|
T41323
|
Dihomo-γ-Linolenic acid methyl ester
|
Others |
Others |
|
Dihomo-γ-Linolenic acid methyl ester 是 Dihomo-γ-Linolenic acid 的甲酯形式，Dihomo-γ-Linolenic acid 具有抗炎和抗增殖作用。 |
|
T84370
|
(R)-HTS-3
|
Acyltransferase |
Metabolism |
|
(R)-HTS-3 是一种溶血磷脂酰胆碱酰基转移酶3 (LPCAT3) 抑制剂，可重塑人体细胞的多不饱和磷脂含量，降低了 RSL3 诱导的癌细胞发生铁死亡现象。 |
|
T4309
|
CIL56
CA3
|
Ferroptosis;
ROS |
Apoptosis;
Immunology/Inflammation |
|
CIL56 (CA3) 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。 |
|
T67929
|
Linoleoyl glycine
|
Others |
Others |
|
Linoleoyl glycine 是一种经过修饰的多不饱和脂肪酸，是一种内源性的亚油酰乙醇酰胺同源物。Linoleoyl glycine 可以从哺乳动物皮肤、脊髓和大脑中提取 对爪蟾卵母细胞表达的人 KCNQ1/KCNE1 (hKCNQ1/hKCNE1) 通道有激活作用，在动物实验中显示出镇痛活性。 |
|
T71704
|
Navamepent
RX-10045
|
Others |
Others |
|
Navamepent (RX-10045) 是 resolvin E1 (一种膳食-3多不饱和脂肪酸代谢物)的类似物，具有强大的抗炎活性，可减少角膜炎症、上皮损伤，加速角膜组织修复。Navamepent 可抑制角膜上皮细胞释放几种关键促炎介质。Navamepent 对干眼和杯状细胞损失非常有效，可加速泪液的产生。 |
|
T13896
|
Soya fatty acids
|
Others |
Others |
|
Soya fatty acids is a class of polyunsaturated fatty acids isolated from soybean. |
|
T34084
|
Plastoquinone
Q 254,Q-254,Q254
|
Others |
Others |
|
Plastoquinone is a polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical |
|
T38278
|
9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid
|
Others |
Others |
|
9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. It has been used to study the desaturation and elongation of ω-3 polyunsaturated fatty acids. It is elongated to form C26:5 or acted on by δ6 desaturase to form C24:6. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is found at low levels in mouse brain and spleen and levels decrease in the brain and spleen of old and exceptionally old mice. |
|
T84385
|
1,2,3-Tri-γ-Linolenoyl Glycerol
γ-Linolenic Acid Triglyceride,γ-Linolenin,Tri-γ-linolenoate
|
Others |
Others |
|
1,2,3-Tri-γ-linolenoyl glycerol, a polyunsaturated triacylglycerol featuring γ-linolenoyl side chains at the C-1, C-2, and C-3 positions, occurs in multiple plant species such as blackcurrant, redcurrant, and borage. |
|
T37968
|
12(S)-HpEPE
|
Others |
Others |
|
12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid. Although the biological activities of 12(S)-HpEPE have not been well characterized, it is expected to behave similarly to 12(S)-HpETE (Catalog No. 44570). |
|
T37402
|
15(S)-HpEPE
|
Others |
Others |
|
15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid. Although the biological activities of 15(S)-HpEPE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Catalog No. 44720). |
|
T83563
|
(2E,9Z)-Octadeca-2,9-dienoic acid
|
Others |
Others |
|
(2E,9Z)-Octadeca-2,9-dienoic acid 是具有多不饱和特性的脂肪酸，适用于研究脂氧合酶依赖的代谢过程。 |
|
T85287
|
12(Z),15(Z)-Heneicosadienoic Acid
C21:2,FA 21:2,C21:2n-6,9
|
Others |
Others |
|
12(Z),15(Z)-Heneicosadienoic acid, an ω-6 very long-chain polyunsaturated fatty acid, serves as a positional isomer of heneicosadienoic acid, which is scarcely found in living organisms. |
|
T40826
|
5(S)-HPETE
|
Others |
Others |
|
5(S)-Hydroperoxyeicosatetraenoic acid (5(S)-HpETE) is a monohydroperoxy polyunsaturated fatty acid (PUFA) generated by the enzymatic conversion of arachidonic acid via 5-lipoxygenase (5-LO). Subsequently, 5(S)-HpETE undergoes metabolism to form leukotriene A4 (LTA4), which serves as a pivotal intermediate in the synthesis of leukotrienes (LTs). |
|
T84384
|
1,2,3-Tri-α-Linolenoyl Glycerol
Glyceryl Trilinolenate,Tri-α-linolenoate,Tri-α-linolenoyl Glycerol,Trilinolenin,Glycerol Trilinolenate
|
Others |
Others |
|
1,2,3-Tri-α-linolenoyl glycerol, a polyunsaturated triacylglycerol featuring α-linolenoyl (18:3) side chains at the C-1, C-2, and C-3 positions, serves a key role in lipid research. |
|
T32783
|
Lipoxin C4
15-OH-Ltc3
|
Others |
Others |
|
Lipoxin C4 is a bioactive autacoid metabolites of arachidonic acid made by various cell types. It is categorized as a nonclassic eicosanoid and member of the specialized pro-resolving mediator (SPMs) family of polyunsaturated fatty acid (PUFA) metabolites |
|
T35620
|
Ethoxyquin Dimer
|
Others |
Others |
|
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2 |
|
T35504
|
(±)10-HDHA
|
Others |
Others |
|
(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Reference：[1]. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984).[2]. Reynaud, ... |
|
T38065
|
5(S)-HpEPE
|
Others |
Others |
|
5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA. It is metabolized to LTA5, a key intermediate in the formation of the 5-series leukotrienes. Alternatively, 5(S)-HpEPE is reduced to 5(S)-HEPE by peroxidases. |
|
T37371
|
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic Acid
|
Others |
Others |
|
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 . While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits. |
|
T37401
|
15(S)-HpEDE
|
Others |
Others |
|
15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid. Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Cat. No. 44720). |
|
T35508
|
(±)13-HDHA
|
Others |
Others |
|
(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. |
|
T36607
|
(±)8-HDHA
|
Others |
Others |
|
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. |
|
T35512
|
(±)16-HDHA
|
Others |
Others |
|
(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. |
|
T37304
|
5-OxoETE methyl ester
|
Others |
Others |
|
5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE . 5-OxoETE methyl ester is an agonist of oxoeicosanoid receptor 1 (OXER1; EC50 = 1.54 μM for β-arrestin recruitment) that has a higher maximal response than 5-oxoETE in a β-arrestin assay. |
|
T37159
|
8(S)-HETrE
|
Others |
Others |
|
8(S)-HETrE is a monohydroxy polyunsaturated fatty acid produced by rabbit neutrophil lipoxygenase when dihomo-γ-linolenic acid is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE . |
|
T36168
|
8-iso-16-cyclohexyl-tetranor Prostaglandin E2
8-iso-16-cyclohexyl-tetranor Prostaglandin E2
|
Others |
Others |
|
8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from polyunsaturated fatty acids during lipid peroxidation. 8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no published studies on the pharmacological properties of 8-iso-16-cyclohexyl-tetranor PGE2. |
|
T76164
|
Lipoxygenase, general
|
|
|
|
Lipoxygenase, general (LOX) 是一种在生化研究中常用的双加氧酶，它能催化如亚油酸和花生四烯酸等多不饱和脂肪酸，生成相应的氢过氧化物。 |
|
T37532
|
Docosahexaenoyl Glycine
|
|
|
|
The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. It can be synthesized from other dietary ω-3 PUFAs or taken as a nutritional supplement. Docosahexaenoyl glycine consists of DHA with glycine attached at its carboxy terminus. |
|
T38066
|
5(Z),8(Z),14(Z)-Eicosatrienoic Acid
|
Others |
Others |
|
5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO). 5-LO from RBL-1 cells converts this fatty acid to 5-hydroxy-6,8,14-eicosatrienoic acid and 5-hydroperoxy-6,8,14-eicosatrienoic acid. Due to the lack of a double bond at C-11, this particular fatty acid cannot be used in leukotriene A formation. |
|
T84603
|
(±)5-HETE methyl ester
(±)-Hydroxyeicosatetraenoic Acid methyl ester
|
Others |
Others |
|
(±)5-HETE, a monohydroxy fatty acid, emerges from the non-enzymatic oxidation of arachidonic acid and is one of six such derivatives. Its methyl ester variant exhibits no unique biological activity and serves as a provided standard. This methyl ester can also be present in oxidatively degraded polyunsaturated fatty acid (PUFA) methyl esters. |
|
T36602
|
(±)4-HDHA
|
Others |
Others |
|
(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 4-HDHA. However, the enzymatic product is most likely the S-isomer. (±)4-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. |
|
T84544
|
Arachidonic acid sodium salt
Immunocytophyt sodium salt
|
Others |
Others |
|
Arachidonic acid (Immunocytophyt) sodium salt 是一种生物膜主要成分的多不饱和 omega-6 脂肪酸，同时作为包括前列腺素(PG)在内的多种脂质介质的底物。此外，Arachidonic acid sodium salt 还能够改善认知反应和心血管功能。 |
|
T37652
|
5(S),6(R)-DiHETE
|
Others |
Others |
|
5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM. |
|
T84500
|
5(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester
Mead Acid methyl ester
|
Others |
Others |
|
Mead acid, a 20-carbon ω-9 polyunsaturated fatty acid, experiences elevated levels in human plasma under conditions of essential fatty acid deficiency. As 1,25(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester (Mead acid methyl ester), it frequently serves as a standard for fatty acid analysis, particularly after fatty acids have been transesterified into methyl esters. |
|
T36606
|
(±)7-HDHA
|
Others |
Others |
|
(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and human neutrophils also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. |
|
T37303
|
5-OxoETE
5-KETE,5-OxoETE
|
Others |
Others |
|
5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.[1] It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.[2] 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.[3],[4],[5],[6] |
|
T36406
|
Pyrrolidine Linoleamide
|
Others |
Others |
|
Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the western diet. Pyrrolidine Linoleamide is a derivative of the amide of linoleic acid that shows potent antiproliferative activity against an array of cancer cell lines, including human glioma U251 cells. It is greater than 4-fold more effective against cancer cells than non-cancer cells. |
|
T37242
|
(±)5(6)-DiHETE
|
Others |
Others |
|
Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. EPA is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. The biological activity of (±)5(6)-DiHETE has not been documented. |
|
T36410
|
9(E),11(E),13(E)-Octadecatrienoic Acid
|
Others |
Others |
|
9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid. It reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner. In vitro, β-ESA induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA. β-ESA decreases protein expression of the apoptosis suppression factor Bcl-2 and induces a... |
|
T35496
|
(±)13(14)-EpDPA
|
Others |
Others |
|
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy m... |
|
T35487
|
Anacardic Acid Diene
|
Others |
Others |
|
Anacardic acid diene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. It has antibacterial activity against methicillin resistant S. aureus (MRSA) and S. mutans (MICs = 12.5 and 6.25 μg/ml, respectively). Anacardic acid diene has schistosomicidal activity against adult S. mansoni worms when used at a concentration of 100 μM. It also inhibits soybean lipoxygenase-1 in a time-dependent manner. |
|
T36426
|
Eicosapentaenoyl 1-propanol-2-amide
|
Others |
Others |
|
Monoacylglycerols (MAGs) of ω-3 polyunsaturated fatty acids have diverse physiological and health effects. In particular, MAGs containing docosahexaenoic acid or eicosapentaenoic acid have anti-proliferative properties against colon and lung cancer cell lines. Eicosapentaenoyl 1-propanol-2-amide is an EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells, producing 98.4% growth inhibition when applied at 3 μM. It is an analog of eicosapentaenoyl ethanolamide... |
|
T36045
|
1a,1b-dihomo Prostaglandin E2
1a,1b-dihomo Prostaglandin E2
|
Others |
Others |
|
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid . This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase. |
|
T37865
|
9(S)-HOTrE
|
Others |
Others |
|
9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid. 9(S)-HOTrE is predominantly localized in cellular ester lipids of Glechoma hederacea leaves and is partially released during artificial dehydration. The biological role of 9(S)-HOTrE in G. hederacea leaves is still undetermined, but it may play a role in natural senescence. 9(S)-HOTrE is an inhibitor of spore germination and germ tube elongation of rice blast fungus with ED50 valu... |
|
T84497
|
CAY10632
|
Others |
Others |
|
Very long chain polyunsaturated fatty acids (VLCPUFA), notably present in the retina, sperm, and brain, have yet to be fully understood in terms of their biosynthesis and functional roles within these tissues. Recent research, particularly with the elongation of very long-chain FA-4 protein, indicates a distinct function for VLCPUFAs in retinal development and the progression of macular degeneration. CAY10632, a specific C32:6 VLCPUFA, while largely unexplored in its biological activities, is be... |
|
T36077
|
cis-Parinaric Acid
cis-Parinaric Acid,α-Parinaric Acid
|
|
|
|
cis-Parinaric acid is a naturally occurring polyunsaturated fatty acid containing an unusual conjugated (Z,E,E,Z) tetraene. This chromophore provides for a natural fluorescence at 432 nm with an excitation wavelength at 320 nm. cis-Parinaric acid occurs naturally in the seeds of the Makita tree, a tropical rainforest tree indigenous to Fiji. Makita seeds are inedible, and this toxicity may be due at least in part to the unstable conjugated fatty acids, including cis-parinaric acid, contained wit... |
|
T35505
|
(±)11-HDHA
|
Others |
Others |
|
(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respe... |
|
T35943
|
15(S)-HpETE
|
Others |
Others |
|
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by peroxidases.[2] [1] 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1. [3] 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inac... |
|
T35493
|
(±)10(11)-EpDPA
|
Others |
Others |
|
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in infla... |
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