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Search Results for " co-factor "

Targets Recommended: EGFR

14

抑制剂 & 化合物

2

天然产物

1

化合物库

18

重组蛋白

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Cat. No.	Product Name
L4100	TGF-β/Smad靶点化合物库		184 compounds
	184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

TGF-β/Smad靶点化合物库

Cat.No: L4100

Compounds: 184

Cat. No.	Product Name	Target	Signaling Pathways
T2369	Rociletinib AVL-301,CNX-419,CO-1686	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Rociletinib (CNX-419) 是一种可口服的EGFR 抑制剂，能够抑制 EGFRL858R/T790M 和 EGFRWT 的活性，IC50值分别为 21.5 nM 和 303.3 nM。
T16486	Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD PF-05231023	FGFR; PROTAC Linker	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 的合成分子。
T27307	Fasnall	Fatty Acid Synthase	Metabolism
	Fasnall 是一种选择性 FASN 抑制剂，通过其辅因子结合位点起作用。 Fasnall 在 HER2(+) 乳腺癌的 MMTV-Neu 模型中显示出有效的抗肿瘤活性，尤其是与卡铂联合使用时。
T27307L	Fasnall HCl Fasnall HCl（929978-58-5 Free base）	Fatty Acid Synthase	Metabolism
	Fasnall HCl 是一种FASN 选择性抑制剂，通过其辅助因子结合位点起作用。Fasnall HCl 在HER2(+)乳腺癌MMTV-Neu 模型中也显示出强大的抗肿瘤活性，特别是与卡铂联合使用时。
T82866	Biotin-PEG-Biotin (MW 20000)
	Biotin-PEG-azide (MW 2000) 为含有生物素标记的聚乙二醇 (PEG) 衍生物。该生物素（Biotin）作为酶辅因子，在蛋白质标记应用中具有重要作用，而PEG是低毒性且具亲水性的水溶性聚合物。
T79741	CARM1 degrader-1	Histone Methyltransferase	Chromatin/Epigenetic
	CARM1 degrader-1 (compound 3b) 是一种针对co-activator associated argininemethyltransferase (CARM1) 的降解剂，其DC50为8.1 nM。它通过VHL和蛋白酶体依赖的途径降解CARM1，从而抑制了CARM1底物（例如PABP1和BAF155）的甲基化，进而抑制乳腺癌细胞的迁移。
T35538	HPI-1 (hydrate) HPI-1 hydrate	Others	Others
	HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, prev...
T79742	CARM1 degrader-2	Histone Methyltransferase	Chromatin/Epigenetic
	CARM1 degrader-2 (compound 3e) 是一种效能高的CARM1降解剂，其DC50为8.8 nM。该化合物通过VHL途径及蛋白酶体作用实现CARM1的降解，进而抑制其底物PABP1和BAF155的甲基化作用，能够有效抑制乳腺癌细胞迁移。
T74566	Phospholipid-PEG-Biotin (MW 5000)	Others	Others
	Phospholipid-PEG-Biotin (MW 5000)为含有磷脂的PEG衍生物，适用于脂质体和细胞表面的修饰，及胰岛细胞移植。Phospholipid具亲水性“头部”与疏水性“尾部”结构，PEG为亲水性低毒聚合物，生物素则作为酶辅因子，用于蛋白质标记。
T74564	Phospholipid-PEG-Biotin (MW 2000)	Others	Others
	Phospholipid-PEG-Biotin (MW 2000) 是一种PROTAClinker，属于 PEG 类。可用于合成PROTAC 分子。Phospholipid 是一类含有亲水“头”和疏水“尾”的脂类；PEG 是一种低毒性的亲水水溶性聚合物；生物素是一种酶辅因子，可用于标记蛋白质。
T82874	Biotin-PEG-Alk (MW 1000)
	Biotin-PEG-Alk (MW 1000) 是藉由PEG基材结合而成的生物素化合物，具有极佳的水溶性与低毒性特性。该分子中的Biotin为一种酶辅因子，常用于蛋白质标记。Alkyne部分允许通过点击化学 (click chemistry) 中的铜催化叠氮-炔环加成反应 (CuAAc) 与Azide修饰的生物分子发生特异性耦联，进而增强生物素的靶向结合能力。
T82873	Biotin-PEG-Alk (MW 10000)
	Biotin-PEG-Alk (MW 10000)为生物素标记的PEG衍生物，是一种点击化学试剂。其中，生物素作为酶辅因子，应用于蛋白质标记；PEG为低毒性的亲水聚合物；而Alk作为无环脂肪烃，具有提高生物素与靶点结合效率的功能。Biotin-PEG-Alk的Alkyne基团可通过CuAAc与含Azide基团的分子发生反应。
T82867	Biotin-PEG-azide (MW 3400)
	Biotin-PEG-azide (MW 3400) 是带有高特异性生物素标记的 PEG 链端修饰化合物。该分子中包含的生物素成分适用于针对性蛋白质标记，而 PEG 作为低毒且亲水的聚合物，增加了分子的水溶性及生物相容性。末端叠氮基团，则能在铜催化的“点击化学”反应中快速与炔烃结合，有效提升生物素与目标分子的结合效率。
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively)....

化合物

Cat.No: T2369

Synonym: AVL-301,CNX-419,CO-1686

Target: EGFR

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD

Cat.No: T16486

Synonym: PF-05231023

Target: FGFR, PROTAC Linker

Cat.No: T27307

Target: Fatty Acid Synthase

Cat.No: T27307L

Synonym: Fasnall HCl（929978-58-5 Free base）

Target: Fatty Acid Synthase

Biotin-PEG-Biotin (MW 20000)

Cat.No: T82866

CARM1 degrader-1

Cat.No: T79741

Target: Histone Methyltransferase

HPI-1 (hydrate)

Cat.No: T35538

Synonym: HPI-1 hydrate

Target: Others

CARM1 degrader-2

Cat.No: T79742

Target: Histone Methyltransferase

Phospholipid-PEG-Biotin (MW 5000)

Cat.No: T74566

Target: Others

Phospholipid-PEG-Biotin (MW 2000)

Cat.No: T74564

Target: Others

Biotin-PEG-Alk (MW 1000)

Cat.No: T82874

Biotin-PEG-Alk (MW 10000)

Cat.No: T82873

Biotin-PEG-azide (MW 3400)

Cat.No: T82867

Urocortin III (human) (trifluoroacetate salt)

Cat.No: T35814

Cat. No.	Product Name	Target	Signaling Pathways
T5692	Pyrroloquinoline quinone	Others; Endogenous Metabolite	Metabolism; Others
	Pyrroloquinoline quinone 是氧化还原辅助因子，一种阴离子型氧化还原循环原醌。它是哺乳动物的必需营养素，对免疫功能很重要。它是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。
T5693	Pyrroloquinoline quinone disodium salt 吡咯喹啉醌二钠盐,Methoxatin disodium salt	Others; Endogenous Metabolite	Metabolism; Others
	Pyrroloquinoline quinone disodium salt (Methoxatin disodium salt) 一种阴离子型氧化还原循环原醌，作为氧化还原辅助因子。它是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。它是哺乳动物的必需营养素，对免疫功能很重要。

天然产物

Pyrroloquinoline quinone

Cat.No: T5692

Target: Others, Endogenous Metabolite

Pyrroloquinoline quinone disodium salt

Cat.No: T5693

Synonym: 吡咯喹啉醌二钠盐,Methoxatin disodium salt

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01285	EEF1D Protein, Human, Recombinant (His) Elongation factor 1-delta,EF1D,EF-1-delta,EEF1D,Ant...	Human	E. coli
	EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
TMPK-00532	CD46 Protein, Cynomolgus, Recombinant (His) CD46,MCP,TLX,MIC10,AHUS2,TRA2.10	Cynomolgus	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cel...
TMPK-00570	CD46 Protein, Canine, Recombinant (His) CD46,AHUS2,TRA2.10,LOC609365,TLX,MCP,MIC10,Membrane co	Canine	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells w...
TMPK-00169	OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated IMD16,ACT-135,OX40 homologue,Ly-70, TXGP1L,TNFRSF4,OX40,OX40...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular wei...
TMPK-00464	OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated CD134,TXGP1L,ACT-135,Ly-70,OX40,Txgp1,OX40L receptor,TNFRSF4	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.2 kDa...
TMPK-00167	OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi) OX40 homologue,Ly-70,OX40, TXGP1L,OX40L receptor,IMD16,CD134...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.2 kDa and the acces...
TMPK-00463	OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi) CD134,OX40 homologue,OX40,IMD16,OX40L receptor, TXGP1L,TNFRS...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.2 kDa and the acces...
TMPK-00109	Artemin Protein, Human, Recombinant (hFc) ARTNE,ARTN,Neublastin,Enovin,Artemin,NBN,EVN	Human	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons.
TMPK-00168	OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated IMD16,TNFRSF4,CD134,ACT-135, TXGP1L,OX40 homologue,OX40,OX40...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight ...
TMPJ-01441	OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (His) OX-40L,TNFSF4,Tumor necrosis factor ligand 2B	Cynomolgus	HEK293 Cells
	Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interact...
TMPJ-00064	OX40L/TNFSF4 Protein, Human, Recombinant (His) TNFSF4,Glycoprotein Gp34,TAX transcriptionally-acti...	Human	HEK293 Cells
	Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proli...
TMPK-00073	TDGF1/Cripto Protein, Human, Recombinant (His) TDGF1,Cripto,CR,CRGF	Human	HEK293 Cells
	TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involve...
TMPJ-00168	HVEM Protein, Mouse, Recombinant (hFc) Tnfrsf14,Herpesvirus entry mediator,ATAR,Tumor necrosis ...	Mouse	HEK293 Cells
	Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ...
TMPY-04468	STK16 Protein, Human, Recombinant (His & NusA) MPSK,serine/threonine kinase 16,TSF1,KRCT,PKL12	Human	E. coli
	Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is ubiquitously expressed at very low levels. STK16 / MPSK1 belongs to the protein kinase superfamily and Ser/Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or c...
TMPY-02765	GM2A Protein, Human, Recombinant (His) GM2 ganglioside activator,SAP-3,GM2-AP	Human	Baculovirus Insect Cells
	GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexo...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc) artemin,neublastin	Mouse	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. It a...
TMPY-04380	DYRK3 Protein, Human, Recombinant (His & GST) REDK,RED,DYRK5,dual-specificity tyrosine-(Y)-phosphorylation...	Human	Baculovirus Insect Cells
	Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hemat...
TMPH-02841	Prohibitin Protein, Mouse, Recombinant (His) Phb1,B-cell receptor-associated protein 32,Prohibitin 1	Mouse	E. coli
	Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.; In the mitochondria, together with...

重组蛋白

EEF1D Protein, Human, Recombinant (His)

Cat.No: TMPH-01285

Species: Human

Expression System: E. coli

CD46 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00532

Species: Cynomolgus

Expression System: HEK293 Cells

CD46 Protein, Canine, Recombinant (His)

Cat.No: TMPK-00570

Species: Canine

Expression System: HEK293 Cells

OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00169

Species: Human

Expression System: HEK293 Cells

OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00464

Species: Mouse

Expression System: HEK293 Cells

OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00167

Species: Human

Expression System: HEK293 Cells

OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-00463

Species: Mouse

Expression System: HEK293 Cells

Artemin Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00109

Species: Human

Expression System: HEK293 Cells

OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated

Cat.No: TMPK-00168

Species: Human

Expression System: HEK293 Cells

OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01441

Species: Cynomolgus

Expression System: HEK293 Cells

OX40L/TNFSF4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00064

Species: Human

Expression System: HEK293 Cells

TDGF1/Cripto Protein, Human, Recombinant (His)

Cat.No: TMPK-00073

Species: Human

Expression System: HEK293 Cells

HVEM Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00168

Species: Mouse

Expression System: HEK293 Cells

STK16 Protein, Human, Recombinant (His & NusA)

Cat.No: TMPY-04468

Species: Human

Expression System: E. coli

GM2A Protein, Human, Recombinant (His)

Cat.No: TMPY-02765

Species: Human

Expression System: Baculovirus Insect Cells

Artemin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01576

Species: Mouse

Expression System: HEK293 Cells

DYRK3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04380

Species: Human

Expression System: Baculovirus Insect Cells

Prohibitin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02841

Species: Mouse

Expression System: E. coli

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