Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19417 |
Urinary Incontinence-Targeting Compound 1
|
Others | Others |
Urinary Incontinence-Targeting Compound 1, used in the research of urinary incontinence, is a sulfonanilide derivative. | |||
T1049L |
Oxybutynin
Oxytrol,奥昔布宁,Ditropan,Oxibutyninum |
Potassium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Oxybutynin (Ditropan) 是一种抗胆碱能药,抑制血管 Kv 通道,IC50为 11.51 μM,可用于治疗尿失禁和膀胱过度活动症。 | |||
T1049 |
Oxybutynin chloride
Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl |
Potassium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物,用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道,IC50为 11.51 μM。 | |||
T5023 |
Propiverine hydrochloride
|
Others; Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
Propiverine hydrochloride 是一种痉挛剂,具有钙拮抗和抗胆碱能特性,用于研究膀胱过度活动和尿失禁。 | |||
T10952 |
Dabuzalgron
达布扎琼,Ro 115-1240 |
Apoptosis; Adrenergic Receptor | Apoptosis; GPCR/G Protein; Neuroscience |
Dabuzalgron (Ro 115-1240) 是一种口服活性选择性 α-1A 肾上腺素受体激动剂,用于治疗尿失禁。它通过维持线粒体功能来预防多柔比星引起的心脏毒性。 | |||
T1472 |
Trospium chloride
Spasmex,Sanctura,曲司氯铵,曲司氯胺 |
AChR | Neuroscience |
Trospium chloride (Spasmex) 是一种可口服的特异竞争性毒蕈碱胆碱能受体拮抗剂,可与毒蕈碱受体 M1、M2 和 M3 高亲和力结合,具有抗毒蕈碱活性。 | |||
T3126 |
Bethanechol chloride
(±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride |
AChR | Neuroscience |
Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂,是毒蕈碱型受体 (mAChR) 激动剂,通过直接刺激副交感神经系统的 mAChR 发挥作用。 | |||
T29687 |
Afacifenacin
Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986 |
AChR | Neuroscience |
Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂,可用于研究缺血性心脏病,尿失禁和膀胱炎和其他疾病。 | |||
T28257L |
(-)-OPC-51803
|
AChR | Neuroscience |
(-)-OPC-51803 是一种抗利尿激素 V2受体激动剂,可用于夜尿症和尿失禁的治疗。 | |||
T1534 |
Darifenacin hydrobromide
氢溴酸达非那新,Darifenacin HBr,UK-88525 |
AChR | Neuroscience |
Darifenacin hydrobromide (UK-88525) 是一种选择性 M3 蕈毒碱受体拮抗剂,pKi 为 8.9。 | |||
T0111 |
Solifenacin succinate
YM905,索非那新琥珀酸盐 |
AChR | Neuroscience |
Solifenacin succinate (YM905) 是毒蕈碱受体拮抗剂,对 M1、M2和M3受体的pKi 值分别为 7.6、6.9 和 8.0。 | |||
T28257 |
OPC-51803
SOU-003,SOU 003,SOU003,OPC51803,OPC 51803 |
Vasopressin Receptor | GPCR/G Protein |
OPC-51803是一种可口服的非肽加压素(AVP)V(2)受体选择性激动剂,可用于治疗尿失禁和夜尿。 | |||
T1460 |
Dicyclomine hydrochloride
|
AChR | Neuroscience |
Dicyclomine hydrochloride 是口服活性毒蕈碱胆碱能受体拮抗剂。它是一种抗痉挛试剂,在体内可缓解胃肠道平滑肌痉挛。它对 M1 受体亚型和 M2 受体亚型,Ki 分别为5.1和54.6nM,在刷状缘膜和基底质膜中均表现出较高的亲和力。 | |||
T10830 |
CL 316243
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
CL316243 是一种高效的 β3 肾上腺素受体选择性激动剂,EC50 为 3 nM。它是一种有效的脂肪细胞脂解刺激剂,可增加棕色脂肪组织的产热和代谢率,具有治疗肥胖症、糖尿病和急迫性尿失禁的潜力。 | |||
T67956L |
Litoxetine HCl
litoxetine HCL(86811-09-8 Free base) |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Litoxetine HCl 是一种选择性5-羟色胺(5-HT)再摄取抑制剂(SSRI)和混合5-羟色胺拮抗剂,可用于治疗尿失禁。Litoxetine HCl 在没有抗毒蕈碱特性的浓度下(10 nM-1 microM)引起大鼠离体食道肌肉粘膜的浓度依赖性松弛,使卡巴胆碱张力降低达37%,更高浓度的Litoxetine HCl(3微摩-300微摩)与明显的松弛有关,直至取消卡巴胆碱张力。以前在离体豚鼠肠道中证明的利托西汀的抗心律失常活性,在浓度大于1 microM 时在大鼠离体食道肌肉粘膜中发挥了作用。 Litoxetine HCl 的5-HT 释放作用可以解释利托西汀对未处理的大鼠组织中的5-HT 诱导的松弛的效力,这种效力被pCPA 处理所逆转。 | |||
T10952L |
Dabuzalgron HCl
R1240,R-450,R450,RO-1151240,R-1240,RO1151240 |
Others | Others |
Dabuzalgron, an adrenoceptor agonist, is used potentially for the treatment of urinary incontinence. | |||
T27401 |
Garomefrine HCl
PNO-49B,NS-49,ABT-232,ABT232,NS49,PNO49B |
Others | Others |
Garomefrine HCl, a α1A-adrenoceptor agonist, is potential for the treatment of urinary incontinence. | |||
T71889 |
Esoxybutynin Chloride
|
Others | Others |
Esoxybutynin Chloride is (S)-enantiomer of oxybutynin. Esoxybutynin Chloride exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence. | |||
T26604 |
Alvameline Tartrate
LU-25-109T,LU 25 109T,LU-25109T,LU 25109T |
Others | Others |
Alvameline Tartrate, a muscarinic M1 receptor agonist and M2/M3 receptor antagonist, is used potentially for treatment of urinary incontinence. | |||
T29667 |
Adosopine
Adosupine |
Others | Others |
Adosopine is a dibenzoazepine which affects urinary bladder hyperreflexia and may be suitable for treating urinary incontinence. | |||
T28465 |
PSD-506
PSD 506,RO 3202904,RO3202904,RO-3202904 |
Others | Others |
PSD-506, a muscarinic M2/M3 antagonist, is used potentially for the treatment of overactive bladder, and urinary incontinence. | |||
T71268 |
Esoxybutynin Free Base
|
Others | Others |
Esoxybutynin Free Base is (S)-enantiomer of oxybutynin. Esoxybutynin Free Base exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence. | |||
T25325 |
Dicyclonon
LAB 145-138H,BAS 145-138 |
Others | Others |
Dicyclonon is a muscarinic antagonist utilized as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It has some local anesthetic properties and is utilized in biliary, gastrointestinal, | |||
T70379 |
PF-04479745 tartrate
|
Others | Others |
PF-04479745, also known as PF-4479745, is a potent and selective 5-HT2C agonist (EC50 = 10 nM). PF-4479745 displayed robust pharmacology in a preclinical canine model of stress urinary incontinence (SUI) and no measurable functional agonism at the key selectivity targets 5-HT2A and 5-HT2B in relevant tissue-based assay systems. | |||
T73572 |
NS-8
|
Others | Others |
NS-8,一种吡咯衍生物,能够激活Ca2+-敏感的K+通道。通过降低盆腔传入神经活动,NS-8有助于抑制排尿反射,适用于尿频与尿失禁的研究。 | |||
T72091 |
ADRA1D receptor antagonist 1 free base
|
Others | Others |
ADRA1D receptor antagonist 1 (free base) (化合物 (R)-9s),是口服高效、强效及选择性的人类α1D-肾上腺素受体(α1D-AR)拮抗剂,具有Ki值为1.6 nM。该化合物能剂量依赖性降低膀胱收缩,IC30值为15 nM,适用于膀胱过度活动症(包括尿急、尿频和尿失禁)的研究。 |