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Search Results for " kynurenine "

Targets Recommended: Others

20

抑制剂 & 化合物

6

天然产物

5

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T3011L	Kynurenine sulfate monohydrate L-Kynurenine sulfate monohydrate	Others	Others
	Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mamma
T37683	3-Hydroxykynurenine 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine	Others	Others
	3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物，可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。
T72430	L-Kynurenine sulfate	Others	Others
	L-Kynurenine sulfate 是一种芳香烃受体AHR 激动剂，可激活 AHR 导向的初始T 细胞极化至抗炎 Treg 表型。
T1896	Ro 61-8048	Hydroxylase	Metabolism
	Ro 61-8048 是一种选择性的、口服有效的犬尿氨酸 3-羟化酶抑制剂(IC50:37 nM)。它能够导致细胞喹啉酸浓度的显著增加。
T4410	LM10	Others	Others
	LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶，它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。
T71760	4-Chlorokynurenine	Others	Others
	4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.
T28368	PF-04859989 HCl PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others	Others
	PF-04859989 HCl 是不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，可透过血脑屏障，抑制 hKATⅡ 和 rKATⅡ 的 IC50分别为 23 和 263 nM。它对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50分别为22、11和 >50 μM)。
T26785	BFF122 BFF 122,BF5,BFF-122	Others	Others
	BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II).
T13258	UPF-648 sodium salt	Others	Others
	UPF-648 sodium salt is an inhibitor of kynurenine 3-monooxygenase (KMO) and exhibits highly active at 1 uM (81 ± 10% KMO inhibition).
T70041	GSK065	Others	Others
	GSK065 is a potent inhibitor of kynurenine-3-monooxygenase (KMO).
T70701	CHDI340246	Others	Others
	CHDI-340246 is a potent and selective kynurenine mono-oxygenase (KMO) inhibitor.
T15426	GSK180	Hydroxylase	Metabolism
	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
T11470	GSK 366	Hydroxylase	Metabolism
	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T13258L	UPF-648	Others	Others
	UPF-648 is a potent kynurenine 3-monooxygenase inhibitor. It also shows highly active at 1 uM (81 ± 10% KMO inhibition).
T24617	PF-04859989	Others	Others
	PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II.
T63613	JM6	Others	Others
	JM6 是弱犬尿氨酸 3-单加氧酶 (kynurenine 3-monooxygenase, KMO) 抑制剂，能够作用于小鼠 KMO (IC50: 19.85 μM)。JM6 能够用于研究阿尔茨海默病。
T4532L	Linrodostat mesylate ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205	Others	Others
	Linrodostat (BMS-986205, ONO-7701, and F001287) is a selective and orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. By inhibiting IDO1 and reducing kynurenine in tumor cells, BMS-986205 restores and promotes the
T69944	NLG802 HCl	Others	Others
	NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod res...
T84434	Kynurenic Acid hydrate KYNA	Others	Others
	Kynurenic acid, an active metabolite of tryptophan, is synthesized through a kynurenine intermediate by kynurenine aminotransferases (KATs). It acts as an antagonist of both NMDA and AMPA receptors, as well as α7 nicotinic acetylcholine receptors (nAChRs; EC50s = 235, 101, and 7 µM, respectively), and functions as an agonist for the aryl hydrocarbon receptor (AhR) and G protein-coupled receptor 35 (GPR35; EC50s = 1.4 and 39 µM, respectively). In a neonatal rat model of cerebral hypoxic-ischemia,...
T73581	HI5	Others	Others
	HI5 是一种有效的微管蛋白 (tublin)和IDO 抑制剂，对 HeLa 细胞的IC50为 70 nM。HI5 抑制IDO 的表达，减少犬尿氨酸的产生，从而刺激 T 细胞活化和增殖。HI5 对 HeLa 细胞可抑制微管蛋白聚合和细胞迁移，引起 G2/M 期阻滞，同时通过线粒体依赖性凋亡途径诱导细胞凋亡 (apoptosis) 并引起反应性氧化应激。HI5 可用于抗癌研究。

化合物

Kynurenine sulfate monohydrate

Cat.No: T3011L

Synonym: L-Kynurenine sulfate monohydrate

Target: Others

3-Hydroxykynurenine

Cat.No: T37683

Synonym: 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine

Target: Others

L-Kynurenine sulfate

Cat.No: T72430

Target: Others

Cat.No: T1896

Target: Hydroxylase

Cat.No: T4410

Target: Others

4-Chlorokynurenine

Cat.No: T71760

Target: Others

PF-04859989 HCl

Cat.No: T28368

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

Cat.No: T26785

Synonym: BFF 122,BF5,BFF-122

Target: Others

UPF-648 sodium salt

Cat.No: T13258

Target: Others

Cat.No: T70041

Target: Others

Cat.No: T70701

Target: Others

Cat.No: T15426

Target: Hydroxylase

Cat.No: T11470

Target: Hydroxylase

Cat.No: T13258L

Target: Others

Cat.No: T24617

Target: Others

Cat.No: T63613

Target: Others

Linrodostat mesylate

Cat.No: T4532L

Synonym: ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205

Target: Others

Cat.No: T69944

Target: Others

Kynurenic Acid hydrate

Cat.No: T84434

Synonym: KYNA

Target: Others

Cat.No: T73581

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T10938	D-Kynurenine D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103	GPR; AhR; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种酮类和氨基酸衍生物，具有多种生物功能，包括血管舒张、免疫调节和神经调节活性。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是烟酸的前体。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 的异常产生与神经系统疾病相关的认知缺陷和抑郁症状有关。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 在某些类型的癌细胞中过度表达，可能被用作评估癌症风险的生物标志物。
T4096	Quinolinic acid 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN	Endogenous Metabolite; NMDAR; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Quinolinic acid (QUIN) 是一种内源性 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂，由 L-色氨酸通过犬尿氨酸途径合成，具有调节 NMDA 神经元损伤和功能障碍的潜力。
T4707	3-Hydroxyanthranilic acid 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸	Others; Antioxidant; Endogenous Metabolite	Metabolism; Others; oxidation-reduction
	3-Hydroxyanthranilic acid是犬尿氨酸途径中的色氨酸代谢物。它已在人类表皮和膀胱组织中发现，并且在多种生物体液中也已检测到，例如尿液和血液。在细胞内，它主要位于细胞质中。它存在于从酵母到人类的所有真核生物中。 3-Hydroxyanthranilic acid 具有抗氧化活性。
T80656	Cannflavin A	Others	Others
	Cannflavin A，源自大麻(Cannabis sativa L)，具备抗癌、神经保护及抗炎活性。该化合物有效抑制Aβ1-42的聚集，并阻断犬尿氨酸-3-单加氧酶(KMO)的活性，进而通过caspase-3裂解途径激活细胞凋亡(apoptosis)。

天然产物

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Cat.No: T10938

Synonym: D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103

Target: GPR, AhR, Endogenous Metabolite

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Cat.No: T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸

Target: Others, Endogenous Metabolite

Quinolinic acid

Cat.No: T4096

Synonym: 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN

Target: Endogenous Metabolite, NMDAR, iGluR

3-Hydroxyanthranilic acid

Cat.No: T4707

Synonym: 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸

Target: Others, Antioxidant, Endogenous Metabolite

Cat.No: T80656

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01595	KMO Protein, Human, Recombinant (His) Kynurenine 3-monooxygenase,KMO,Kynurenine ...	Human	E. coli
	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
TMPH-01597	KYAT1 Protein, Human, Recombinant (His & SUMO) Kynurenine aminotransferase 1,KYAT1,Glutamine--phen...	Human	E. coli
	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cl...
TMPH-01598	CCBL2 Protein, Human, Recombinant (His & SUMO) KAT3,Kynurenine--oxoglutarate transaminase 3,CCBL2,...	Human	E. coli
	CCBL2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.4 kDa and the accession number is Q6YP21.
TMPH-01596	AADAT Protein, Human, Recombinant (His & SUMO) 2-aminoadipate transaminase,Glycine transaminase AADAT,Alpha...	Human	E. coli
	Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
TMPY-02803	IDO2 Protein, Human, Recombinant (His) indoleamine 2,3-dioxygenase 2,INDOL1	Human	E. coli
	IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in the liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human ti...

重组蛋白

KMO Protein, Human, Recombinant (His)

Cat.No: TMPH-01595

Species: Human

Expression System: E. coli

KYAT1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01597

Species: Human

Expression System: E. coli

CCBL2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01598

Species: Human

Expression System: E. coli

AADAT Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01596

Species: Human

Expression System: E. coli

IDO2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02803

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0071	L-Kynurenine-d4
	L-Kynurenine-d4 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
TMIJ-0518	L-Kynurenine-d4-1
	L-Kynurenine-d4-1 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
TMID-0171	Kynurenic Acid-d5
	Kynurenic Acid-d5 是 Kynurenic Acid 的氘代化合物。Kynurenic Acid 的 CAS 号为 492-27-3。Kynurenic acid 是一种内源性色氨酸代谢物，是针对靶点NMDA、谷氨酸、α7烟碱型乙酰胆碱受体的广谱拮抗剂。它也是GPR35/CXCR8激动剂。

同位素标记化合物

L-Kynurenine-d4

Cat.No: TMID-0071

L-Kynurenine-d4-1

Cat.No: TMIJ-0518

Kynurenic Acid-d5

Cat.No: TMID-0171

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