40
10
5
26
1
Cat. No. | Product Name | ||
---|---|---|---|
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; | |||
L5400 | 抗心血管疾病化合物库 | 1408 compounds | |
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L4800 | 血管生成库 | 1353 compounds | |
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选; | |||
L6710 | 中药抗炎分子库 | 1246 compounds | |
1246 种具有抗炎活性或靶向炎症相关靶点的中药单体集合,是药物开发、药理研究的有效工具; | |||
L4700 | 免疫/炎症分子化合物库 | 4720 compounds | |
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22459 |
Xanthinol Nicotinate
Angioamin,烟酸占替诺,Complamin |
Others | Others |
Xanthinol Nicotinate (Complamin) 是血管扩张剂,可直接作用于小动脉和毛细血管的平滑肌,能够扩大血管,改善血液流变学并降低外周血管阻力。 | |||
T0042 |
Xylometazoline hydrochloride
盐酸赛洛唑啉,Xylometazoline HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Xylometazoline hydrochloride (Xylometazoline HCl) 是一种 α- 肾上腺素受体激动剂,是一种鼻血管收缩药。 | |||
T1615 |
Irbesartan
厄贝沙坦,SR-47436,BMS-186295 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂,IC50为1.3 nM。 | |||
T1275 |
Phentolamine mesylate
Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的,具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂,能够扩张使血管,降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压,心力衰竭和勃起功能障碍。 | |||
T21231 |
Almotriptan
阿莫曲坦,LAS 31416,阿莫曲普坦 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Almotriptan (LAS 31416) 是一种用于研究偏头痛的5-HT1B/1D 受体激动剂。 | |||
T6863 |
Isosorbide Mononitrate
单硝酸异山梨酯,Isosorbide-5-mononitrate,5-单硝酸异山梨酯,Imdur,Mononit,Corangin,Monoket,Elantan |
Others; Autophagy | Autophagy; Others |
Isosorbide Mononitrate (Corangin) 是一种硝酸盐血管扩张剂,扩张血管从而降低血压,可用于心绞痛。 | |||
T0504 |
Cyclandelate
安脉生,BS 572,环扁桃酯,3,5,5-Trimethylcyclohexyl mandelate |
Acyltransferase | Metabolism |
Cyclandelate (BS 572) 是直接作用的平滑肌松弛剂,用于扩张血管。 | |||
T5161 |
Gadodiamide
|
Others | Others |
Gadodiamide 是一种含钆造影剂,可用于医学成像。 | |||
T4509 |
Inositol nicotinate
Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate |
Others | Others |
Inositol nicotinate (Mesotal) 是一种血管扩张剂,可用于研究外周动脉疾病。 | |||
T12478L |
Pinacidil
吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134 |
Potassium Channel | Membrane transporter/Ion channel |
Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化,显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。 | |||
T4287 |
Succinobucol
Probucol monosuccinate,AGI-1067 |
Antioxidant; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Succinobucol (Probucol monosuccinate) 是酚类抗氧化剂,具有抗炎、抗血小板聚集活性。 | |||
T3996 |
Dapiprazole Hydrochloride
盐酸达哌唑,Glamidolo Hydrochloride,Reversil Hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Dapiprazole Hydrochloride (Glamidolo Hydrochloride) 是 α-adrenergic 阻断剂的药物。 | |||
T4506 |
Gadopentetate dimeglumine
Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt |
Others | Others |
Gadopentetate dimeglumine 可用于核磁共振成像 (MRI) 中,使血管、器官和其他非骨组织能够更清晰地被看到。Gadopentetate dimeglumine 可诱导生精细胞萎缩。 | |||
T19512 |
Phalloidin
|
Others | Others |
Phalloidin 是一种在鹅膏菌中发现的双环七肽,参与 F-肌动蛋白染色。 Phalloidin 是一种肌动蛋白不可逆聚合成微丝的化合物。Phalloidin 可干扰细胞的运动和生长,可用于标记脑血管。 | |||
T0397 |
Tetrahydrozoline
四氢唑林,四氢唑啉,Tetryzolin,Tetryzoline |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Tetrahydrozoline (Tetryzoline) 是一种咪唑啉的衍生物,是一种 α-肾上腺素能 (α-adrenergic) 激动剂,能引起血管收缩,广泛用于研究鼻充血、结膜充血。 | |||
T21447 |
Tolazoline
Priscol,妥拉苏林,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Tolazoline (Benzalolin) 是一种竞争性的α-肾上腺素受体拮抗剂。 | |||
TP1277 |
Bradykinin
缓激肽 |
Endogenous Metabolite; Bradykinin Receptor | GPCR/G Protein; Metabolism |
Bradykinin 是由激肽释放酶-激肽系统产生的活性肽。 它是炎症调节因子和神经调节因子,对几种血管和肾功能也有调节作用。 | |||
T12315 |
OR-1896
|
PDE | Metabolism |
OR-1896 是 Levosimendan 的活性代谢产物,是一种高特异性磷酸二酯酶 (PDE III) 抑制剂,是一种血管扩张剂,具有部分抗炎特性,通过激活 ATP 敏感 (KATP) 和其他钾通道在不同类型的血管中产生血管舒张。OR-1896 可用于研究心力衰竭与血管功能障碍。 | |||
T37436 |
C12-Ceramide
N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine |
||
C12-Ceramide (C12 Ceramide (d18:1/12:0)) 是一种存在于先兆子痫妇女所生婴儿围绕脐带血管的保护膜的神经酰胺,是 C12 鞘磷脂被酸性鞘磷脂酶(ASM)水解后形成的,可用于评估 A 型或 B 型尼曼-皮克病患者血浆中的 ASM 活性水平。 | |||
T0075 |
Nicorandil
SG-75,尼可地尔 |
Potassium Channel | Membrane transporter/Ion channel |
Nicorandil (SG-75) 是一种有效的钾通道激活剂,靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯,具有血管舒张和心脏保护作用,并具有治疗心绞痛和缺血性心脏病的潜力。 | |||
T6602 |
Naratriptan hydrochloride
Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂,有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用,从而减少促炎神经肽的释放。 | |||
T1056 |
Isoprenaline hydrochloride
NCI-c55630,Isoproterenol hydrochloride,Isoprenaline HCl,盐酸异丙肾上腺素 |
PI3K; Endogenous Metabolite; Adrenergic Receptor; PDE | GPCR/G Protein; Metabolism; Neuroscience; PI3K/Akt/mTOR signaling |
Isoprenaline hydrochloride (Isoproterenol hydrochloride) 是一种 β-肾上腺素能受体激动剂,具有非选择性和口服活性。Isoprenaline hydrochloride 可以扩张支气管,提高心率和心输出量,而不会收缩血管。 | |||
T19478 |
Nicotinoyl cyclandelate
RV 12128,米西烟酯 |
Others | Others |
Nicotinoyl cyclandelate can effectively reduce blood pressure in the femoral artery and perfusion pressure in cerebral blood vessels. | |||
T25173 |
Bradykinin potentiator-5
BPP-5a\,BPP 5a\,BPP5a\ |
Others | Others |
Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall. | |||
T31857 |
Fosbretabulin [free base]
Fosbretabulin,Combretastatin A-4,CA4DP |
Others | Others |
Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels. | |||
T25670 |
Lercanidipine. (R)-
(-)-Lercanidipine,(R)-Lercanidipine |
Others | Others |
Lercanidipine. (R)- is an enantiomer of antihypertensive drugs Lercanidipine. Lercanidipine acts by blocking L-type calcium channels, allowing relaxation and opening of blood vessels. | |||
T68478 |
Arnolol
|
Others | Others |
Arnolol is a beta blocker. Beta blockers block the hormone epinephrine, also known as adrenaline. This causes the heart to beat more slowly and with less force, thereby reducing blood pressure. Beta blockers also help blood vessels open up to improve blood flow. | |||
T69813 |
AZD-6126
|
Others | Others |
AZD6126, also known as ANG-453, a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. AZD-6126 is an angiogenesis inhibitor and tubulin inhibitor potentially for the treatment of solid tumours. AZD6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cel apoptosis, the selective occlusio... | |||
T61729 |
Terazosin
|
Others | Others |
Terazosin, a quinazoline derivative, is an orally active and competitive antagonist of α1-adrenoceptors. Its mechanism of action involves relaxing blood vessels and promoting bladder opening. Terazosin exhibits therapeutic potential for treating benign prostatic hyperplasia (BPH) and high blood pressure [1][2][3]. | |||
T71583 |
Amlodipine hydrochloride, (R)-
|
Others | Others |
Amlodipine hydrochloride, (R)-, is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina. | |||
T68367 |
Amlodipine orotate
|
Others | Others |
Amlodipine orotate is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina. | |||
T3443 |
Argiprestocin
精氨缩宫素,Arginine vasotocin |
Others | Others |
Argiprestocin (Arginine vasotocin) 也称为抗利尿激素,在维持渗透压中起关键作用。它是在大多数哺乳动物中发现的一种神经垂体激素。用于引起血管收缩的药物。 | |||
T31396 |
Dexbrompheniramine maleate
D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral |
Others | Others |
Dexbrompheniramine is an antihistamine with anticholinergic properties. It is used to treat allergic diseases such as hay fever or urticaria. It can compete with histamine for H1 receptor sites on effector cells of the gastrointestinal tract, blood vessel | |||
T1120L2 |
Dacarbazine citrate
DTIC citrate |
Others | Others |
Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Soft tissue sarcoma (cancer of muscles | |||
T60263 |
Povafonidine
|
Others | Others |
Povafonidine (PGE-6201204) 是一种有效的 α-2 肾上腺素受体激动剂。Povafonidine 可以收缩血管,减轻粘膜充血,可用于鼻塞研究。 | |||
T69452 |
AG-13958 monohydrochloride
|
Others | Others |
AG-13958 monohydrochloride is the HCl salt of AG-13958 --- a VEGFA inhibitor potentially for the treatment of age-related macular degeneration. Neovascular AMD, a subtype characterized by the growth of new, pathologic blood vessels, results in most of the cases of severe and rapid vision loss associated with AMD. A critical activator of angiogenesis in neovascular AMD is VEGF. | |||
T9922 |
Matuzumab
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Matuzumab 是一种用于癌症治疗的人源化单克隆抗体。它对 EGFR 具有高亲和力,通常与恶性肿瘤中血管的生长有关,从而促进肿瘤的生长和存活。 | |||
T76550 |
CooP
|
||
CooP为一种针对线性胶质母细胞瘤的九肽,与胶质母细胞瘤细胞及其相关血管系统中的乳腺来源生长抑制剂/脂肪酸结合蛋白3 (FABP3) 发生结合。该化合物主要应用于化学疗法和多种纳米粒子的靶向递送。 | |||
T83681 |
IRBP (1-20) (human, rat) TFA
IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20) |
||
IRBP1-20(1-20)是IRBP的一个十二肽片段,亦称视黄醇结合蛋白3,负责运输视锥细胞中的视黄醇和视黄醛至视网膜色素上皮,参与色素再生。在携带H-2b等位基因型的C57BL/6小鼠中,IRBP1-20用于诱导自身免疫性葡萄膜视网膜炎。IRBP1-20(3 µM)能增加初级小鼠脾淋巴细胞分泌IL-4、IL-5和IL-6的水平。用IRBP1-20免疫并再次挑战,可增加IFN-γ缺乏小鼠的耳部肿胀、眼部血管炎症、免疫细胞浸润和视锥细胞层损伤,以及视网膜脱落。 | |||
T67442 |
CGP-53716
|
Others | Others |
The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation[1]. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smoo... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13509 |
4-Vinylphenol
|
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
4-Vinylphenol 是酒中乳酸菌对香豆酸和阿魏酸的代谢产物,在白花蛇舌草中发现。 4-Vinylphenol 在体内诱导细胞凋亡。 | |||
T2230 |
Paeoniflorin
芍药苷,Peoniflorin |
HSP; COX | Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience |
Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷,具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂,通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。 | |||
T6535 |
Histamine Phosphate
组胺磷酸盐,Histamine diphosphate,二磷酸组胺,Histamine acid phosphate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Histamine Phosphate (Histamine acid phosphate) 是组胺受体的强激活剂和血管扩张神经剂,可激活一氧化氮合成酶。 | |||
T6S0657 |
Isorhynchophylline
IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline |
Others | Others |
Isorhynchophylline (7-Isorhyncophylline) 是一种分离自钩藤中的生物碱类化合物,具有舒张血管、降血压、保护神经免于局部缺血造成损伤的作用。 | |||
T5074 |
Cholesteryl palmitate
|
Others; Endogenous Metabolite | Metabolism; Others |
Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。 | |||
T3752 |
4-Hydroxybenzyl alcohol
4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物,具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长,有神经保护作用。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
TN7327 |
3'-Hydroxy-2,4,5-trimethoxydalbergiquinol
|
Others | Others |
R-3'-Hydroxy-2,4,5-trimethoxydalbergiquinol exhibited activity that relaxes blood vessels in a concentration-dependent manner. | |||
T80867 |
Villocarine A
|
||
Villocarine A为一种天然源自的吲哚生物碱类化合物,具有血管松弛作用。 | |||
T2S0118 |
Daurinoline
|
Calcium Channel; 5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00261 |
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth inhibitor,G... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... | |||
TMPJ-01204 |
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1... |
Human | HEK293 Cells |
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... | |||
TMPJ-00865 |
VEGF121 Protein, Human, Recombinant (His)
VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu... |
Human | HEK293 Cells |
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel... | |||
TMPJ-01398 |
ITM2B Protein, Human, Recombinant (His)
Transmembrane Protein BRI,Protein E25B,BRI2,imBRI2,Immature ... |
Human | HEK293 Cells |
Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervou... | |||
TMPK-00695 |
N Cadherin Protein, Human, Recombinant (hFc)
CDHN,Neural cadherin,CDH2,N-cadherin,CDw325,CD325,NCAD |
Human | HEK293 Cells |
Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and hematopoietic microenvironment. | |||
TMPK-01153 |
PLVAP Protein, Human, Recombinant (His)
PV1,FELS |
Human | HEK293 Cells |
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases... | |||
TMPY-01217 |
ANGPTL5 Protein, Human, Recombinant (GST)
angiopoietin like 5,ANGPTL5 |
Human | Baculovirus Insect Cells |
The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. In addition, there are a number of proteins that are closely related to angiopoietins (ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL6, ANGPTL7). Angiopoietin-like 5 (ANGPTL5) is mainly expressed in adult heart. Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-te... | |||
TMPH-00780 |
CACNA1C Protein, Guinea Pig, Recombinant (His)
CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu... |
Guinea pig | E. coli |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur... | |||
TMPK-00978 |
ECSCR Protein, Human, Recombinant (hFc)
ECSM2,ECSCR,ARIA |
Human | HEK293 Cells |
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... | |||
TMPY-01345 |
ACBD6 Protein, Human, Recombinant (His)
acyl-CoA binding domain containing 6 |
Human | Baculovirus Insect Cells |
Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequenc... | |||
TMPK-00988 |
ECSCR Protein, Mouse, Recombinant (hFc)
ECSCR,ARIA,ECSM2 |
Mouse | HEK293 Cells |
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... | |||
TMPK-01048 |
Aggrecan Protein, Human, Recombinant (His)
CSPG1,MSK16,AGC1,ACAN |
Human | HEK293 Cells |
Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vess... | |||
TMPK-00872 |
ICAM-1/CD54 Protein, Canine, Recombinant (His)
ICAM-1,CD54,BB2 |
Canine | HEK293 Cells |
Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. ICAM-1/CD... | |||
TMPK-00497 |
ICAM-1/CD54 Protein, Cynomolgus, Recombinant (His)
ICAM-1,CD54,BB2 |
Cynomolgus | HEK293 Cells |
Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. ICAM-1/CD... | |||
TMPJ-01088 |
PCDH1 Protein, Human, Recombinant (His)
PC42,PCDH1,Protocadherin-1,Cadherin-Like Protein 1,Protocadh... |
Human | HEK293 Cells |
Protocadherin-1, also known as Cadherin-like protein 1, Protocadherin-42 and PCDH1, belongs to the protocadherin subfamily within the cadherin superfamily. PCDH1 contains seven cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. PCDH1 can be detected as early as embryonic day 9.5. In early embryogenesis, expression is especially prominent in blood vessels. The tight spatial and temporal regulation of Pcdh1 expression suggests that this protocadherin plays multiple ... | |||
TMPJ-00921 |
COL8A1 Protein, Human, Recombinant (His)
Vastatin,Endothelial Collagen,Collagen Alpha-1(VIII) Chain,C... |
Human | HEK293 Cells |
Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium o... | |||
TMPJ-00771 |
TGF beta 1 Protein, Mouse/Rat, Recombinant
TGFB,TGFbeta,CEDLAP,TGF-beta-1,TGF-beta 1 protein,latency-as... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)... | |||
TMPH-01213 |
DNASE1L3 Protein, Human, Recombinant (His)
DNase I homolog protein DHP2,DNAS1L3,DNase I-like 3,Deoxyrib... |
Human | Baculovirus Insect Cells |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... | |||
TMPJ-00012 |
CXCL4 Protein, Human, Recombinant (His)
SCYB4,PF4,Iroplact,Platelet Factor 4,PF-4,Oncostatin-A,CXCL4... |
Human | HEK293 Cells |
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokin... | |||
TMPH-01214 |
DNASE1L3 Protein, Human, Recombinant
DHP2,Deoxyribonuclease I-like 3,Deoxyribonuclease gamma,DNas... |
Human | E. coli |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... | |||
TMPH-01212 |
DNASE1L3 Protein, Human, Recombinant (His & Myc)
LSD,Liver and spleen DNase,Deoxyribonuclease I-like 3,DNAS1L... |
Human | E. coli |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... | |||
TMPY-03963 |
CALCB Protein, Human, Recombinant (mFc)
CGRP-II,calcitonin-related polypeptide β,calcitonin-related ... |
Human | HEK293 Cells |
CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ... | |||
TMPJ-01166 |
IGFBP-7 Protein, Mouse, Recombinant (His)
TAF,IGFBP-rP1,Insulin-like growth factor-binding protein 7,T... |
Mouse | HEK293 Cells |
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of bloo... | |||
TMPY-02014 |
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin conversion acceler... |
Human | HEK293 Cells |
Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... | |||
TMPY-02839 |
Adrenomedullin Protein, Human, Recombinant (hFc)
AM,PAMP,adrenomedullin |
Human | HEK293 Cells |
Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report... | |||
TMPY-00741 |
CXCL4 Protein, Human, Recombinant
PF-4,platelet factor 4,SCYB4,CXCL4 |
Human | E. coli |
Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils a... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0183 |
Terazosin-d8
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Terazosin-d8 是 Terazosin 的氘代化合物。Terazosin 的 CAS 号为 63590-64-7。 |