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Search Results for " dephosphorylation "

Targets Recommended: Apoptosis AMPK AChR

24

抑制剂 & 化合物

5

天然产物

3

TargetMol 试剂盒

21

重组蛋白

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Cat. No.	Product Name	Form	Specificity Of Inhibition
C0004	Phosphatase Inhibitor Cocktail III (2 Tubes, 100x) 磷酸酶抑制剂 Cocktail III (2 Tubes, 100x)	2 Tube Solution (100×)	Each Tube has different specificity of inhibition
C0002	Phosphatase Inhibitor Cocktail I (100× ddH2O) 磷酸酶抑制剂 Cocktail I (100× ddH2O)	Solution (100× in ddH2O)	Acid Phosphatase, Alkaline phosphatase, PTPs, ATPases
C0003	Phosphatase Inhibitor Cocktail II (100× DMSO) 磷酸酶抑制剂 Cocktail II (100× DMSO)	Solution (100× in DMSO)	Alkaline phosphatases, Ser/Thr phosphatases, Acid and PP1 and PP2A

TargetMol 试剂盒

磷酸酶抑制剂 Cocktail III (2 Tubes, 100x)

Cat.No: C0004

磷酸酶抑制剂 Cocktail I (100× ddH2O)

Cat.No: C0002

磷酸酶抑制剂 Cocktail II (100× DMSO)

Cat.No: C0003

Cat. No.	Product Name	Target	Signaling Pathways
T7955	EB-3D	Apoptosis; AMPK; AChR	Apoptosis; Chromatin/Epigenetic; Neuroscience; PI3K/Akt/mTOR signaling
	EB-3D 是一种选择性胆碱激酶 α 抑制剂，对 ChoKα1 的IC50值为 1 μM。它影响 ChoKα 表达、AMPK 激活、细胞凋亡、内质网应激和脂质代谢，具有抗癌活性。
TP1015	NFAT Inhibitor VIVIT peptide	Others	Others
	NFAT Inhibitor (VIVIT peptide) 是NFAT 的细胞渗透性肽抑制剂，能够选择性抑制钙调磷酸酶介导的NFAT 脱磷酸作用。
T16156	MT 63-78	Apoptosis; AMPK; mTOR	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MT 63-78 是一种有效的直接AMPK 激活剂，EC50为 25 μM。它诱导细胞有丝分裂阻滞和细胞凋亡，通过抑制脂肪生成和mTORC1途径来阻止前列腺癌的生长，具有抗肿瘤作用。
T8978	DD1 3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome	Proteases/Proteasome; Ubiquitination
	DD1 (HUN85111) 是一种蛋白酶体抑制剂，可诱导人髓系肿瘤选择性凋亡。
TP1015L	NFAT Inhibitor acetate VIVIT peptide acetate,NFAT Inhibitor acetate（249537-73-3 free base）
	NFAT Inhibitor acetate (VIVIT peptide acetate) 是一种具有细胞渗透性和选择性的 NFAT 多肽抑制，对钙调磷酸酶介导的 NFAT 脱磷酸作用有抑制作用。
T24398	Lenaldekar LDK	Akt; IGF-1R; S6 Kinase	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Lenaldekar (LDK) 抑制 T 细胞扩增和自身免疫性脑脊髓炎。 Lenaldekar 导致 PI3 激酶/AKT/mTOR 通路成员的去磷酸化并延迟有丝分裂晚期的敏感细胞。
T2208	Bacitracin Zinc 杆菌肽锌,Bacitracin zinc salt,Zinc bacitracin	c-Met/HGFR; Antibacterial; Antibiotic	Microbiology/Virology; Tyrosine Kinase/Adaptors
	Bacitracin Zinc 是 C55-异戊二烯焦磷酸酯的去磷酸化干扰物，可抑制 Met-enkephalin 中 Tyr 的裂解，IC50为10 μM。
T16115	MLi-2	LRRK2	Autophagy
	MLi-2 是一种结构新颖、高效、选择性的 LRRK2 激酶抑制剂，具有中枢神经系统活性，IC50为 0.76 nM，有潜力用于帕金森氏病。
T10927	Cyt-PTPε Inhibitor-1 Cyt-PTP\|A Inhibitor-1	Phosphatase; Src	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Cyt-PTPε Inhibitor-1 (A Inhibitor-1) 是胞质蛋白酪氨酸磷酸酶 ε 的抑制剂。 Cyt-PTPε Inhibitor-1 阻断 c-Src 的去磷酸化并表现出抗破骨活性。
T35806	N-Stearoylsphingosine C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide	Phosphatase	Metabolism
	N-Stearoylsphingosine (Cer(d18:1/18:0)) 是一种广泛存在真核生物体内的酰胺类化合物，通过干扰PP2A与PP2A抑制剂2的结合来增强蛋白质磷酸酶2A(PP2A)活性，导致Akt去磷酸化。N-Stearoylsphingosine 可用于研究前列腺癌。
T71648	CK37	Others	Others
	CK37 controls the biological activity of Choline Kinase-α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
T40507	BTO-1	Others	Others
	BTO-1 is a compound known as a Polo-like kinase (Plk) inhibitor, commonly employed for its effectiveness in regulating processes involving phosphorylation and dephosphorylation.
T40445	Cyclocreatine	Others	Others
	Cyclocreatine, a Creatine analogue, exhibits potent bioenergetic protection by elevating ATP levels. It demonstrates the ability to traverse cell membranes, including the blood-brain barrier, wherein it undergoes phosphorylation and dephosphorylation by creatine kinases.
T77934	PhosTAC7	PROTACs	PROTAC
	PhosTAC7类似于PROTACs通过诱导三元复合物的作用机制，其主要作用是招募Ser/Thr磷酸酶至磷酸化底物，从而介导目标蛋白的去磷酸化。
T28092	MPT0B206	Others	Others
	MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1 and the dephosphorylation of Cdc2.
T69091	CBP501	Others	Others
	CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.
T35937	D-myo-Inositol-1,5,6-triphosphate (sodium salt)	Others	Others
	The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, andmotility. D-myo-Inositol-1,5,6-triphosphate is an intermediate compound, produced by the dephosphorylation of various inositol-tetrakisphosphate forms. The triphosphate can be further metabolized to produce inositol-biphosphate mediators. The biological roles of D-myo-inositol-1,5,6-triphosphate remain to be de...
T69200	CGP74514A	Others	Others
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...
T71217	MPT0B214	Others	Others
	MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of th...
T26456	A 83586C A83586C,A-83586C	Others	Others
	A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating o
T35938	D-myo-Inositol-4-phosphate (ammonium salt)	Others	Others
	D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intr...
T37040	DiIC1(5) DiIC1(5)	Others	Others
	DiIC1(5) is a signal-off fluorescent probe for the detection of mitochondrial membrane potential disruption. It accumulates in mitochondria and its fluorescence intensity decreases when the mitochondrial membrane potential is disrupted. DilC1(5) has been used in combination with a variety of cell damage and cell death markers to classify nine stages of cell death using flow cytometry. It has also been used as a quencher for the detection of serine phosphorylation and tyrosine dephosphorylation p...
T60737	LG308	Others	Others
	LG308 是一种新型合成化合物，具有抗微管活性。LG308 诱导细胞凋亡和细胞死亡，并且显著抑制肿瘤生长，具有前列腺癌的研究潜力。LG308 诱导有丝分裂阻滞并显着抑制 G2/M 的进程，这与细胞周期蛋白 B1 和有丝分裂标志物 MPM-2 的上调以及 cdc2 的去磷酸化有关。
T35892	Q134R Q134R	Others	Others
	Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo...

化合物

Cat.No: T7955

Target: Apoptosis, AMPK, AChR

Cat.No: TP1015

Synonym: VIVIT peptide

Target: Others

Cat.No: T16156

Target: Apoptosis, AMPK, mTOR

Cat.No: T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Proteasome

NFAT Inhibitor acetate

Cat.No: TP1015L

Synonym: VIVIT peptide acetate,NFAT Inhibitor acetate（249537-73-3 free base）

Cat.No: T24398

Synonym: LDK

Target: Akt, IGF-1R, S6 Kinase

Bacitracin Zinc

Cat.No: T2208

Synonym: 杆菌肽锌,Bacitracin zinc salt,Zinc bacitracin

Target: c-Met/HGFR, Antibacterial, Antibiotic

Cat.No: T16115

Target: LRRK2

Cyt-PTPε Inhibitor-1

Cat.No: T10927

Synonym: Cyt-PTP|A Inhibitor-1

Target: Phosphatase, Src

N-Stearoylsphingosine

Cat.No: T35806

Synonym: C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide

Target: Phosphatase

Cat.No: T71648

Target: Others

Cat.No: T40507

Target: Others

Cat.No: T40445

Target: Others

Cat.No: T77934

Target: PROTACs

Cat.No: T28092

Target: Others

Cat.No: T69091

Target: Others

D-myo-Inositol-1,5,6-triphosphate (sodium salt)

Cat.No: T35937

Target: Others

Cat.No: T69200

Target: Others

Cat.No: T71217

Target: Others

Cat.No: T26456

Synonym: A83586C,A-83586C

Target: Others

D-myo-Inositol-4-phosphate (ammonium salt)

Cat.No: T35938

Target: Others

Cat.No: T37040

Synonym: DiIC1(5)

Target: Others

Cat.No: T60737

Target: Others

Cat.No: T35892

Synonym: Q134R

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2185	L-Ascorbic acid 2-phosphate trisodium L-抗坏血酸-2-磷酸三钠盐（维生素C）,L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐	Reactive Oxygen Species; c-Met/HGFR; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB; Tyrosine Kinase/Adaptors
	L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) 是长效的维生素 C 衍生物，能够刺激胶原蛋白的表达和形成。Sodium L-ascorbyl-2-phosphate 提高成骨细胞分化过程中 hASC 中的碱性磷酸酶活性和 runx2A 的表达，因此，能够促进人脂肪干细胞的成骨分化。
T72100	D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride	Others	Others
	D-erythro-Sphingosine (Erythrosphingosine) hydrochloride 是一种特异性 TRPM3活化剂。D-erythro-Sphingosine 还诱导视网膜母细胞瘤蛋白 (retinoblastoma protein) 去磷酸化。
T37977	Succinyladenosine	Others	Others
	Succinyladenosine is a biochemical marker of adenylosuccinase (ASL) deficiency. It is formed through the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase [1].
TN6419	Chamaejasmine
	Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

L-Ascorbic acid 2-phosphate trisodium

Cat.No: T2185

Synonym: L-抗坏血酸-2-磷酸三钠盐（维生素C）,L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐

Target: Reactive Oxygen Species, c-Met/HGFR, Endogenous Metabolite

D-erythro-Sphingosine hydrochloride

Cat.No: T72100

Synonym: Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride

Target: Others

Succinyladenosine

Cat.No: T37977

Target: Others

Cat.No: TN6419

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02398	ASA dehydrogenase Protein, Legionella pneumophila, Recombinant (His) Aspartate-beta-semialdehyde dehydrogenase,asd,Aspartate-semi...	Legionella pneumophila	E. coli
	Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
TMPH-01251	DUSP26 Protein, Human, Recombinant (His & SUMO) MKP-8,NATA1,DSP-4,SKRP3,DUSP26,MKP8,LDP-4,LDP4,DUSP24,Dual s...	Human	E. coli
	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
TMPY-02893	NT5C3A/NT5C3 Protein, Human, Recombinant P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN1,UMPH1,UMPH,POMP,5'-nucleo...	Human	E. coli
	NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but...
TMPH-03719	YopH Protein, Yersinia enterocolitica, Recombinant (His & Myc) yopH,Virulence protein,Tyrosine-protein phosphatase YopH	Yersinia enterocolitica	E. coli
	Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP) MKP6,MKP-L,dual specificity phosphatase 14	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (...
TMPH-00266	Galectin-1/LGALS1 Protein, Bovine, Recombinant (His & SUMO) Galectin-1,S-Lac lectin 1,14 kDa lectin,LGALS1,Beta-galactos...	Bovine	E. coli
	Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Galectin-1/LGALS1 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.6 kDa and the accession number is P11116.
TMPY-02964	Calcineurin B/PPP3R1 Protein, Human, Recombinant (His) protein phosphatase 3, regulatory subunit B, alpha,CNB1,CALN...	Human	Baculovirus Insect Cells
	PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. PPP3R1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase which takes a vital part in the T cell activatio...
TMPH-02013	PTPRZ1 Protein, Human, Recombinant (His) Protein-tyrosine phosphatase receptor type Z polypeptide 2,R...	Human	P. pastoris (Yeast)
	Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. PTPRZ1 Protein, Human, Recombinant (His) is exp...
TMPK-00489	TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) TNFSF15,TNF superfamily member 15,TL1,VEGI192A,TL1A,VEGI-251...	Cynomolgus,Rhesus	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weigh...
TMPK-00115	CD79B Protein, Human, Recombinant (His & Avi) Ig-beta,CD79B,IGB,CD79b molecule,Ig-β,B29,IGBAGM6	Human	HEK293 Cells
	CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruit...
TMPK-00143	TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) TL1A,TL1,TNFSF15,VEGI,VEGI192A,VEGI-251	Human	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight...
TMPJ-00870	NCK1 Protein, Human, Recombinant (His) SH2/SH3 Adaptor Protein NCK-α,SH2/SH3 Adaptor Protein NCK-Al...	Human	E. coli
	Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing...
TMPH-02870	PDXP Protein, Mouse, Recombinant (His & SUMO) Pdxp,Pyridoxal phosphate phosphatase,Chronophin,Pyridoxal 5'...	Mouse	E. coli
	Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskel...
TMPH-02126	SORBS2 Protein, Human, Recombinant (His) Sorbin and SH3 domain-containing protein 2,Arg-binding prote...	Human	E. coli
	Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. SORBS2 Pro...
TMPJ-00908	LMW-PTP Protein, Human, Recombinant (His) Low Molecular Weight Cytosolic Acid Phosphatase,Adipocyte Ac...	Human	E. coli
	Low Molecular Weight Phosphotyrosine Protein Phosphatase (LMW-PTP) is a member of the low molecular weight phosphotyrosine protein phosphatase family. LMW-PTP serves as an acid phosphatase and a protein tyrosine phosphatase (PTPase) by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. LMW-PTP can be detected in all human tissues, including adipocytes. LMW-PTP is a cytosolic enzyme that regulate cell proliferation and growth of leiomyomas during dephosphorylation of t...
TMPY-02197	PPM1G Protein, Human, Recombinant (aa 317-546, His) protein phosphatase, Mg2+/Mn2+ dependent, 1G,PP2Cγ,PPP2CG,PP...	Human	E. coli
	Protein phosphatase 1G, also known as Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, Protein phosphatase magnesium-dependent 1 gamma, PP2C-gamma, PPM1G and PPM1C, is a cytoplasm protein that belongs to the PP2C family. PPM1G / PP2C-gamma is widely expressed. It is most abundant in testis, skeletal muscle, and heart. Alternatively spliced transcript variants encoding the same protein have been described. PP2C family members are known to be negative regulators of cell stress respons...
TMPH-02697	GNA12 Protein, Mouse, Recombinant (His & Myc) Guanine nucleotide-binding protein subunit alpha-12,Gna12	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by ac...
TMPY-03439	UBASH3A Protein, Human, Recombinant (aa 354-623, His) TULA,STS-2,CLIP4,ubiquitin associated and SH3 domain contain...	Human	E. coli
	UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A pro...
TMPH-02878	PTPRS Protein, Mouse, Recombinant (His & Myc) Receptor-type tyrosine-protein phosphatase S,Ptprs,PTPNU-3,R...	Mouse	E. coli
	Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteo...
TMPY-02131	Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST) acid phosphatase 1, soluble,HAAP	Human	E. coli
	The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphoryl...
TMPY-02198	ILKAP Protein, Human, Recombinant (His) ILKAP3,PP2C-δ,PP2C-DELTA,integrin-linked kinase-associated s...	Human	HEK293 Cells
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels are evident in various smooth muscle tissues. ILKAP may play a role in the regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferat...

重组蛋白

ASA dehydrogenase Protein, Legionella pneumophila, Recombinant (His)

Cat.No: TMPH-02398

Species: Legionella pneumophila

Expression System: E. coli

DUSP26 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01251

Species: Human

Expression System: E. coli

NT5C3A/NT5C3 Protein, Human, Recombinant

Cat.No: TMPY-02893

Species: Human

Expression System: E. coli

YopH Protein, Yersinia enterocolitica, Recombinant (His & Myc)

Cat.No: TMPH-03719

Species: Yersinia enterocolitica

Expression System: E. coli

DUSP14 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPY-02595

Species: Human

Expression System: E. coli

Galectin-1/LGALS1 Protein, Bovine, Recombinant (His & SUMO)

Cat.No: TMPH-00266

Species: Bovine

Expression System: E. coli

Calcineurin B/PPP3R1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02964

Species: Human

Expression System: Baculovirus Insect Cells

PTPRZ1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02013

Species: Human

Expression System: P. pastoris (Yeast)

TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00489

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD79B Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00115

Species: Human

Expression System: HEK293 Cells

TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00143

Species: Human

Expression System: HEK293 Cells

NCK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00870

Species: Human

Expression System: E. coli

PDXP Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02870

Species: Mouse

Expression System: E. coli

SORBS2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02126

Species: Human

Expression System: E. coli

LMW-PTP Protein, Human, Recombinant (His)

Cat.No: TMPJ-00908

Species: Human

Expression System: E. coli

PPM1G Protein, Human, Recombinant (aa 317-546, His)

Cat.No: TMPY-02197

Species: Human

Expression System: E. coli

GNA12 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02697

Species: Mouse

Expression System: E. coli

UBASH3A Protein, Human, Recombinant (aa 354-623, His)

Cat.No: TMPY-03439

Species: Human

Expression System: E. coli

PTPRS Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02878

Species: Mouse

Expression System: E. coli

Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02131

Species: Human

Expression System: E. coli

ILKAP Protein, Human, Recombinant (His)

Cat.No: TMPY-02198

Species: Human

Expression System: HEK293 Cells

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