首页工具

登录

搜索结果

Search Results for " aryl "

Targets Recommended: Aryl Hydrocarbon Receptor AhR Aryl Hydrocarbon Receptor

96

抑制剂 & 化合物

27

天然产物

1

化合物库

7

重组蛋白

3

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L7810	高溶解性多官能团片段化合物库		1159 compounds
	高溶解性多官能团片段库包含1159 种片段分子

化合物库

高溶解性多官能团片段化合物库

Cat.No: L7810

Compounds: 1159

Cat. No.	Product Name	Target	Signaling Pathways
T7202	ITE	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	ITE 是一种有效的芳烃受体 (AhR) 内源性激动剂，Ki 值为 3 nM。它具有免疫抑制作用。
T21966	MeBIO	GSK-3; Aryl Hydrocarbon Receptor; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
	MeBIO 是一种芳烃受体激动剂，对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
T1960	YL-109	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	YL-109是一种抗肿瘤剂，可以通过芳烃受体 AhR 信号传导诱导 Hsp70 相互作用蛋白 (CHIP) 表达，具有抑制乳腺癌细胞生长和侵袭性的能力。
T4608	PDM2	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	PDM2 是一种有效的选择性芳烃受体 (AhR) 拮抗剂，Ki 为 1.2±0.4 nM。
T15410	GNF351	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	GNF351 是芳烃受体 (AhR) 的完全拮抗剂，具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争，IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。
T5622	BAY-218 AHR antagonist 1	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	BAY-218 (AHR antagonist 1) 是一种芳基烃受体(AHR)拮抗剂，在人细胞系中的IC50值为 39.9 nM。
T20625	Prochloraz 咪鲜胺,Sporgon,Prelude	Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用，由此抑制麦角固醇的生物合成，从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和雄激素受体的拮抗剂，IC50分别为25 μM 和4 μM，并激活芳烃受体，EC50为1μM。
T10007	1,4-Chrysenequinone Chrysene-1,4-dione,1,4-屈醌	AhR	Immunology/Inflammation; Metabolism
	1,4-Chrysenequinone (Chrysene-1,4-dione) 是多环芳香烃类，是芳烃受体 (AhR) 的激活剂
T10270	BAY 2416964	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	BAY 2416964 是一种可口服的芳基烃受体拮抗剂，IC50为 341 nM，可用于研究实体瘤。
T2448	CH-223191 CH 223191	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	CH-223191 是一种特异性有效的芳烃受体 (AhR) 拮抗剂，可抑制 TCDD 介导的核转位和 AhR 的 DNA 结合，抑制 TCDD 诱导的荧光素酶活性的 IC50值为 0.03 μM。
T4607	CAY 10465 CAY10465,CAY10465 Exclusive	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	CAY 10465 是一种选择性和高亲和力的芳香烃受体(AhR)激动剂，Ki 值为 0.2 nM。
T1831	StemRegenin 1 SR1	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	StemRegenin 1 (SR1) 是一种芳香烃受体拮抗剂，IC50为 127 nM。
TQ0257	FICZ 6-Formylindolo[3,2-b]carbazole	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	FICZ (6-Formylindolo[3,2-b]carbazole) 是芳烃受体 (AhR) 的有效芳基激动剂，Kd 值为70 pM。
T21704	5-fluoro 203 5F-203,NSC-703786	Others	Others
	5-fluoro 203 (NSC-703786) 是一种细胞毒性分子。它可激活芳香烃受体(AhR) 信号传导，诱导 CYP1A1 的转录，从而形成 DNA 加合物以及细胞周期阻滞。它可以提高活性氧水平，并激活 ERK、p38以及JNK。
T13276	VAF347 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	VAF347 是细胞可渗透且高度亲和力的芳烃受体激动剂，可诱导AhR 信号传导，具有抗炎作用。它抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+单核细胞的发育。
T2623	PD98059 PD 98059	ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy	Autophagy; Immunology/Inflammation; MAPK
	PD98059 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=2/50 μM)，具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。
T2148	Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T0640	Benzyl butyl phthalate BBP,邻苯二甲酸丁苄酯,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate	Others; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Others
	Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) 是邻苯二甲酸酯的一员，可激活乳腺癌细胞中的芳香烃受体，刺激 SPHK1/S1P/S1PR3 信号传导，促进转移性乳腺癌干细胞的形成。它通过上调 Zeb1 的表达，可引起血管瘤细胞的迁移和侵袭。
T3389	Antitumor agent-21 TRX818	Others	Others
	Antitumor agent-21 (TRX818) 是一种具有潜在的抗癌、抗炎、抗增殖、抗激素作用和抑制血管生成拟态作用的芳基-喹啉衍生物。
T2707	Pifithrin-α hydrobromide Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide	Ferroptosis; Aryl Hydrocarbon Receptor; p53	Apoptosis; Immunology/Inflammation
	Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂，可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。
T0790	Carbaryl 1-naphthyl methylcarbamate,甲萘威,Sevin	AChR	Neuroscience
	Carbaryl (1-naphthyl methylcarbamate) 可作为一种杀虫剂。
T13012	Stearyldiethanolamine PEG-2 Stearamine,2,2'-(Octadecylazanediyl)diethanol,2,2'-(Octadecylimino)diethanol	Others	Others
	Stearyldiethanolamine (2,2'-(Octadecylazanediyl)diethanol) 可用于抗菌无纺布和抗菌保鲜膜的研究。
T13662	Diarylalkane derivative 1	Others	Others
	Diarylalkane derivative 1 is used for the research of pancreatitis.
T76448	Arylomycin A2
	Arylomycin A2，一种脂肽I型信号肽酶(SPase I)抑制剂抗生素(antibiotic)，具有抗菌作用。
T31481	Diisostearyl adipate	Others	Others
	Diisostearyl adipate can be used for skin care.
T82293	Glutaryl coenzyme A lithium	Others	Others
	Glutaryl coenzyme A lithium为Glutaryl coenzyme A的衍生物，后者为一重要内源性代谢物。该化合物常应用于HMG-CoA及Glutaryl coenzyme A相关实验。
T22268	Benzyldimethylstearylammonium chloride Benzyldimethylstearylammonium Chloride Hydrate,十八烷基二甲基苄基氯化铵	Others	Others
	Benzyl dimethyl stearyl ammonium chloride hydrate is a kind of mild smell chemical
T73752	Glutarylcarnitine lithium	Others	Others
	Glutarylcarnitine lithium 丙二酸尿症和 I 型戊二酸尿症的重要诊断代谢物。
T34714	Stearylbetaine NSC 36343,NSC-36343,NSC-9859,NSC 9859,NSC36343	Others	Others
	Stearylbetaine is a bioactive chemical.
T34713	Stearyl tyrosine Stearyl-tyrosine,Stearyltyrosine	Others	Others
	Stearyl tyrosine is an immunoadjuvants, long-chain stearyl ester of amino acids and peptides.
T34957	Tristearyl citrate	Others	Others
	Tristearyl citrate is a bioactive chemical.
T19912	Distearyl thiodipropionate NSC65493,NSC-65493,NSC 65493	Others	Others
	Distearyl thiodipropionate is an agent of biochemical.
T31948	Glutarylleucine Glutaryl-L-leucine	Others	Others
	Glutarylleucine is a bioactive chemical.
T76163	Arylsulfatase	Others	Others
	Arylsulfatase 是原核生物和真核生物的一类酶。Arylsulfatase 是一种硫酸酯酶，常用于生化研究。
T10106	3-arylisoquinolinamine derivative	Others	Others
	3-arylisoquinolinamine derivative is a compound with antitumor activity.
T65655	Stearyl gallate	Others	Others
	Stearyl gallate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65655，CAS号为 10361-12-3。
T34712	Stearyl caprate Octadecyl decanoate	Others	Others
	Stearyl caprate is a biochemicla.
T22036	Arylquin 1	Others	Others
	Arylquin 1 是一种前列腺-凋亡-反应-4(Par-4)促分泌剂，靶向波形蛋白诱导 Par-4 分泌。Arylquin 1 通过诱导溶酶体膜通透性 (LMP) 诱导癌细胞非凋亡性细胞死亡。
T9658	DCZ3301 NPS ALX Compound 4a hydrochloride(1:1)(299433-10-6 Free base)	Others	Others
	DCZ3301是一种新的芳基胍抑制剂。
T8980	SGA360	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	SGA360 是选择性芳烃 (Ah) 受体调节剂。它具有抗炎特性。
T84322	N-[(4-methylphenyl)carbamothioyl]-2-nitrobenzamide	Others	Others
	N-[(4-methylphenyl)carbamothioyl]-2-nitrobenzamide 可用于 N-aryl-N'-(o-nitrobenzoyl)thiourea derivatives 的合成以及相关研究。
T12071	MKC9989	IRE1	Cell Cycle/Checkpoint
	MKC9989 是一种羟基芳基醛 (HAA) 的抑制剂，抑制 IRE1α的 IC50值在 0.23 到 44 μM 之间。
T19446	N-Boc-O-tosyl hydroxylamine	Others	Others
	N-Boc-O-tosyl hydroxylamine 是高效的、安全的芳基和烷基胺 N-氨基化的氮源。
T9704	1-Ethynylpyrene	P450	Metabolism
	1-Ethynylpyrene 是有效的细胞色素P450 1A1, 1A2和2B1抑制剂，抑制的IC50分别为 0.18，0.32 和 0.04 μM。
T10269	AHR antagonist 2	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	AHR antagonist 2 是芳基烃受体的拮抗剂。人 AHR 和小鼠 AHR 的 IC50 分别为 0.885 和 2.03 nM。
T5103	AKOS B018304 (5E)-5-(2-硝基苯亚甲基)-2-硫代-四氢噻唑-4-酮	Others; Antiviral	Immunology/Inflammation; Others
	AKOS B018304 是芳基衍生物，能够在para位置进行极性替换。AKOS B018304 是一种基孔肯雅病毒抑制剂.
T5541	PDM11 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11	AhR	Immunology/Inflammation; Metabolism
	PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) 是抗氧化剂白藜芦醇的衍生物。它在白藜芦醇活性测定中不活跃。它对辐射分解产生的羟基自由基引发的亚油酸胶束氧化没有明显的保护作用。
T10325	ANI-7	Chk	Cell Cycle/Checkpoint
	ANI-7是芳香烃受体（AhR）途径的激活剂。ANI-7抑制多种癌症细胞的生长，并有效且选择性地抑制MCF-7乳腺癌症细胞的生长（GI50:0.56μM）。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T10526	β-NF-JQ1	Others; PROTACs	Others; PROTAC
	β-NF-JQ1是一种PROTAC，可将芳烃受体E3 （AhR E3）连接酶招募到目标蛋白上。β-NF-JQ1使用β-NF 作为AhR 配体靶向含溴odomain（BRD）的蛋白，诱导AhR 和BRD 蛋白相互作用。β-NF-JQ1显示出与蛋白敲除活性相关的强大的抗癌活性。

化合物

Cat.No: T7202

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T21966

Target: GSK-3, Aryl Hydrocarbon Receptor, CDK

Cat.No: T1960

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T4608

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T15410

Target: Aryl Hydrocarbon Receptor

Cat.No: T5622

Synonym: AHR antagonist 1

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T20625

Synonym: 咪鲜胺,Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

1,4-Chrysenequinone

Cat.No: T10007

Synonym: Chrysene-1,4-dione,1,4-屈醌

Target: AhR

Cat.No: T10270

Target: Aryl Hydrocarbon Receptor

Cat.No: T2448

Synonym: CH 223191

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T4607

Synonym: CAY10465,CAY10465 Exclusive

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T1831

Synonym: SR1

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: TQ0257

Synonym: 6-Formylindolo[3,2-b]carbazole

Target: Aryl Hydrocarbon Receptor

Cat.No: T21704

Synonym: 5F-203,NSC-703786

Target: Others

Cat.No: T13276

Synonym: 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺

Target: Aryl Hydrocarbon Receptor

Cat.No: T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Carbidopa monohydrate

Cat.No: T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Benzyl butyl phthalate

Cat.No: T0640

Synonym: BBP,邻苯二甲酸丁苄酯,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate

Target: Others, Aryl Hydrocarbon Receptor

Antitumor agent-21

Cat.No: T3389

Synonym: TRX818

Target: Others

Pifithrin-α hydrobromide

Cat.No: T2707

Synonym: Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide

Target: Ferroptosis, Aryl Hydrocarbon Receptor, p53

Cat.No: T0790

Synonym: 1-naphthyl methylcarbamate,甲萘威,Sevin

Target: AChR

Stearyldiethanolamine

Cat.No: T13012

Synonym: PEG-2 Stearamine,2,2'-(Octadecylazanediyl)diethanol,2,2'-(Octadecylimino)diethanol

Target: Others

Diarylalkane derivative 1

Cat.No: T13662

Target: Others

Arylomycin A2

Cat.No: T76448

Diisostearyl adipate

Cat.No: T31481

Target: Others

Glutaryl coenzyme A lithium

Cat.No: T82293

Target: Others

Benzyldimethylstearylammonium chloride

Cat.No: T22268

Synonym: Benzyldimethylstearylammonium Chloride Hydrate,十八烷基二甲基苄基氯化铵

Target: Others

Glutarylcarnitine lithium

Cat.No: T73752

Target: Others

Cat.No: T34714

Synonym: NSC 36343,NSC-36343,NSC-9859,NSC 9859,NSC36343

Target: Others

Stearyl tyrosine

Cat.No: T34713

Synonym: Stearyl-tyrosine,Stearyltyrosine

Target: Others

Tristearyl citrate

Cat.No: T34957

Target: Others

Distearyl thiodipropionate

Cat.No: T19912

Synonym: NSC65493,NSC-65493,NSC 65493

Target: Others

Glutarylleucine

Cat.No: T31948

Synonym: Glutaryl-L-leucine

Target: Others

Arylsulfatase

Cat.No: T76163

Target: Others

3-arylisoquinolinamine derivative

Cat.No: T10106

Target: Others

Stearyl gallate

Cat.No: T65655

Target: Others

Stearyl caprate

Cat.No: T34712

Synonym: Octadecyl decanoate

Target: Others

Cat.No: T22036

Target: Others

Cat.No: T9658

Synonym: NPS ALX Compound 4a hydrochloride(1:1)(299433-10-6 Free base)

Target: Others

Cat.No: T8980

Target: Aryl Hydrocarbon Receptor

N-[(4-methylphenyl)carbamothioyl]-2-nitrobenzamide

Cat.No: T84322

Target: Others

Cat.No: T12071

Target: IRE1

N-Boc-O-tosyl hydroxylamine

Cat.No: T19446

Target: Others

1-Ethynylpyrene

Cat.No: T9704

Target: P450

AHR antagonist 2

Cat.No: T10269

Target: Aryl Hydrocarbon Receptor

Cat.No: T5103

Synonym: (5E)-5-(2-硝基苯亚甲基)-2-硫代-四氢噻唑-4-酮

Target: Others, Antiviral

Cat.No: T5541

Synonym: 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11

Target: AhR

Cat.No: T10325

Target: Chk

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Cat.No: T10526

Target: Others, PROTACs

Cat. No.	Product Name	Target	Signaling Pathways
TN1451	Brevifolincarboxylic acid	AhR; Aryl Hydrocarbon Receptor; Glucosidase	Immunology/Inflammation; Metabolism
	Brevifolincarboxylic acid 是从头状蓼中分离得到的一种天然产物，抑制芳烃受体(AhR)。它是一种 α-葡萄糖苷酶抑制剂，IC50 为 323.46 μM。
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T5786	TETRAHYDROPIPERINE 四氢胡椒碱,Cosmoperine	P450; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Tetrahydropiperine (Cosmoperine) 是胡椒碱的环己基类似物，也是一种天然芳基戊酰胺，从Piper longum 分离得到。它对细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH；IC50=23 µM)具有抑制作用。
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T0878	Diosmin Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）	Aryl Hydrocarbon Receptor; Norepinephrine	Immunology/Inflammation; Neuroscience
	Diosmin (Venosmine) 是在各种柑橘类水果中发现的类黄酮，也是芳烃受体激动剂，有增强血管壁的作用。
T4644	Tapinarof GSK2894512,Benvitimod,苯烯莫德,WBI 1001	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物，可消除炎症。它是芳烃受体 (AhR) 激动剂，EC50为 13 nM。
TN2883	3',4'-Dimethoxyflavone	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准，类黄酮化合物具有多种药用活性。
T4939	Indole-3-pyruvic acid 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid	Others	Others
	Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物，Indole-3-acetic acid 是一种植物激素，在调节生长和对环境变化的反应中起重要作用。
T5281	Skatole 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole	AhR; p38 MAPK; Aryl Hydrocarbon Receptor; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal	Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology
	Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的，通过激活芳基烃受体和 p38调节肠上皮细胞功能。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
T5802	Stearyl glycyrrhetinate	Antiviral; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	Stearyl glycyrrhetinate 是甘草提取物中的主要成分之一，具有抗菌作用，对金黄色葡萄球菌菌株的 MIC 大于 256 mg/L。
T19340	Glutarylcarnitine O-glutaroyl-L-carnitine	Endogenous Metabolite	Metabolism
	Glutarylcarnitine (O-glutaroyl-L-carnitine) 是大多数串联质谱新生儿筛查计划中监测的丙二酸尿症和谷草酸尿症 I 型的诊断代谢物。
TN6363	Tsaokoarylone
	Tsaokoarylone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6363，CAS号为 811471-20-2。
TN4433	Licoarylcoumarin	cAMP; HIV Protease; Antifection	GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome
	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
TN2028	p-Coumaryl alcohol	Others	Others
	p-Coumaryl alcohol derivatives have antioxidant activity.
TN7326	8'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid	Others	Others

TN3842	Diarylcomosol III	Others	Others
	Diarylcomosol III shows inhibitory effects on melanogenesis in B16 melanoma cells, it is a promising therapeutic agent for the treatment of skin disorders.
T83542	(E)-p-Coumaryl alcohol (E)-p-Hydroxycinnamyl alcohol
	(E)-p-Coumaryl alcohol，一种香豆素的代谢产物，从高良姜和红景天中分离，具显著的细胞毒性，应用于炎症研究。
T81506	Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside
	Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside 是葡萄中可分离提取的天然产物。
T8281	(R)-Sulforaphane L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷	Nrf2	Immunology/Inflammation
	L-Sulforaphane 是高效的Keap1/Nrf2/ARE途径诱导剂。与 S-异构体相比，它对大鼠肝脏和肺部的致癌解毒酶系统的诱导能力更强。
T83321	4-Demethyldeoxypodophyllotoxin	Chk	Cell Cycle/Checkpoint
	4-Demethyldeoxypodophyllotoxin 是一种来自 Podophyllum peltatum 根部的芳基四氢萘木酚素类化合物，具有抗癌活性，可调节 MCF-7乳腺癌细胞中的Chk-2信号通路。
T3776	Rhapontigenin 丹叶大黄素,Protigenin	P450; Antibacterial; Antifungal	Metabolism; Microbiology/Virology
	Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶，可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T4938	Potassium 1H-indol-3-yl sulfate 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂，Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚，吲哚被吸收到血液中，然后在肝脏中进一步代谢为硫酸吲哚，通常通过尿液排出体外。在肾功能受损的慢性肾病患者中，Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累，诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化，促进大鼠近端小管细胞TGF-β1和Smad3的表达，与促纤维化活性相关。
TN6366	Lupinalbin A 鲁冰花
	Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw
T75433	Norisoboldine hydrochloride	Others	Others
	Norisoboldine hydrochloride是一种口服活性天然芳基烃受体(AhR)激动剂，作为林参中的主要异喹啉类生物碱，适用于类风湿性关节炎和溃疡性结肠炎的研究。
T73402	Flavipin	Others	Others
	Flavipin 是一种芳香烃受体(Ahr)激动剂，可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能，这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力，IC50值为7.2 μM，对α-葡萄糖苷酶具有较强的抑制作用，IC50值为 33.8 μM。

天然产物

Brevifolincarboxylic acid

Cat.No: TN1451

Target: AhR, Aryl Hydrocarbon Receptor, Glucosidase

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

TETRAHYDROPIPERINE

Cat.No: T5786

Synonym: 四氢胡椒碱,Cosmoperine

Target: P450, TRP/TRPV Channel

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Cat.No: T0878

Synonym: Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）

Target: Aryl Hydrocarbon Receptor, Norepinephrine

Cat.No: T4644

Synonym: GSK2894512,Benvitimod,苯烯莫德,WBI 1001

Target: AhR, Aryl Hydrocarbon Receptor

3',4'-Dimethoxyflavone

Cat.No: TN2883

Target: Others, PARP

Indole-3-pyruvic acid

Cat.No: T4939

Synonym: 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid

Target: Others

Cat.No: T5281

Synonym: 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole

Target: AhR, p38 MAPK, Aryl Hydrocarbon Receptor, Endogenous Metabolite, Antibacterial, Autophagy, Antifungal

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Stearyl glycyrrhetinate

Cat.No: T5802

Target: Antiviral, Antibacterial

Glutarylcarnitine

Cat.No: T19340

Synonym: O-glutaroyl-L-carnitine

Target: Endogenous Metabolite

Cat.No: TN6363

Licoarylcoumarin

Cat.No: TN4433

Target: cAMP, HIV Protease, Antifection

p-Coumaryl alcohol

Cat.No: TN2028

Target: Others

8'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid

Cat.No: TN7326

Target: Others

Diarylcomosol III

Cat.No: TN3842

Target: Others

(E)-p-Coumaryl alcohol

Cat.No: T83542

Synonym: (E)-p-Hydroxycinnamyl alcohol

Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside

Cat.No: T81506

(R)-Sulforaphane

Cat.No: T8281

Synonym: L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷

Target: Nrf2

4-Demethyldeoxypodophyllotoxin

Cat.No: T83321

Target: Chk

Cat.No: T3776

Synonym: 丹叶大黄素,Protigenin

Target: P450, Antibacterial, Antifungal

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Potassium 1H-indol-3-yl sulfate

Cat.No: T4938

Synonym: 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

Target: AhR, Endogenous Metabolite

Cat.No: TN6366

Synonym: 鲁冰花

Norisoboldine hydrochloride

Cat.No: T75433

Target: Others

Cat.No: T73402

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02916	SULT1A1 Protein, Mouse, Recombinant (His & Myc) Sulfotransferase 1A1,ST1A4,Aryl sulfotransferase,Su...	Mouse	E. coli
	SULT1A1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.0 kDa and the accession number is P52840.
TMPH-03376	SULT1A1 Protein, Rat, Recombinant (His & Myc & SUMO) Sulfokinase,Aryl sulfotransferase IV,Phenol sulfotr...	Rat	E. coli
	SULT1A1 Protein, Rat, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10XHis-SUMO and C-Myc tag. The predicted molecular weight is 53.9 kDa and the accession number is P17988.
TMPH-00958	AHR Protein, Human, Recombinant (His) Aryl hydrocarbon receptor,Class E basic helix-loop-...	Human	E. coli
	AHR Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-00586	SULT1A2 Protein, Human, Recombinant (His) STP2,Aryl Sulfotransferase 2,ST1A2,Phenol Sulfotran...	Human	E. coli
	Sulfotransferase 1A2 (SULT1A2) is a member of the Sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. SULT1A2 is a cytoplasmic protein and exists as a homodimer. SULT1A2 mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and might thus participate as a modulating factor of cancer risk.
TMPH-00957	ARNT Protein, Human, Recombinant (His) Hypoxia-inducible factor 1-beta,Class E basic helix-loop-hel...	Human	P. pastoris (Yeast)
	ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPY-05911	Influenza B (B/Maryland/1959) Hemagglutinin/HA Protein (His) Harvey rat sarcoma viral oncogene homolog	Influenza B	HEK293 Cells
	Influenza B (B/Maryland/1959) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is AAA43701.
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...

重组蛋白

SULT1A1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02916

Species: Mouse

Expression System: E. coli

SULT1A1 Protein, Rat, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03376

Species: Rat

Expression System: E. coli

AHR Protein, Human, Recombinant (His)

Cat.No: TMPH-00958

Species: Human

Expression System: E. coli

SULT1A2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00586

Species: Human

Expression System: E. coli

ARNT Protein, Human, Recombinant (His)

Cat.No: TMPH-00957

Species: Human

Expression System: P. pastoris (Yeast)

Influenza B (B/Maryland/1959) Hemagglutinin/HA Protein (His)

Cat.No: TMPY-05911

Species: Influenza B

Expression System: HEK293 Cells

HIF-1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01709

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0060	Glutaryl carnitine-d3 HCl
	Glutaryl carnitine-d3 HCl 是 Glutaryl carnitine HCl 的氘代化合物。
TMIJ-0516	Carbaryl-d3
	Carbaryl-d3 是 Carbaryl 的氘代化合物。Carbaryl 的 CAS 号为 63-25-2。Carbaryl 可作为一种杀虫剂。
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A12) in the liver. Indoxyl sulfate activates the aryl* hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...

同位素标记化合物

Glutaryl carnitine-d3 HCl

Cat.No: TMIJ-0060

Cat.No: TMIJ-0516

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼