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Search Results for " corticosteroid "

Targets Recommended: Glucocorticoid Receptor

68

抑制剂 & 化合物

6

天然产物

2

重组蛋白

8

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T14981	Clobetasone butyrate	Glucocorticoid Receptor	Endocrinology/Hormones
	Clobetasone butyrate 是糖皮质类固醇，特别是在皮肤上，具有局部抗炎活性。它可用于改善皮质类固醇反应性症状，如特应性皮炎、牛皮癣。
T12829	Salmeterol 沙美特罗,GR33343X	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Salmeterol (GR33343X) 是一种选择性的人β2肾上腺素受体激动剂。它能够有效刺激 cAMP 积累，作用于 CHO 细胞，对人β2，β1和β3肾上腺素受体的 pEC50分别为 9.6、6.1 和 5.9。
T5000	Diflucortolone valerate Afusona,戊酸双氟可龙,Diflucortolone 21-valerate	Others; Antibacterial; Antifungal	Microbiology/Virology; Others
	Diflucortolone valerate (Diflucortolone 21-valerate) 是一种强效皮质类固醇，可研究各种皮肤疾病。
T21404	Fluticasone furoate Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。
T1531	Mometasone furoate 糠酸莫美他松,糠酸莫米松,Sch32088	Glucocorticoid Receptor	Endocrinology/Hormones
	Mometasone furoate (Sch32088) 是糖皮质激素受体激动剂，具有抗炎和抗过敏作用。它是皮质固醇类试剂，动物模型中，可局部应用于气道炎症、慢性皮肤湿疹、哮喘。
T6653	Salmeterol Xinafoate Salmetedur,昔美酸沙美特罗,沙美特罗昔萘酸酯,GR 33343X xinafoate,Arial	HIV Protease; Adrenergic Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Salmeterol Xinafoate (GR 33343X xinafoate) 是选择性人β2肾上腺素受体激动剂。Salmeterol 有效刺激 cAMP 积累，能够作用于 CHO 细胞，对人β2，β1和β3肾上腺素受体的 pEC50分别为 9.6、6.1 和 5.9。
T6503	Fluorometholone Acetate NSC 47438,Flarex,Eflone,氟米龙醋酸酯,Oxylone acetate	Glucocorticoid Receptor; Carbonic Anhydrase	Endocrinology/Hormones; Metabolism
	Fluorometholone Acetate (Oxylone acetate) 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对 hCA-I(IC50:2.18 μM)和 hCA-II(IC50:17.5 μM)。它具有抗炎活性，可用于研究外部眼部炎症。
T1561	Clobetasol propionate Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725	Glucocorticoid Receptor; P450	Endocrinology/Hormones; Metabolism
	Clobetasol propionate (CGP9555) 是CYP3A5的选择性抑制剂(IC50:0.206 μM)，而对 CYP3A4 或其他主要 CYP 无抑制作用。它是皮质类固醇，对于牛皮癣和其他皮肤病具有潜在的研究价值。
T0188	Fluticasone (propionate) 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate	Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Endocrinology/Hormones; Metabolism; Microbiology/Virology
	Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂，是一种局部抗炎激素，亲和力KD 为 0.5 nM。具有抗病毒活性。
T0261	Amcinonide 安西奈德,CL-34699	Glucocorticoid Receptor; Annexin A	Endocrinology/Hormones; GPCR/G Protein
	Amcinonide (CL-34699) 是皮质类固醇。它能够抑制NO 从活化的小胶质细胞释放(IC50:3.38 nM)，具有糖皮质激素受体亲和力。它是皮质类固醇激素受体激动剂。
T0107	Halcinonide Halcimat,Halciderm,哈西奈德,Halcinonida,氯氟舒松,SQ-18566	Glucocorticoid Receptor; Smo	Endocrinology/Hormones; Stem Cells
	Halcinonide (Halciderm) 是一种糖皮质激素，可用于局部皮肤感染的研究。
T21193	Isoflupredone Acetate	Others	Others
	Isoflupredone Acetate 是一种具有局部抗炎活性的皮质类固醇。
T0181	Loteprednol etabonate Lotemax,Alrex,氯替泼诺	Glucocorticoid Receptor; Antibacterial; Antibiotic	Endocrinology/Hormones; Microbiology/Virology
	Loteprednol etabonate (Lotemax) 是具有抗炎活性的皮质类固醇，用于眼科。
T1171L	Methylprednisolone Aceponate MPA,SH 440,SH-440,SH440,Advantan,醋丙甲泼尼龙	Others	Others
	Methylprednisolone Aceponate (SH 440) 是一种非卤化皮质类固醇，是一种有效的抗炎剂。
TP2236L	Cortistatin-8 acetate Cortistatin-8 acetate(485803-62-1 Free base)	GHSR	GPCR/G Protein
	Cortistatin-8 acetate 是一种皮质抑素类似物，是一种GHS-R拮抗剂，对生长激素促分泌素受体有抑制作用。Cortistatin-8 acetate 是一种合成皮质抑素衍生的生长素释放肽受体配体，不会改变人类对酰化生长素释放肽或海沙瑞林的内分泌反应。
T6472	Difluprednate Myser,Epitopic,二氟孕甾丁酯,CM 9155	Others	Others
	Difluprednate (Myser) 是一种可用于术后眼睛疼痛和炎症的皮质类固醇。
T4572	Desoximetasone 去羟米松,Desoximetasonum,Topicort,Desoxymethasone,Desoximetasona	Others	Others
	Desoximetasone (Desoximetasona) 是一种可缓解皮疹等多种皮肤疾病的皮质类固醇。
T1666L	Fludrocortisone 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,氟氢可的松,Fludrocortisone acetate,Astonin,9α-Fluorcortisol	Others	Others
	Fludrocortisone (Florinef) 是一种合成皮质类固醇，具有中等的糖皮质激素效力和更大的盐皮质激素效力。Fludrocortisone (Florinef) 可用于治疗低血压的研究。
T0820	Triamcinolone acetonide 曲安奈德,Aristogel,Azmacort,Aristoderm	Glucocorticoid Receptor	Endocrinology/Hormones
	Triamcinolone acetonide (Azmacort) 是皮质类固醇。它是皮质类固醇激素受体激动剂。它是抗炎糖皮质激素，局部用于治疗各种皮肤疾病。它的有效性是 prednisone 的八倍。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T41303	Isoflupredone Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone	Others	Others
	Isoflupredone (Isoflupredonum) 是一种合成的皮质类固醇，通过与动物 (如马) 的糖皮质激素和矿皮质激素受体结合抑制炎症细胞和抑制炎症介质的表达在生物体内发挥作用。Isoflupredone 具有抗炎和免疫抑制作用，可应用于治疗各种肌肉骨骼、过敏性和全身炎症性疾病。
T20763	Betamethasone disodium phosphate Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616	Others	Others
	Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) 是一种具有抗炎活性的皮质类固醇，通过减少促炎细胞因子的分泌促进 M1 至 M2 巨噬细胞极化，可用于研究瘢痕疙瘩和类风湿性关节炎。
T29328	21-deacetyldeflazacort	Others	Others
	21-deacetyldeflazacort 是 Deflazacort 的代谢物，它是一种全身性皮质类固醇和泼尼松龙的衍生物。
T31719	Etiprednol dicloacetate BNP 166,BNP166,BNP-166	Others	Others
	Etiprednol dicloacetate (BNP-166) 是一种具有抗炎活性的皮质类固醇，可有效降低了脂多糖刺激淋巴细胞中的细胞因子产生，并减弱了凝集素诱导的组织培养中血液单核细胞的增殖。。Etiprednol dicloacetate 抑制嗜酸性粒细胞的积累，可用于哮喘等炎症性气管疾病的研究和治疗克罗恩病。
T21443	Prednicarbate Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D	Others	Others
	Prednicarbate (Hoe 777) 是一种外用皮质类固醇。Prednicarbate 可用于炎症性皮肤病的研究，如特应性皮炎。
T4602	Hydrocortisone hemisuccinate Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate	Glucocorticoid Receptor; Others; Interleukin	Endocrinology/Hormones; Immunology/Inflammation; Others
	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) 是糖皮质激素，是口服有活性的甾体抗炎剂。它能够降低IL-6(IC50:6.7 μM)、IL-3(IC50:21.4 μM)的生物活性，可用于研究溃疡性结肠炎。
T61864	Melengestrol acetate	Progesterone Receptor	Others
	Melengestrol acetate 是孕酮的衍生物，充当皮质类固醇激素。 Melengestrol acetate 可以促进月经活动和妊娠维持的子宫内膜增殖延迟。
T0947	Dexamethasone acetate Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471	Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体，有抗炎和免疫抑制活性。它可研究眼部感染。
T3316	Fluorometholone 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluorometholone (Fluoromethalone) 是合成糖皮质激素，具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂，能够用于干眼症的研究。
T1666	Fludrocortisone acetate 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate	Glucocorticoid Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素，可减少尿液中钠丢失量，也用于增加血压，有用于阿狄森氏病的研究潜力。
T27153	Dexamethasone cipecilate NS126,NS-126,NS 126	Others	Others
	Dexamethasone cipecilate is a long-acting intranasal corticosteroid and a highly lipophilic anti-inflammatory corticosteroid.
T34416	RS 85095 RS85095,RS-85095	Others	Others
	RS 85095 is a thiol ester corticosteroid that is topical.
T32838	Locicortolone RU-24476,RU 24476,RU24476	Others	Others
	Locicortolone is a synthetic glucocorticoid corticosteroid which was never marketed.
T21103	Betamethasone acetate Betamethasone 21-acetate	Others	Others
	Betamethasone acetate, the 21-acetate ester of betamethasone, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.
T19358	Hydrocortisone cypionate	Others	Others
	Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid.
T31563	Domoprednate Domoprednatum,Ddomoprednato	Others	Others
	Domoprednate is a synthetic glucocorticoid corticosteroid. The brand name is Stermonid.
T13200	Triamcinolone Benetonide	Others	Others
	Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid exhibiting potent anti-inflammatory properties.
T30375	Benzodrocortisone	Others	Others
	Benzodrocortisone is a corticosteroid.
T23984	Dexamethasone phosphate Neodecadron,EGP437,Hexadrol phosphate,EGP 437,EGP-437	Others	Others
	Dexamethasone phosphate is a synthetic adrenal corticosteroid. It also has potent anti-inflammatory properties.
T34883	Timobesone acetate RS85446-007,RS 85446-007,RS-85446-007	Others	Others
	Timobesone acetate is a topical corticosteroid.
T14209	Amebucort	Others	Others
	Amebucort is a synthetic glucocorticoid corticosteroid. It may used for the research of inflammatory disorders.
T21190	Flumethasone 21-acetate	Others	Others
	Flumethasone 21-acetate is an anti-inflammatory corticosteroid.
T13927	Timobesone	Others	Others
	Timobesone is a topical corticosteroid.
T34410	RS 21314 RS-21314,RS21314	Others	Others
	RS 21314 is a thiol ester corticosteroid that is topical.
T32839	Locicortolone dicibate	Others	Others
	Locicortolone dicibate is a synthetic glucocorticoid corticosteroid which was never marketed.
T24888	Tixocortol pivalate JO1016,Pivalone,JO 1016,JO-1016	Others	Others
	Tixocortol pivalate is a corticosteroid that has anti-inflammatory properties similar to hydrocortisone.
T25426	Flucloronide RS 2252,RS-2252,RS2252,Fluclorolone acetonide	Others	Others
	Flucloronide is a corticosteroid for topical use on the skin. It has anti-inflammatory properties.
T38768	Ocedurenone	Others	Others
	Ocedurenone, a corticosteroid receptor antagonist, is a compound utilized in the investigation of kidney disease (WO2018054357, compound I).
T72391	Clocortolone pivalate	Others	Others
	Clocortolone pivalate是一种合成糖皮质激素和皮质类固醇酯，适用于治疗脂溢性皮炎、接触性皮炎、特应性皮炎及银屑病。

化合物

Cat.No: T2548

Target: Glucocorticoid Receptor

Clobetasone butyrate

Cat.No: T14981

Target: Glucocorticoid Receptor

Cat.No: T12829

Synonym: 沙美特罗,GR33343X

Target: Adrenergic Receptor

Diflucortolone valerate

Cat.No: T5000

Synonym: Afusona,戊酸双氟可龙,Diflucortolone 21-valerate

Target: Others, Antibacterial, Antifungal

Fluticasone furoate

Cat.No: T21404

Synonym: Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate

Target: Glucocorticoid Receptor

Mometasone furoate

Cat.No: T1531

Synonym: 糠酸莫美他松,糠酸莫米松,Sch32088

Target: Glucocorticoid Receptor

Salmeterol Xinafoate

Cat.No: T6653

Synonym: Salmetedur,昔美酸沙美特罗,沙美特罗昔萘酸酯,GR 33343X xinafoate,Arial

Target: HIV Protease, Adrenergic Receptor

Fluorometholone Acetate

Cat.No: T6503

Synonym: NSC 47438,Flarex,Eflone,氟米龙醋酸酯,Oxylone acetate

Target: Glucocorticoid Receptor, Carbonic Anhydrase

Clobetasol propionate

Cat.No: T1561

Synonym: Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725

Target: Glucocorticoid Receptor, P450

Fluticasone (propionate)

Cat.No: T0188

Synonym: 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate

Target: Glucocorticoid Receptor, Virus Protease, Estrogen/progestogen Receptor, Phospholipase, Endogenous Metabolite, ADC Cytotoxin

Cat.No: T0261

Synonym: 安西奈德,CL-34699

Target: Glucocorticoid Receptor, Annexin A

Cat.No: T0107

Synonym: Halcimat,Halciderm,哈西奈德,Halcinonida,氯氟舒松,SQ-18566

Target: Glucocorticoid Receptor, Smo

Isoflupredone Acetate

Cat.No: T21193

Target: Others

Loteprednol etabonate

Cat.No: T0181

Synonym: Lotemax,Alrex,氯替泼诺

Target: Glucocorticoid Receptor, Antibacterial, Antibiotic

Methylprednisolone Aceponate

Cat.No: T1171L

Synonym: MPA,SH 440,SH-440,SH440,Advantan,醋丙甲泼尼龙

Target: Others

Cortistatin-8 acetate

Cat.No: TP2236L

Synonym: Cortistatin-8 acetate(485803-62-1 Free base)

Target: GHSR

Cat.No: T6472

Synonym: Myser,Epitopic,二氟孕甾丁酯,CM 9155

Target: Others

Cat.No: T4572

Synonym: 去羟米松,Desoximetasonum,Topicort,Desoxymethasone,Desoximetasona

Target: Others

Fludrocortisone

Cat.No: T1666L

Synonym: 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,氟氢可的松,Fludrocortisone acetate,Astonin,9α-Fluorcortisol

Target: Others

Triamcinolone acetonide

Cat.No: T0820

Synonym: 曲安奈德,Aristogel,Azmacort,Aristoderm

Target: Glucocorticoid Receptor

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Cat.No: T41303

Synonym: Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone

Target: Others

Betamethasone disodium phosphate

Cat.No: T20763

Synonym: Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616

Target: Others

21-deacetyldeflazacort

Cat.No: T29328

Target: Others

Etiprednol dicloacetate

Cat.No: T31719

Synonym: BNP 166,BNP166,BNP-166

Target: Others

Cat.No: T21443

Synonym: Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D

Target: Others

Hydrocortisone hemisuccinate

Cat.No: T4602

Synonym: Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate

Target: Glucocorticoid Receptor, Others, Interleukin

Melengestrol acetate

Cat.No: T61864

Target: Progesterone Receptor

Dexamethasone acetate

Cat.No: T0947

Synonym: Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy, ADC Cytotoxin

Fluorometholone

Cat.No: T3316

Synonym: 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson

Target: Glucocorticoid Receptor

Fludrocortisone acetate

Cat.No: T1666

Synonym: 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate

Target: Glucocorticoid Receptor, Autophagy

Dexamethasone cipecilate

Cat.No: T27153

Synonym: NS126,NS-126,NS 126

Target: Others

Cat.No: T34416

Synonym: RS85095,RS-85095

Target: Others

Cat.No: T32838

Synonym: RU-24476,RU 24476,RU24476

Target: Others

Betamethasone acetate

Cat.No: T21103

Synonym: Betamethasone 21-acetate

Target: Others

Hydrocortisone cypionate

Cat.No: T19358

Target: Others

Cat.No: T31563

Synonym: Domoprednatum,Ddomoprednato

Target: Others

Triamcinolone Benetonide

Cat.No: T13200

Target: Others

Benzodrocortisone

Cat.No: T30375

Target: Others

Dexamethasone phosphate

Cat.No: T23984

Synonym: Neodecadron,EGP437,Hexadrol phosphate,EGP 437,EGP-437

Target: Others

Timobesone acetate

Cat.No: T34883

Synonym: RS85446-007,RS 85446-007,RS-85446-007

Target: Others

Cat.No: T14209

Target: Others

Flumethasone 21-acetate

Cat.No: T21190

Target: Others

Cat.No: T13927

Target: Others

Cat.No: T34410

Synonym: RS-21314,RS21314

Target: Others

Locicortolone dicibate

Cat.No: T32839

Target: Others

Tixocortol pivalate

Cat.No: T24888

Synonym: JO1016,Pivalone,JO 1016,JO-1016

Target: Others

Cat.No: T25426

Synonym: RS 2252,RS-2252,RS2252,Fluclorolone acetonide

Target: Others

Cat.No: T38768

Target: Others

Clocortolone pivalate

Cat.No: T72391

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1560	Prednisolone 氢化泼尼松,Predonine,Hydroretrocortine,泼尼松龙,Metacortandralone	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Prednisolone (Hydroretrocortine) 是有口服活性的皮质类固醇和糖皮质激素。它的抗炎特性约为氢化可的松的四倍，同时减少了水和盐的保留。它能够用于眼部抗炎研究。
T0269	Dichlorisone Acetate 糊状叶绿素,Diloderm,醋酸二氯松	Endogenous Metabolite; AChE	Metabolism; Neuroscience
	Dichlorisone Acetate (Diloderm) 一种是合成的糖皮质激素皮质类固醇，具有抗炎特性。
T2884	Cortisone Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone,可的松	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone (17-Hydroxy-11-dehydrocorticosterone) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。Cortisone 具有消炎和免疫抑制的作用。Cortisone 在高浓度下对 Glucocorticoid 与Glucocorticoid-receptor 的结合具有部分干预作用。
T1243	Hydrocortisone acetate Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松	Glucocorticoid Receptor; Annexin A; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism
	Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇，能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。
T19614	18-Hydroxycorticosterone	Others	Others
	18-Hydroxycorticosterone is a corticosteroid and corticosterone derivative, which can lead to serious electrolyte imbalances.
T36915	21-Deoxycortisol	Others	Others
	21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive...

天然产物

Cat.No: T1560

Synonym: 氢化泼尼松,Predonine,Hydroretrocortine,泼尼松龙,Metacortandralone

Target: Glucocorticoid Receptor, Endogenous Metabolite

Dichlorisone Acetate

Cat.No: T0269

Synonym: 糊状叶绿素,Diloderm,醋酸二氯松

Target: Endogenous Metabolite, AChE

Cat.No: T2884

Synonym: Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone,可的松

Target: Glucocorticoid Receptor, Endogenous Metabolite

Hydrocortisone acetate

Cat.No: T1243

Synonym: Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松

Target: Glucocorticoid Receptor, Annexin A, Endogenous Metabolite

18-Hydroxycorticosterone

Cat.No: T19614

Target: Others

21-Deoxycortisol

Cat.No: T36915

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00843	HSD11B1 Protein, Human, Recombinant (His & SUMO) 7-oxosteroid reductase,11-beta-hydroxysteroid dehydrogenase ...	Human	E. coli
	Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol. HSD11B1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P28845.
TMPH-00844	HSD11B2 Protein, Human, Recombinant (His) HSD11B2,11-beta-hydroxysteroid dehydrogenase type 2,Short ch...	Human	P. pastoris (Yeast)
	Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. HSD11B2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession number is P80365.

重组蛋白

HSD11B1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00843

Species: Human

Expression System: E. coli

HSD11B2 Protein, Human, Recombinant (His)

Cat.No: TMPH-00844

Species: Human

Expression System: P. pastoris (Yeast)

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0130	CORTISONE(2,2,4,6,6,9,12,12-d8)
	CORTISONE(2,2,4,6,6,9,12,12-d8) 是 CORTISONE 的氘代化合物。CORTISONE 的 CAS 号为 53-06-5。Cortisone 是 Cortisol（一种糖皮质激素）的氧化代谢产物。Cortisone 具有消炎和免疫抑制的作用。Cortisone 在高浓度下对 Glucocorticoid 与Glucocorticoid-receptor的结合具有部分干预作用。
TMID-0110	18-Hydroxycorticosterone-d4
	18-Hydroxycorticosterone-d4 是 18-Hydroxycorticosterone 的氘代化合物。18-Hydroxycorticosterone 的 CAS 号为 561-65-9。
TMID-0248	Triamcinolone acetonide-d6
	Triamcinolone acetonide-d6 是 Triamcinolone acetonide 的氘代化合物。Triamcinolone acetonide 的 CAS 号为 76-25-5。Triamcinolone acetonide 是皮质类固醇。它是皮质类固醇激素受体激动剂。它是抗炎糖皮质激素，局部用于治疗各种皮肤疾病。它的有效性是 prednisone 的八倍。
TMID-0112	21-Deoxycortisol-d8
	21-Deoxycortisol-d8 是 21-Deoxycortisol 的氘代化合物。21-Deoxycortisol 的 CAS 号为 641-77-0。
TMID-0135	Melengestrol acetate-d3
	Melengestrol acetate-d3 是 Melengestrol acetate 的氘代化合物。Melengestrol acetate 的 CAS 号为 2919-66-6。Melengestrol acetate 是孕酮的衍生物，充当皮质类固醇激素。 Melengestrol acetate 可以促进月经活动和妊娠维持的子宫内膜增殖延迟。
T71893	Clobetasol Propionate-d5
	Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the t...
TMIJ-0505	Fluticasone Furoate-d3
	Fluticasone Furoate-d3 是 Fluticasone Furoate 的氘代化合物。Fluticasone Furoate 的 CAS 号为 397864-44-7。Fluticasone furoate 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。
TMID-0006	Budesonide-d8 mixture of diastereomers-d8
	Budesonide-d8 是 Budesonide 的氘代化合物。Budesonide 的 CAS 号为 51333-22-3。Budesonide 是吸入型糖皮质类固醇，是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积，逆转 DNA 低度甲基化，调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。

同位素标记化合物

CORTISONE(2,2,4,6,6,9,12,12-d8)

Cat.No: TMID-0130

18-Hydroxycorticosterone-d4

Cat.No: TMID-0110

Triamcinolone acetonide-d6

Cat.No: TMID-0248

21-Deoxycortisol-d8

Cat.No: TMID-0112

Melengestrol acetate-d3

Cat.No: TMID-0135

Clobetasol Propionate-d5

Cat.No: T71893

Fluticasone Furoate-d3

Cat.No: TMIJ-0505

Cat.No: TMID-0006

Synonym: mixture of diastereomers-d8

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