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Search Results for " ephrin receptor "

Targets Recommended: Ephrin Receptor Ephrin Receptor

8

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1561	123C4	Ephrin Receptor	Tyrosine Kinase/Adaptors
	123C4 是选择性的、竞争性的受体酪氨酸激酶EPHA4激动剂，Ki 为 0.65 μM.
T4344	ALW-II-41-27 Eph receptor tyrosine kinase inhibitor	Ephrin Receptor	Tyrosine Kinase/Adaptors
	ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor) 是一种 Eph 受体酪氨酸激酶抑制剂，可用于治疗癌症。
T19487	NVP-BHG712 isomer	Ephrin Receptor	Tyrosine Kinase/Adaptors
	NVP-BHG712 isomer 是一种 NVP-BHG712 的位置异构体，能够与EPHA2和EPHB4显示保守非键结合。
T5451	Eph inhibitor 2 Ehp-inhibitor-1	Ephrin Receptor	Tyrosine Kinase/Adaptors
	Eph inhibitor 2 是一种 Eph 家族酪氨酸激酶抑制剂。
T3476	JI-101 CGI-1842,JI 101	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	JI-101 (CGI-1842) 是一种有口服活性的多靶点激酶抑制剂，能够抑制VEGFR2，PDGFRβ和EphB4，具有抗癌作用。
T6348	NVP-BHG712	Raf; Bcr-Abl; Src; Ephrin Receptor	Angiogenesis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	NVP-BHG712 是一种特异性的 EphB4 抑制剂，ED50=25 nM，可区分 VEGFR 和 EphB4 抑制。它还显示对 c-Raf (IC50:0.395 μM)、c-Src (IC50:1.266 μM) 和 c-Abl (IC50:1.667 μM) 的活性。
TQ0166	Tesevatinib KD-019,XL-647,EXEL-7647	EGFR; VEGFR; FLT; Ephrin Receptor	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tesevatinib (XL-647) 是一种口服的多靶点酪氨酸激酶抑制剂，对 EGFR、ErbB2、KDR、Flt4和 EphB4的 IC50值分别为 0.3、16、1.5、8.7和 1.4 nM。
T38511	AWL-II-38.3	Ephrin Receptor	Tyrosine Kinase/Adaptors
	AWL-II-38.3 is a highly effective inhibitor of EphA3, a receptor for ephrin-A. It demonstrates potent kinase inhibitory activity against EphA3 and does not show significant cellular activity against Src-family kinases or b-raf [1] [2].

化合物

Cat.No: TP1561

Target: Ephrin Receptor

Cat.No: T4344

Synonym: Eph receptor tyrosine kinase inhibitor

Target: Ephrin Receptor

NVP-BHG712 isomer

Cat.No: T19487

Target: Ephrin Receptor

Eph inhibitor 2

Cat.No: T5451

Synonym: Ehp-inhibitor-1

Target: Ephrin Receptor

Cat.No: T3476

Synonym: CGI-1842,JI 101

Target: VEGFR, PDGFR, Ephrin Receptor

Cat.No: T6348

Target: Raf, Bcr-Abl, Src, Ephrin Receptor

Cat.No: TQ0166

Synonym: KD-019,XL-647,EXEL-7647

Target: EGFR, VEGFR, FLT, Ephrin Receptor

Cat.No: T38511

Target: Ephrin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00424	EphB2 Protein, Human, Recombinant (hFc) EPHB2,Ephrin type-B receptor 2,EPHB2 prote...	Human	HEK293 Cells
	Ephrin type-B receptor 2(EPHB2) belongs to the protein kinase superfamily and Ephrin receptor subfamily. EPHB2 contains 1 Eph LBD domain, 2 fibronectin type-III domains, 1 protein kinase domain and 1 SAM domain. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphospha...
TMPK-00980	EPhA2 Protein, Cynomolgus, Recombinant (hFc) EC:2.7.10.1,Ephrin type-A receptor 2,EPHA2	Cynomolgus	HEK293 Cells
	Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 83.1 kDa and the accession number is Q1KL86.
TMPK-00979	EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) EPHA2,EC:2.7.10.1,Ephrin type-A receptor 2	Cynomolgus	HEK293 Cells
	Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59.2 kDa and the accession number is Q1KL86.
TMPJ-00085	EFNA4 Protein, Human, Recombinant (hFc & His) LERK-4,LERK4,EPH-Related Receptor Tyrosine Kinase L...	Human	HEK293 Cells
	Ephrin-A4 is a member of the ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. Ephrin-A4 consists of approximately 125 amino acids and includes four invariant cysteines, It has been shown to bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. Ephrin-A4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional s...
TMPJ-00224	EFNB2 Protein, Mouse, Recombinant (hFc & His) Ephrin-B2,Htkl,Lerk5.,ELF-2,Epl5,Eplg5,EPH-related ...	Mouse	HEK293 Cells
	Ephrin-B2 is a single-pass type I membrane protein and it contains 1 ephrin RBD (ephrin receptor-binding) domain. Ephrin-B2 belongs to the ephrin (EPH) family and it is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. The ephrins and EPH-related receptors contain the largest subfamily of receptor protein-tyrosine kinases and have been associated ...
TMPJ-00405	EphA4 Protein, Human, Recombinant (hFc) Ephrin type-A receptor 4,SEK,hEK8,TYRO1,Ty...	Human	HEK293 Cells
	EphA4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P54764.
TMPJ-00404	EphA4 Protein, Human, Recombinant Ephrin type-A receptor 4,TYRO1,HEK8,EK8,EP...	Human	HEK293 Cells
	EphA4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 60-80 KDa and the accession number is P54764.
TMPJ-00114	EFNA3 Protein, Mouse, Recombinant (hFc) EFL2,LERK-3,EFNA3,Ephrin-A3,EHK1-L,EPLG3,EFL-2,EHK1...	Mouse	HEK293 Cells
	Ephrins-A3 belongs the Ephrins ligand family which involved in a variety of biological processes, especially in the nervous system and in erythropoiesis. It is shown that Ephrin-A3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. Ephrin-A3 has a GPI anchor following the extracellular sequence and a signal sequence of 22 amino acids. Ephrin-A3 can bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8 and EphB1. Futhe...
TMPJ-00406	EphA8 Protein, Human, Recombinant (His) EPH- and ELK-related tyrosine kinase,EPH receptor A...	Human	HEK293 Cells
	EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent c...
TMPJ-00230	EFNB1 Protein, Mouse, Recombinant (hFc & His) EFNB1,LERK-2,EPH-related receptor tyrosine kinase l...	Mouse	HEK293 Cells
	Mouse Ephrin-B1 is a single-pass type I membrane protein which belongs to the ephrin family. It contains an ephrin RBD (ephrin receptor-binding) domain, and expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Ephrin-B1 is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It binds promiscuously Eph receptors residing on...
TMPJ-00403	EphB1 Protein, Human, Recombinant (hFc) EPHT2,EPH Tyrosine Kinase 2,EK6,Tyrosine-Protein Kinase ...	Human	HEK293 Cells
	Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule i...
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc) TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced Protein 4,Imme...	Human	HEK293 Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the...
TMPJ-00088	EFNA1 Protein, Mouse, Recombinant (hFc & His) Epgl1,Epl1,Immediate early response protein B61,Lerk1,EPH-re...	Mouse	HEK293 Cells
	Ephrin-A1 is a cell membrane protein and contains 1 ephrin RBD (ephrin receptor-binding) domain. EFNA1 belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membran...
TMPK-00223	Ephrin B2/EFNB2 Protein, Human, Recombinant (hFc) Ephrin B2,EFNB2,EPLG5,LERK5,HTKL	Human	HEK293 Cells
	Ephrin-B2 controls platelet-derived growth factor receptor β (PDGFRβ) distribution in the VSMC plasma membrane, endocytosis, and signaling in a fashion that is highly distinct from its role in the endothelium. Ephrin-B2 is an important regulator of PDGFRβ endocytosis and thereby acts as a molecular switch controlling the downstream signaling activity of this receptor in mural cells.
TMPK-01019	EPHA5 Protein, Mouse, Recombinant (His) TYRO4,HEK7,EHK-1,EphA5,EK7,BSK,Rek7,EHK1,TYRO4HEK7CEK7	Mouse	HEK293 Cells
	The aim of the present study was to evaluate ephrin type-A receptor 5 (EphA5) expression and its clinicopathological significance in gastric cancer. Gastric cancer tissues were analyzed by immunohistochemistry. The association between EphA5 expression and clinicopathological parameters, human epidermal growth factor receptor 2 (HER2) status and Ki-67 proliferation index was statistically analyzed.
TMPK-00563	EPHB2 Protein, Cynomolgus, Recombinant (His) DRT,Nuk,Sek3,TYRO5,EPHT3,HEK5,EphB2,Qek2,PCBC,EPHT3MGC87492,...	Cynomolgus	HEK293 Cells
	EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia.
TMPK-00529	EPHA5 Protein, Cynomolgus, Recombinant (His) EHK-1,BSK,Rek7,EK7,EphA5,HEK7,TYRO4,TYRO4HEK7CEK7,EHK1	Cynomolgus	HEK293 Cells
	Ephrin type-A receptor 5 (EphA5) expression was detected in all non-tumor gastric epithelia but was differentially expressed among gastric cancer samples. EphA5 is differentially expressed in gastric cancer. EphA5 may therefore be a potential therapeutic target and may have clinical utility as a marker for lymph node metastasis in gastric cancer. EPHA5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 61.73 kDa and the...
TMPK-00899	EPHA5 Protein, Human, Recombinant (His) HEK7,EK7,Rek7,EphA5,EHK1,TYRO4HEK7CEK7,TYRO4,BSK,EHK-1	Human	HEK293 Cells
	Ephrin type-A receptor 5 (EphA5) expression was detected in all non-tumor gastric epithelia but was differentially expressed among gastric cancer samples. EphA5 is differentially expressed in gastric cancer. EphA5 may therefore be a potential therapeutic target and may have clinical utility as a marker for lymph node metastasis in gastric cancer. EPHA5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 61.9 kDa and the acces...

重组蛋白

EphB2 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00424

Species: Human

Expression System: HEK293 Cells

EPhA2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPK-00980

Species: Cynomolgus

Expression System: HEK293 Cells

EPhA2 Protein, Cynomolgus, Recombinant (His & Avi)

Cat.No: TMPK-00979

Species: Cynomolgus

Expression System: HEK293 Cells

EFNA4 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00085

Species: Human

Expression System: HEK293 Cells

EFNB2 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00224

Species: Mouse

Expression System: HEK293 Cells

EphA4 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00405

Species: Human

Expression System: HEK293 Cells

EphA4 Protein, Human, Recombinant

Cat.No: TMPJ-00404

Species: Human

Expression System: HEK293 Cells

EFNA3 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00114

Species: Mouse

Expression System: HEK293 Cells

EphA8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00406

Species: Human

Expression System: HEK293 Cells

EFNB1 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00230

Species: Mouse

Expression System: HEK293 Cells

EphB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00403

Species: Human

Expression System: HEK293 Cells

EFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00546

Species: Human

Expression System: HEK293 Cells

EFNA1 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00088

Species: Mouse

Expression System: HEK293 Cells

Ephrin B2/EFNB2 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00223

Species: Human

Expression System: HEK293 Cells

EPHA5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01019

Species: Mouse

Expression System: HEK293 Cells

EPHB2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00563

Species: Cynomolgus

Expression System: HEK293 Cells

EPHA5 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00529

Species: Cynomolgus

Expression System: HEK293 Cells

EPHA5 Protein, Human, Recombinant (His)

Cat.No: TMPK-00899

Species: Human

Expression System: HEK293 Cells

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