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Search Results for " loop "

43

抑制剂 & 化合物

3

天然产物

2

化合物库

38

重组蛋白

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Cat. No.	Product Name
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
TP2330	D-loop peptide, synthetic D-Loop protein
	D-loop peptide, synthetic is an antigenic peptide. It cyclizes through a peptide bond between the side chain carboxylic group of Asp10 and the terminal amide of the peptide.
TP1740	GroES mobile loop
	GroES mobile loop is a flexible region of unbound GroES that interacts with GroEL via the residues located at the tip of the loop.
T10441	Azosemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Azosemide 是磺胺类环利尿剂和NKCC1抑制剂，对 hNKCC1A 和 NKCC1B 的IC50分别为 0.246 和 0.197 µM。
TP1563	Gap19	Gap Junction Protein	Cytoskeletal Signaling
	Gap19 是一种衍生自 Cx43 细胞质环九个氨基酸的肽，是选择性连接蛋白 43 半通道阻滞剂。它可以防止 C 末端与 CL 的分子内相互作用，具有保护心肌作用。
T22461	YKL-5-124	CDK	Cell Cycle/Checkpoint
	YKL-5-124 是选择性不可逆CDK7共价抑制剂，对CDK7和CDK7/Mat1/CycH 的IC50分别为 53.5 nM 和 9.7 nM。它诱导强烈的细胞周期停滞，并抑制 E2F 驱动的基因表达。它对 CDK7 的生化和细胞选择性优于 CDK12/13。它对CDK7的选择性比 CDK9 和 CDK2 高 100 倍以上。
T20807	Looplure ENT 33266,Pherocon CL,AI3-33266,Cabblemone,(Z)-7-Dodecen-1-olacetate	Others	Others
	Looplure is a chemosterilant, insect attractant and repellent.
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T13932	TLR1 N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺	Others; MyD88	Immunology/Inflammation; Others
	TLR1 是细胞穿透 Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop 的小分子模拟物，能够阻碍 IL-1 受体介导的反应。
T8705	BOT-64	IκB/IKK	NF-κB
	BOT-64 是一种 IKK-2 抑制剂，靶向激酶激活环结构域中的 Ser177 和/或 Ser181 残基。BOT-64 是一种可渗透细胞的苯并恶硫醇化合物。
T0114	Trichlormethiazide Naqua,Metahydrin,三氯噻嗪,Trichlormetazid	ATPase; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	Trichlormethiazide (Naqua) 是一种口服具有活力的噻嗪类利尿剂，具有降压作用。它能够提高急性肾功能衰竭大鼠的尿量、Na 和 K 排泄，并有改善降低的肌酐清除率。
T4564	Ethacrynic acid Edecrin,利尿酸,Etacrynic Acid,Hydromedin	Others; Calcium Channel; NF-κB; GST	Membrane transporter/Ion channel; Metabolism; NF-κB; Others; oxidation-reduction
	Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。
TP1813L	Dynorphin A 1-10 acetate(79994-24-4 free base)	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Dynorphin A 1-10 acetate(79994-24-4 free base) 是一种内源性 opioid 样物质神经肽，与 κ-opioid 样物质受体的细胞外环 2 结合。 Dynorphin A (1-10) 还阻断 NMDA 激活的电流，IC50 为 42.0 μM。
T13387L	Zatebradine hydrochloride UL-FS-49CL,UL-FS-49	Others; HCN Channel	Membrane transporter/Ion channel; Others
	Zatebradine hydrochloride (UL-FS-49CL) 是一种高效的、有效的HCN Channel 抑制剂( IC50 ：1.96 µM)。 HCN Channel 是一种有效的超极化激活环核苷酸门控通道。 Zatebradine hydrochloride 阻止通过人类 HCN1，HCN2，HCN3 和 HCN4 通道的缓慢内向电流，其 IC50 值分别为 1.83 µM，2.21 µM，1.90 µM 和 1.88 µM。
T35336	Furosemide sodium Frusemide Sodium,Lasix	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Furosemide sodium (Frusemide Sodium) 是 Na+/K+/2Cl- (NKCC)，NKCC1 和 NKCC2 共转运蛋白的有效的和具有口服活性抑制剂。Furosemide sodium 也是 GABAA 受体拮抗剂，对含 α6 受体的选择性是含 α1 受体的 100 倍。Furosemide sodium 用作利尿试剂，用于充血性心力衰竭，高血压和水肿的研究。
TP2311	C-MYC PEPTIDE EPITOPE TFA	Others	Others
	C-MYC PEPTIDE EPITOPE TFA 是 c-myc 原癌基因的产物，是一种螺旋-环-螺旋亮氨酸拉链磷蛋白，可调节细胞增殖、细胞分化和凋亡中的基因转录。该肽是人类 c-myc 表位。
T24076	FzM1 FzM 1,FzM-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	FzM1 是卷曲蛋白受体 FZD4 的负变构调节剂 (NAM)。 FzM1减少 WNT5A 依赖的 WNT 反应元件 (WRE) 活性 (log EC50inh=-6.2)。 FzM1 与位于 FZD4 细胞内环 3 (ICL3) 的变构结合位点结合并改变受体的构象，从而抑制 WNT/β-连环蛋白级联反应。
T10936	D-I03 DI03	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	D-I03 是一种选择性的RAD52 抑制剂，Kd 为 25.8 µM。D-I03 抑制 RAD52 依赖性单链退火 (SSA) 和 D 环形成，IC50 分别为 5 µM 和 8 µM。D-I03 抑制 BRCA1 和 BRCA2 缺陷细胞的生长，并抑制顺铂诱导的 RAD52 病灶形成，但对 RAD51 无影响。
T19788	Piretanide Eurelix,Tauliz,Arelix	Others	Others
	Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic.
T30590	Brocrinat HP 522	Others	Others
	Brocrinat (HP 522) is an active diuretic with at least one site of action in the medulla oblongata branch of the Henle loop.
TP1813	Dynorphin A (1-10) Dynorphin A 1-10
	Dynorphin A (1-10), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.
T68607	AP23848	Others	Others
	AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.
T68581	AP23464	Others	Others
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells. Biochemical assays with purified glutathione S transferase (GST)-Abl kinase domain confirmed that AP23464 directly inhibits Abl activity. Importantly, the lo...
T18527	PDdB-Pfp	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	PDdB-Pfp is a reducible ADC (antibody-drug conjugate) linker designed for agents targeting the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1).
T33851	Ozolinone W 3282,W3282,W-3282	Others	Others
	Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hypertension and edema often due to cong
T72001	CB096	Others	Others
	CB096 is a novel inhibitor of RAN translation. specifically binds to a repeating 1 × 1 GG internal loop structure, 5'CGG/3'GGC, that is formed when r(G4C2)exp folds, also acting as a potent vasorelaxant agent, showing antihypertensive effect.
T80580	Zinlirvimab 10-1074
	Zinlirvimab是一种IgG1-λ2类人源化HIV中和抗体，专一性靶向HIV-1 gp120包膜糖蛋白(IIIB gp120 V3环)。
T28536	RI(dl)-2 TFA RI(dl)-2	Others	Others
	RI(dl)-2 TFA 是一种有效的选择性 RAD51 介导的 D 环形成 (RAD51-mediated D-loop formation) 抑制剂，IC50为 11.1 μM，并抑制人细胞中的同源重组 (HR) 活性，IC50为 3.0 μM。
T75988	Dynorphin A (1-10) (TFA)
	Dynorphin A (1-10) (TFA) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) (TFA) 也阻断 NMDA 激活的电流，IC50为 42.0 μM。
T61713	Bumetanide sodium	Others	Others
	Bumetanide sodium is a potent loop diuretic that acts as a blocker for the sodium-potassium-chloride cotransporter (NKCC). It selectively inhibits NKCC1 and NKCC2, with IC50 values of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively [1] [2].
T33432	MK-3281 MK 3281,MK3281	Others	Others
	MK-3281 is a potent, orally bioavailable hepatitis C virus NS5B polymerase finger-loop inhibitor. It is also an inhibitor of attractive molecular properties with good potency in HCV subgenomic replication trials and suitable for clinical candidates.
T19849	2-PADQZ 2PADQZ,2-PADQZ	Others	Others
	DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B.
T18531	PDP-Pfp	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	PDP-Pfp is a reducible ADC linker primarily utilized for targeting agents aimed at the extracellular loop 1 (ECL1) of TM4SF1, a member of the transmembrane 4 L6 family, as supported by reference [1].
T62355	HBV-IN-14	Others	Others
	HBV-IN-14 是一种吡啶并嘧啶酮类化合物，也是一种有效的共价闭合环状 DNA (cccDNA) 抑制剂。其中 cccDNA 是一种病毒 RNA 转录和随后病毒 DNA 生成的模板。HBV-IN-14 具有潜力进行 HBV 感染的研究。
T71586	Z-VAE(OMe)-fmk	Others	Others
	Z-VAE(OMe)-fmk is a cell-permeable and irreversible UCHL1 inhibitor. The inhibitor approaches the active-site cleft from the opposite side of the crossover loop as compared to the direction of approach of ubiquitin's C-terminal tail, thereby occupying the P1' (leaving group) site, a binding site perhaps used by the unknown C-terminal extension of ubiquitin in the actual in vivo substrate(s) of UCHL1.
T75795	Gap 26 TFA
	Gap 26 TFA 是一种连接蛋白 (connexin) 模拟肽，由连接蛋白 connexin 43 (gap junction 阻滞剂)一个胞外环的第 63-75 残基组成，包含SHVR 氨基酸基序。
T39459	THZ-P1-2 THZ-P1-2	Others	Others
	THZ-P1-2 is a novel, specific inhibitor of PI5P4K that effectively targets PI5P4Kα. With an IC 50 of 190 nM, THZ-P1-2 selectively inhibits PI5P4Kα by forming covalent bonds with cysteine residues located on a disordered loop present in PI5P4Kα/β/γ. This mechanism not only disrupts autophagy but also elevates TFEB signaling. Moreover, THZ-P1-2 exhibits potent anticancer effects in leukemia cell lines, making it a promising candidate for therapeutic applications.
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
TP1581	C-Type Natriuretic Peptide (1-53), human
	CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs shar
T82683	Connexin mimetic peptide 40GAP27
	Connexin mimetic peptide 40GAP27 是一种生物活性肽，对应于主要的血管连接蛋白Cx40第二个细胞外环的GAP27结构域（40Gap27）。该化合物在研究氧化应激所致的损伤以及间隙连接通讯机制中有应用。40Gap27能够在给药后减少内皮依赖性的内膜下平滑肌的超极化现象。
T82684	Connexin mimetic peptide 40,37GAP26
	Connexin mimetic peptide 40,37GAP26是一种生物活性肽，对应Cx37和Cx40主要血管连接蛋白的胞外环GAP26结构域，命名基于Cx同源性为37,40Gap26。本化合物主要用于研究间隙连接对环吡嗪酸(CPA)通过啮齿动物髂动脉壁导致的内皮超极化扩散的影响。Cx37和Cx40形成的间隙连接斑块在内皮细胞中高度丰富，而Connexin mimetic peptide 40,37GAP26能抑制内膜下超极化。
T75820	Gap19 TFA
	Gap19 TFA，源自Cx43胞浆环(CL)的九个氨基酸肽，是高效且选择性的连接蛋白43 (Cx43) 半通道阻滞剂。该肽阻止C末端（CT）与CL之间的分子内相互作用，但不影响GJ通道或Cx40/pannexin-1半通道。此外，Gap19 TFA对心肌有保护作用。
T68525	Nafarelin acetate hydrate	Others	Others
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T69200	CGP74514A	Others	Others
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...

化合物

D-loop peptide, synthetic

Cat.No: TP2330

Synonym: D-Loop protein

GroES mobile loop

Cat.No: TP1740

Cat.No: T10441

Target: Na-K-Cl cotransporter

Cat.No: TP1563

Target: Gap Junction Protein

Cat.No: T22461

Target: CDK

Cat.No: T20807

Synonym: ENT 33266,Pherocon CL,AI3-33266,Cabblemone,(Z)-7-Dodecen-1-olacetate

Target: Others

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Cat.No: T13932

Synonym: N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺

Target: Others, MyD88

Cat.No: T8705

Target: IκB/IKK

Trichlormethiazide

Cat.No: T0114

Synonym: Naqua,Metahydrin,三氯噻嗪,Trichlormetazid

Target: ATPase, Carbonic Anhydrase

Ethacrynic acid

Cat.No: T4564

Synonym: Edecrin,利尿酸,Etacrynic Acid,Hydromedin

Target: Others, Calcium Channel, NF-κB, GST

Dynorphin A 1-10 acetate(79994-24-4 free base)

Cat.No: TP1813L

Target: Opioid Receptor

Zatebradine hydrochloride

Cat.No: T13387L

Synonym: UL-FS-49CL,UL-FS-49

Target: Others, HCN Channel

Furosemide sodium

Cat.No: T35336

Synonym: Frusemide Sodium,Lasix

Target: Na-K-Cl cotransporter

C-MYC PEPTIDE EPITOPE TFA

Cat.No: TP2311

Target: Others

Cat.No: T24076

Synonym: FzM 1,FzM-1

Target: Wnt/beta-catenin

Cat.No: T10936

Synonym: DI03

Target: DNA/RNA Synthesis

Cat.No: T19788

Synonym: Eurelix,Tauliz,Arelix

Target: Others

Cat.No: T30590

Synonym: HP 522

Target: Others

Dynorphin A (1-10)

Cat.No: TP1813

Synonym: Dynorphin A 1-10

Cat.No: T68607

Target: Others

Cat.No: T68581

Target: Others

Cat.No: T18527

Target: Others, ADC Linker

Cat.No: T33851

Synonym: W 3282,W3282,W-3282

Target: Others

Cat.No: T72001

Target: Others

Cat.No: T80580

Synonym: 10-1074

Cat.No: T28536

Synonym: RI(dl)-2

Target: Others

Dynorphin A (1-10) (TFA)

Cat.No: T75988

Bumetanide sodium

Cat.No: T61713

Target: Others

Cat.No: T33432

Synonym: MK 3281,MK3281

Target: Others

Cat.No: T19849

Synonym: 2PADQZ,2-PADQZ

Target: Others

Cat.No: T18531

Target: Others, ADC Linker

Cat.No: T62355

Target: Others

Cat.No: T71586

Target: Others

Cat.No: T75795

Cat.No: T39459

Synonym: THZ-P1-2

Target: Others

TNF-α Antagonist

Cat.No: T36127

C-Type Natriuretic Peptide (1-53), human

Cat.No: TP1581

Connexin mimetic peptide 40GAP27

Cat.No: T82683

Connexin mimetic peptide 40,37GAP26

Cat.No: T82684

Cat.No: T75820

Nafarelin acetate hydrate

Cat.No: T68525

Target: Others

Cat.No: T69200

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3862	Irigenin	NF-κB; Integrin	Cytoskeletal Signaling; NF-κB
	Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点，介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡，具有抗癌作用。
T19146	5,6-Dihydrouridine	Endogenous Metabolite	Metabolism
	5,6-Dihydrouridine 是一种修饰碱基，存在于真核生物、细菌和某些古细菌tRNA D 环的保守位置。
T72208	1-Dehydro-[10]-gingerdione	Others	Others
	1-Dehydro-[10]-gingerdione 通过靶向IKKβ的激活环直接抑制 IKKβ 活性，从而破坏用激动剂刺激的巨噬细胞中 IKKβ 催化的 IκBα 磷酸化。1-Dehydro-[10]-gingerdione 抑制 LPS 诱导的NF-κB 转录活性。1-Dehydro-[10]-gingerdione 具有用于NF-κB 相关炎症和自身免疫性疾病研究的潜力。

天然产物

Cat.No: T3862

Target: NF-κB, Integrin

5,6-Dihydrouridine

Cat.No: T19146

Target: Endogenous Metabolite

1-Dehydro-[10]-gingerdione

Cat.No: T72208

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00958	AHR Protein, Human, Recombinant (His) Aryl hydrocarbon receptor,Class E basic helix-loop-...	Human	E. coli
	AHR Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01775	N-myc Protein, Human, Recombinant (His) MYCN,Class E basic helix-loop-helix protein 37,N-my...	Human	P. pastoris (Yeast)
	Positively regulates the transcription of MYCNOS in neuroblastoma cells. N-myc Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 51.6 kDa and the accession number is P04198.
TMPJ-01040	MAX Protein, Human, Recombinant (His) Protein Max,MAX,bHLHd4,Myc-Associated Factor X,Class D Basic...	Human	E. coli
	Myc-Associated Factor X (MAX) is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It contains 1 basic helix-loop-helix (bHLH) domain. It is found in the brain, heart, and lung at high levels while lower levels are seen in the liver, kidney, and skeletal muscle. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MA...
TMPH-02791	c-Myc Protein, Mouse, Recombinant (GST) bHLHe39,MYC,Transcription factor p64,Class E basic helix-	Mouse	E. coli
	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. c-Myc Protein, Mouse, Recombinant (GST) is...
TMPH-00879	ASCL1 Protein, Human, Recombinant (His) BHLHA46,ASH-1,Achaete-scute homolog 1,ASCL1,Class A basic he...	Human	E. coli
	ASCL1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.6 kDa and the accession number is P50553.
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...
TMPH-01720	c-Myc Protein, Human, Recombinant (His) Myc proto-oncogene protein,Transcription factor p64,Proto-on...	Human	E. coli
	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. c-Myc Protein, Human, Recombinant (His) is...
TMPH-01721	c-Myc Protein, Human, Recombinant (Avi & His & MBP), Biotinylated BHLHE39,Class E basic helix-loop-helix protein 39,T...	Human	E. coli
	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. c-Myc Protein, Human, Recombinant (Avi & H...
TMPH-00957	ARNT Protein, Human, Recombinant (His) Hypoxia-inducible factor 1-beta,Class E basic helix-loop...	Human	P. pastoris (Yeast)
	ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-01243	ID1 Protein, Human, Recombinant (His & SUMO) Inhibitor of differentiation 1,Inhibitor of DNA binding 1,ID...	Human	E. coli
	ID1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.1 kDa and the accession number is P41134.
TMPK-00641	IgG2C Protein, Mouse, Recombinant Ighg2c,IgG2C	Mouse	HEK293 Cells
	Mouse IgG2c is a subclass of mouse antibody IgG, it can bind FcγRIV with high affinity and the Fc loop residues of mouse IgG2c promote greater receptor-binding affinity than mouse IgG2b or human IgG1.
TMPH-02320	ZC3H7B Protein, Human, Recombinant (His & Myc) Rotavirus 'X'-associated non-structural protein,Zinc finger ...	Human	E. coli
	May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop.
TMPH-00538	Epstein-Barr virus (strain GD1) EBNA3 Protein (His & Myc) Epstein-Barr nuclear antigen 3A,Epstein-Barr nuclear antigen...	EBV	E. coli
	Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
TMPY-02425	Serpin B4, Protein, Human, Recombinant (His) SCCA-2,LEUPIN,SCCA1,serpin peptidase inhibitor, clade B (ova...	Human	Baculovirus Insect Cells
	Overexpression of SERPINB4 in tumor cells inhibited recombinant GrM-induced as well as NK cell-mediated cell death and this inhibition depended on the reactive center loop of the serpin.
TMPJ-01019	NHP2L1 Protein, Human, Recombinant (His) High Mobility Group-Like Nuclear Protein 2 Homolog 1,hSNU13,...	Human	E. coli
	NHP2-Like Protein 1 (NHP2L1) is a member of the ribosomal protein L7Ae family. NHP2L1 proteinis limited to the nucleus, primarily focused in the dense fibrillar component of the nucleolus. NHP2L1 has been shown to interact with RAD17and PRPF31. The protein undergoes a conformational change upon RNA-binding. NHP2L1 binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly, prior to step I of splicing catalysis.
TMPH-00665	RecG Protein, E. coli O157:H7, Recombinant (His & SUMO) ATP-dependent DNA helicase RecG,recG	E. coli	E. coli
	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (CsdR) and R-loop formation.
TMPH-00537	Epstein-Barr virus (strain B95-8) EBNA3 Protein (His & Myc) Epstein-Barr nuclear antigen 3,EBNA3,Epstein-Barr nuclear an...	EBV	E. coli
	Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
TMPJ-00262	Serpin A12 Protein, Human, Recombinant (GST) Visceral Adipose Tissue-Derived Serine Protease Inhibitor,Va...	Human	E. coli
	Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets, nine α-helices, and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, i...
TMPH-02280	SNRNP70 Protein, Human, Recombinant (His) U1 small nuclear ribonucleoprotein 70 kDa,SNRNP70	Human	E. coli
	Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.; Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.; Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. SNRNP70 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.7 kDa and the accession n...
TMPY-03390	LSM1 Protein, Human, Recombinant (His) LSM1 homolog, mRNA degradation associated,CASM,YJL124C,LSM1	Human	E. coli
	LSM1 is an Sm-like protein. Sm-like proteins can be detected in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins include the Sm sequence motif, which consists of two regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM1 has a role in replication-dependent histone mRNA degradation and binds specif...
TMPY-00286	Neuropeptide Y Protein, Human, Recombinant (hFc) PYY4,neuropeptide Y	Human	HEK293 Cells
	NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY is a neuromodulator that is widely expressed throughout the central nervous system (CNS) and is consecrated with classic neurotransmitters including GABA and glutamate. NPY/Agouti-related protein (AgRP) ne...
TMPJ-01311	EPT1 Protein, Human, Recombinant (GST) hEPT1,Selenoprotein I,SELI,EPT1,Ethanolaminephosphotransfera...	Human	E. coli
	Ethanolaminephosphotransferase 1 (EPT1) is an enzyme that belongs to the CDP-Alcohol Phosphatidyltransferase Class-I Family. EPT1 is a Selenoprotein, which contains a Selenocysteine (Sec) residue at its active site. The Selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of Selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop sig...
TMPY-04550	JNK2 Protein, Human, Recombinant (His) JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAPK,JNK2BETA,mitogen-activate...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n...
TMPY-03344	LSM3 Protein, Human, Recombinant (His) SMX4,YLR438C,USS2,LSM3 homolog, U6 small nuclear RNA associa...	Human	E. coli
	LSM3 (LSM3 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. LSM3 is a member of the snRNP Sm proteins family. It plays role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as a component of the pre-catalytic spliceosome (spliceosome B complex). Sm-like proteins can be detected in a variety of organisms. They all have the Sm sequence motif, which consists of 2 regions separated by a linker ...
TMPH-03729	Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His) Transcriptional activator VP30,EbolaVP30,Minor nucleoprotein...	ZEBOV	E. coli
	Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists a...
TMPY-04403	NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) nemo-like kinase,LAK1	Human	Baculovirus Insect Cells
	Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. As a serine/threonine-protein kinase, Nemo-like kinase regulates some transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling...
TMPH-03289	EIF3I Protein, Rat, Recombinant (E. coli, His) eIF3 p36,eIF3i,eIF-3-beta,Eukaryotic translation initiation ...	Rat	E. coli
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPY-02482	Aconitase 1 Protein, Human, Recombinant (His) HEL60,IRP1,ACONS,aconitase 1, soluble,IREBP,IREBP1,IREB1	Human	Baculovirus Insect Cells
	Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 ...
TMPY-02888	MAX Protein, Human, Recombinant (His & GST) MYC associated factor X,bHLHd4	Human	Baculovirus Insect Cells
	MYC associated factor X contains 1 basic helix-loop-helix (bHLH) domain and belongs to the MAX family. It is highly expressed in the brain, heart, and lung while lower levels are seen in the liver, kidney, and skeletal muscle. MYC associated factor X can form homodimers and heterodimers with other family members, which include Mad, Mxi1, and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation, and apoptosis. The homodimers and heterodimers compete for a common DNA target...
TMPH-03288	EIF3I Protein, Rat, Recombinant (His) eIF3i,Eif3s2,eIF-3-beta,Eukaryotic translation initiation fa...	Rat	Baculovirus Insect Cells
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPY-02522	OTUB2 Protein, Human, Recombinant (His) OTU deubiquitinase, ubiquitin aldehyde binding 2,OTU2,OTB2,C...	Human	E. coli
	Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a nov...
TMPY-02135	S100A16 Protein, Human, Recombinant S100F,DT1P1A7,S100 calcium binding protein A16,MGC17528,AAG1...	Human	E. coli
	S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has be...
TMPY-02768	Selenoprotein M Protein, Human, Recombinant (His) SEPM	Human	E. coli
	Selenoprotein M is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine M is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures....
TMPY-04397	PAK-3 Protein, Human, Recombinant (His) PAK3β,hPAK3,bPAK,PAK3beta,MRX30,MRX47,CDKN1A,p21 protein (Cd...	Human	Baculovirus Insect Cells
	PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group...
TMPY-03442	MOB4A/MOB1B Protein, Human, Recombinant (GST) MOB kinase activator 1B,MOBKL1A,MATS2,MOB4A	Human	E. coli
	MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO...
TMPY-02510	HIST2H2BE Protein, Human, Recombinant MGC129734,H2BGL105,H2B.1,histone cluster 2, H2be,H2B,H2BFQ,G...	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and 2. subtype diversity in a class(H1, H2A, H2B, H3 or H4) within a species. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enz...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kappa light polypeptide gene en...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...
TMPH-00616	DNA-binding protein H-NS Protein, E. coli, Recombinant (His) hns,DNA-binding protein H-NS,Protein B1,Protein H1,Heat-stab...	E. coli	E. coli
	A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription. Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Many of these loci were horizontally transfe...

重组蛋白

AHR Protein, Human, Recombinant (His)

Cat.No: TMPH-00958

Species: Human

Expression System: E. coli

N-myc Protein, Human, Recombinant (His)

Cat.No: TMPH-01775

Species: Human

Expression System: P. pastoris (Yeast)

MAX Protein, Human, Recombinant (His)

Cat.No: TMPJ-01040

Species: Human

Expression System: E. coli

c-Myc Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02791

Species: Mouse

Expression System: E. coli

ASCL1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00879

Species: Human

Expression System: E. coli

HIF-1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01709

Species: Human

Expression System: E. coli

c-Myc Protein, Human, Recombinant (His)

Cat.No: TMPH-01720

Species: Human

Expression System: E. coli

c-Myc Protein, Human, Recombinant (Avi & His & MBP), Biotinylated

Cat.No: TMPH-01721

Species: Human

Expression System: E. coli

ARNT Protein, Human, Recombinant (His)

Cat.No: TMPH-00957

Species: Human

Expression System: P. pastoris (Yeast)

ID1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01243

Species: Human

Expression System: E. coli

IgG2C Protein, Mouse, Recombinant

Cat.No: TMPK-00641

Species: Mouse

Expression System: HEK293 Cells

ZC3H7B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02320

Species: Human

Expression System: E. coli

Epstein-Barr virus (strain GD1) EBNA3 Protein (His & Myc)

Cat.No: TMPH-00538

Species: EBV

Expression System: E. coli

Serpin B4, Protein, Human, Recombinant (His)

Cat.No: TMPY-02425

Species: Human

Expression System: Baculovirus Insect Cells

NHP2L1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01019

Species: Human

Expression System: E. coli

RecG Protein, E. coli O157:H7, Recombinant (His & SUMO)

Cat.No: TMPH-00665

Species: E. coli

Expression System: E. coli

Epstein-Barr virus (strain B95-8) EBNA3 Protein (His & Myc)

Cat.No: TMPH-00537

Species: EBV

Expression System: E. coli

Serpin A12 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00262

Species: Human

Expression System: E. coli

SNRNP70 Protein, Human, Recombinant (His)

Cat.No: TMPH-02280

Species: Human

Expression System: E. coli

LSM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03390

Species: Human

Expression System: E. coli

Neuropeptide Y Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00286

Species: Human

Expression System: HEK293 Cells

EPT1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01311

Species: Human

Expression System: E. coli

JNK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04550

Species: Human

Expression System: Baculovirus Insect Cells

LSM3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03344

Species: Human

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)

Cat.No: TMPH-03729

Species: ZEBOV

Expression System: E. coli

NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04403

Species: Human

Expression System: Baculovirus Insect Cells

EIF3I Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03289

Species: Rat

Expression System: E. coli

Aconitase 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02482

Species: Human

Expression System: Baculovirus Insect Cells

MAX Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02888

Species: Human

Expression System: Baculovirus Insect Cells

EIF3I Protein, Rat, Recombinant (His)

Cat.No: TMPH-03288

Species: Rat

Expression System: Baculovirus Insect Cells

OTUB2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02522

Species: Human

Expression System: E. coli

S100A16 Protein, Human, Recombinant

Cat.No: TMPY-02135

Species: Human

Expression System: E. coli

Selenoprotein M Protein, Human, Recombinant (His)

Cat.No: TMPY-02768

Species: Human

Expression System: E. coli

PAK-3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04397

Species: Human

Expression System: Baculovirus Insect Cells

MOB4A/MOB1B Protein, Human, Recombinant (GST)

Cat.No: TMPY-03442

Species: Human

Expression System: E. coli

HIST2H2BE Protein, Human, Recombinant

Cat.No: TMPY-02510

Species: Human

Expression System: E. coli

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

Cat.No: TMPY-01710

Species: Human

Expression System: E. coli

DNA-binding protein H-NS Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00616

Species: E. coli

Expression System: E. coli

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