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Search Results for " thyroid hormone "

Targets Recommended: Thyroid hormone receptor(THR) TSH Receptor

50

抑制剂 & 化合物

6

天然产物

1

化合物库

28

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L2400	内分泌激素分子库		784 compounds
	784 种与内分泌系统相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

内分泌激素分子库

Cat.No: L2400

Compounds: 784

Cat. No.	Product Name	Target	Signaling Pathways
T12073	ML-109	TSH Receptor	GPCR/G Protein
	ML-109 是一种促甲状腺激素受体的有效激动剂，EC50值为 40 nM。
T5360	Eprotirome 伊罗替罗,KB2115	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Eprotirome (KB2115) 是一种肝脏选择性甲状腺激素受体 (thyroid hormone receptor, TR) 激动剂。它对 TRβ的亲和力略高于TRα。它降低了低密度脂蛋白 (LDL) 胆固醇的浓度，可用于研究血脂异常和肥胖症。
T40548	NH-3	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	NH-3是一种高效的口服活性甲状腺激素受体（THR）拮抗剂，具有可逆行为，其IC 50为55 nM。NH-3源自选择性甲状腺激素模拟物GC-1，有效地抑制甲状腺激素与相应受体的结合，从而阻碍辅因子的招募。
T1604	Tiratricol 3,3',5-Triiodothyroacetic acid,替拉曲可	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Tiratricol (3,3',5-Triiodothyroacetic acid) 是 T3 和 T4 甲状腺激素的代谢物；促进高脂血症、局部脂肪营养不良和肥胖。它已用于研究 Allan-Herndon-Dudley 综合征治疗的试验。
T12192	NCGC00229600	Others; TSH Receptor	GPCR/G Protein; Others
	NCGC00229600 是促甲状腺激素受体 (TSHR) 的变构反向激动剂。 NCGC00229600 抑制 TSH 和刺激 TSHR 的内源性激活抗体，可用于格雷夫斯病的研究。
T3595	Resmetirom VIA-3196,MGL3196	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Resmetirom (VIA-3196) 是一种高度选择性的THR-β激动剂(EC50:0.21 μM)。
T5383	D3-βArr NCGC00379308	TSH Receptor	GPCR/G Protein
	D3-βArr (NCGC00379308) 是一种促甲状腺激素受体正变构调节剂，通过直接激活促甲状腺激素受体启动 β-Arr 1 的易位，EC50为 11.6 μM。它还可增强促甲状腺激素介导的体外成骨细胞分化。
T13072	Taltirelin acetate TA-0910 acetate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Taltirelin acetate (TA-0910 acetate) 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM)，能够刺激细胞溶质Ca2+浓度增加 (Ca2+释放) ，其EC50值为 36 nM。
T1669	Liothyronine sodium 3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,三碘代甲状腺素钠盐,Sodium L-3,3',5-triiodothyronine,Cytomel	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Liothyronine sodium (3,3',5-Triiodo-L-thyronine sodium) 是甲状腺激素，能够结合并激活 β1 甲状腺激素受体。
T13492	3,5-Diiodothyropropionic acid C082182,Ditpa cpd,3,5-二碘甲腺丙酸	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	3,5-Diiodothyropropionic acid (C082182) 是一种甲状腺激素类似物，能够诱导 α-肌球蛋白重链 mRNA 表达。它可与甲状腺激素受体结合，作用于 TRα1 (Ka:2.40 M-1) 和 TRβ1 (Ka:4.06 M-1) 。
T5313	Sobetirome IACS-010759,QRX-431	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Sobetirome (IACS-010759) 是一种甲状腺激素受体 β (TRβ) 激动剂，能够选择性的结合到TRβ-1(EC50:0.16 μM)。
TP1022	Protirelin Acetate TSH-RF Acetate,TRH Acetate,TRF Acetate,醋酸普罗瑞林	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Protirelin Acetate (TRH Acetate) 是高度保守的神经肽，具有促甲状腺激素水平的激素控制作用，及神经调节的能力。
T7578	REVERSE T3 碘塞罗宁,3,3',5'-triiodo-L-thyronine	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Reverse T3 (3,3',5'-triiodo-L-thyronine) 是由甲状腺素原脱碘后产生的甲状腺激素。它可抑制由其它甲状腺激素类似物引起的新生大鼠心肌细胞中钠电流增加的作用。
T22355	L-Thyroxine sodium 左旋甲状腺素钠,LT4 sodium,Levothyroxine sodium,L-T4 sodium	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	L-Thyroxine sodium (LT4 sodium) 是一种合成的甲状腺激素，用于研究甲状腺功能减退症。DIO 酶能够将Levothyroxine 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
T7590	Taltirelin TA-0910,他替瑞林	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Taltirelin (TA-0910) 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM)，能够刺激细胞溶质 Ca2+浓度增加 (Ca2+释放) (EC50:36 nM)。
T15699	L-Thyroxine sodium salt pentahydrate 左旋甲状腺素钠五水合物,Sodium levothyroxine pentahydrate,Levothyroxine,L-甲状腺素钠五水合物	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	L-Thyroxine sodium salt pentahydrate (Levothyroxine) 是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。
T13435	TR antagonist 1	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	TR antagonist 1 是一种高效甲状腺激素受体（TR）拮抗剂（对 TRα 和 TRβ 的 IC50 分别为 36 和 22 nM），可用于研究内分泌异常引起的疾病。
T16403	Org41841 Org-41841	TSH Receptor	GPCR/G Protein
	Org41841 是黄体生成素/绒毛膜促性腺激素受体和促甲状腺激素受体的激动剂（EC50s：分别为 0.2 和 7.7 μM），可用于研究甲状腺亢进。
T23673	AH-3960 AH3960	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	AH-3960 是一种甲状腺激素受体 1 (PTHR1) 激动剂。
T8672	2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE BisOPP-A,双酚0PPA	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE 是针对促甲状腺激素受体（人）。
T7407	Thyrotropin-Releasing Hormone (TRH), Free Acid TRH-OH	Others	Others
	Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) 是一种促甲状腺激素释放激素的生理代谢产物。
TP1028L	Calcitonin eel acetate Calcitonin eel acetate (57014-02-5 Free base),降钙素,Thyrocalcitonin eel	Others	Others
	Calcitonin eel acetate (Calcitonin eel acetate (57014-02-5 Free base)) 是调节钙稳态的甲状腺激素肽。
T0304	Methylthiouracil 甲基硫脲嘧啶,甲硫氧嘧啶,NSC-193526,NSC-9378,MTU	ERK; Antiviral; TNF; NF-κB; Interleukin	Apoptosis; Immunology/Inflammation; MAPK; NF-κB
	Methylthiouracil (NSC-193526) 是一种抗甲状腺剂。它抑制TNF-α和IL-6的产生以及NF-κB 和ERK1/2的活化。
T27714	KB-141	Others	Others
	KB-141 is an agonist of thyroid hormone receptor.
T34870	Thyroxamine L-Thyroxamine	Others	Others
	Thyroxamine is a major hormone from the thyroid gland.
T1669L	Liothyronine HCl Triiodothyronine,L-T3,NSC 80203,Liothyronine,Liotironina,L-Liothyronine	Others	Others
	Liothyronine is a T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine.
T29011	Triiodothyronine Sulfate	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Triiodothyronine sulfate 是一种甲状腺激素三碘甲状腺原氨酸的主要代谢物，是一种甲状腺激素，与 β1 甲状腺激素受体结合并激活其特性。
T19571	T3-ATA (S-isomer)	Others	Others
	T3-ATA S-isomer, the S-isomer of T3-ATA, represents the active form of the thyroid hormone.
T80985	Thyrotropin Pretiron,TSH
	Thyrotropin (TSH)为促甲状腺激素，由垂体前叶的促甲状腺细胞分泌，主要功能是调节甲状腺的内分泌活动。
T79089	THR-β modulator-1	Others	Others
	THR-β modulator-1（compound 1a）是高效的甲状腺激素受体β（THR-β）调节剂，适用于甲状腺激素受体相关疾病的研究。
T19572	T4-ATA (S-isomer)	Others	Others
	T4-ATA S-isomer, the active form of the thyroid hormone, represents the S-isomer of T4-ATA.
T60771	Metamizol	Others	Others
	Metamizol (Methamizole) 阻止甲状腺产生甲状腺激素，是一种抗甲状腺药物。然而，Metamizol 具有肝毒性的副作用。
T11376	GC 14	Others	Others
	GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.
T11954	MB-07344	Others	Others
	MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM.
TP1027	Calcitonin, eel TFA (57014-02-5 free base) Thyrocalcitonin eel (TFA),Calcitonin, eel TFA
	Calcitonin,eel TFA is a thyroid hormone polypeptide that can regulate calcium homeostasis and is widely used in the study of postmenopausal osteoporosis.
T10103	3,3'-Diiodo-L-thyronine 3,3'-T2	Others	Others
	3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. It significantly enhances COX activity.
T16756	Risarestat CT 112	Reductase	Endocrinology/Hormones; Metabolism
	Risarestat (CT-112)是一种有效的醛糖还原酶抑制剂和甲状腺激素受体（TR）拮抗剂，可用于治疗低血糖症。
T19511	PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	Others	Others
	PGlu-3-methyl-His-Pro-NH2 TFA, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.
T63876	TRβ agonist 1	Others	Others
	TRβ agonist 1 为一种选择性且对突变敏感的甲状腺激素受体 β (TRβ) 激动剂，其EC50值为21 nM。该化合物适用于血脂异常、非酒精性脂肪性肝炎 (NASH) 与甲状腺激素抵抗 (RTH) 研究。
T35999	3,5-Diiodothyroacetic Acid	Others	Others
	3,5-Diiodothyroacetic acid 是一种甲状腺激素类似物，研究发现能降低胆固醇浓度，可用于甲状腺功能减退症的研究。
T15670	KT5823	Apoptosis; PKA	Apoptosis; Tyrosine Kinase/Adaptors
	KT5823 是一种具有选择性和有效性的 cGMP 依赖性蛋白激酶 (PKG) 抑制剂，对 PKA 和 PKG 有抑制作用。KT5823 在甲状腺细胞中通过调节碘化钠交感蛋白的表达和活性来增加甲状腺刺激激素诱导的 (Na+/I- symporter) NIS 表达和碘离子摄取。 KT5823 诱导细胞凋亡。
T78372	Calcitonin, eel TFA Thyrocalcitonin eel TFA
	Calcitonin, eel TFA，一种甲状腺激素多肽，调节钙稳态，主要应用于绝经后骨质疏松症研究。
T11954L	MB-07344 sodium	Others	Others
	MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM.
TP1302	Somatostatin
	Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and
T64268	Liothyronine sodium hydrate	Others	Others
	Liothyronine sodium hydrate 是一种有效的甲状腺激素。Liothyronine sodium hydrate 也是一种 TRα 和 TRβ 的有效激动剂，能够作用于 hTRα (IC50: 2.33 nM) 和 hTRβ (IC50: 2.33 nM)。
TP1677	Calcitonin (8-32), salmon
	Calcitonin (8-32), salmon is a highly selective amylin receptor antagonist.Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid g
T35839	3-Iodothyronamine (hydrochloride)	Others	Others
	3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output. It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-...
T62570	THR-β agonist 1	Others	Others
	THRβ Agonist 1 是一种有效的、选择性的THRβ激动剂。其中甲状腺激素受体介导甲状腺激素的生理活性，在机体正常生长发育和维持代谢平衡中发挥着关键作用。THRβ Agonist 1 具有潜力进行甲状腺激素受体相关疾病的研究。
T74785	THR-β agonist 6	Others	Others
	THR-β agonist 6 是一种口服活性的选择性甲状腺激素受体 β（THR-β）激动剂，其对THR-β和THR-α的EC50值分别为0.03 μM和0.22 μM，展示出93:1显著的肝血清比，在小鼠中证明其优异性。此化合物在非酒精性脂肪性肝炎（NASH）研究中显示出潜在应用价值。
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride	Others	Others
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...

化合物

Cat.No: T12073

Target: TSH Receptor

Cat.No: T5360

Synonym: 伊罗替罗,KB2115

Target: Thyroid hormone receptor(THR)

Cat.No: T40548

Target: Thyroid hormone receptor(THR)

Cat.No: T1604

Synonym: 3,3',5-Triiodothyroacetic acid,替拉曲可

Target: Thyroid hormone receptor(THR)

Cat.No: T12192

Target: Others, TSH Receptor

Cat.No: T3595

Synonym: VIA-3196,MGL3196

Target: Thyroid hormone receptor(THR)

Cat.No: T5383

Synonym: NCGC00379308

Target: TSH Receptor

Taltirelin acetate

Cat.No: T13072

Synonym: TA-0910 acetate

Target: Thyroid hormone receptor(THR)

Liothyronine sodium

Cat.No: T1669

Synonym: 3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,三碘代甲状腺素钠盐,Sodium L-3,3',5-triiodothyronine,Cytomel

Target: Thyroid hormone receptor(THR)

3,5-Diiodothyropropionic acid

Cat.No: T13492

Synonym: C082182,Ditpa cpd,3,5-二碘甲腺丙酸

Target: Thyroid hormone receptor(THR)

Cat.No: T5313

Synonym: IACS-010759,QRX-431

Target: Thyroid hormone receptor(THR)

Protirelin Acetate

Cat.No: TP1022

Synonym: TSH-RF Acetate,TRH Acetate,TRF Acetate,醋酸普罗瑞林

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T7578

Synonym: 碘塞罗宁,3,3',5'-triiodo-L-thyronine

Target: Thyroid hormone receptor(THR)

L-Thyroxine sodium

Cat.No: T22355

Synonym: 左旋甲状腺素钠,LT4 sodium,Levothyroxine sodium,L-T4 sodium

Target: Thyroid hormone receptor(THR)

Cat.No: T7590

Synonym: TA-0910,他替瑞林

Target: Thyroid hormone receptor(THR)

L-Thyroxine sodium salt pentahydrate

Cat.No: T15699

Synonym: 左旋甲状腺素钠五水合物,Sodium levothyroxine pentahydrate,Levothyroxine,L-甲状腺素钠五水合物

Target: Thyroid hormone receptor(THR)

TR antagonist 1

Cat.No: T13435

Target: Thyroid hormone receptor(THR)

Cat.No: T16403

Synonym: Org-41841

Target: TSH Receptor

Cat.No: T23673

Synonym: AH3960

Target: Thyroid hormone receptor(THR)

2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE

Cat.No: T8672

Synonym: BisOPP-A,双酚0PPA

Target: Thyroid hormone receptor(THR)

Thyrotropin-Releasing Hormone (TRH), Free Acid

Cat.No: T7407

Synonym: TRH-OH

Target: Others

Calcitonin eel acetate

Cat.No: TP1028L

Synonym: Calcitonin eel acetate (57014-02-5 Free base),降钙素,Thyrocalcitonin eel

Target: Others

Methylthiouracil

Cat.No: T0304

Synonym: 甲基硫脲嘧啶,甲硫氧嘧啶,NSC-193526,NSC-9378,MTU

Target: ERK, Antiviral, TNF, NF-κB, Interleukin

Cat.No: T27714

Target: Others

Cat.No: T34870

Synonym: L-Thyroxamine

Target: Others

Liothyronine HCl

Cat.No: T1669L

Synonym: Triiodothyronine,L-T3,NSC 80203,Liothyronine,Liotironina,L-Liothyronine

Target: Others

Triiodothyronine Sulfate

Cat.No: T29011

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

T3-ATA (S-isomer)

Cat.No: T19571

Target: Others

Cat.No: T80985

Synonym: Pretiron,TSH

THR-β modulator-1

Cat.No: T79089

Target: Others

T4-ATA (S-isomer)

Cat.No: T19572

Target: Others

Cat.No: T60771

Target: Others

Cat.No: T11376

Target: Others

Cat.No: T11954

Target: Others

Calcitonin, eel TFA (57014-02-5 free base)

Cat.No: TP1027

Synonym: Thyrocalcitonin eel (TFA),Calcitonin, eel TFA

3,3'-Diiodo-L-thyronine

Cat.No: T10103

Synonym: 3,3'-T2

Target: Others

Cat.No: T16756

Synonym: CT 112

Target: Reductase

PGlu-3-methyl-His-Pro-NH2 TFA

Cat.No: T19511

Synonym: A-42872 TFA

Target: Others

Cat.No: T63876

Target: Others

3,5-Diiodothyroacetic Acid

Cat.No: T35999

Target: Others

Cat.No: T15670

Target: Apoptosis, PKA

Calcitonin, eel TFA

Cat.No: T78372

Synonym: Thyrocalcitonin eel TFA

MB-07344 sodium

Cat.No: T11954L

Target: Others

Cat.No: TP1302

Liothyronine sodium hydrate

Cat.No: T64268

Target: Others

Calcitonin (8-32), salmon

Cat.No: TP1677

3-Iodothyronamine (hydrochloride)

Cat.No: T35839

Target: Others

THR-β agonist 1

Cat.No: T62570

Target: Others

THR-β agonist 6

Cat.No: T74785

Target: Others

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6956	Protirelin Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,普罗瑞林,TRF	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Protirelin (Thyroliberin) 是高度保守的神经肽，具有促甲状腺激素水平的激素控制作用，及神经调节功能。
T1653	Liothyronine Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,碘噻罗宁,Triiodothyronine,三碘甲状腺原氨酸,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Liothyronine (Tresitope) 是一种人工合成的甲状腺激素，能够激活 β1 甲状腺激素受体 (TRβ1)。Liothyronine 能促进糖、蛋白质和脂肪三大物质的代谢，加速组织细胞的氧化过程，维持正常的基础代谢率，有利于机体的生长发育。
T5568	H-Tyr(3-I)-OH 3-碘-L-酪氨酸,3-Iodo-L-tyrosine	Endogenous Metabolite	Metabolism
	H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) 是酪氨酸羟化酶抑制剂和甲状腺激素的中间体。
T0864	L-Thyroxine Levothyroxine,NSC 36397,L-甲状腺素,T4	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	L-Thyroxine (NSC 36397) 是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。在 DIO 酶作用下，L-Thyroxine (NSC 36397) 转化成具有生物特性的三碘甲状腺氨酸(T3)。
T16442	PCO371 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) 是口服具有活性的甲状旁腺激素受体 1 的完全激动剂，对 PTHR2 无作用
T3665	Tectoridin 射干苷,Shekanin	Estrogen Receptor/ERR; Reductase	Endocrinology/Hormones; Metabolism
	Tectoridin (Shekanin) 是分离自 Maackia amurensis 中的异黄酮，是一种植物雌激素，能够激活雌激素和甲状腺激素受体。它通过 ER 依赖性基因组途径和 GPR30 依赖性非基因组途径发挥雌激素作用。

天然产物

Cat.No: T6956

Synonym: Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,普罗瑞林,TRF

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T1653

Synonym: Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,碘噻罗宁,Triiodothyronine,三碘甲状腺原氨酸,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T5568

Synonym: 3-碘-L-酪氨酸,3-Iodo-L-tyrosine

Target: Endogenous Metabolite

Cat.No: T0864

Synonym: Levothyroxine,NSC 36397,L-甲状腺素,T4

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T16442

Synonym: 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-

Target: Thyroid hormone receptor(THR)

Cat.No: T3665

Synonym: 射干苷,Shekanin

Target: Estrogen Receptor/ERR, Reductase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04127	CIp4 Protein, Human, Recombinant (His) CIP4,thyroid hormone receptor interactor 1...	Human	Baculovirus Insect Cells
	CIp4 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 64 kDa and the accession number is Q15642-2.
TMPY-06821	THRB Protein, Human, Recombinant (His) THRB1,GRTH,THR1,ERBA2,C-ERBA-2,THRB2,thyroid ho...	Human	E. coli
	Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present...
TMPH-03386	TSHB Protein, Rat, Recombinant (E. coli, His & Myc) Thyrotropin beta chain,Tshb,Thyrotropin subunit beta,Thy...	Rat	E. coli
	Indispensable for the control of thyroid structure and metabolism. TSHB Protein, Rat, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 19.9 kDa and the accession number is P04652.
TMPH-03387	TSHB Protein, Rat, Recombinant (His & Myc) Thyrotropin subunit beta,Thyroid-stimulating ho...	Rat	P. pastoris (Yeast)
	Indispensable for the control of thyroid structure and metabolism. TSHB Protein, Rat, Recombinant (His & Myc) is expressed in yeast with N-6xHis and C-Myc tag. The predicted molecular weight is 16.4 kDa and the accession number is P04652.
TMPH-02204	THRB Protein, Human, Recombinant (His & SUMO) c-erbA-beta,THRB,Thyroid hormone receptor ...	Human	E. coli
	Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
TMPH-00488	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) Follicle-stimulating hormone alpha chain,Glycoprote...	Canine	P. pastoris (Yeast)
	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) is expressed in Yeast.
TMPH-00489	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc) Follitropin alpha chain,CGA,Luteinizing hormone alp...	Canine	E. coli
	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02203	THRA Protein, Human, Recombinant (His) c-erbA-1,c-erbA-alpha,THRA,Thyroid hormone...	Human	E. coli
	Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. THRA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.9 kDa and the accession number is P10827.
TMPH-03370	Serpin A3K Protein, Rat, Recombinant (His & Myc) GHR-P63,Thyroid hormone-regulated protein,...	Rat	E. coli
	Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. Serpin A3K Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 52.0 kDa and the accession number is P05545.
TMPH-01648	MED1 Protein, Human, Recombinant (His & SUMO) Activator-recruited cofactor 205 kDa component,Mediator comp...	Human	E. coli
	MED1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.2 kDa and the accession number is Q15648.
TMPY-04853	TSHR Protein, Human, Recombinant (His) TSHR,hTSHR-I,TSH Receptor,LGR3,CHNG1	Human	Baculovirus Insect Cells
	Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.
TMPY-02779	Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His) thyroid peroxidase,MSA,TPX,TDH2A	Human	Baculovirus Insect Cells
	Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. It used to be taken as the formerly so-called `microsomal antigen` several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two i...
TMPH-02685	GPHB5 Protein, Mouse, Recombinant (His & Myc) Glycoprotein hormone beta-5,Thyrostimulin subunit b...	Mouse	E. coli
	Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
TMPH-02684	GPHB5 Protein, Mouse, Recombinant (His) Thyrostimulin subunit beta,Glycoprotein hormone bet...	Mouse	P. pastoris (Yeast)
	Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. GPHB5 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 13.3 kDa and the accession number is Q812B2.
TMPH-02947	Transthyretin Protein, Mouse, Recombinant Prealbumin,Transthyretin,Ttr	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.5 kDa and the accession number is P07309.
TMPH-02242	Transthyretin Protein, Human, Recombinant (hFc & Myc) TTR,ATTR,Transthyretin,Prealbumin,TBPA	Human	HEK293 Cells
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
TMPH-03262	Cathepsin K Protein, Rat, Recombinant (His) CTSO,CTSO2,Cathepsin O2,Cathepsin X,Cathepsin O,CTSK,Catheps...	Rat	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
TMPK-00874	Thyroid Peroxidase Protein, Mouse, Recombinant (His) MK-CSF,MGDF,ML,MPLLG,THPO,TPOMKCSF,Thrombopoietin,MKCSF,MGDF...	Mouse	HEK293 Cells
	Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune t...
TMPH-02946	Transthyretin Protein, Mouse, Recombinant (His & SUMO) Transthyretin,Prealbumin,Ttr	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.6 kDa and the accession number is P07309.
TMPH-02565	Cathepsin K Protein, Mouse, Recombinant (His) Cathepsin O,Cathepsin K,CTSK,Cathepsin O2,CTSO2,Cathepsin X,...	Mouse	E. coli
	Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Cathepsin K Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.4 kDa and the accession number is P...
TMPH-01061	Cathepsin K Protein, Human, Recombinant (His) CTSO2,Cathepsin X,Cathepsin O2,CTSK,Cathepsin O,Cathepsin K,...	Human	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Cathepsin K Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The pre...
TMPH-03385	Thyroglobulin Protein, Rat, Recombinant (His & SUMO) Tg,Thyroglobulin	Rat	E. coli
	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. Thyroglobulin Protein, Rat, Recombin...
TMPJ-00705	BCAS2 Protein, Human, Recombinant (His, T7) BCAS2,DNA Amplified in Mammary Carcinoma 1 Protein,Pre-mRNA-...	Human	E. coli
	Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator ...
TMPY-00186	GHRH Protein, Human, Recombinant (hFc) GRF,INN,growth hormone releasing hormone,G...	Human	HEK293 Cells
	The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of gamma-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. GHRH may pl...
TMPY-04445	PDK4 Protein, Mouse, Recombinant (His & GST) AV005916,pyruvate dehydrogenase kinase 4	Mouse	Baculovirus Insect Cells
	Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxida...
TMPY-01617	SULT1B1 Protein, Human, Recombinant (His) sulfotransferase family, cytosolic, 1B, member 1,SULT1B2,ST1...	Human	E. coli
	Sulfotransferase family cytosolic 1B member 1, also known as Sulfotransferase 1B1, Sulfotransferase 1B2, Thyroid hormone sulfotransferase, SULT1B1 and ST1B2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver, perip...
TMPH-02221	TRIM24 Protein, Human, Recombinant (His & SUMO) Transcription intermediary factor 1-alpha,E3 ubiquitin-prote...	Human	E. coli
	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apopt...
TMPY-02883	C1D Protein, Human, Recombinant (GST) SUNCOR,Rrp47,SUN-CoR,hC1D,C1D nuclear receptor corepressor,L...	Human	E. coli
	C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid hormone receptor. It is thought that C1D nuclear receptor corepressor regulates TRAX/Translin complex formation. It is expressed in kidney, heart, brain, spleen, lung, testis, liver and small intestine. It plays a role in the recruitment of the RNA exosome complex to pre-rRNA to m...

重组蛋白

CIp4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04127

Species: Human

Expression System: Baculovirus Insect Cells

THRB Protein, Human, Recombinant (His)

Cat.No: TMPY-06821

Species: Human

Expression System: E. coli

TSHB Protein, Rat, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03386

Species: Rat

Expression System: E. coli

TSHB Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03387

Species: Rat

Expression System: P. pastoris (Yeast)

THRB Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02204

Species: Human

Expression System: E. coli

Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His)

Cat.No: TMPH-00488

Species: Canine

Expression System: P. pastoris (Yeast)

Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc)

Cat.No: TMPH-00489

Species: Canine

Expression System: E. coli

THRA Protein, Human, Recombinant (His)

Cat.No: TMPH-02203

Species: Human

Expression System: E. coli

Serpin A3K Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03370

Species: Rat

Expression System: E. coli

MED1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01648

Species: Human

Expression System: E. coli

TSHR Protein, Human, Recombinant (His)

Cat.No: TMPY-04853

Species: Human

Expression System: Baculovirus Insect Cells

Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His)

Cat.No: TMPY-02779

Species: Human

Expression System: Baculovirus Insect Cells

GPHB5 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02685

Species: Mouse

Expression System: E. coli

GPHB5 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02684

Species: Mouse

Expression System: P. pastoris (Yeast)

Transthyretin Protein, Mouse, Recombinant

Cat.No: TMPH-02947

Species: Mouse

Expression System: E. coli

Transthyretin Protein, Human, Recombinant (hFc & Myc)

Cat.No: TMPH-02242

Species: Human

Expression System: HEK293 Cells

Cathepsin K Protein, Rat, Recombinant (His)

Cat.No: TMPH-03262

Species: Rat

Expression System: E. coli

Thyroid Peroxidase Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00874

Species: Mouse

Expression System: HEK293 Cells

Transthyretin Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02946

Species: Mouse

Expression System: E. coli

Cathepsin K Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02565

Species: Mouse

Expression System: E. coli

Cathepsin K Protein, Human, Recombinant (His)

Cat.No: TMPH-01061

Species: Human

Expression System: E. coli

Thyroglobulin Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03385

Species: Rat

Expression System: E. coli

BCAS2 Protein, Human, Recombinant (His, T7)

Cat.No: TMPJ-00705

Species: Human

Expression System: E. coli

GHRH Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00186

Species: Human

Expression System: HEK293 Cells

PDK4 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04445

Species: Mouse

Expression System: Baculovirus Insect Cells

SULT1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01617

Species: Human

Expression System: E. coli

TRIM24 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02221

Species: Human

Expression System: E. coli

C1D Protein, Human, Recombinant (GST)

Cat.No: TMPY-02883

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T36383	L-Thyroxine-13C9,15N L-Thyroxine-13C9,15N
	L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse mode...
TMID-0104	L-Thyroxine-13C6
	L-Thyroxine-13C6 是 L-Thyroxine 的 13C 的标记化合物。L-Thyroxine 的 CAS 号为 51-48-9。L-Thyroxine (T4)是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。在DIO 酶作用下， L-Thyroxine (T4)转化成具有生物特性的三碘甲状腺氨酸 (T3)。

同位素标记化合物

L-Thyroxine-13C9,15N

Cat.No: T36383

Synonym: L-Thyroxine-13C9,15N

L-Thyroxine-13C6

Cat.No: TMID-0104

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