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Search Results for " skin infection "

Targets Recommended: Antibiotic Antifungal

7

抑制剂 & 化合物

2

天然产物

1

化合物库

6

重组蛋白

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Cat. No.	Product Name
L7600	趋化因子抑制剂库		59 compounds
	59 种趋化因子或其受体抑制剂的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

趋化因子抑制剂库

Cat.No: L7600

Compounds: 59

Cat. No.	Product Name	Target	Signaling Pathways
T2411	Luliconazole NND 502,卢立康唑	Antibiotic; Antifungal	Microbiology/Virology
	Luliconazole (NND 502) 是一种咪唑类抗生素，具有广谱抗真菌活性。它可研究皮肤感染。
T27710	K6PC-5 K6PC5,K6PC 5	S1P Receptor	GPCR/G Protein
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.
T15095	Dehydroemetine	Others; Parasite	Microbiology/Virology; Others
	Dehydroemetine 是一种有效的抗原虫剂，是二盐酸艾美汀的合成类似物，可用于预防和治疗阿米巴感染和疾病，具有治疗伴有皮肤损伤的利什曼原虫感染和耐甲硝唑阿米巴病的作用。
T0134L	Imiquimod 2HCl Imiquimod 2HCl(99011-02-6 Free base)	Antiviral; TLR	Immunology/Inflammation
	Imiquimod 2HCl 是一种 toll 样受体7 (TLR7) 激动剂，也是一种免疫调节剂，具有抗病毒和抗肿瘤活性。Imiquimod 2HCl可用于构建银屑病样小鼠模型，可以用于研究眼周皮肤癌、天疱疮叶状疱疮和 COVID-19 感染。
T15734	Lenampicillin hydrochloride 盐酸仑氨苄西林,KBT 1585 hydrochloride	Antibacterial	Microbiology/Virology
	Lenampicillin hydrochloride is an orally active prodrug of Ampicillin. Lenampicillin hydrochloride is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins. It is applied in the investigation of suppurative skin
T71860	Ambuic acid	Others	Others
	Ambuic acid is a cyclohexanone that has phytopathogenic antifungal, quorum sensing inhibitory, and antibacterial activities. Ambuic acid inhibits the biosynthesis of cyclic peptides involved in quorum sensing, including gelatinase biosynthesis-activating pheromone (GBAP) in E. faecalis, autoinducing peptide I (AIP-I) in S. aureus, and LsrD698 and LsrD826 in L. innocua. It suppresses abcess formation in a mouse model of skin infection induced by methicillin-resistant S. aureus (MRSA) when adminis...
T64692	AMY-101 acetate
	Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses[3]. In C3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. This suggests that the complement system and its component C3 contribute...

化合物

Cat.No: T2411

Synonym: NND 502,卢立康唑

Target: Antibiotic, Antifungal

Cat.No: T27710

Synonym: K6PC5,K6PC 5

Target: S1P Receptor

Cat.No: T15095

Target: Others, Parasite

Cat.No: T0134L

Synonym: Imiquimod 2HCl(99011-02-6 Free base)

Target: Antiviral, TLR

Lenampicillin hydrochloride

Cat.No: T15734

Synonym: 盐酸仑氨苄西林,KBT 1585 hydrochloride

Target: Antibacterial

Cat.No: T71860

Target: Others

AMY-101 acetate

Cat.No: T64692

Cat. No.	Product Name	Target	Signaling Pathways
T0729	Benzyl benzoate Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester	Parasite	Microbiology/Virology
	Benzyl benzoate (Benzoic acid benzyl ester) 是化妆品中的香料成分，可研究疥疮和蠕形螨相关的炎症性皮肤病。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。

天然产物

Benzyl benzoate

Cat.No: T0729

Synonym: Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester

Target: Parasite

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06802	HSV 2 (strain 333) Glycoprotein D/gD Protein (His)	HSV2	HEK293 Cells
	Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. Herpes simplex virus type 2–associated neurological disease may result from primary infection or reactivation of latent HSV-2. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immun...
TMPH-01575	KRT10 Protein, Human, Recombinant (His) Keratin, type I cytoskeletal 10,Keratin-10,Cytokeratin-10,KR...	Human	E. coli
	Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occu...
TMPK-00668	IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His) NILR,IL-21 receptor,IL-21R,CD360	Cynomolgus	HEK293 Cells
	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker i...
TMPY-01909	Elafin Protein, Human, Recombinant (His) WAP3,ESI,peptidase inhibitor 3,SKALP,cementoin,MGC13613,WFDC...	Human	HEK293 Cells
	Elafin, also known as Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, PI3, WAP3 and WFDC14, is a secreted protein that contains one WAP domain. Elafin / PI3 consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain at the N-terminus serves as an anchor to localize elafin covalently to specific si...
TMPY-01953	CALML5 Protein, Human, Recombinant (His & GST) calmodulin like 5,CLSP	Human	E. coli
	Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily a...
TMPJ-01337	IL-21R Protein, Mouse, Recombinant (aa 20-236, His) Nilr,IL-21R,Interleukin-21 receptor,IL-21 receptor,Il21r	Mouse	HEK293 Cells
	Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells, and keratinocytes. Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture. B cell IL-21 R engagement i...

重组蛋白

HSV 2 (strain 333) Glycoprotein D/gD Protein (His)

Cat.No: TMPY-06802

Species: HSV2

Expression System: HEK293 Cells

KRT10 Protein, Human, Recombinant (His)

Cat.No: TMPH-01575

Species: Human

Expression System: E. coli

IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His)

Cat.No: TMPK-00668

Species: Cynomolgus

Expression System: HEK293 Cells

Elafin Protein, Human, Recombinant (His)

Cat.No: TMPY-01909

Species: Human

Expression System: HEK293 Cells

CALML5 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01953

Species: Human

Expression System: E. coli

IL-21R Protein, Mouse, Recombinant (aa 20-236, His)

Cat.No: TMPJ-01337

Species: Mouse

Expression System: HEK293 Cells

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