tlr7/8

TLR7 8 9 antagonist 2 是一种具有口服活性和较高生物利用度的 vTLR7 8 9 拮抗剂。TLR7 8 9 antagonist 2 对 HEK hTLR7、HEK hTLR8 和 HEK hTLR9 具有抑制作用，IC50 分别为 0.011 μM、0.029 μM 和 0,052 μM。TLR7 8 9 antagonist 2 可用于研究系统性红斑狼疮或狼疮性肾炎等自身炎症性疾病。

TLR7 8 9-IN-1 是具有口服活性的Toll 样受体7 8 9小分子拮抗剂，IC50为43 nM。

TLR7 8 agonist 1 dihydrochloride (TLR7 8 agonist-5d) 是 toll 样受体TLR7 TLR8的双重激动剂。

TLR7 8 agonist 3 是TLR7 8激动剂。

TLR7 8 agonist 9 (Compound 25a) 是一种能够增强PD-1 PD-L1阻断疗法抗肿瘤效果的化合物，主要用于癌症免疫疗法研究。它对hTLR7和hTLR8的EC50分别为40 nM和23 nM，显示出其对这两种受体的高亲和力以及潜在的抗肿瘤活性。

TLR7 8 agonist 4 (compound 41) 是具有抗癌活性的，TLR7 8 的有效激动剂。

TLR7/8 agonist-7d 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64606。

TLR7 8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate employed in antibody-drug conjugates (ADC). This compound exhibits remarkable antitumor activity by utilizing TLR7 8 agonist 4, which acts as a potent activator of TLR7 8. The TLR7 8 agonist 4 is linked to hydroxy-PEG10-acid, the ADC linker, via a cleavable bond. Overall, it demonstrates promising pharmaceutical potential in the context of ADC-based therapeutics.

TLR7 8 agonist 1是一种 toll 样受体 (TLR7) TLR8的双重激动剂。

TLR7 8 agonist 4 TFA (compound 41) is a highly potent TLR7 8 agonist that exhibits significant anti-cancer activity.

TLR7 8 agonist 4hydroxy-PEG6-acid 为ADC药物-连接子偶联物（Drug-Linker Conjugates for ADC）。该合成物结合了TLR7 8 agonist 4与连接子hydroxy-PEG6-acid，专门用于ADC合成。

TLR7/8 agonist 7 是一种 TLR7/8激动剂。TLR7/8 agonist 7 可激活多种免疫细胞，可用于合成抗体-免疫刺激偶联物 ISAC 分子。TLR7/8 agonist 7 可用于免疫的研究。

TLR7 8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugate used in antibody-drug conjugates (ADCs) with high efficacy against tumors. It consists of TLR7 8 agonist 4, a potent TLR7 8 agonist, linked to the ADC linker hydroxy-PEG10-acid which can be cleaved.

TLR7 8 agonist 4hydroxy-PEG6-acid hydrochloride为一种用于抗体药物偶联体(ADC)的药物-连接子偶联物。该化合物为TLR7 8 agonist 4hydroxy-PEG6-acid的盐酸盐形式，由TLR7 8 agonist 4与连接子 Hydroxy-PEG6-acid构成，适用于ADC合成。

TLR7 8-IN-1，是一种结晶态TLR7 TLR8抑制剂，对于自身免疫性疾病研究具有重要价值[1]。

TLR7 8 agonist 6 (Compound 4) 是一种咪唑喹啉衍生物，是一种有效的 TLR7 8 激动剂，对 TLR7 和 TLR8 的 IC50 值分别为 0.18 和 5.34 μM。其中 Toll 样受体 (TLR) 7 和 8 是一种治疗传染病、癌症和自身免疫性疾病的免疫调节药物开发的关键靶点。

TLR7 8 agonist 8（compound 24m）是一种高效的TLR7 8双重激动剂，对hTLR7和hTLR8的EC50值分别为27 nM和12 nM。该化合物能增强PD-1 PD-L1阻断剂的抗癌效果。

TLR7 8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7 8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promising candidate for the treatment and investigation of autoimmune diseases, including lupus erythematosus, which is associated with inappropriate activation of TLR7 and TLR8. Consequently, TLR7 8 antagonist 2 represents a valuable tool for research in the field of autoimmune diseases [1].

TLR7 8 Antagonist 1 (Compound 16c) 是一种咪唑喹啉衍生物，是一种有效的 TLR7 8 激动剂，对 TLR7 和 TLR8 的 IC50 值分别为 3.91 和 2.19 μM。其中 Toll 样受体 (TLR) 7 和 8 是一种治疗传染病、癌症和自身免疫性疾病的免疫调节药物开发的关键靶点。

5-Hydroxy-7-acetoxy-8-methoxyflavone 是一种类黄酮化合物，可以抑制脂质过氧化，可能具有抗流感病毒活性。

8-Acetyl-7-Hydroxycoumarin 是一种天然化合物，具有抗真菌和抗菌活性。

7-Hydroxy-4-methyl-8-nitrocoumarin 是香豆素衍生物的一种。

Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

8-O-Methylretusin-7-O-beta-D-glucopyranoside 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124388。

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66423，CAS号为 112811-57-1。

2-Amino -7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-2,3,5-tri-O-actyl-xylofuranosyl)purine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU1331，CAS号为 2389988-52-5。

[(2R,3S,4R,5R)-3,4-diacetyloxy-5-[2-amino-7-(cyclopropylmethyl)-8-oxopurin-9-yl]oxolan-2-yl]methyl acetate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 TNU1306。

5-Hydroxy-7-methoxy-8-methylflavanone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131489。

7',8'-Dihydroobolactone can inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.

8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3267，CAS号为 144398-34-5。

1,10:4,5-Diepoxy-7(11)-germacren-8-one 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2476，CAS号为 32179-18-3。

Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)，是一种血管活性肠肽，起到VIP1受体拮抗剂的作用。

(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases. Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane synthesis in isolated platelets.

7-Amino-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67151。

2-Amino-7-cyclopropyl methyl-7,8-dihydro-8-oxo-9-(beta-D-xylo furanosyl)purine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU0169，CAS号为 2389988-30-9。

3,5,6,7,8,3',4'-Heptemthoxyflavone 是来自蜜柑皮中的黄酮，具有抗肿瘤起始活性和抗神经炎症作用。它能通过 cAMP ERK CREB 信号诱导脑源性神经营养因子表达，降低 C6 细胞磷酸二酯酶活性。它能抑制胶原酶的活性，增加人真皮成纤维细胞新生细胞中 I 型前胶原含量。

Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting vasodilation, inhibiting angiogenesis, and decreasing inflammatory and neuropathic pain. (±)7(8)-EpDPA is a substrate of soluble epoxide hydrolase (KM = 15 μM), which converts it to the corresponding diol.

(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(tosyloxy)acetate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64681。

7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine is a building block.1It has been used in the synthesis of PI3K inhibitors. 1.Scott, W.J., Hentemann, M.F., Rowley, R.B., et al.Discovery and SAR of novel 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: Identification of copanlisib (BAY 80-6946)ChemMedChem.11(14)1517-1530(2016)

Nucleoside Derivatives - 7-Deaza-8-aza-purine nucleosides

7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU0451，CAS号为 2389988-55-8。

8-Aza-7-bromo-7-deazaguanosine is a Nucleoside Derivative - 7-Deaza-8-aza-purine nucleoside; Halo-nucleoside; Scaffold and Template.

(6R,7R)-7-Amino-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66940，CAS号为 30246-33-4。

2',4'-Dihydroxy-7-methoxy-8-prenylflavan 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2720，CAS号为 331954-16-6。

7-methoxy-8-hydroxy-4-methylcoumarin 是分离自酸橙 (Citrus aurantium) 的一种化合物。

Selina-4(15),7(11)-dien-8-one 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3467，CAS号为 54707-47-0。