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<div style = 'overflow: hidden; width: 100%; height: auto; display: inline-block;'><div class="text-dsp"> <div class="vblock zh"> <div style="margin: 0 auto;"> <p class="MsoNormal" style="mso-pagination: widow-orphan; text-align: center; background: #ffffff;" align="center"><img src="https://cdn.targetmol.cn/group3/M00/3E/FB/CgoaEGbQQtOET3hwAAAAAFmwqN4810.png" style="display: block; margin-left: auto; margin-right: auto;;width: 100%"></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 12pt;">NF-κB</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;"><span style="font-family: Microsoft YaHei UI;">(</span><span style="font-family: Microsoft YaHei UI;">Nuclear Factor kappa-light-chain-enhancer of activated B cells)通路是一种在细胞信号传递中极为重要的途径,它在&nbsp;</span></span><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 12pt;">调控免疫反应</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">、</span><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 12pt;">炎症反应</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">、</span><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 12pt;"><span style="font-family: Microsoft YaHei UI;">细胞生长与死亡</span><span style="font-family: Microsoft YaHei UI;">&nbsp;</span></span></strong><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;"><span style="font-family: Microsoft YaHei UI;">等多种生理过程中起着关键作用。这一通路能够响应多种刺激,包括</span> <span style="font-family: Microsoft YaHei UI;">促炎细胞因子、自由基、紫外线辐射、细菌和病毒感染等,进而调控多种基因的表达。</span></span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 13.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 12pt;">NF-κB 是一组蛋白质复合体的统称,主要包含 RelA (p65)、RelB、c-Rel、p50/p105 (NF-κB1) 和 p52/p100 (NF-κB2) 等亚单位。</span></strong></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 13.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;"><span style="font-family: Microsoft YaHei UI;">在未被激活状态下,</span><span style="font-family: Microsoft YaHei UI;">NF-κB 位于细胞质中,与抑制蛋白 IκB 绑定,从而被保持在非活化状态。当细胞受到特定信号的刺激时,IκB 被磷酸化并随后降解,从而释放 NF-κB。NF-κB 之后转移到细胞核中,激活目标基因的转录。</span></span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;">&nbsp;</p> <p class="MsoNormal"><img src="https://cdn.targetmol.cn/group3/M00/3E/F7/CgoaEWbQQtOEazxsAAAAAJBeKqM512.png" style="display: block; margin-left: auto; margin-right: auto;"></p> <p class="MsoNormal" style="text-align: center;"><span style="mso-spacerun: 'yes'; font-family: 宋体; font-size: 11.5000pt; mso-font-kerning: 0.0000pt;">Schematic structures of nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) superfamily and the inhibitor ofNF-κB (IκB) family.</span></p> <p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 12pt;">NF-κB 通路主要包括两种信号激活机制:经典途径(canonical pathway)和非经典途径(noncanonical pathway)。</span></strong></p> <p class="MsoNormal" style="background: #ffffff; text-align: center;"><img src="https://cdn.targetmol.cn/group3/M00/3E/F7/CgoaEWbQQtOERZU9AAAAAIPS3gs623.png" style="display: block; margin-left: auto; margin-right: auto;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 13.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span><span style="mso-spacerun: 'yes'; font-family: 宋体; color: #9196a1; font-size: 11.5000pt; mso-font-kerning: 0.0000pt;">Canonical and noncanonical pathwaysof NF-κB activation.</span></p> <p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span></p> <p class="MsoNormal" style="margin-left: 36.0000pt; text-indent: -18.0000pt; mso-pagination: widow-orphan; background: #ffffff; mso-list: l0 level1 lfo1;"> <!-- [if !supportLists]--><span style="font-family: 微软雅黑; mso-bidi-font-family: 宋体; color: #191b1f; font-weight: bold; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">1.&nbsp;</span> <!--[endif]--><strong><span style="font-family: 微软雅黑; color: #191b1f; font-size: 12pt;"><span style="font-family: 微软雅黑;">经典途径</span> </span></strong><span style="mso-spacerun: 'yes'; font-family: 微软雅黑; mso-bidi-font-family: 宋体; color: #191b1f; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;"><span style="font-family: 微软雅黑;">主要响应于炎症、免疫反应等信号,其特点是依赖于</span> </span><strong><span style="font-family: 微软雅黑; color: #191b1f; font-size: 12pt;">IκB激酶复合体(IKK)</span></strong><span style="mso-spacerun: 'yes'; font-family: 微软雅黑; mso-bidi-font-family: 宋体; color: #191b1f; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;"><span style="font-family: 微软雅黑;">的激活,特别是</span> <span style="font-family: 微软雅黑;">IKKβ 的活化,进而导致 IκB 的磷酸化和降解,释放 NF-κB(通常是 p50/RelA 的二聚体)进入细胞核。</span></span></p> <p class="MsoNormal" style="margin-left: 36pt; text-indent: -18pt; background: #ffffff; text-align: left;"> <!-- [if !supportLists]--><span style="font-family: 微软雅黑; mso-bidi-font-family: 宋体; color: #191b1f; font-weight: bold; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">2.&nbsp;</span> <!--[endif]--><strong><span style="font-family: 微软雅黑; color: #191b1f; font-size: 12pt;"><span style="font-family: 微软雅黑;">非经典途径</span> </span></strong><span style="mso-spacerun: 'yes'; font-family: 微软雅黑; mso-bidi-font-family: 宋体; color: #191b1f; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;"><span style="font-family: 微软雅黑;">主要响应于某些细胞因子,如</span> <span style="font-family: 微软雅黑;">CD40L 或 BAFF 的刺激,这一过程依赖于</span></span><strong><span style="font-family: 微软雅黑; color: #191b1f; font-size: 12pt;">&nbsp;<span style="font-family: 微软雅黑;">NF-κB 诱导激酶(NIK)</span></span></strong><span style="mso-spacerun: 'yes'; font-family: 微软雅黑; mso-bidi-font-family: 宋体; color: #191b1f; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;"><span style="font-family: 微软雅黑;">和</span> <span style="font-family: 微软雅黑;">IKKα 的激活,进而导致 p100 被部分降解成 p52,与 RelB 形成二聚体,进入细胞核。</span></span><img src="https://cdn.targetmol.cn/group3/M00/3E/FB/CgoaEGbQQtSEM2jZAAAAAMrMbN0862.png" style="display: block; margin-left: auto; margin-right: auto;"></p> <p class="MsoNormal" style="margin-left: 36pt; text-indent: -18pt; background: #ffffff; text-align: center;"><span style="mso-spacerun: 'yes'; font-family: 微软雅黑; mso-bidi-font-family: 宋体; color: #191b1f; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span><span style="mso-spacerun: 'yes'; font-family: 宋体; color: #9196a1; font-size: 11.0000pt; mso-font-kerning: 0.0000pt;">NF-κB-independent functionsof IKK complex subunits.</span></p> <p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">NF-κB 通路的调节错综复杂,其激活与否影响着细胞的生存、增殖、凋亡等重要生命活动。因此,NF-κB 的异常激活与多种疾病的发生发展有着密切关系,包括但不限于自身免疫疾病、炎症反应性疾病、以及某些类型的癌症。这也使得 NF-κB 成为药物开发中的一个重要靶点。</span></p> <p class="MsoNormal" style="background: #ffffff; text-align: center;"><img src="https://cdn.targetmol.cn/group3/M00/3E/FB/CgoaEGbQQtSEMOg_AAAAAFDCXVQ713.png" style="display: block; margin-left: auto; margin-right: auto;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 13.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span><span style="mso-spacerun: 'yes'; font-family: 宋体; color: #9196a1; font-size: 11.0000pt; mso-font-kerning: 0.0000pt;">Activation of canonical and noncanonical NF-κB pathways.</span></p> <p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 12pt;">TargetMol</span></strong><a href="https://www.targetmol.cn/compound-library/NF_%CE%BAB_Signaling_Compound_Library"><strong><u><span style="font-family: 'Microsoft YaHei UI'; color: #0000ff; letter-spacing: 0.4pt; font-size: 12pt;"><span style="font-family: Microsoft YaHei UI;">NF-κB信号通路分子库</span></span></u></strong></a><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;是由 740 个&nbsp;</span><a href="https://www.targetmol.cn/compound-library/NF_%CE%BAB_Signaling_Compound_Library"><u><span style="font-family: 'Microsoft YaHei UI'; color: #0000ff; letter-spacing: 0.4pt; font-size: 12pt;"><span style="font-family: Microsoft YaHei UI;">NF-κB</span></span></u></a><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;信号通路相关的小分子化合物组成的独特集合,用于</span><a href="https://www.targetmol.cn/compound-library/NF_%CE%BAB_Signaling_Compound_Library"><u><span style="font-family: 'Microsoft YaHei UI'; color: #0000ff; letter-spacing: 0.4pt; font-size: 12pt;"><span style="font-family: Microsoft YaHei UI;">NF-κB信号通路</span></span></u></a><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;相关的研究及药物的筛选,可用于高通量、高内涵筛选。</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><a href="https://www.targetmol.cn/compound-library/NF_%CE%BAB_Signaling_Compound_Library"><strong><u><span style="font-family: 'Microsoft YaHei UI'; color: #0000ff; letter-spacing: 0.4pt; font-size: 13pt;"><span style="font-family: Microsoft YaHei UI;">化合物库组成:</span></span></u></strong></a></p> <p class="MsoNormal"><img style="display: block; margin-left: auto; margin-right: auto;" src="https://cdn.targetmol.cn/group3/M00/3E/F7/CgoaEWbQQtSEaaoXAAAAALAMJnw522.png"><span style="mso-spacerun: 'yes'; font-family: 宋体; font-size: 12.0000pt; mso-font-kerning: 0.0000pt;">&nbsp;</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><strong><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 13pt;">参考文献:</span></strong></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 10.5000pt; mso-font-kerning: 0.0000pt;">1. Zhang T, Ma C, Zhang Z, Zhang H, Hu H. NF-κB signaling in inflammation and cancer.&nbsp;</span><em><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 10.5pt;">MedComm</span></em><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 10.5000pt; mso-font-kerning: 0.0000pt;">. 2021;2(4):618-653. doi:10.1002/mco2.104</span></p> <p class="MsoNormal" style="mso-pagination: widow-orphan; background: #ffffff;"><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 10.5000pt; mso-font-kerning: 0.0000pt;">2. Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NF-κB signaling pathways.&nbsp;</span><em><span style="font-family: 'Microsoft YaHei UI'; letter-spacing: 0.4pt; font-size: 10.5pt;">Nat Immunol</span></em><span style="mso-spacerun: 'yes'; font-family: 'Microsoft YaHei UI'; mso-bidi-font-family: 宋体; letter-spacing: 0.4000pt; font-size: 10.5000pt; mso-font-kerning: 0.0000pt;">. 2011;12(8):695-708. doi:10.1038/ni.2065</span></p> <p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 等线; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">&nbsp;</span></p> </div> </div> </div> <div style="height: 50px;"></div></div>

NF-κBNuclear Factor kappa-light-chain-enhancer of activated B cells)通路是一种在细胞信号传递中极为重要的途径,它在 调控免疫反应炎症反应细胞生长与死亡 等多种生理过程中起着关键作用。这一通路能够响应多种刺激,包括 促炎细胞因子、自由基、紫外线辐射、细菌和病毒感染等,进而调控多种基因的表达。

 

NF-κB 是一组蛋白质复合体的统称,主要包含 RelA (p65)、RelB、c-Rel、p50/p105 (NF-κB1) 和 p52/p100 (NF-κB2) 等亚单位。

 

在未被激活状态下,NF-κB 位于细胞质中,与抑制蛋白 IκB 绑定,从而被保持在非活化状态。当细胞受到特定信号的刺激时,IκB 被磷酸化并随后降解,从而释放 NF-κB。NF-κB 之后转移到细胞核中,激活目标基因的转录。

 

Schematic structures of nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) superfamily and the inhibitor ofNF-κB (IκB) family.

 

NF-κB 通路主要包括两种信号激活机制:经典途径(canonical pathway)和非经典途径(noncanonical pathway)。

 Canonical and noncanonical pathwaysof NF-κB activation.

 

1.  经典途径 主要响应于炎症、免疫反应等信号,其特点是依赖于 IκB激酶复合体(IKK)的激活,特别是 IKKβ 的活化,进而导致 IκB 的磷酸化和降解,释放 NF-κB(通常是 p50/RelA 的二聚体)进入细胞核。

2.  非经典途径 主要响应于某些细胞因子,如 CD40L 或 BAFF 的刺激,这一过程依赖于 NF-κB 诱导激酶(NIK) IKKα 的激活,进而导致 p100 被部分降解成 p52,与 RelB 形成二聚体,进入细胞核。

 NF-κB-independent functionsof IKK complex subunits.

 

NF-κB 通路的调节错综复杂,其激活与否影响着细胞的生存、增殖、凋亡等重要生命活动。因此,NF-κB 的异常激活与多种疾病的发生发展有着密切关系,包括但不限于自身免疫疾病、炎症反应性疾病、以及某些类型的癌症。这也使得 NF-κB 成为药物开发中的一个重要靶点。

 Activation of canonical and noncanonical NF-κB pathways.

 

TargetMolNF-κB信号通路分子库 是由 740 个 NF-κB 信号通路相关的小分子化合物组成的独特集合,用于NF-κB信号通路 相关的研究及药物的筛选,可用于高通量、高内涵筛选。

化合物库组成:

 

参考文献:

1. Zhang T, Ma C, Zhang Z, Zhang H, Hu H. NF-κB signaling in inflammation and cancer. MedComm. 2021;2(4):618-653. doi:10.1002/mco2.104

2. Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NF-κB signaling pathways. Nat Immunol. 2011;12(8):695-708. doi:10.1038/ni.2065