 Cells |
DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated ... | |||
TMPJ-00740 |
PTH Protein, Human, Recombinant
PTH,Parathyrin,Parathyroid Hormone,Parathormone |
Human | E. coli |
Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone. After intracellular processi... | |||
TMPH-02162 |
Synaptotagmin-1 Protein, Human, Recombinant (His)
SYT1,Synaptotagmin-1,p65,Synaptotagmin I |
Human | E. coli |
Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at leas... | |||
TMPY-00151 |
Alpha SNAP Protein, Human, Recombinant (His)
N-ethylmaleimide-sensitive factor attachment protein, alpha,... |
Human | E. coli |
NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. NAPA represents an anti-apoptotic protein that promotes resistance to cisplatin in cancer cells by inducing the degradation of the tumor suppressor p53. NAPA overexpression decreased the ubiquitination and degradation of s... | |||
TMPH-03741 |
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F |
Clostridium botulinum | E. coli |
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ... | |||
TMPJ-00193 |
TREML1 Protein, Human, Recombinant (hFc)
TLT-1,Trem-Like Transcript 1 Protein,TLT1,Triggering Recepto... |
Human | HEK293 Cells |
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic... | |||
TMPJ-00741 |
PTH Protein, Human, Recombinant (His)
Parathyroid hormone,Parathyrin,PTH,Parathormone |
Human | HEK293 Cells |
Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormon... | |||
TMPY-01960 |
Munc18c/STXBP3 Protein, Human, Recombinant (His & GST)
syntaxin binding protein 3,MUNC18C,UNC-18C,MUNC18-3,PSP |
Human | Baculovirus Insect Cells |
Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, Unc-18C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to the STXBP/unc-18/SEC1 family. STXBP3 is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. STXBP3, together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking / fusion of intracellular GLUT4-containing vesic... | |||
TMPJ-00448 |
NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)
NRG1β,HGL,NDF,NRG1,HRGA,HRG1-beta 1,Pro-neuregulin-1,HRG1-β1... |
Human | E. coli |
Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and ... | |||
TMPJ-00684 |
SNCA Protein, Mouse, Recombinant (His)
Snca,Non-A β component of AD amyloid,Non-A4 component of amy... |
Mouse | E. coli |
Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important... | |||
TMPY-04422 |
Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)
CK1g2,casein kinase 1, γ2,casein kinase 1, gamma 2,Casein Ki... |
Human | Baculovirus Insect Cells |
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T23983 |
Deutetrabenazine metabolite M4
SD-1018,Deuterated monohydroxy tetrabenazine,D6-tetrabenazine metabolite M4 |
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Deutetrabenazine metabolite M4 is believed to be related to its effect as a reversible depletion of monoamines from nerve terminals. The major circulating metabolites of Deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake | |||
TMID-0075 |
Reserpine-d9
|
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Reserpine-d9 是 Reserpine 的氘代化合物。Reserpine 的 CAS 号为 50-55-5。Reserpine 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中,导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。 |