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Search Results for " vasoactive "

Targets Recommended: RAAS SARS-CoV

36

抑制剂 & 化合物

2

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1016L	Aviptadil Acetate 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt	RAAS; SARS-CoV	Endocrinology/Hormones; Microbiology/Virology
	Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物，具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。
T80866	VIP(Guinea pig) TFA Vasoactive Intestinal Peptide, guinea pig TFA
	VIP Guinea pig TFA，作为一种胃肠激素，兼具神经递质功能，能够刺激胚胎生长，起到营养和有丝分裂因子的作用。
TP1016	Aviptadil Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔
	Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction.
TP1174	Endothelin-2 (49-69), human Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine),人内皮素2	Others	Others
	Endothelin-2 (49-69), human (Human endothelin-2) 是一种由 21 个氨基酸组成的血管活性肽。它可与 G 蛋白连接的跨膜受体，ET-RA 和ET-RB 结合。
T68853	Diproteverine HCl	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Diproteverine HCl 是具有抗心绞痛特性的新型钙拮抗剂,具有解痉活性和血管活性。
TP1627L	Prepro VIP (111-122), human acetate Prepro VIP (111-122), human acetate(123025-94-5 free base)	Others	Others
	Prepro VIP (111-122), human acetate(123025-94-5 free base) 是一种前血管活性肠多肽 (VIP) 衍生肽，对应于残基 111-122。
TP2103L	[D-p-Cl-Phe6,Leu17]-VIP acetate	Others	Others
	[D-p-Cl-Phe6,Leu17]-VIP acetate 是一种竞争性和选择性的血管活性肠肽 (VIP) 受体拮抗剂 (IC50 = 125.8 nM)。
TP1283L	VIP(6-28)(human, rat, porcine, bovine) acetate	Others	Others
	VIP(6-28)(human, rat, porcine, bovine) acetate 是外源性血管活性肠肽 (VIP) 受体对颈上神经节 (SCG) 中 cAMP 作用的拮抗剂。
T37496L	Alamandine TFA	RAAS	Endocrinology/Hormones
	Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员，是一种血管活性肽，是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。
T4200	Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt	Neprilysin	Metabolism
	Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T0317L	Buflomedil Buflomedilum	Others	Others
	Buflomedil is a vasoactive compound. Buflomedil has been used for peripheral arterial diseases.
TP2103	[D-p-Cl-Phe6,Leu17]-VIP
	Selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.
TP2143	Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA	Others	Others
	Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB.
TP1627	Prepro VIP (111-122), human
	Prepro VIP (111-122), human is a prepro-vasoactive intestinal polypeptide (VIP)–derived peptide, corresponding to residues 111-122.
TP1173	Endothelin 3 (Rat,Human) (TFA) Endothelin-3, human, mouse, rabbit, rat TFA
	Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that specifically interacts with G-protein-linked transmembrane receptors, ET-RA and ET-RB.
T27042	Clobenoside Ba-43853,Ba 43853,Ba43853	Others	Others
	Clobenoside is a non-steroidal anti-inflammatory agent. Clobenoside also has an edema-protective effect while not influencing blood pressure nor heart rat and not producing any direct vasoactive effects.
TP1635	Prepro VIP (81-122), human
	Prepro VIP (81-122), human is a prepro-vasoactive intestinal polypeptide (VIP) derived peptide, corresponding to residues 81-122.
TP1283	VIP(6-28)(human, rat, porcine, bovine)
	VIP(6-28)(human, rat, porcine, bovine) is a potent antagonist that effectively counteracts the effects of exogenous vasoactive intestinal peptide (VIP) on cyclic adenosine monophosphate (cAMP) signaling.
T41088	Diadenosine pentaphosphate pentalithium	Others	Others
	Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide, isolated from thrombocytes. It is a member of the diadenosine polyphosphates (ApnA, n=2–7) and is found in secretory vesicles of platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes.
T36635	[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)
	[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) 是GRF的类似物，是一种血管活性肠肽 (VIP) 拮抗剂。
T80865	VIPhyb
	VIPhyb（VIP Antagonist）是针对血管活性肠多肽（VIP）受体的拮抗剂，主要用于非小细胞肺癌（NSCLC）等癌症的科学研究。
T37309	Diadenosine pentaphosphate pentaammonium	Others	Others
	Diadenosine pentaphosphate pentaammonium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, is one component of the diadenosine polyphosphates (ApnA, n=2-7) family. These compounds are found in secretory vesicles, including those in platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes[1][2].
T37310	Diadenosine pentaphosphate pentasodium	Others	Others
	Diadenosine pentaphosphate pentasodium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, serves as a key component of secretory vesicles in platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes. This compound, along with other diadenosine polyphosphates (ApnA, n=2-7), plays a crucial role in physiological processes[1][2].
T83195	Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)
	Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)，是一种血管活性肠肽，起到VIP1受体拮抗剂的作用。
TP1054	PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA)
	PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP), gastrin releasing peptide (GRP),
T80876	Vasomera
	Vasomera是一種穩定的長效血管活性腸肽（VIP）激動劑，主要作用於G蛋白偶聯的VPAC2受體，適用於與肌肉營養不良症相關的心肌病研究。
T36428	PACAP-related Peptide (human) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP). PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.
T82217	Helospectin I
	Helospectin I属于血管活性肠肽(VIP)家族的一种神经肽，能够引起血管扩张，具有抗高血压效果，可用于降低血压。该化合物最早是从Heloderma suspectum蜥蜴的唾液腺毒液中分离得到。
T83491	[K15,R16,L27]VIP(1-7)/GRF(8-27)
	[K15,R16,L27]VIP(1-7)/GRF(8-27)作为VIP1激动剂，对人类VIP1、大鼠VIP1及大鼠VIP2的结合IC50分别为2 nM、1 nM和30000 nM。
T78003	[D-p-Cl-Phe6,Leu17]-VIP TFA
	[D-p-Cl-Phe6,Leu17]-VIP TFA，为竞争性及选择性血管活性肠肽(VIP)受体拮抗剂，其IC50为125.8 nM。该化合物针对胰高血糖素、促胰液素和GRF受体均不表现活性。
T80069	PACAP (6-27) (human, ovine, rat) Pituitary adenylate cyclase-activating peptide (6-27)
	PACAP (6-27) (human, ovine, rat) 是一种对PACAP受体具有拮抗作用的化合物，可以抑制犬肾上腺对外源性VIP的反应。此化合物在心血管疾病和神经系统疾病研究中展现出应用潜力。
T82216	Helospectin II
	Helospectin II，一种属于血管活性肠肽（VIP）家族的神经肽，具备血管扩张作用及抗高血压活性，能够降低血压。该化合物最初从蜥蜴Heloderma suspectum的唾液腺毒液中分离得到。
T78035	[K15,R16,L27]VIP(1-7)/GRF(8-27) acetate
	[K15,R16,L27]VIP(1-7)/GRF(8-27)(acetate)为[K15,R16,L27]VIP(1-7)/GRF(8-27)的醋酸盐形态，作为VIP1激动剂，与人类和大鼠的肠血管活性肽1 (VIP 1) 及大鼠的肠血管活性肽2 (VIP 2) 的结合IC50值分别为2 nM、1 nM和30000 nM。
T81571	PACAP (1-38) free acid TFA
	PACAP (1-38) free acid TFA，一种内源性神经肽，能有效促进胃窦运动，增强体液蛋白分泌，同时抑制胃泌素释放。此外，它刺激血管活性肠肽、胃泌素释放肽和P物质的释放，并通过RACK1增强N-甲基-D-天门冬氨酸受体功能及脑源性神经营养因子表达。
T76305	[Ala2] Endothelin-3, human
	[Ala2] Endothelin-3, human 为ET-3的线性类似物，其结构中的Cys残基被Ala所替代。ET-3是由人体横纹肌肉瘤细胞系产生，且仅在此细胞系中表达的一种具有血管活性的肽。在非肌肉来源的肉瘤细胞系中不表达。该肽能够作为旁分泌因子，促进内皮细胞迁移。
T81572	PACAP (1-38) free acid
	PACAP (1-38) free acid 是一种具有多重生物功能的内源性神经肽，主要作用包括刺激胃窦运动、增进体液蛋白分泌、抑制胃泌素分泌，以及促进血管活性肠肽、胃泌素释放肽和P 物质的释放。此外，PACAP (1-38) free acid 通过与RACK1互作，可以增强N-甲基-D-天门冬氨酸受体的功能并促进脑源性神经营养因子的表达。

化合物

Aviptadil Acetate

Cat.No: TP1016L

Synonym: 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt

Target: RAAS, SARS-CoV

VIP(Guinea pig) TFA

Cat.No: T80866

Synonym: Vasoactive Intestinal Peptide, guinea pig TFA

Cat.No: TP1016

Synonym: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔

Endothelin-2 (49-69), human

Cat.No: TP1174

Synonym: Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine),人内皮素2

Target: Others

Diproteverine HCl

Cat.No: T68853

Target: Calcium Channel

Prepro VIP (111-122), human acetate

Cat.No: TP1627L

Synonym: Prepro VIP (111-122), human acetate(123025-94-5 free base)

Target: Others

[D-p-Cl-Phe6,Leu17]-VIP acetate

Cat.No: TP2103L

Target: Others

VIP(6-28)(human, rat, porcine, bovine) acetate

Cat.No: TP1283L

Target: Others

Cat.No: T37496L

Target: RAAS

Sacubitril hemicalcium salt

Cat.No: T4200

Synonym: AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt

Target: Neprilysin

Cat.No: T0317L

Synonym: Buflomedilum

Target: Others

[D-p-Cl-Phe6,Leu17]-VIP

Cat.No: TP2103

Endothelin-2 (49-69), human TFA

Cat.No: TP2143

Synonym: Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA

Target: Others

Prepro VIP (111-122), human

Cat.No: TP1627

Endothelin 3 (Rat,Human) (TFA)

Cat.No: TP1173

Synonym: Endothelin-3, human, mouse, rabbit, rat TFA

Cat.No: T27042

Synonym: Ba-43853,Ba 43853,Ba43853

Target: Others

Prepro VIP (81-122), human

Cat.No: TP1635

VIP(6-28)(human, rat, porcine, bovine)

Cat.No: TP1283

Diadenosine pentaphosphate pentalithium

Cat.No: T41088

Target: Others

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)

Cat.No: T36635

Synonym: [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)

Cat.No: T80865

Diadenosine pentaphosphate pentaammonium

Cat.No: T37309

Target: Others

Diadenosine pentaphosphate pentasodium

Cat.No: T37310

Target: Others

Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)

Cat.No: T83195

PACAP (1-38), human, ovine, rat TFA

Cat.No: TP1054

Synonym: Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA)

Cat.No: T80876

PACAP-related Peptide (human) (trifluoroacetate salt)

Cat.No: T36428

Target: PACAP

Cat.No: T82217

[K15,R16,L27]VIP(1-7)/GRF(8-27)

Cat.No: T83491

[D-p-Cl-Phe6,Leu17]-VIP TFA

Cat.No: T78003

PACAP (6-27) (human, ovine, rat)

Cat.No: T80069

Synonym: Pituitary adenylate cyclase-activating peptide (6-27)

Cat.No: T82216

[K15,R16,L27]VIP(1-7)/GRF(8-27) acetate

Cat.No: T78035

PACAP (1-38) free acid TFA

Cat.No: T81571

[Ala2] Endothelin-3, human

Cat.No: T76305

PACAP (1-38) free acid

Cat.No: T81572

Cat. No.	Product Name	Target	Signaling Pathways
T4809	Pyrimidine 嘧啶,Metadiazine	Others; Endogenous Metabolite	Metabolism; Others
	Pyrimidine (Metadiazine) 是内源性代谢产物的一种。
T7044	Norepinephrine 去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol	MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome
	Norepinephrine (Levophed) 属于生物碱类天然产物，是一种神经递质，一种肾上腺素能受体 (AR) 的激动剂，对 α1、α2 和 β1 AR 具有激活活性。Norepinephrine 被用作抗休克的血管活性剂。

天然产物

Cat.No: T4809

Synonym: 嘧啶,Metadiazine

Target: Others, Endogenous Metabolite

Cat.No: T7044

Synonym: 去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol

Target: MMP, Endogenous Metabolite, Adrenergic Receptor, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03597	VIP Protein, Human, Recombinant (His) PHM27,vasoactive intestinal peptide	Human	HEK293 Cells
	VIP, or vasoactive intestinal peptide, is a neuropeptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, and it exerts its actions through three G-protein-coupled receptors (PAC1, VPAC1, and VPAC2). VIP is synthesized by trophoblast cells; it regulates trophoblast cell function and interaction with the major immune cell populations present in the pregnant uterus.
TMPY-01120	VPAC2 Protein, Human, Recombinant (mFc) VPCAP2R,PACAP-R-3,VIP-R-2,vasoactive intestinal pep...	Human	HEK293 Cells
	VIP and PACAP receptor 2, or VIPR2 encodes the VPAC2 receptor, which binds both VIP and PACAP. VPAC2 is expressed throughout the central nervous system and the periphery. Mutations in the VIPR2 homolog in the mouse cause hypoactivity, as well as disruptions in circadian rhythm. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
TMPK-00766	KLKB1 Protein, Human, Recombinant (His) PKK,Kininogenin,KLK3,KLKB1,Fletcher factor,Plasma kallikrein	Human	HEK293 Cells
	Plasma kallikrein, also known as Fletcher factor or kallikrein B1 (KLKB1), is a serine endopeptidase, like its homologs tissue kallikrein and kallikrein-related peptidases (KLKs). Its physiological role is to catalyze the release of kinins and other vasoactive peptides. KLKB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 70.3 kDa and the accession number is P03952.
TMPH-02581	Chymase 1 Protein, Mouse, Recombinant (His) Mast cell protease 5,Mast cell protease I,Alpha-chymase,Chym...	Mouse	E. coli
	Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Chymase 1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.2 kDa and the accession number is P21844.
TMPK-00857	KLKB1 Protein, Mouse, Recombinant (His) Kininogenin,KLK3,Fletcher factor,Plasma kallikrein,KLKB1,PKK	Mouse	HEK293 Cells
	Plasma kallikrein, also known as Fletcher factor or kallikrein B1 (KLKB1), is a serine endopeptidase, like its homologs tissue kallikrein and kallikrein-related peptidases (KLKs). Its physiological role is to catalyze the release of kinins and other vasoactive peptides. KLKB1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 70.3 kDa and the accession number is P26262.
TMPH-03328	Mcpt1 Protein, Rat, Recombinant (Myc) Mast cell protease I,Mcpt1,Chymase,Mast cell protease 1,Chym...	Rat	E. coli
	Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein which ultimately aggregates into amyloid-beta deposits. Mcpt1 Protein, Rat, Recombinant (Myc) is expressed in E. coli expression system with N-Myc tag. The predicted molecular weight is 28.6 kDa and the accession number is P09650.
TMPK-00525	KLKB1 Protein, Cynomolgus, Recombinant (His) KLK3,Plasma kallikrein,KLKB1,PKK,Kininogenin,Fletcher factor	Cynomolgus	HEK293 Cells
	Plasma kallikrein, also known as Fletcher factor or kallikrein B1 (KLKB1), is a serine endopeptidase, like its homologs tissue kallikrein and kallikrein-related peptidases (KLKs). Its physiological role is to catalyze the release of kinins and other vasoactive peptides. KLKB1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 70.19 kDa and the accession number is A0A2K5VTJ9.
TMPJ-00475	Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His) Tissue Kallikrein,Kidney/Pancreas/Salivary Gland Kallikrein,...	Human	HEK293 Cells
	Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays ...
TMPY-00410	EPHX2 Protein, Human, Recombinant (His) SEH,CEH,epoxide hydrolase 2, cytoplasmic	Human	Baculovirus Insect Cells
	Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vas...
TMPY-02120	XPNPEP2 Protein, Human, Recombinant (His) AEACEI,X-prolyl aminopeptidase (aminopeptidase P) 2, membran...	Human	HEK293 Cells
	Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution ...

重组蛋白

VIP Protein, Human, Recombinant (His)

Cat.No: TMPY-03597

Species: Human

Expression System: HEK293 Cells

VPAC2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-01120

Species: Human

Expression System: HEK293 Cells

KLKB1 Protein, Human, Recombinant (His)

Cat.No: TMPK-00766

Species: Human

Expression System: HEK293 Cells

Chymase 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02581

Species: Mouse

Expression System: E. coli

KLKB1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00857

Species: Mouse

Expression System: HEK293 Cells

Mcpt1 Protein, Rat, Recombinant (Myc)

Cat.No: TMPH-03328

Species: Rat

Expression System: E. coli

KLKB1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00525

Species: Cynomolgus

Expression System: HEK293 Cells

Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)

Cat.No: TMPJ-00475

Species: Human

Expression System: HEK293 Cells

EPHX2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00410

Species: Human

Expression System: Baculovirus Insect Cells

XPNPEP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02120

Species: Human

Expression System: HEK293 Cells

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