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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9263 |
cim0216
N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
CIM0216 是选择性的TRPM3激动剂,对 TRPM3 的选择性高于 TRPM1、TRPM2 和 TRPM4-8。它以TRPM3依赖性的方式引起疼痛并唤起感觉神经末梢的神经肽释放,可用于神经源性炎症的相关研究。 | |||
T13830 |
Propoxycaine hydrochloride
Propoxycaine HCl |
Sodium Channel | Membrane transporter/Ion channel |
Propoxycaine hydrochloride 是一种酯类局部麻醉剂,抑制电压门控的钠通道,可调节神经冲动,可诱导感觉丧失。Propoxycaine hydrochloride 可调节SPMVs脂质双层的流动。 | |||
T16723 |
Ranirestat
AS3201,SX3030,SX-3030,AS 3201,AS-3201 |
Reductase | Endocrinology/Hormones; Metabolism |
Ranirestat (AS-3201) 是一种具有口服活性和高效性的醛糖还原酶 (AR) 抑制剂,具有神经保护作用,可改善晚期糖尿病多发性神经病大鼠的周围神经功能障碍。Ranirestat 抑制高葡萄糖暴露内皮细胞的炎症反应,可用于研究糖尿病感觉运动性多发性神经病。 | |||
T1092 |
Zolmitriptan
佐米曲普坦,311C90,BW-311C90 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂,可用于偏头痛的研究,对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。 | |||
T6602 |
Naratriptan hydrochloride
Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂,有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用,从而减少促炎神经肽的释放。 | |||
T71559 |
Melanotan II acetate
|
Others | Others |
Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases in sensory nerve conduction velocity. Melanotan II acetate increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol. | |||
T35461 |
δ14-Triamcinolone acetonide
|
Others | Others |
δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a ... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00100 |
Artemin Protein, Human, Recombinant
ARTN,Artemin,EVN,Enovin,Neublastin |
Human | E. coli |
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I... |