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Search Results for " macrocyclic "

Targets Recommended: Antibiotic Parasite

64

抑制剂 & 化合物

9

天然产物

1

化合物库

2

重组蛋白

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Cat. No.	Product Name
L9300	大环化合物库		210 compounds
	210 种活性已知的大环化合物，用于高通量、高内涵筛选；

化合物库

大环化合物库

Cat.No: L9300

Compounds: 210

Cat. No.	Product Name	Target	Signaling Pathways
T7605	Avermectin B1a 阿维菌素 B1a,Abamectin B1a,Avamectin B1a	Antibiotic; Parasite	Microbiology/Virology
	Avermectin B1a 是能够使线虫瘫痪的一种抗寄生虫剂。
T13303	Virginiamycin M1 Pristinamycin IIA,Ostreogrycin A	Antibacterial	Microbiology/Virology
	Virginiamycin M1 (Pristinamycin IIA)是一种大环内酯肽类抗生素，是链菌素a 类抗生素的成员。
T19637	Aluminum phthalocyanine chloride Phthalocyanine Chloroaluminum,铝酞菁,Chloroaluminum Phthalocyanine	Others	Others
	Aluminum phthalocyanine chloride (Phthalocyanine Chloroaluminum) 是一种强烈的蓝绿色芳香大环化合物，广泛用于染色。
T4072	Methyl-β-cyclodextrin Methyl-beta-cyclodextrin,甲基-β-环糊精,甲基倍他环糊精,beta-Cyclodextrin methyl ethers	Others	Others
	Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 是一种大环化合物，可以作为疏水性化合物的增溶剂用于生物实验中。Methyl-β-cyclodextrin 也是一种脂筏抑制剂，具有降胆固醇活性，还具有潜在抗肿瘤活性。
T0124	UK-124114 UNII-A2669OWX9N,西拉菌素,Selamectin	Others	Others
	UK-124114 (Selamectin) 是伊维菌素的大环内酯衍生物，伊维菌素是一种驱虫剂，可增强线虫中谷氨酸和 GABA 门控氯离子通道的开放。在 H. contortus 幼虫发育试验中，赛拉菌素 (0.1 µg/ml) 显示出生长抑制作用。
T4059	Selamectin UK-124114,司拉克丁,塞拉菌素	Chloride channel; P-gp; Parasite	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Selamectin (UK-124114) 是半合成的大环内酯，是一种驱虫剂，可增强线虫中谷氨酸和 GABA 门控氯离子通道的开放。它还是抗寄生虫剂，可激活神经元和咽肌中的谷氨酸门控氯离子通道，以预防恶丝虫，淋巴丝虫和线虫感染。它还是 P-糖蛋白底物和抑制剂，IC50为 120 nM。
T24193	Janthinocin C	Others	Others
	Janthinocin C is a novel macrocyclic peptide lactone antibiotic.
T24192	Janthinocin B	Others	Others
	Janthinocin B is a novel macrocyclic peptide lactone antibiotic.
T24191	Janthinocin A	Others	Others
	Janthinocin A is a macrocyclic peptide lactone antibiotic.
T24195	Jatrophone NSC-135037,NSC135037,Jatropha principle,NSC 135037	Others	Others
	Jatrophone is a novel inhibitor of the macrocyclic diterpenoid tumor.
T68278	NB-216	Others	Others
	NB-216 is a macrocyclic peptidic BACE-1 inhibitor.
T71383	NB-533	Others	Others
	NB-533 is a macrocyclic peptidic BACE-1 inhibitor.
T70422	MDL-104168	Others	Others
	MDL-104168 is a macrocyclic HIV-protease inhibitor.
T19098	2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a macrocyclic DOTA derivative designed for tumor pretargeting.
T26076	Rhizoxin WF1360,WF 1360,WF-1360	Others	Others
	Rhizoxin is an antitumor drug isolated from the fungus Rhizopus chinensis. It is a macrocyclic lactone compound that binds to tubulin and inhibits microtubule assembly.
T31258	Deacylgymnemic acid DAGA	Others	Others
	Deacylgymnemic acid is a macrocyclic compound for proteomics research.
T33544	Myrotoxin B Myrotoxin-B	Others	Others
	Myrotoxin B is a macrocyclic trichothecene first isolated in 1985.
T70457	MDL-73669	Others	Others
	MDL-73669 is a macrocyclic HIV-protease inhibitor that contains a difluorostatone peptide mimetic.
T25882	7-O-Demethyl rapamycin CJ 12263,CJ12263,7-O-Demethyl Rapammune,Novolimus (80%),7-O-Demethyl Cypher,Novolimus,CJ-12263	Others	Others
	Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.
T70458	FXIa-6f	Others	Others
	FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species
T31360	Deepoxy-deoxynivalenol DOM-I,DOM-1	Others	Others
	Deepoxy-deoxynivalenol is Metabolite of deoxynivalenol. Deepoxydeoxynivalenol is a macrocyclic polyol compound for proteomics research. Environmental contaminants; Food contaminants.
T85173	15-hydroxy Pentadecanoic Acid methyl ester Methyl 15-hydroxy Pentadecanoate	Others	Others
	15-Hydroxy Pentadecanoic Acid Methyl Ester is a hydroxylated fatty acid methyl ester (FAME) crucial for synthesizing musk-odored macrocyclic lactones, specifically cyclopentadecanolide and exaltolide [Matreya, LLC. Catalog No. 1882].
T85034	Lepimectin A4 Lepimectin A4	Others	Others
	Lepimectin A4, a synthetic macrocyclic lactone, constitutes a component of the insecticide lepimectin.
T68335	MK-1220	Others	Others
	MK-1220 is a novel Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
T12033	Micrococcin P1 微球菌素 P1	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
T85177	17-hydroxy Heptadecanoic Acid ω-hydroxy Heptadecanoic Acid	Others	Others
	17-Hydroxyheptadecanoic acid, a hydroxylated fatty acid identified in aeolian particles from the Frioul Islands and the outer bark of E. globulus, serves in the synthesis of diverse macrocyclic lactones. [Matreya, LLC. Catalog No. 1760]
T40838	20-O-Demethyl-AP3 20-O-Demethyl-AP3	Others	Others
	20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3, and Ansamitocin P-3 is a macrocyclic antitumor antibiotic exerting its therapeutic effects by inhibiting microtubules.
T8675	Vaniprevir	Others	Others
	Vaniprevir is a macrocyclic hepatitis C virus NS3/4a protease inhibitor and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir has good plasma exposure and excellent liver exposure in multiple species.
T82958	ASGPR modulator-1	Others	Others
	ASGPR modulator-1（Compound 5TJX）为一大环化合物，专用于蛋白质间相互作用研究。
T11972	Mcl-1 inhibitor 3	BCL	Apoptosis
	Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay).
T82650	Cy5-PEG7-endo-BCN
	Cy5-PEG7-endo-BCN为Cyanine 5 (Cy5)染料的PEGylated衍生物，具有7个聚乙二醇(PEG)单元和亲液性二齿大环配体endo-BCN。该化合物能在点击化学反应中与叠氮化合物无催化剂地共价耦合，形成稳定的1,2,3-三氮唑环。
T79719	8304-vs	Parasite	Microbiology/Virology
	8304-vs为一种大环类(antimalarial)化合物，以共价、不可逆的方式靶向疟原虫蛋白酶体，能有效抑制恶性疟原虫生长。
T82678	Coumarin-C2-exo-BCN
	Coumarin-C2-exoBCN是一种Coumarin染料衍生物。该化合物含有亲脂性双齿大环配体exo-BCN，可用于合成大环复合物。在点击化学中，exo-BCN能在无催化剂条件下与含有叠氮基团的分子发生反应，生成稳定的三唑。
T80538	Lib2-1
	Lib2-1为大环肽类IL-17C/IL-17RE相互作用抑制剂，用于自身免疫与炎症疾病研究。
T34053	Phthalocyanine
	Phthalocyanine is an intensely blue-green-coloured aromatic macrocyclic compound that is widely used in dyeing. Phthalocyanine can be used as an agent for Photodynamic Therapy and Imaging. Phthalocyanines form coordination complexes with most elements of
T71853	Enzastaurin HCl	Others	Others
	Enzastaurin HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin HCl selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.
T82659	Cy3-PEG2-endo-BCN
	Cy3-PEG2-endo-BCN是一种Cy3染料衍生物，包含2个PEG单元及亲液性二齿大环配体endo-BCN。该化合物可用于合成大环配合物，且在点击化学反应中，endo-BCN能在无需催化剂的条件下与含叠氮基团的分子反应，形成稳定的三氮唑。
T82652	Cy5-PEG2-exo-BCN
	Cy5-PEG2-exo-BCN 为含Cyanine 5 (Cy5) 基团及2个PEG单元的染料衍生物，配备亲液性的二齿大环配体BCN，适用于进一步合成大环配合物。在点击化学应用中，该BCN能与含叠氮基团的分子在无需催化剂条件下形成稳定的三氮唑环结构。
T82651	Cy5-PEG3-endo-BCN
	Cy5-PEG3-endo-BCN是Cyanine 5染料衍生物，含有三个聚乙二醇(PEG)单元和亲液性二齿大环配体endo-BCN。该化合物可以用于合成大环配合物，且在点击化学反应中，endo-BCN能在无催化剂条件下与含有叠氮基团的分子反应形成稳定的三氮唑环。
T84849	BCN-endo-PEG4-NHS	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	BCN-endo-PEG4-NHS 是一种含有4个PEG单元的ADC Linker，具备亲液性二齿大环配体endo-BCN，它能够用于合成大环配合物。在点击化学反应中，endo-BCN能够在没有催化剂的情况下与含叠氮基的分子反应，形成稳定的三氮唑。
T74390	VD2173	Others	Others
	VD2173 是一种HGF 激活丝氨酸蛋白酶的侧链环化大环肽抑制剂。VD2173 有效抑制matriptase 和hepsin。VD2173 可用于肺癌的研究。
T69354	Enzastaurin 2HCl	Others	Others
	Enzastaurin 2HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin 2HCl selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.
T76276	Zilucoplan
	Zilucoplan (RA101495)为含15个氨基酸的大环肽，兼作有效的补体成分5 (C5) 抑制剂，适用于免疫介导的坏死性肌病 (IMNM) 研究。
T63713	Mytoxin B	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Mytoxin B 是一种大环内脂，作用与 LY294002 相似，也是一种 ADC 细胞毒素 (ADC cytotoxin)。Mytoxin B 能够利用 PI3K/Akt 通路，进而诱导细胞凋亡 (apoptosis)。
T78042	JB-95 acetate
	JB-95 acetate 是一种 β-发夹大环肽，对大肠杆菌具有有效抗菌活性。该化合物能选择性破坏大肠杆菌外膜，而不影响其内膜。
T76231	Cyclotheonellazole A	Others	Others
	Cyclotheonellazole A为一天然大环肽类化合物，对弹性蛋白酶具显著的抑制效果（IC50=0.034 nM），且对糜蛋白酶亦有抑制作用，IC50值达0.62 nM。
T39106	BMSpep-57
	BMSpep-57, a potent macrocyclic peptide inhibitor, competitively disrupts the PD-1/PD-L1 interaction, demonstrating a significant inhibitory concentration (IC50) of 7.68 nM. It exhibits binding affinity towards PD-L1 with dissociation constants (Kd) of 19 nM and 19.88 nM in MicroScale Thermophoresis (MST) and Surface Plasmon Resonance (SPR) assays, respectively. This compound enhances T cell functionality by promoting Interleukin-2 (IL-2) production within Peripheral Blood Mononuclear Cells (PBM...
T36885	BMSpep-57 hydrochloride
	BMSpep-57 hydrochloride, a potent macrocyclic peptide, competitively inhibits PD-1/PD-L1 interaction, exhibiting an IC50 value of 7.68 nM. It binds to PD-L1 with dissociation constants (Kds) of 19 nM and 19.88 nM as determined by MST and SPR assays, respectively. This compound enhances T cell functionality by promoting IL-2 production in PBMCs[1].
T80083	Zilucoplan TFA RA101495 TFA	Complement System	Immunology/Inflammation
	Zilucoplan TFA (RA101495)为含15个氨基酸的大环肽，有效抑制补体组分5 (C5)。该化合物适用于免疫介导的坏死性肌病 (IMNM) 研究。
T62150	Cap-dependent endonuclease-IN-25	Others	Others
	Cap-dependent endonuclease-IN-25 是一种大环吡啶并三嗪衍生物，也是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-25 具有潜力进行由 Orthomyxoviridae 家族病毒引起的病毒感染的研究。

化合物

Cat.No: T7605

Synonym: 阿维菌素 B1a,Abamectin B1a,Avamectin B1a

Target: Antibiotic, Parasite

Virginiamycin M1

Cat.No: T13303

Synonym: Pristinamycin IIA,Ostreogrycin A

Target: Antibacterial

Aluminum phthalocyanine chloride

Cat.No: T19637

Synonym: Phthalocyanine Chloroaluminum,铝酞菁,Chloroaluminum Phthalocyanine

Target: Others

Methyl-β-cyclodextrin

Cat.No: T4072

Synonym: Methyl-beta-cyclodextrin,甲基-β-环糊精,甲基倍他环糊精,beta-Cyclodextrin methyl ethers

Target: Others

Cat.No: T0124

Synonym: UNII-A2669OWX9N,西拉菌素,Selamectin

Target: Others

Cat.No: T4059

Synonym: UK-124114,司拉克丁,塞拉菌素

Target: Chloride channel, P-gp, Parasite

Cat.No: T24193

Target: Others

Cat.No: T24192

Target: Others

Cat.No: T24191

Target: Others

Cat.No: T24195

Synonym: NSC-135037,NSC135037,Jatropha principle,NSC 135037

Target: Others

Cat.No: T68278

Target: Others

Cat.No: T71383

Target: Others

Cat.No: T70422

Target: Others

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

Cat.No: T19098

Target: Others, ADC Linker

Cat.No: T26076

Synonym: WF1360,WF 1360,WF-1360

Target: Others

Deacylgymnemic acid

Cat.No: T31258

Synonym: DAGA

Target: Others

Cat.No: T33544

Synonym: Myrotoxin-B

Target: Others

Cat.No: T70457

Target: Others

7-O-Demethyl rapamycin

Cat.No: T25882

Synonym: CJ 12263,CJ12263,7-O-Demethyl Rapammune,Novolimus (80%),7-O-Demethyl Cypher,Novolimus,CJ-12263

Target: Others

Cat.No: T70458

Target: Others

Deepoxy-deoxynivalenol

Cat.No: T31360

Synonym: DOM-I,DOM-1

Target: Others

15-hydroxy Pentadecanoic Acid methyl ester

Cat.No: T85173

Synonym: Methyl 15-hydroxy Pentadecanoate

Target: Others

Cat.No: T85034

Synonym: Lepimectin A4

Target: Others

Cat.No: T68335

Target: Others

Cat.No: T12033

Synonym: 微球菌素 P1

Target: HCV Protease

17-hydroxy Heptadecanoic Acid

Cat.No: T85177

Synonym: ω-hydroxy Heptadecanoic Acid

Target: Others

20-O-Demethyl-AP3

Cat.No: T40838

Synonym: 20-O-Demethyl-AP3

Target: Others

Cat.No: T8675

Target: Others

ASGPR modulator-1

Cat.No: T82958

Target: Others

Mcl-1 inhibitor 3

Cat.No: T11972

Target: BCL

Cy5-PEG7-endo-BCN

Cat.No: T82650

Cat.No: T79719

Target: Parasite

Coumarin-C2-exo-BCN

Cat.No: T82678

Cat.No: T80538

Cat.No: T34053

Enzastaurin HCl

Cat.No: T71853

Target: Others

Cy3-PEG2-endo-BCN

Cat.No: T82659

Cy5-PEG2-exo-BCN

Cat.No: T82652

Cy5-PEG3-endo-BCN

Cat.No: T82651

BCN-endo-PEG4-NHS

Cat.No: T84849

Target: Others, ADC Linker

Cat.No: T74390

Target: Others

Enzastaurin 2HCl

Cat.No: T69354

Target: Others

Cat.No: T76276

Cat.No: T63713

Target: Others, ADC Cytotoxin

Cat.No: T78042

Cyclotheonellazole A

Cat.No: T76231

Target: Others

Cat.No: T39106

BMSpep-57 hydrochloride

Cat.No: T36885

Cat.No: T80083

Synonym: RA101495 TFA

Target: Complement System

Cap-dependent endonuclease-IN-25

Cat.No: T62150

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6732	Oenothein B	Apoptosis; HCV Protease; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Oenothein B 是一种聚（ADP-核糖）糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。
T9327	ω-Pentadecalactone Cyclopentadecanolide,ω-十五内酯,Oxacyclohexadecan-2-one,Exaltolide,Pentadecanolide	Others	Others
	ω-Pentadecalactone (Exaltolide) 是香料成分，是一种香味结构组大环内酯和丙交酯衍生物的成员。
T9076	Spinosad	Others	Others
	Spinosad 是在土壤细菌 S. spinosa 中发现的一种杀虫剂，是大环内酯多杀菌素 A 和多杀菌素 D 的混合物，可作为昆虫烟碱乙酰胆碱酯酶受体 (nAChRs) 的激动剂。它具有优良的环境和哺乳动物毒理学特征，以及杀灭幼虫的活性。
T16340	Nosiheptide RP 9671,Multhiomycin,那西肽	Antibacterial; Antibiotic	Microbiology/Virology
	Nosiheptide (Multhiomycin) 是一种由 Streptomyces actuosus 生产的硫肽类抗生素，已被广泛用作动物生长的饲料添加剂。它抑制细菌蛋白质合成，并在特征性大环核心上带有独特的吲哚侧环系统和区域特异性羟基。
T75529	Malacidin B	Others	Others
	Malacidin B 是一种大环脂肽抗生素，以钙依赖的方式发挥抗菌活性。
T75493	Ellipyrone B	Others	Others
	Ellipyrone B，一种大环肽，对二肽基肽酶 4 (dipeptidyl peptidase-4: IC50=0.48 mM) 表现出抑制作用。
TN7268	Milbemycin A4 Antibiotic B 41A4,Milbemycin α3	Others	Others
	Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.
T75492	Ellipyrone A	Others	Others
	Ellipyrone A为一种大环肽，对二肽基肽酶 4 (dipeptidyl peptidase-4: IC50=0.35 mM) 显示出抑制活性，并对α-葡萄糖苷酶 (IC50=0.74 mM) 及α-淀粉酶 (IC50=0.59 mM) 也具有明显的抑制效果，表现出其抗碳水化合物分解的性能。
T38243	Hygrolidin	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan...

天然产物

Cat.No: TN6732

Target: Apoptosis, HCV Protease, Antibacterial, Antifungal

ω-Pentadecalactone

Cat.No: T9327

Synonym: Cyclopentadecanolide,ω-十五内酯,Oxacyclohexadecan-2-one,Exaltolide,Pentadecanolide

Target: Others

Cat.No: T9076

Target: Others

Cat.No: T16340

Synonym: RP 9671,Multhiomycin,那西肽

Target: Antibacterial, Antibiotic

Cat.No: T75529

Target: Others

Cat.No: T75493

Target: Others

Cat.No: TN7268

Synonym: Antibiotic B 41A4,Milbemycin α3

Target: Others

Cat.No: T75492

Target: Others

Cat.No: T38243

Target: Others, ADC Cytotoxin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00830	UROIIIS Protein, Human, Recombinant (His) Hydroxymethylbilane Hydrolyase [Cyclizing],Uroporphyrinogen-...	Human	E. coli
	Uroporphyrinogen-III Synthase is an enzyme which belongs to the uroporphyrinogen-III synthase family. Uroporphyrinogen-III Synthase is ubiquitous and it is involved in Porphyrin metabolism. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as Methionine synthesis (Vitamin B12) or oxygen transport (Heme). Uroporphyrinogen-III Synthase can catalyze cyclization of the linear Tetrapyrrole, Hydroxymethylbilane, to the Macrocyclic Uroporphy...
TMPY-01679	LCN1 Protein, Human, Recombinant (His) TLC,MGC71975,TP,VEGP,Lipocalin 1,PMFA	Human	HEK293 Cells
	Lipocalin-1, also known as Von Ebner gland protein, VEG protein, Tear Prealbumin, VEGP, Tear lipocalin, and LCN1 is a secreted protein that belongs to the calycin superfamily and Lipocalin family. Human Lipocalin-1 / VEGP was originally described as a major protein of human tear fluid, which was thought to be tear specific. Lipocalin-1 / VEGP is identical to lingual von Ebner's gland protein and is also produced in the prostate, nasal mucosa, and tracheal mucosa. Homologous proteins have been fo...

重组蛋白

UROIIIS Protein, Human, Recombinant (His)

Cat.No: TMPJ-00830

Species: Human

Expression System: E. coli

LCN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01679

Species: Human

Expression System: HEK293 Cells

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