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Search Results for " thickness "

Targets Recommended: AChR

10

抑制剂 & 化合物

1

天然产物

5

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8383	Cyclopentolate Hydrochloride	AChR	Neuroscience
	Cyclopentolate Hydrochloride 是一种阿托品样毒蕈碱受体拮抗剂，是眼科常用的抗毒蕈碱剂，对睫状肌毒蕈碱受体的 pKB 值为 7.8。
T38776	LP-922056	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	LP-922056 是 Notum Pectinacetylesterase 的抑制剂，对人和小鼠的 EC50 值分别为 21 nM 和 55 nM。
TP2490	Palmitoyl Hexapeptide-12 Acetate Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)	Others	Others
	Palmitoyl Hexapeptide-12 Acetate (Palmitoyl Hexapeptide-12 Acetate (171263-26-6 Free base)) 可以促进胶原蛋白、弹性蛋白和透明质酸的增殖。可用于改善皮肤含水量，增加真皮层厚度，减少细纹。
TP2497	Myristoyl Tetrapeptide-12 Acetate 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)	Others	Others
	Myristoyl Tetrapeptide-12 Acetate (Myristoyl Tetrapeptide-12 Acetate (959610-24-3 Free base)) 是肉豆蔻酸和 Tetrapeptide-12 的反应产物，是一种刺激头发和睫毛生长并增强睫毛和/或眉毛外观的肽。 Myristoyl tetrapeptide-12 可以增加角质形成细胞的增殖，改善外观、紧致弹性和皮肤厚度。
T40908	KLD-12
	KLD-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (BMSCs). Moreover, KLD-12 hydrogel can effectively fill full-thickness osteochondral defects in their original location, leading to improved cartilage repair.
T37983	GM 1489	Others	Others
	GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor...
T76895	Abicipar pegol
	Abicipar pegol (AGN-150998, MP0112) 是一种抗VEGFDARPin 分子，DARPin 分子是一类新型的小蛋白，含有工程化的 ankyrin 重复结构域，以高特异性和亲和力与靶蛋白结合。Abicipar pegol 可有效抑制血管生成和血管通透性，通过玻璃体内注射，降低平均视网膜厚度和渗漏面积，用于眼部炎症等相关疾病研究。
T68182	3-Hydroxykynurenamine	Others	Others
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...
T83744	Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17是一种环状肽，属于tigerinin-RC1和tigerinin-RC2的衍生物，这两种化合物是在螃蟹吃蛙（F. cancrivora）皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时，Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖，并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外，Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中，局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。
T83721	Hexafluoropropylene Oxide Dimer Acid FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA	Others	Others
	Hexafluoropropylene oxide dimer acid (HFPO-DA)作为一种全氟烷基醚羧酸(PFECA)，于HepG2细胞中以250 µM的浓度使用时，可诱导凋亡并增加活性氧种类(ROS)的水平。HFPO-DA以每个蛋4 mg/kg的剂量，会减少孵化鸡右心室壁厚度，增加心率，并诱导肝脏脂肪积累，这些效应可通过敲除过氧化物酶体增殖物激活受体α(Ppara)基因编码实现预防。它减少了斑马鱼胚胎的存活百分比(LC50 = 7,651 mg/L)。在孕妇大鼠给药下，HFPO-DA（250 mg/kg）降低了新生大鼠的平均出生体重、存活时间和血清葡萄糖水平，并增加了血清胆固醇和甘油三酯水平。它已经被发现污染海水和河水。

化合物

Cyclopentolate Hydrochloride

Cat.No: T8383

Target: AChR

Cat.No: T38776

Target: Wnt/beta-catenin

Palmitoyl Hexapeptide-12 Acetate

Cat.No: TP2490

Synonym: Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)

Target: Others

Myristoyl Tetrapeptide-12 Acetate

Cat.No: TP2497

Synonym: 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)

Target: Others

Cat.No: T40908

Cat.No: T37983

Target: Others

Cat.No: T76895

3-Hydroxykynurenamine

Cat.No: T68182

Target: Others

Cat.No: T83744

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

Hexafluoropropylene Oxide Dimer Acid

Cat.No: T83721

Synonym: FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0875	Acetylcysteine N-Acetylcysteine,乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,N-Acetyl Cysteine,易咳净	Apoptosis; TNF; Ferroptosis; Influenza Virus; Reactive Oxygen Species; ROS; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Acetylcysteine (NAC) 是半胱氨酸的 N-乙酰衍生物，是一种 ROS 抑制剂和粘液溶解剂。Acetylcysteine 可诱导细胞凋亡，可用于减少粘液的厚度，还具有抗流感病毒活性。

天然产物

Cat.No: T0875

Synonym: N-Acetylcysteine,乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,N-Acetyl Cysteine,易咳净

Target: Apoptosis, TNF, Ferroptosis, Influenza Virus, Reactive Oxygen Species, ROS, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00754	Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST) Gene product D,Auxiliary protein D,Major capsid protein D,gp...	Escherichia phage lambda	E. coli
	Stabilizes the expansion of the capsid head shell after genome packaging. The packaging of viral genome in the procapsid triggers a dramatic reconfiguration of the capsid shell, expanding from roughly 50nm to 60nm while the capsid thickness decreases. 415 capsid decoration protein molecules cooperatively bind the expanded capsid, thereby stabilizing the mature capsid shell. Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST) is expressed in E. coli expression system with N-GST...
TMPJ-00079	IL-11 Protein, Mouse, Recombinant (hFc) IL-11,Il11,白细胞介素,白介素,Interleukin-11	Mouse	HEK293 Cells
	Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cellproliferation and differentiation and could be use as a therapeutic for osteoporosis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thicknes...
TMPK-00368	MMP-9 Protein, Human, Recombinant (His & Avi), Biotinylated Gelatinase B,MMP-9,MANDP2,CLG4B,GELB	Human	HEK293 Cells
	Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Human, Recombina...
TMPK-00503	MMP-9 Protein, Cynomolgus, Recombinant (His) MMP-9,CLG4B,Gelatinase B,MANDP2,GELB	Cynomolgus	HEK293 Cells
	Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Cynomolgus, Reco...
TMPK-00367	MMP-9 Protein, Human, Recombinant (His & Avi) MANDP2,CLG4B,Gelatinase B,GELB,MMP-9	Human	HEK293 Cells
	Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Human, Recombina...

重组蛋白

Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST)

Cat.No: TMPH-00754

Species: Escherichia phage lambda

Expression System: E. coli

IL-11 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00079

Species: Mouse

Expression System: HEK293 Cells

MMP-9 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00368

Species: Human

Expression System: HEK293 Cells

MMP-9 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00503

Species: Cynomolgus

Expression System: HEK293 Cells

MMP-9 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00367

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...

同位素标记化合物

Cat.No: T69600

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