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Search Results for " muscular "

Targets Recommended: PPAR

59

抑制剂 & 化合物

1

天然产物

1

化合物库

21

重组蛋白

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Cat. No.	Product Name
L2620	神经退行性疾病化合物库		2154 compounds
	2154 种与神经退行性疾病相关的化合物，可用于高通量和高内涵筛选；

化合物库

神经退行性疾病化合物库

Cat.No: L2620

Compounds: 2154

Cat. No.	Product Name	Target	Signaling Pathways
T39516	Bocidelpar	PPAR	DNA Damage/DNA Repair; Metabolism
	Bocidelpar 是一种有效的过氧化物酶体增殖物激活受体 delta 调节剂，可改善杜兴肌营养不良肌肉细胞中的线粒体生物合成和功能。
T7837	SR8278	Others	Others
	SR8278 是竞争性核血红素受体REV-ERB 合成拮抗剂，能够抑制 REV-ERBα 转录活性(EC50:0.47 μM)。它可用于调节生物体内的代谢和研究生物节律。
T16545	Pivanex Pivalyloxymethyl butyrate,AN-9	Apoptosis; HDAC; Bcr-Abl	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物，是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。
T17217	Vamorolone 地塞米松EP杂质E,VBP15	Glucocorticoid Receptor; NF-κB	Endocrinology/Hormones; NF-κB
	Vamorolone (VBP15) 是一种首创的，具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。它抑制 (NF-κB) 抑制作用，并降低了激素的影响。它改善肌营养不良，无副作用。
T4641	Branaplam LMI 070,NVS-SM1	Others; Potassium Channel; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Others
	Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂，对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期，也抑制 hERG，IC50为 6.3 μM。
T3424	Ezutromid BMN 195,VOX-C1100,依珠曲米,SMT C1100	Others	Others
	Ezutromid (BMN 195) 是一种具有口服活性的、首创的苯并恶唑 utrophin 调节剂，EC50=0.91 μM。它抑制人肝微粒体 CYP1A2 酶活性，IC50=5.4 μM。它可用于 Duchenne 型肌营养不良症 (DMD) 的研究。
T13491	Neuromuscular-targeting compound 1	Others	Others
	Neuromuscular-targeting compound 1 可用于研究肌肉萎缩和神经肌肉相关疾病。
T10059	Neuromuscular Disorder-Targeting Compound 1	Others	Others
	Neuromuscular Disorder-Targeting Compound 1 is a compound used in the research of neuromuscular disorders, for example, symptoms of chronic fatigue syndrome and fibromyalgia syndrome.
T12718L	RG7800 RO6885247	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	RG7800 (RO6885247) 是一种 SMN2 拼接修饰剂，有用于治疗脊髓性肌萎缩的研究潜力。
T15198	Edasalonexent CAT-1004	NF-κB	NF-κB
	Edasalonexent (CAT-1004) 是一种可口服的 NF-κB 抑制剂，可用于改善杜氏肌营养不良症。
T7722	Feprazone Prenazone,非普拉宗,DA 2370,DA2370,DA-2370	Others	Others
	Feprazone (DA-2370) 具有抗炎和抗脂肪生成特性。 Feprazone 可用于治疗关节和肌肉疼痛的研究。
T3336	Rg3039 PF-06687859	Others	Others
	Rg3039 (PF-06687859) 是一种具有口服活性、能够透过血脑屏障的DcpS 抑制剂，其IC50=0.069 nM。
T12935	SMN-C3 MV8T2MCK57	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SMN-C3 (MV8T2MCK57) 是口服有效的 SMN2 剪接调节剂。SMN-C3可用于脊椎肌肉萎缩 (SMA) 的研究。
T77445	Apitegromab SRK-015	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Apitegromab (SRK-015) 是一种新型肌肉生长抑制素抑制剂，是一种靶向肌肉生长抑制素前体的抗体,可用于研究脊髓性肌萎缩症在内的神经肌肉疾病。
T0319	Suxibuzone 琥布宗,Calibene,Suxibuzonum,Suxibuzona	COX	Immunology/Inflammation; Neuroscience
	Suxibuzone (Suxibuzona) 是非甾体类抗炎药 Phenylbutazone 的前药，可用于关节和肌肉疼痛研究。
T1805	Ataluren PTC124	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ataluren (PTC124) 是一种可口服的 CFTR-G542X 无义等位基因抑制剂。
T73475	SMN-C2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SMN-C2 是一种选择性的 SMN2 基因剪接调节剂，是risdiplam类似物，是调节前 mRNA 剪接的选择性 RNA 结合配体，通过结合 SMN2 pre-mRNA 来发挥作用。SMN-C2 具有研究脊髓性肌萎缩症 (SMA) 的潜力。
T9821	ART-CHEM-BB B025267 2-(4-二乙基氨基苯基)-6-甲基-5-苯并三唑胺	Others	Others
	ART-CHEM-BB B025267 是 utrophin 生成的上调剂，EC50 为 1.8 μM，可用于治疗 Duchenne 肌营养不良症的研究。
T2553	Etofenamate	COX	Immunology/Inflammation; Neuroscience
	Etofenamate 是非甾体类抗炎小分子，也是非选择性的 COX 抑制剂，具有抗风湿和解热抗炎作用，可用于缓解疼痛、关节炎等炎症相关疾病的研究。
T72073	AKOS037652256	Others	Others
	AKOS037652256可作为 TRPML 调节剂，可用于治疗如溶酶体积存病、肌肉萎缩症、与年龄相关的常见神经退行性疾病、氧化应激或活性氧(ROS)相关疾病以及衰老等与 TRPML 活性相关的疾病。
T0511	Tolperisone hydrochloride 盐酸托哌酮,Muscalm,Midocalm,托哌酮盐酸盐,Tolperisone HCl	Sodium Channel	Membrane transporter/Ion channel
	Tolperisone hydrochloride (Muscalm) 是中枢作用肌肉松弛剂，可用于研究神经疾病引起的病理性横纹肌硬化(锥体束损伤、脊髓病、多发性硬化症、脑脊髓炎)、痉挛性麻痹及其他肌肉张力障碍相关的脑病。
T72072	2-benzylsulfanyl-6-methoxy-4-methylquinazoline	ROS	Immunology/Inflammation
	2-benzylsulfanyl-6-methoxy-4-methylquinazoline 可作为TRPML 调节剂，可用于治疗与TRPML 活性相关的疾病，如溶酶体储存病、肌肉萎缩症、氧化应激或活性氧(ROS)相关疾病和衰老。
T15945	MA-0204	PPAR	DNA Damage/DNA Repair; Metabolism
	MA-0204 是一种高选择性，可口服的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂，对于人，小鼠和大鼠 PPARδ 的 EC50分别为 0.4、7.9 和 10 nM。它有用于 Duchene 肌营养不良症 (DMD) 的研究潜力。
T21792	CGP 3466B maleate 马来酸CGP3466B,Omigapil (Maleate),Omigapil maleate	Apoptosis	Apoptosis
	CGP 3466B maleate (Omigapil maleate) 是一种口服有效的 GAPDH 亚硝基化抑制剂，可消除 Aβ1-42 诱导的小鼠 tau 乙酰化，记忆障碍和运动功能障碍，Omigapil maleate 具有研究阿尔茨海默症的潜力。Omigapil maleate (CGP3446B maleate) 是一种有效的凋亡 (apoptosis) 抑制剂。Omigapil maleate 可用于研究先天性肌营养不良 (CMD)。
T31168	D153249 D 153249,D-153249	Others	Others
	D153249 is a promoter of spinal muscular atrophy (SMA).
T38554	Eteplirsen 依特立生；依特普森,AVI 4658	Others	Others
	Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide utilized in research for Duchenne muscular dystrophy.
T83175	Activated DPG Subunit	Others	Others
	Activated DPG Subunit 用于合成可诱导外显子 51 跳跃的外显子跳跃寡聚物偶联物。这些偶联物与人抗肌萎缩蛋白基因中选定的靶位点互补，有助于肌肉萎缩症的研究。
T79918	α7β1 integrin modulator-1	Integrin	Cytoskeletal Signaling
	α7β1integrinmodulator-1，作为一种高效的α7β1integrin调节剂，展现出在肌营养不良症研究中的应用潜力。
T34425	RTC13 Read-through compound 13,RTC 13,RTC-13	Others	Others
	RTC13, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T83177	Activated A Subunit	Others	Others
	Activated A Subunit 适用于合成促进外显子跳跃的寡聚物偶联体。所合成的偶联体与人类抗肌萎缩蛋白基因内特定的序列配对互补，能够有效促进外显子51的跳跃，为肌萎缩疾病研究提供了一种工具。
T39517	Suvodirsen WVE-210201	Others	Others
	Suvodirsen (WVE-210201) is an oligonucleotide compound with potential applications in the study of Duchenne muscular dystrophy (DMD).
T83176	Activated C Subunit	Others	Others
	Activated C Subunit 用于合成可诱导外显子51跳跃的外显子跳跃寡聚物偶联物。所得寡聚物偶联物与人类抗肌萎缩蛋白基因特定靶位点互补，有助于研究肌肉萎缩症。
T83174	Activated EG3 Tail	Others	Others
	Activated EG3 Tail 适用于合成外显子跳跃寡聚物偶联物。该寡聚物偶联物能与人类抗肌萎缩蛋白基因特定的靶位点匹配，进而诱导外显子 51 的跳跃。此类偶联物对于肌肉萎缩症研究具有重要价值。
T7710L	Mofebutazone sodium BRN0213056,BRN 0213056,BRN-0213056	Others	Others
	Mofebutazone sodium is, a nonsteroidal antiinflammatory drug (NSAID), is used to treat joint and muscular pain.
T34426	RTC14 Read-through compound-14,RTC 14,RTC-14,Read-through compound 14	Others	Others
	RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T81693	NCP2 Anchor	Others	Others
	NCP2 Anchor用于合成外显子跳跃寡聚物偶联物。它的偶联物与人抗肌萎缩蛋白基因特定靶位点配对互补，从而诱导外显子52的跳跃。该偶联物常应用于肌肉萎缩症的科学研究。
T34664	SMN2-Stablizer-27 SMN2-Stablizer 27,SMN2 Stablizer-27	Others	Others
	SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA).
T83173	Activated T Subunit	Others	Others
	Activated T Subunit 用于合成可诱导外显子51跳跃的外显子跳跃寡聚物偶联物。该寡聚物偶联物与人类抗肌萎缩蛋白基因中选定靶位点互补，适用于肌肉萎缩症研究。
T60594	OX01914	Others	Others
	OX01914 是一种水溶性和细胞膜可渗透的 utrophin 调节剂，能够上调 utrophin 蛋白水平，EC50值为 20.5 μM。 OX01914 可用于研究杜氏肌肉营养不良症(DMD)。
T66481	TG-693	Others	Others
	TG693, an orally available inhibitor of CLK1, promotes the skipping of the endogenous mutated exon 31 in Duchenne muscular dystrophy (DMD) patient-derived cells and increased the production of the functional exon 31-skipped dystrophin protein.
T38860	Golodirsen Golodirsen,SRP-4053	Others	Others
	Golodirsen (SRP-4053) is a phosphorodiamidate morpholino oligomer (PMO) designed to selectively bind and target exon 53 of dystrophin pre-mRNA, with applications in the investigation of Duchenne muscular dystrophy (DMD).
T39455	Viltolarsen NS-065,NCNP-01	Others	Others
	Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide that specifically targets the splicing of exon 53 in the dystrophin gene. It is utilized in research related to Duchenne muscular dystrophy (DMD).
T14129	Adenylosuccinic acid Aspartyl adenylate,Adenylosuccinate	Others	Others
	Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1] and can be co
T61645	Utrophin modulator 1	Others	Others
	Utrophin Modulator 1 (UM1) is a highly effective agent that upregulates utrophin protein levels, displaying an EC 50 of 0.11 μM. Its application in the investigation of Duchenne Muscular Dystrophy (DMD) has been well-established [1].
T33595	Naproxcinod AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582	Others	Others
	Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In a
T60261	Clorprenaline	Others	Others
	Clorprenaline 是一种有效的β2-adrenergic 激动剂。Clorprenaline 促进动物肌肉生长并减少脂肪堆积。Clorprenaline 是一种潜在的新型瘦肉增效饲料添加剂。
T82222	H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe
	H-D-MeAla-EtVal-Val-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVal-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe 是一种非免疫抑制性的环孢菌素A衍生物，具备研究先天性肌营养不良症潜力[1]。
T78046	RG7800 tetrahydrochloride RO6885247 tetrahydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RG7800 hydrochloride为一可口服SMN2剪接调节剂，其对SMN2剪接及SMN蛋白的EC1.5x值分别为23 nM及87 nM。
T73321	CLK1-IN-2	Others	Others
	CLK1-IN-2 是代谢稳定的Clk1抑制剂。CLK1-IN-2 对 Clk1 具有选择性，IC50值为 1.7 nM。CLK1-IN-2 可用于肿瘤、杜氏肌营养不良症和病毒感染如HIV-1和流感的研究。
T82778	Cardioexcitatory peptide 1
	Cardioexcitatory peptide 1为从非洲大蜗牛(Achatina)心房分离的心兴奋性神经肽。该化合物对心脏具有显著的兴奋效应，并能影响肌肉组织的运动及神经活动。

化合物

Cat.No: T39516

Target: PPAR

Cat.No: T7837

Target: Others

Cat.No: T16545

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Cat.No: T17217

Synonym: 地塞米松EP杂质E,VBP15

Target: Glucocorticoid Receptor, NF-κB

Cat.No: T4641

Synonym: LMI 070,NVS-SM1

Target: Others, Potassium Channel, DNA/RNA Synthesis

Cat.No: T3424

Synonym: BMN 195,VOX-C1100,依珠曲米,SMT C1100

Target: Others

Neuromuscular-targeting compound 1

Cat.No: T13491

Target: Others

Neuromuscular Disorder-Targeting Compound 1

Cat.No: T10059

Target: Others

Cat.No: T12718L

Synonym: RO6885247

Target: Others, DNA/RNA Synthesis

Cat.No: T15198

Synonym: CAT-1004

Target: NF-κB

Cat.No: T7722

Synonym: Prenazone,非普拉宗,DA 2370,DA2370,DA-2370

Target: Others

Cat.No: T3336

Synonym: PF-06687859

Target: Others

Cat.No: T12935

Synonym: MV8T2MCK57

Target: DNA/RNA Synthesis

Cat.No: T77445

Synonym: SRK-015

Target: Opioid Receptor

Cat.No: T0319

Synonym: 琥布宗,Calibene,Suxibuzonum,Suxibuzona

Target: COX

Cat.No: T1805

Synonym: PTC124

Target: CFTR, Autophagy

Cat.No: T73475

Target: DNA/RNA Synthesis

ART-CHEM-BB B025267

Cat.No: T9821

Synonym: 2-(4-二乙基氨基苯基)-6-甲基-5-苯并三唑胺

Target: Others

Cat.No: T2553

Target: COX

Cat.No: T72073

Target: Others

Tolperisone hydrochloride

Cat.No: T0511

Synonym: 盐酸托哌酮,Muscalm,Midocalm,托哌酮盐酸盐,Tolperisone HCl

Target: Sodium Channel

2-benzylsulfanyl-6-methoxy-4-methylquinazoline

Cat.No: T72072

Target: ROS

Cat.No: T15945

Target: PPAR

CGP 3466B maleate

Cat.No: T21792

Synonym: 马来酸CGP3466B,Omigapil (Maleate),Omigapil maleate

Target: Apoptosis

Cat.No: T31168

Synonym: D 153249,D-153249

Target: Others

Cat.No: T38554

Synonym: 依特立生；依特普森,AVI 4658

Target: Others

Activated DPG Subunit

Cat.No: T83175

Target: Others

α7β1 integrin modulator-1

Cat.No: T79918

Target: Integrin

Cat.No: T34425

Synonym: Read-through compound 13,RTC 13,RTC-13

Target: Others

Activated A Subunit

Cat.No: T83177

Target: Others

Cat.No: T39517

Synonym: WVE-210201

Target: Others

Activated C Subunit

Cat.No: T83176

Target: Others

Activated EG3 Tail

Cat.No: T83174

Target: Others

Mofebutazone sodium

Cat.No: T7710L

Synonym: BRN0213056,BRN 0213056,BRN-0213056

Target: Others

Cat.No: T34426

Synonym: Read-through compound-14,RTC 14,RTC-14,Read-through compound 14

Target: Others

Cat.No: T81693

Target: Others

SMN2-Stablizer-27

Cat.No: T34664

Synonym: SMN2-Stablizer 27,SMN2 Stablizer-27

Target: Others

Activated T Subunit

Cat.No: T83173

Target: Others

Cat.No: T60594

Target: Others

Cat.No: T66481

Target: Others

Cat.No: T38860

Synonym: Golodirsen,SRP-4053

Target: Others

Cat.No: T39455

Synonym: NS-065,NCNP-01

Target: Others

Adenylosuccinic acid

Cat.No: T14129

Synonym: Aspartyl adenylate,Adenylosuccinate

Target: Others

Utrophin modulator 1

Cat.No: T61645

Target: Others

Cat.No: T33595

Synonym: AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582

Target: Others

Cat.No: T60261

Target: Others

H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe

Cat.No: T82222

RG7800 tetrahydrochloride

Cat.No: T78046

Synonym: RO6885247 tetrahydrochloride

Target: DNA/RNA Synthesis

Cat.No: T73321

Target: Others

Cardioexcitatory peptide 1

Cat.No: T82778

Cat. No.	Product Name	Target	Signaling Pathways
T0399	Methyl salicylate Gaultheria oil,Methyl 2-hydroxybenzoate,2-Carbomethoxyphenol,Betula oil,水杨酸甲酯,Natural wintergreen oil,Wintergreen oil	COX; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Methyl salicylate (Gaultheria oil) 是从番泻叶中提取的一种天然三萜皂苷，是一种局部缓解疼痛和抗炎作用的药物。它还用作食品和烟草制品中的农药、变性剂、香料成分和调味剂。

天然产物

Methyl salicylate

Cat.No: T0399

Synonym: Gaultheria oil,Methyl 2-hydroxybenzoate,2-Carbomethoxyphenol,Betula oil,水杨酸甲酯,Natural wintergreen oil,Wintergreen oil

Target: COX, TRP/TRPV Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02429	Fukutin Protein, Cynomolgus, Recombinant (His & Myc) FKTN,Fukutin,Fukuyama-type congenital muscular dyst...	Cynomolgus	E. coli
	Fukutin Protein, Cynomolgus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.0 kDa and the accession number is Q60HG0.
TMPH-02666	Fukutin Protein, Mouse, Recombinant (His & Myc) Fktn,Fukutin,Ribitol-5-phosphate transferase FKTN,Fukuyama-t...	Mouse	E. coli
	Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-b...
TMPY-02078	HtrA2/Omi Protein, Human, Recombinant (His) PARK13,OMI,HtrA serine peptidase 2,PRSS25	Human	E. coli
	Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor...
TMPY-02840	Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST) UBE1,ubiquitin-like modifier activating enzyme 1,UBA1A,SMAX2...	Human	Baculovirus Insect Cells
	UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue w...
TMPH-03219	Rabies virus (RABV) (strain India) Glycoprotein (His) Glycoprotein,G	RABV	P. pastoris (Yeast)
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPJ-00799	ANXA2 Protein, Human, Recombinant ANXA2,Calpactin I Heavy Chain,ANX2,p36,LPC2D,PAP-IV,ANX2L4,C...	Human	E. coli
	Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression reduce of ANXA2 is associated with osteosarcoma metastases. ANXA2 functions as an autocrine factor, it can increases osteoclast formation and bone resorption. ANXA2 is involved in muscular dystrophies. In humans, the up-regulation of ANXA2 is related with colon adenocarcinoma cell...
TMPH-03222	Rabies virus (RABV) (strain ERA) Glycoprotein (His) Glycoprotein,G	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03223	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His) G,Glycoprotein	RABV	Baculovirus Insect Cells
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03221	Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO) G,Glycoprotein	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPY-03451	SPF30 Protein, Human, Recombinant (His) SPF30,SMNR,TDRD16C,survival motor neuron domain containing 1	Human	E. coli
	SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. SMNDC1 is necessary for spliceosome assembly. Its overexpression causes apoptosis.
TMPJ-01251	POMGNT1 Protein, Human, Recombinant (His) 2-N-Acetylglucosaminyltransferase 1,UDP-GlcNAc:α-D-Mannoside...	Human	HEK293 Cells
	Protein O-Linked-Mannose β-1 2-N-Acetylglucosaminyltransferase 1 (POMGNT1) belongs to the Glycosyltransferase 13 family. Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. It is suggested that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form. Defects in POMGNT1 are the cause of muscular dystr...
TMPH-03037	Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) Alpha-CT,Alpha-Ctx,Alpha-EPTX-Nk2a,Long neurotoxin 1,Alpha-C...	Naja kaouthia	E. coli
	Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2)...
TMPH-03224	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His) G,Glycoprotein	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03220	Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO) Glycoprotein,G	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPJ-00713	GDF-11 Protein, Human, Recombinant Growth/differentiation factor 11,Bone morphogenetic protein ...	Human	HEK293 Cells
	Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The si...
TMPJ-00157	CD82 Protein, Human, Recombinant (hFc) Tetraspanin-27,KAI1,ST6,TSPAN27,TSPAN274F9,CD82 molecule,Tsp...	Human	HEK293 Cells
	CD82 antigen, also known as Kai-1, is a widely expressed palmitoylated molecule of the tetraspanin superfamily. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signaling. CD82/Kai-1 is a component of the promiscuous TIMP-1 interacting protein complex on the cell surface of human adenocarcinoma cells and gives insight into tumorigenic metastatic potential. CD82/Kai-1...
TMPJ-01374	UPB1 Protein, Human, Recombinant (His) β-Ureidopropionase,Beta-Alanine Synthase,β-Alanine Synthase,...	Human	E. coli
	β-Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. β-Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. β-Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidi...
TMPY-03385	FKBP14 Protein, Human, Recombinant (His) IPBP12,EDSKMH,FK506 binding protein 14, 22 kDa,FKBP22	Human	HEK293 Cells
	FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehler...
TMPY-02196	VAPB Protein, Human, Recombinant (His) ALS8,VAP-B,VAMP (vesicle-associated membrane protein)-associ...	Human	E. coli
	Vesicle-associated membrane protein-associated protein B / C, also known as VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C and VAPB, is a single-pass type IV membrane protein that belongs to the VAMP-associated protein (VAP) family. VAPB contains one MSP domain. VAPB may play a role in vesicle trafficking. VAPB forms a heterodimer with VAPA. VAPB interacts with VAMP1 and VAMP2. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 ( ALS8 ) which is a familial form of amy...
TMPY-01480	LTC4S Protein, Human, Recombinant (His) LTC4S,MGC33147,leukotriene C4 synthase	Human	Baculovirus Insect Cells
	Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells, and platelets. LTC4S is essential for the production of cysteinyl leukotrienes (Cys...
TMPY-00564	MCP-4 Protein, Human, Recombinant (His) MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-...	Human	P. pastoris (Yeast)
	Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem...

重组蛋白

Fukutin Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02429

Species: Cynomolgus

Expression System: E. coli

Fukutin Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02666

Species: Mouse

Expression System: E. coli

HtrA2/Omi Protein, Human, Recombinant (His)

Cat.No: TMPY-02078

Species: Human

Expression System: E. coli

Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02840

Species: Human

Expression System: Baculovirus Insect Cells

Rabies virus (RABV) (strain India) Glycoprotein (His)

Cat.No: TMPH-03219

Species: RABV

Expression System: P. pastoris (Yeast)

ANXA2 Protein, Human, Recombinant

Cat.No: TMPJ-00799

Species: Human

Expression System: E. coli

Rabies virus (RABV) (strain ERA) Glycoprotein (His)

Cat.No: TMPH-03222

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His)

Cat.No: TMPH-03223

Species: RABV

Expression System: Baculovirus Insect Cells

Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO)

Cat.No: TMPH-03221

Species: RABV

Expression System: E. coli

SPF30 Protein, Human, Recombinant (His)

Cat.No: TMPY-03451

Species: Human

Expression System: E. coli

POMGNT1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01251

Species: Human

Expression System: HEK293 Cells

Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)

Cat.No: TMPH-03037

Species: Naja kaouthia

Expression System: E. coli

Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His)

Cat.No: TMPH-03224

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO)

Cat.No: TMPH-03220

Species: RABV

Expression System: E. coli

GDF-11 Protein, Human, Recombinant

Cat.No: TMPJ-00713

Species: Human

Expression System: HEK293 Cells

CD82 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00157

Species: Human

Expression System: HEK293 Cells

UPB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01374

Species: Human

Expression System: E. coli

FKBP14 Protein, Human, Recombinant (His)

Cat.No: TMPY-03385

Species: Human

Expression System: HEK293 Cells

VAPB Protein, Human, Recombinant (His)

Cat.No: TMPY-02196

Species: Human

Expression System: E. coli

LTC4S Protein, Human, Recombinant (His)

Cat.No: TMPY-01480

Species: Human

Expression System: Baculovirus Insect Cells

MCP-4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00564

Species: Human

Expression System: P. pastoris (Yeast)

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