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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6456 |
CRT0044876
NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
CRT0044876 (7-NO2-ICA) 是一种高选择性的嘌呤/嘧啶核苷核酸内切酶 1 抑制剂,IC50约为 3 μM。它也是 APE1 所属的核酸外切酶 III 家族的特异性抑制剂,可抑制 APE1 的 AP 内切酶、3′-磷酸二酯酶和 3′-磷酸酶活性,可增强几种 DNA 碱基靶向化合物的细胞毒性。 | |||
T9497 |
Niraparib tosylate monohyrate
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Niraparib tosylate monohyrate 也称为 MK-4827,是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂,具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性,增强 DNA 链断裂的积累,促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。 | |||
T50098 |
TIQ-A
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
TIQ-A 是一种 PARP1 抑制剂,通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发,其过度激活已被认为是许多病理状况的致病因素,包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。 | |||
T21320 |
Methoxyamine HCl
甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102 |
Others | Others |
Methoxyamine HCl (Methoxyamine) 与脱嘌呤/脱嘧啶 (AP) DNA 损伤位点共价结合并抑制碱基切除修复 (BER),这可能导致 DNA 链断裂和细胞凋亡增加。 Methoxyamine 是一种具有潜在佐剂活性的口服生物可利用的小分子抑制剂。该药剂可增强烷化剂的抗肿瘤活性。 | |||
T60904 |
ERCC1-XPF-IN-2
|
Others | Others |
ERCC1-XPF-IN-2 在核苷酸切除修复、顺铂增强和 γH2AX 测定中具有活性。ERCC1-XPF-IN-2 是 ERCC1-XPF 核酸内切酶的有效抑制剂,IC50值为 0.6 μM。 | |||
T3353 |
Niraparib hydrochloride
尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride) |
Apoptosis; Others; PARP | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
Niraparib hydrochloride (MK-4827 hydrochloride) 是一种具有口服活性的PARP1和PARP2抑制剂,IC50值分别为 3.8 nM 和 2.1 nM。它抑制 DNA 损伤修复,诱导凋亡并具有抗肿瘤活性。 | |||
T28017 |
Merbarone
RLBN-1001,NSC-336628,RLBN1001,NSC336628 |
Others | Others |
Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n | |||
T28293 |
Pamiparib maleate
BGB290,BGB 290,BGB-29 maleat 0 |
Others | Others |
Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, pro | |||
T73299 |
APE1-IN-2
|
Apoptosis | Apoptosis |
APE1-IN-2(compound AP1)是一种具有抗癌活性的Pt(IV)前体,靶向BER关键蛋白APE1。该化合物能诱导细胞内铂的积累,并激活DNA损伤反应及凋亡信号。 | |||
T80045 |
Defensin HNP-3 human
|
Antibiotic | Microbiology/Virology |
Defensin HNP-3 human 是一种具有抑制金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌活性的细胞毒性抗生素肽。该肽原先以94个氨基酸的preproHNP(1-94)形式合成,随后水解为proHNP(20-94),最终通过去除阴离子前体转化为成熟形式的HNP(65-94)。 | |||
T70115 |
Pamiparib hydrate
|
Others | Others |
Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo... | |||
T71467 |
Nemorubicin HCL
|
Others | Others |
Nemorubicin HCL is the salt form of Nemorubicin, also known as PNU152243A, a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway... | |||
T78451 |
Patent Blue V
Acid blue 1 |
||
Patent Blue V(Acid blue 1)是一款应用于眼科的新型生物染料,特别是在进行视网膜切除手术时,用以染色以便去除内限制膜(ILM)。该染料在玻璃体视网膜手术中确保了对视网膜结构的有效标记,从而实现精确去除。光谱分析揭示,Patent Blue V在450 nm以下和600 nm以上具有强烈的吸收特性,展现蓝绿色。此外,它亦作为淋巴管造影术中的追踪剂,在染色活检手术中使用以助于淋巴结的切除。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02300 |
RAD23A Protein, Human, Recombinant (His)
UV excision repair protein RAD23 homolog A,RAD23A |
Human | E. coli |
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucle... | |||
TMPH-02863 |
LOX Protein, Mouse, Recombinant (His & Myc)
Ras excision protein,Protein-lysine 6-oxidase,Lysyl... |
Mouse | Baculovirus Insect Cells |
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. | |||
TMPH-01380 |
ERCC3 Protein, Human, Recombinant (GST)
General transcription and DNA repair factor IIH helicase sub... |
Human | E. coli |
ERCC3 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 115.6 kDa and the accession number is P19447. | |||
TMPJ-00792 |
DNA PolymeraseBeta Protein, Human, Recombinant (His)
DNA Polymeraseβ,POLB,DNA Polymerase Beta,DNA Polymerase β |
Human | E. coli |
Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a proce... | |||
TMPH-00611 |
DNA helicase II Protein, E. coli, Recombinant
mutU,DNA 3'-5' helicase II,DNA helicase II,recL,rad,pdeB,uvr... |
E. coli | E. coli |
A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA. DNA helicase II Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 82.0 kDa and the acce... | |||
TMPY-02798 |
NEIL1 Protein, Human, Recombinant (His)
NEI1,nei endonuclease VIII-like 1 (E. coli),FPG1,hFPG1 |
Human | E. coli |
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision r... | |||
TMPJ-00464 |
APE Protein, Human, Recombinant
APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic... |
Human | E. coli |
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down... | |||
TMPH-00755 |
Integrase Protein, Escherichia phage lambda, Recombinant (His)
Integrase,int |
Escherichia phage lambda | E. coli |
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. Integrase Protein, Escherichia phage lambda, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.3 kDa and the accession number is P03700. | |||
TMPJ-00907 |
GADD45A Protein, Human, Recombinant (His)
GADD45,DDIT1,Growth Arrest and DNA Damage-Inducible Protein ... |
Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating ... | |||
TMPH-01008 |
PNKP Protein, Human, Recombinant (His & SUMO)
Polynucleotide kinase-3'-phosphatase,PNKP,DNA 5'-kinase/3'-p... |
Human | E. coli |
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. PNKP Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The ... | |||
TMPJ-00707 |
Coagulation factor X/F10 Protein, Mouse, Recombinant (His)
Stuart factor,Coagulation factor X,F10 |
Mouse | HEK293 Cells |
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initiall... | |||
TMPJ-00301 |
Coagulation Factor X Protein, Human, Recombinant (hFc)
Stuart-Prower factor,Stuart factor,Coagulation factor X |
Human | HEK293 Cells |
F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways activate Factor X to Xa, which consists of light (residues 41‑179) and heavy (residues 235‑488) chains linked by a disulfide bond. Coagulation factor X is initially synthesized in the liver. The two chains are formed from a single-chain precursor by the excision of two Arg residue... | |||
TMPJ-01386 |
STUB1 Protein, Human, Recombinant
Carboxy Terminus of Hsp70-Interacting Protein,STIP1 Homology... |
Human | E. coli |
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.... | |||
TMPY-02000 |
UNG Protein, Human, Recombinant (GST)
uracil-DNA glycosylase,HIGM4,UNG15,UNG1,DGU,UNG2,HIGM5,UDG |
Human | E. coli |
Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil... | |||
TMPH-01237 |
POLQ Protein, Human, Recombinant (E. coli, His)
DNA polymerase eta,POLQ,DNA polymerase theta |
Human | E. coli |
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul... | |||
TMPH-01238 |
POLQ Protein, Human, Recombinant (His)
DNA polymerase eta,POLQ,DNA polymerase theta |
Human | Baculovirus Insect Cells |
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul... | |||
TMPH-01239 |
XPC Protein, Human, Recombinant (His)
Xeroderma pigmentosum group C-complementing protein,p125,XPC... |
Human | E. coli |
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein i... |